| Document |
Document Title |
|
WO/2010/016551A1 |
A process for removing a dibenzofulvene-amine adduct, which comprises bringing a reaction mixture containing a dibenzofulvene-amine adduct into contact with carbon dioxide and then removing the formed carbonate of the dibenzofulvene -ami...
|
|
WO/2010/009630A1 |
Disclosed is a process for preparing chiral pharmaceutical intermediates of R-beta-amino phenylbutyric acid derivatives (I) and the pharmaceutically acceptable salts thereof, which affords the desired object compounds having specific opt...
|
|
WO/2010/007964A1 |
Disclosed is a method for producing a 6-aryloxyquinoline derivative which is useful as a pesticide or bactericide for agricultural and horticultural use. The method comprises a cyclization step wherein a quinolone derivative is obtained...
|
|
WO/2010/006954A1 |
The present invention relates to β-amino acid esters of Formula (2), and to a method for the preparation of β-amino acid esters of formula (2) by reduction of the corresponding enamines or amination of a β-keto ester followed by conde...
|
|
WO/2010/004220A2 |
The invention relates to a method for synthesising 9-aminononanoic acid or the esters thereof from natural unsaturated fatty acids, comprising at least one step of metathesis of the natural fatty acid and an oxidation step by oxidative c...
|
|
WO/2010/004219A2 |
The invention relates to a method for synthesising ω- amino-alkanoic acids or the esters thereof from mono-unsaturated natural fatty acids comprising at least one step of forming the unsaturated diacid corresponding to the original fatt...
|
|
WO/2010/000856A1 |
The present invention relates to a method for producing substituted aminobiphenylene, in particular 2-aminobiphenylene, and a method for producing (het)acrylic acid amides of such aminobiphenyenes, in particular 2-aminobiphenyene.
|
|
WO/2009/153889A1 |
A method of producing a purified optically active 4-amino-3-(substituted phenyl)butanoic acid compound characterized by involving the step of contacting a crude optically active 4-amino-3-(substituted phenyl)butanoic acid compound with a...
|
|
WO/2009/149928A1 |
Processes for making a diester compound of formula (B) and for converting it to pregabalin, especially via a compound of formula (2), can provide several advantages. The compound (B) can be converted to the compound (2) via reductive hyd...
|
|
WO/2009/147528A1 |
Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of pregabalin in high yield and purity. The present invention also provides a process for the purification of (S)-pregabalin.
|
|
WO/2009/147141A2 |
The invention relates to functionalised diols of diamondoids wherein one of the two hydroxy groups is masked by a protective group, and to methods for producing said functionalised diols. The protective group is a -CHR1R2 group, wherein ...
|
|
WO/2009/148046A1 |
A method of producing an optically active α-amino acid derivative comprising reacting an α-haloester derivative represented by general formula (1), which is obtained by converting an ester group into an optically active alcohol derivat...
|
|
WO/2009/147434A1 |
The present invention relates to a novel process for the preparation of γ-amino acids, such 5 as (±)-3-(aminomethyl)-5-methyl-hexanoic acid (1), which is a key intermediate in the preparation of the potent anticonvulsant pregabalin, (S...
|
|
WO/2009/138665A1 |
The invention relates to a method of enantioselective and diastereoselective synthesis of 6-fluoro-L-Dopa and the analogs thereof.
|
|
WO/2009/135843A1 |
A process for converting tryptophan into kynurenine. Theconversion of tryptophan into kynurenine is carried out by irradiating a substance comprising tryptophan with electromagnetic radiationcomprising waves withwavelength in the range o...
|
|
WO/2009/136249A1 |
The invention relates to an improved process for the preparation of Levothyroxine sodium with reduced levels of impurities. The invention also provides Levothyroxine sodium pentahydrate free from 3,5-Diiodothyronine or d-enantiomer of th...
|
|
WO/2009/133178A1 |
The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and esters thereof, 2‑(aminomethylidene)-4,4-difluoro-3-oxobutyric esters of the formula (I), where R1, R2 and R3 are ...
|
|
WO/2009/133789A1 |
By reacting a β-hydroxy-a-amino acid with sulphuryl fluoride (SO2F2) in the presence of an organic base, it is possible to produce an a-fluoro-β-amino acid represented by formula [2]. [2] By using a C8-12 tertiary amine having two or m...
|
|
WO/2009/127982A2 |
A method of synthesizing carboxylated amines is disclosed. The method comprises reacting a mixture of a potassium salt of either a primary or secondary amine with a potassium salt of a halogenated carboxylic acid wherein the halogenated ...
|
|
WO/2009/127446A1 |
Method for the preparation of p-hydroxyphenylglycine enriched with the D- enantiomer (D-HPG), using an asymmetric transformation of a (racemic) mixture of the enantiomers of p-hydroxyphenylglycine (HPG) with the aid of D-bromocamphorsulp...
|
|
WO/2009/125427A2 |
Disclosed herein is a process for the preparing (S)-3-(aminomethyl)-5- methylhexanoic acid by optical resolution of (±)-3-(aminomethyl)-5-methylhexanoic acid and a resolving agent employing a suitable solvent.
|
|
WO/2008/115149A9 |
A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting an α, β-unsaturated aldehyde with nitrosobenzene in the presence of a N...
|
|
WO/2009/122215A1 |
The present invention relates to a novel process of preparing an enantiomerically enriched γ-amino acid, such as enantiomerically enriched (S)-pregabalin.
|
|
WO/2009/116435A1 |
A fluorine-containing acylacetic acid derivative represented by general formula (3) is produced by adding a halogenating agent into a mixture which contains a base, a fluorine-containing alkylcarboxylic acid derivative and an acrylic aci...
|
|
WO/2009/114633A1 |
The present invention relates to a process for the preparation of (2S,3S)-3-amino-N- cyclopropyl-2-hydroxyalkanamides, and their use in the preparation of HCV inhibitors and cathepsin inhibitors.
|
|
WO/2009/109544A1 |
The present invention relates to a method for the production of aminodicarboxylic acid-N,N,diacetic acids of the general Formula I, wherein X independently of one another represents hydrogen or an alkali metal and n represents a number 1...
|
|
WO/2009/103822A1 |
The present invention concerns a process for the preparation of free flowing granules of low hygroscopicity of one or more methylglycine diacetic acid (MGDA) salts, of the formula wherein R = CH3 and M is hydrogen, alkali metal, alkaline...
|
|
WO/2009/098792A1 |
A novel high-performance material. In one aspect, there is provided a process for producing dimethyl 2,3-bis(N,N-bis(p-anisyl)4-aminophenylethynyl)fumarate, characterized in that dimethyl 2,3-bis(N,N-bis(p-anisyl)4-aminophenylethynyl)mal...
|
|
WO/2009/087674A2 |
The present invention provides a process for resolving racemic pregabalin to S-pregabalin by using a chiral acid to form a pregabalin salt, purifying the salt to obtain a purified S- pregabalin salt then neutralizing the salt to obtain S...
|
|
WO/2009/087650A2 |
A novel process of preparation of racemic pregabalin from comprising an intermediate of structure III comprising reductive ring opening to form a structure IV followed few alternative routes that yield racemic pregabalin that is resolved...
|
|
WO/2009/083134A1 |
The present invention relates to a method for the production of 2-fluoroacyl-3-amino-acrylic acid derivatives by reacting fluorinated carboxylic acids with dialkylaminoacrylic acid derivatives and acid halogenides.
|
|
WO/2009/082861A1 |
Disclosed is a new resolution process of (S)-3-aminomethyl-5-methylhexanoic acid, which process comprises the following steps: employing benzoyl-L-glutamic acid, p-methylbenzoyl-L-glutamic acid, benzenesulfonyl-L-glutamic acid or p-methy...
|
|
WO/2009/079861A1 |
Disclosed is a 'one-pot' method for preparing and separating iminodiacetic acid from hydroxyl acetonitrile. The method has such advantages as high yield, little waste discharge, and easy preparation and purification of the product.
|
|
WO/2009/081208A1 |
The present invention relates to a novel method for the preparation of racemic pregabalin (1) or a single enantiomer thereof, (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid (2).
|
|
WO/2009/078040A2 |
This invention deals with a novel class of diamino alkanoic acids having a straight chain of seven to eleven carbon atoms with two terminal amino groups and a -COOH group (attached to alpha carbon atom ) which are capable of effecting co...
|
|
WO/2009/078039A2 |
This invention deals with a novel straight chain compound, namely, 1,6-diamino alkanoic acid having a straight chain of six carbon atoms with two terminal amino groups and accompanying -COOH group, which is capable of effecting controlle...
|
|
WO/2009/078813A1 |
A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R1 - R3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R...
|
|
WO/2009/073947A1 |
The present invention relates to stable salts of β -alanine and an organic acid selected from the group consisting of malate, citrate and fumarate, endowed with enhanced nutritional and/or therapeutical efficacy in respect to their indi...
|
|
WO/2009/071630A2 |
The present invention discloses a method of producing an aqueous solution of partially deprotonated aminopolycarboxylic acid from a partially or fully deprotonated aminopolycarboxylic acid. Additionally it discloses such aqueous solution...
|
|
WO/2009/068967A1 |
The present invention is related to processes suitable for industrial synthesis of pregabalin from (i?)-(-)-3-(carbamoylmethyl)-5-methylhexanoic using sodium hypochlorite as described herein. In addition, the present invention is related...
|
|
WO/2009/065987A2 |
The invention relates to a method for the stereoselective preparation of amino acid derivatives, comprising a reaction involving the hydrogenation of a compound having formula (III), or alternatively the enantiomer thereof, in which R is...
|
|
WO/2009/062731A1 |
Betaines of formula R3N+-Q-COO- (I), wherein R is C1-4 alkyl and Q is C1-4 alkanediyl, optionally substituted with hydroxy, are prepared in one step by adding an ω-halocarboxylate of formula X-Q-COOR' (II), wherein Q is as defined above...
|
|
WO/2009/064476A1 |
Intermediate compounds in the synthesis of Sitagliptin, 3-amino-4-(2,4,5- trifluorophenyl)but-2-enoic acid alkyl ester, and amino protected-3-amino-4-(2,4,5- trifluorophenyl)but-2-enoic acid alkyl ester, and the stereoselective reduction...
|
|
WO/2009/060886A1 |
Disclosed is a novel selective reduction method which can selectively reduce a nitro compound containing an easily reducible group such as a nitrostyrene derivative to an amino compound containing an easily reducible group such as an ami...
|
|
WO/2009/059188A1 |
A method and composition for treating vitamin B12 deficiency in mammals that fail to respond to oral vitamin B12 therapy, including preparing a pharmaceutical composition for oral administration containing vitamin B12 and at least one su...
|
|
WO/2009/052341A1 |
The present invention relates the use of compounds having the general Formula I, wherein the definitions or R1 and R2 are provided in the specification. Said compounds of Formula I are useful for the synthesis of a variety of g-secretase...
|
|
WO/2009/050365A2 |
The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and the salts thereof. The invention is characterised in that it includes a step comprising the peptide coupling of 4 ...
|
|
WO/2009/047446A2 |
The invention relates to a method for converting ricinoleic acid, that comprises the following successive steps: a) fermentation of the ricinoleic acid with a bacterium, a yeast or a fungus in order to obtain 7-hydroxy-9-octadecenedioic-...
|
|
WO/2009/046309A2 |
The present invention provides 3- (aminomethyl)-5-methylhex-4-enoic acid (Pregabalin- 4-eliminate or PRG-4E) and 3- (aminomethyl)-5-methylhex-5-enoic acid (Pregabalin-5-eliminate or PRG-5E), and their uses as reference markers and standa...
|
|
WO/2009/044409A2 |
Present invention relates to a novel and improved process for the resolution of racemic pregabalin of formula (I) into (S)-(+)-pregabalin [(S)-(+)-3-aminomethyl-5-methylhexanoic acid] of formula (III) via the novel acid addition salt [(S...
|
