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WO/2020/004043A1 |
The present invention provides a method which uses an aniline derivative as a starting material, and which is capable of producing an α-azidoaniline derivative or an α, α'-diazide derivative. The present invention comprises a method f...
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WO/2019/243087A1 |
The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear o...
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WO/2019/232706A1 |
A method for preparing a pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting Compound (I) 3-isobutylglutaric acid, as a raw material, w...
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WO/2019/235493A1 |
The present invention provides a method by which a diaminobenzoic acid ester and a benzimidazole derivative are able to be produced more easily with use of lower cost materials. The present invention includes a method for producing a dia...
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WO/2019/233671A1 |
The invention relates to a method for producing a composition containing at least one metal amino acid compound, in which method - a basic compound of a divalent metal is first reacted together with an alpha amino acid in a molar relatio...
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WO/2019/228849A1 |
Process for making solid methylglycine diacetate (MGDA) alkali metal salt (a), said process comprising the steps of (A) providing a 40 to 60% by weight aqueous solution of said MGDA salt having a temperature in the range of from50 to 90Â...
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WO/2019/221192A1 |
The present invention provides a method for producing an amino acid aminoalkyl ester or an inorganic acid salt thereof by reacting a compound represented by general formula (I) or a compound represented by general formula (III), or a sal...
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WO/2019/219942A1 |
Provided is a process for producing an amine via a hydroaminoalkylation reaction of a non-aromatic C-C double bond or C-C triple bond, said process comprising a step of reacting a compound comprising a non-aromatic C-C double bond or C-C...
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WO/2019/175175A1 |
Method of purifying an alkali metal salt of a compound of the general Formula (I) or Formula (II) R1R2N-CHR3-COOH (I) or R1R2N-CHR3CHR3-COOH (II) wherein R1, R2 and R3 are independently H, an alkyl, an alkenyl, or a hydroxyalkyl radical ...
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WO/2019/175169A1 |
The application relates to a process for drying a composition comprising an alkali metal salt of a compound of general formula (I) R1 R2N- CHR3-COOM or formula (II) R1 R2N-CHR3CHR3-COOM, in particular N,N- dimethyl glycinate salt, and th...
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WO/2019/168269A1 |
The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using ...
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WO/2019/157426A1 |
The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermedia...
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WO/2019/154151A1 |
The present invention relates to an intermediate compound of formula II-1 or formula II-2 or a salt thereof, and a preparation method therefor. The present invention further relates to a process for synthesizing a compound of formula I b...
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WO/2019/137083A1 |
Disclosed in the present invention are a one-step process for producing a nylon 5X salt and a prepared high-purity nylon 5X salt. The process comprises: subjecting a lysine fermentation liquid to ion exchange and desorption to obtain a p...
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WO/2019/135189A1 |
The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as descri...
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WO/2019/118072A1 |
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid ...
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WO/2019/110371A1 |
The application relates to a process for the synthesis of organic sulfonic acid salts of amino acid esters comprising the steps of (i) reacting at least one lactam with at least 3 carbon atoms in the lactam ring with at least one organic...
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WO/2019/080155A1 |
The present invention relates to a conjugate salt of N,N-dimethylglycine and a metal organic acid, a preparation method therefor, and an application thereof. The conjugate salt of N,N-dimethylglycine and a metal organic acid has the foll...
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WO/2019/080009A1 |
Disclosed are an N,N-dimethylglycine organic acid polyvalent metal ion compound salt or a solvate thereof, and an application thereof in preparation of novel feed additives and feeds. Also disclosed is a feeding composition comprising th...
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WO/2019/066412A1 |
The present invention relates to a method for preparing a glutamate-based surfactant. More specifically, the present invention provides a method for preparing a glutamate-based surfactant, the method being very economical and being capab...
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WO/2019/057627A1 |
The present invention relates to a method for purifying polyaspartic acid ester compositions and to the provision of polyaspartic acid ester compositions that contain 0.01 to < 2% by weight fumaric acid dialkyl esters.
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WO/2019/037591A1 |
The present invention relates to a melphalan hydrochloride crystal form, a preparation method therefor and an application thereof. The preparation method is convenient to operate, has a short reaction period, reduces environmental pollut...
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WO/2019/040177A1 |
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid ...
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WO/2019/034114A1 |
Provided is a composition containing L-carnitine-β-hydroxybutyrate wherein the L-carnitine and β-hydroxybutyrate compounds in the molecule exist in the form of an intramolecular salt, and the composition is used for losing weight and p...
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WO/2019/016745A1 |
Aspects of the present application relate to process for the preparation of Pyrrolidine derivatives useful as key intermediates for active ingredients. Specific aspects relate to alternate process for the preparation of Upadacitinib inte...
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WO/2019/013954A1 |
There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) mixing the mixed amide derivatives with an aqueous solution of ammonia or ammonium hydroxide in the presence or absence...
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WO/2019/010016A1 |
There is disclosed a process for the production of long chain amino acid and long chain dibasic acid, comprising: (1) reacting long chain keto fatty acid with hydroxylamine or subjecting keto fatty acid to an ammoximation reaction to yie...
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WO/2019/007944A1 |
The present invention relates to a methylglycine-N,N-diacetic acid trisodium salt in the form of a crystal, comprising a crystalline modification referred to as crystal type III characterized by the below reflections when analyzed with X...
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WO/2019/007943A1 |
The present invention relates to a process for the preparation of a solid composition of an amino acid diacetic acid compound wherein the amino acid diacetic acid compound is methyl glycine-N,N-diacetic acid or a salt thereof, or glutami...
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WO/2019/002022A1 |
The present invention is directed towards a process for manufacturing a complexing agent, said process comprising the steps of (a) Providing a nitrile according to general formula (I a) or (I b) (formula I a, I b) With M being selected f...
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WO/2019/002685A1 |
The present invention relates to a process for in situ the preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine derivatives with maleic acid and then with 2-halocarboxylic acid, to mixtures of chelating ag...
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WO/2019/005628A1 |
There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) recovering alkylamine by distilling or by extracting with an extractant solvent; (2) adding an acid and an extractant s...
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WO/2019/005630A1 |
There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) recovering alkylamine from an aqueous solution of an alkali hydroxide hydrolysis of the mixed amide derivatives by dist...
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WO/2019/005629A1 |
There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) adding water and an extractant solvent to the aqueous suspension of an acid hydrolysis of the mixed amide derivatives t...
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WO/2019/002684A1 |
The present invention relates to a process for the in situ preparation of mixtures of chelating agents by catalyzed reactions of diethanolamine with maleic acid and then with 2-halocarboxylic acid, mixtures obtainable using said process ...
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WO/2019/005631A1 |
There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) cooling the hydrolysis solution to crystallize and separate alkali salt of long chain dibasic acid to provide an aqueou...
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WO/2018/226841A1 |
Zwitterionic monomers, camitine-derived zwitterionic polymers, carnitine ester cationic monomers, carnitine ester cationic polymers, conjugate compositions including a carnitine-derived zwitterionic polymer, and related compositions' and...
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WO/2018/226340A1 |
A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution, EDCI HCI is added to the first soluti...
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WO/2018/212162A1 |
The purpose of the present invention is to provide a method for easily producing a diaminobenzene compound and a benzimidazole compound at low cost. The present invention provides a method for producing a diaminobenzene compound or N-pro...
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WO/2018/206728A1 |
The invention relates to the use of a precursor for the production of carbon-11-labelled amino acids or derivatives thereof. According to the invention, the precursor is a compound of formula I: (formula I), where R1 and R2 are selected ...
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WO/2018/207693A1 |
A 1–amino cyclopropane carboxylic acid nonhydrate can be produced as a result of: using a tertiary amine to treat a 1–amino cyclopropane carboxylic acid hydrochloride in the presence of a C3–C4 alcohol and water; maintaining the re...
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WO/2018/207694A1 |
A 1–amino cyclopropane carboxylic acid nonhydrate can be produced as a result of: using a tertiary amine to treat a 1–amino cyclopropane carboxylic acid hydrochloride in the presence of a C3–C4 alcohol and water; maintaining the re...
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WO/2018/208677A1 |
Embodiments of the present disclosure are related to improved processes for making L-ornithine phenylacetate without using any silver salts or forming any L-ornithine intermediate salts, such as a benzoate salt. The present processes may...
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WO/2018/191999A1 |
The present invention relates to a process for preparing perindopril, the process mainly involving oxidizing ethyl 3-ketohexanoate as a raw material to synthesize ethyl 2-ketovalerate, then subjecting same to condensation ammoniation and...
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WO/2018/187324A1 |
The subject invention relates to a process of prepating (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying wit...
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WO/2018/174826A1 |
This invention relates to a method for producing an alkenyl 1 -aminocyclopropane-1 -carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B ...
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WO/2018/164662A1 |
A resveratrol ester has the following structure: (I). R1, R2 and R3 are H or (II). Each R4 is independently a carbon chain of 2 to 4 carbon atoms comprising a terminal carboxylic acid moiety, a carbon chain of 1 to 5 carbon atoms compris...
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WO/2018/157842A1 |
The present invention provides a use of 2-(substituted phenylamino)benzoic acid FTO inhibitor in treating leukemia.
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WO/2018/143492A1 |
The present invention relates to an aminobenzaldehyde derivative and an amino acid chiral extractant comprising the same, wherein the amino acid chiral extractant can allow amino acids in an aqueous solution to be extracted with high chi...
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WO/2018/139311A1 |
[Problem] To provide a novel diamine compound with which it is possible to synthesize a polyimide compound having high solubility in organic solvents and high melt moldability. [Solution] This diamine compound is characterized by being r...
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