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WO/2020/007836A1 |
The present invention is directed to a crystalline salt of 5-methyl-(6S)-tetrahydrofolic acid and L-isoleucine ethyl ester wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to L-isoleucine ethyl ester is from 1:0.3 to 1:2.0 (...
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WO/2020/006340A1 |
The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, deli...
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WO/2020/004043A1 |
The present invention provides a method which uses an aniline derivative as a starting material, and which is capable of producing an α-azidoaniline derivative or an α, α'-diazide derivative. The present invention comprises a method f...
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WO/2019/243970A1 |
The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, form...
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WO/2019/243087A1 |
The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear o...
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WO/2019/243112A1 |
The application relates to alkoxylated compounds of general formula (I) and to their use as adjuvant in the treatment of soil and plants. The presently claimed invention further relates to a composition comprising at least one biocide an...
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WO/2019/241484A1 |
This disclosure relates to anti-agglomerant low dosage hydrate inhibitors that can inhibit the formation of hydrate agglomerants and/or plugs. Thus, provided herein are carboxy alkyl ester compounds that can be used in hydrate inhibitor ...
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WO/2019/232706A1 |
A method for preparing a pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting Compound (I) 3-isobutylglutaric acid, as a raw material, w...
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WO/2019/235493A1 |
The present invention provides a method by which a diaminobenzoic acid ester and a benzimidazole derivative are able to be produced more easily with use of lower cost materials. The present invention includes a method for producing a dia...
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WO/2019/233671A1 |
The invention relates to a method for producing a composition containing at least one metal amino acid compound, in which method - a basic compound of a divalent metal is first reacted together with an alpha amino acid in a molar relatio...
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WO/2019/231175A1 |
The present invention relates to a peptide with amidated carboxy terminus having melanogenesis inhibitory activity and a composition comprising same, and more specifically, to a peptide with amidated (-NH2) carboxy terminus, composed of ...
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WO/2018/177383A9 |
The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a...
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WO/2019/227093A1 |
Provided herein are processes, compounds and compositions for making (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxyl
ic acid. Also provided herein a pharmaceutical composition containing (S)-3-amino-4-(difluoromethylenyl)cyc...
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WO/2019/219000A1 |
Crystalline forms of the drug conjugate (S)-3-((((R)-1-((S)-2-(6-methoxynaphthalen-2-yl)propanoyloxy
)ethoxy)carbonyl-amino)methyl)-5-methylhexanoic acid and their pharmaceutical compositions are described herein. Also described are meth...
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WO/2019/221192A1 |
The present invention provides a method for producing an amino acid aminoalkyl ester or an inorganic acid salt thereof by reacting a compound represented by general formula (I) or a compound represented by general formula (III), or a sal...
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WO/2019/219942A1 |
Provided is a process for producing an amine via a hydroaminoalkylation reaction of a non-aromatic C-C double bond or C-C triple bond, said process comprising a step of reacting a compound comprising a non-aromatic C-C double bond or C-C...
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WO/2019/219938A1 |
The invention discloses Fmoc protected (2S)-2-amino-8-[(1,1- dimethylethoxy)amino]-8-oxo-octanoic acid, (S)-2-amino-8- oxononanoic acid and (S)-2-amino-8-oxodecanoic acid for use in peptide synthesis, such as solid phase synthesis, as we...
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WO/2019/197231A1 |
The present invention relates to new methods for producing cis-alkoxy substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and new intermediates or starting compounds that are used in the method according to the invention.
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WO/2019/193607A1 |
The present invention relates to an improved process for the preparation of 3-isobutyl glutaric acid compound of formula-1 which is used as the key intermediate in the preparation of Pregabalin compound of formula-A. The present inventio...
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WO/2019/190823A1 |
The application relates to pharmaceutically acceptable salts of [3-(4- {2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lH-imidazol-4-yl}-p
henoxy) -propyl]-diethylamine (Azeliragon) useful in the treatment of RAGE mediated diseases such as Alzh...
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WO/2019/184663A1 |
Provided is a preparation method for herbal medicine, comprising the following steps: mixing one or more lipid components and/or with any one or more of the following: nucleic acid, compounds, and macromolecules; and performing heat trea...
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WO/2019/189110A1 |
A photosensitive resin composition, a cured film, a laminate, a method for manufacturing a cured film, and a semiconductor device, in which: a heterocycle-containing polymer precursor, a thermal base generator, and a radically polymeriza...
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WO/2019/184991A1 |
The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and th...
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WO/2019/175169A1 |
The application relates to a process for drying a composition comprising an alkali metal salt of a compound of general formula (I) R1 R2N- CHR3-COOM or formula (II) R1 R2N-CHR3CHR3-COOM, in particular N,N- dimethyl glycinate salt, and th...
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WO/2019/175897A1 |
The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tau...
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WO/2019/168269A1 |
The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using ...
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WO/2019/168866A1 |
Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods,...
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WO/2019/166537A1 |
The present invention describes novel chelators (multidentate ligands) and precompounds for complexation of radiometals and non-radioactive counterparts, for use in radiopharmacy. The invention includes a process and a kit involving such...
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WO/2019/162469A1 |
The present invention relates to novel surface active compounds based on polyhydroxy acids. The compounds are of formula (I), where X represents hydrogen or a cation; n is 4 and Y represents a group of formula (II) or formula (III), wher...
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WO/2019/161526A1 |
Provided is a one-pot method for preparing twin dicarboxylic acid diamine complex platinum (II) derivatives, the method does not comprise the separation of intermediate carboplatin or carboplatin analogue. Compared with the prior art, ac...
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WO/2019/154797A1 |
Cleaning solution comprising a) one or more surfactant(s) according to Formula (I), wherein R1 is a linear, branched, or cyclic, saturated or unsaturated aliphatic group having from 3 to 7 carbon atoms or an aryl group having 6 or 7 carb...
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WO/2019/157426A1 |
The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermedia...
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WO/2019/154151A1 |
The present invention relates to an intermediate compound of formula II-1 or formula II-2 or a salt thereof, and a preparation method therefor. The present invention further relates to a process for synthesizing a compound of formula I b...
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WO/2019/148827A1 |
Provided by the present invention are a self-aligning material, a self-aligning liquid crystal material, and a method for manufacturing a liquid crystal panel. The self-aligning material of the present invention can align liquid crystal ...
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WO/2019/150323A1 |
Ionic liquids of creatine comprising a creatine anion and a cation., as well as their means of manufacture. Examples of the ionic liquids of creatine are choline creatinate, betaine ethyl ester creatinate and agmatine creatinate are desc...
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WO/2019/141246A1 |
The present disclosure relates to compounds useful in the treatment, imaging, and/or diagnosis of Epstein-Barr virus (EBV)-positive cells, such as cancer.
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WO/2019/137083A1 |
Disclosed in the present invention are a one-step process for producing a nylon 5X salt and a prepared high-purity nylon 5X salt. The process comprises: subjecting a lysine fermentation liquid to ion exchange and desorption to obtain a p...
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WO/2019/140038A1 |
The invention provides branched hydrophobes for the production of surfactants with improved properties over linear hydrophobes. The invention also provides branched C10-12 enals and aldehydes that are oxidized to branched fatty acids or ...
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WO/2019/135189A1 |
The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as descri...
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WO/2019/136025A1 |
Described herein are compounds, including pharmaceutically acceptable salts and solvates thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non-a...
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WO/2019/131839A1 |
The present invention provides: a technique that makes it possible to introduce active components, in particular nucleic acids, into cells with excellent efficiency; and cationic lipids, etc. used in the technique. This compound or a sal...
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WO/2019/126859A1 |
The present invention relates to a compound derived from an amino acid that emits fluorescence that is seen in blue and can be seen in common filters. The present invention also relates to the method for obtaining said compound and the u...
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WO/2019/128918A1 |
Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in t...
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WO/2019/121946A1 |
The present invention relates to a zwitterionic pillararene derivative having a structure according to the following general formula (I). Thereby, residue R is a zwitterionic hydrocarbon chain. The invention further relates to uses of su...
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WO/2019/118072A1 |
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid ...
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WO/2019/113693A1 |
Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are re...
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WO/2019/111845A1 |
The present invention addresses the problem of providing a polar compound which exhibits high chemical stability, high ability to align liquid crystal molecules, high solubility in a liquid crystal composition and a high voltage retentio...
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WO/2019/110371A1 |
The application relates to a process for the synthesis of organic sulfonic acid salts of amino acid esters comprising the steps of (i) reacting at least one lactam with at least 3 carbon atoms in the lactam ring with at least one organic...
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WO/2019/107533A1 |
The present invention provides a compound for suppressing cell transformation, the compound being represented by the following general formula (wherein n is 1 or 2; R1 is H, methoxy(-OCH3), or Cl; R2 is H, -OCH3, or Cl; R3 is H, -OCH3, C...
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WO/2019/108685A1 |
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein....
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