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WO/2015/028766A1 |
The invention relates to new α-vinyl carbonylated compounds corresponding to general formula (I), wherein R1, R2, R3, R4, R5 and Y are as defined in claim 1, their isomers, their diastereoisomers and acid addition salts or a pharmaceuti...
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WO/2015/027773A1 |
The present invention relates to an application of dimethylaminopyridine (DMAP) hydrochloride serving as recyclable catalyst in an acylation reaction (as represented by equation I). The application comprises: dissolving DMAP into a nonpo...
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WO/2015/026538A1 |
N-Acyl amino acid salt compositions and an improved process for making them from fatty alkyl esters are disclosed. The process comprises reacting a fatty alkyl ester with an amino acid salt in the presence of an alkoxide catalyst at a pr...
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WO/2015/025960A1 |
Provided are: a compound having high activity against harmful organisms; a harmful organism control agent comprising the compound; and a method for controlling harmful organisms by applying the compound. A phenoxyalkylbenzamide-type comp...
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WO/2015/024385A1 |
The invention provides a preparation method of N-acyl acidic amino acid or a salt thereof, comprising subjecting a fatty acyl chloride and an amino acid to an amidation reaction under an alkaline condition. The preparation method is char...
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WO/2015/026234A1 |
The invention relates to a method for preparing a chemical compound, comprising subjecting a levulinic acid source, preferably a compound selected from the group of levulinic acid, levulinic acid anhydrides, levulinic acid salts, levulin...
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WO/2015/024991A1 |
The invention relates to a novel synthesis route towards R- biphenylalaninol and to the intermediates applied in this synthesis route. The process according to the invention and the intermediate compounds are useful in the synthesis of p...
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WO/2015/022119A1 |
Process for the production of a thermoplastic polymer comprising segments of a diamide, the process comprising: 1) a first step of preparing a reaction mixture comprising a diamine H2N-Y-NH2 Form. (I), and a diester of a dicarboxylic aci...
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WO/2015/019928A1 |
The present invention relates to a novel synthesis method that is capable of producing an optically active binaphthyldiamine derivative, under conditions whereby the binaphthyldiamine derivative can be produced more safely and efficientl...
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WO/2015/016521A1 |
The present invention relates to a method for preparing amide and imide from alcohol and a nitrogen-containing heterocyclic compound and, more particularly, to a method for preparing amide and imide by using: a catalyst composition obtai...
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WO/2015/011032A1 |
The present invention relates to a process for preparing substituted biphenylanilides of the formula I in which R1 is selected from a protected amino group, NO2, NH2 and NHR3, in which a compound of the formula II is reacted in the prese...
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WO/2015/012259A1 |
Provided is a reaction accelerator used in a reaction between a compound having an isocyanate group that does not directly bond to an aromatic ring, in each molecule, and a compound having an active hydrogren-containing group. The reacti...
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WO/2015/007909A1 |
The invention relates to a thermal conversion vessel (200) used during amidification step of acetone cyanohydrin (ACH), in the industrial process for production of a methyl methacrylate (MMA) or methacrylic acid (MAA). The thermal conver...
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WO/2015/008740A1 |
The present invention is a method for producing an α-hydroxyisobutyric acid amide by hydration of an acetone cyanohydrin under the presence of a catalyst composed mainly of manganese oxide using a reactor in which at least two reaction ...
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WO/2014/072998A9 |
The present invention provides an improved process for preparing agomelatine of formula (I). The process comprises reacting 7-methoxy tetralone with cyanoacetic acid in an organic solvent to obtain (7-methoxy-3,4-dihydro- 1 -naphthalenyl...
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WO/2015/003615A1 |
The present invention provides simultaneously an acyl(-N,N-dialkyl) diamine surfactant and a preparation method of the surfactant. The method uses an oleic acid as an initial reactant, followed by an alkylation reaction, an chloroformyla...
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WO/2015/003858A1 |
The present invention relates to a process for manufacturing haloacetamides of formula (I), comprising sub-step (a): reacting halones of formula (II) with oleum; followed by sub-step (b): reacting the reaction mixture obtained in sub-ste...
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WO/2014/207071A1 |
The present invention relates to novel strobilurine type compounds, to compositions comprising at least one such compound, to methods for combating phytopathogenic fungi, to the use of such compounds and to seeds coated with at least one...
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WO/2014/207769A1 |
Described herein are processes for the preparation of nepafenac and related intermediates, particularly wherein 2-aminobenzophenone is treated with a 2-(alkylthio)acetamide in the presence of sulfuryl chloride to afford a 2-(2-amino-3-be...
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WO/2014/206254A1 |
The present invention provides a 4-Benzyl-1-phenethyl-piperazine-2,6-dione (formula IV compound) key new intermediate formula III compound, a pharmaceutically acceptable salt thereof and a preparation method thereof. The present inventio...
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WO/2014/200094A1 |
[Problem] To provide a novel production method for a stereoselective, optically active alcohol compound. [Solution] From the compound represented by formula (3), the optically active alcohol compound represented by formula (8) can be pro...
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WO/2014/198372A1 |
The invention relates to compositions of formula (I), and in particular medications containing at least one composition of formula (I), for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions tri...
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WO/2014/197860A1 |
Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, in...
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WO/2014/191090A1 |
The present invention relates to a mixture containing tertiary isononanoic acids, starting from 2-ethylhexanol, to the production thereof by dehydration of 2-ethylhexanol to give an octene mixture and subsequent hydroxycarboxylation with...
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WO/2014/188783A1 |
The purpose of the invention is to provide a production method that makes possible the industrial production of an optically active α-amino acid at high yield and high enantioselectivity, to provide a simple method for producing optical...
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WO/2014/187274A1 |
Disclosed are an intermediate N-[4-(1-(2-propinyl)-3, 4-dioxo normal-butyl) benzoyl]-L-glutamic acid diester (I) of pralatrexate and a preparation method therefor. The preparation comprises the following steps: condensing 4-(1-hydroxyl-3...
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WO/2014/184235A1 |
Compounds of formula I, pharmaceutically acceptable salts thereof, diastereomers, enantiomers, or mixtures thereof: wherein R, X, Y, Z, n and A are as defined in the specification, as well as pharmaceutical compositions including the com...
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WO/2014/178083A1 |
The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formul...
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WO/2014/166885A1 |
The invention provides a process for the synthesis of carboxamides, comprising the steps: a) provision of a carboxylic acid ester of the formula RCOOR' and ammonia (NH3), b) mixing of the carboxylic acid ester of the formula RCOOR' and o...
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WO/2014/164867A1 |
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDMIA, and methods of increasing gamma globin gene expression in a human or animal subje...
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WO/2014/163883A2 |
A compound having a plurality of primary amine functional groups, such as the reaction product of a metathesized natural oil and a bis(aminoalkyl) amine and/or a compound represented by Structure I, may be used to form a dendritic molecu...
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WO/2014/159802A1 |
The present invention provides compounds of Formula (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulator...
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WO/2014/157651A1 |
An amino acid amide compound production method that has a heating step for heating a water-soluble liquid represented by general formula (1), which contains an acid and an imidazolidine compound, at a temperature exceeding 50°C, and yie...
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WO/2014/155264A1 |
The present invention provides an improved and commercial process for the preparation of Lacosamide having formula (I). Further, the present invention also provides the novel intermediate compounds of formula (VI) and (VII) and their pro...
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WO/2014/038963A9 |
This invention relates to certain dendrimer compounds. In particular, this invention relates to novel dendrimer compounds that can be elaborated to give increasingly large and complex compounds. These elaborated compounds can be attached...
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WO/2014/135096A1 |
An Ivacaftor preparation method and intermediate thereof, the method forms a quinoline ring by condensing the compound of formula III under an alkaline condition, or conducting reduction and cyclization reactions for the compound of form...
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WO/2014/129265A1 |
Provided is a novel tertiary-nitrogen-atom-containing lactone polymer having a polymerizable group, which is useful as a raw material monomer for various functional polymeric materials. The tertiary-nitrogen-atom-containing lactone polym...
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WO/2014/118361A1 |
The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram- positive and Gram-negative pathogens, with particular efficacy in tetrac...
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WO/2014/115638A1 |
This method for manufacturing 3,5-dimethyl-1-adamantanamine includes the following steps (i) through (iii). (i) A step for reacting 3,5-dimethyl-1-adamantanol with oxygen and nitrile in an organic solvent to obtain a reaction solution. (...
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WO/2014/114615A1 |
The present invention concerns a process for the preparation with high selectivity of a compound of formula (I) by isomerization at room temperature of compound of formula (II) in the presence of a complex of formula [Ru(dienyl)2H]X.
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WO/2014/111856A1 |
This invention relates to the synthesis of a multifunctional hair color protector, p-methoxy cinnamidoproyl dimethyl behenyl ammonium chloride of Formula (I) and the compositions containing the same for hair care.
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WO/2014/108564A1 |
The subject matter of the present invention is the novel molecules of formulae E, E' and F. These molecules prove to be synthesis intermediates that are very advantageous for the manufacture of derivatives of sphingosine or of ceramides ...
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WO/2014/106856A1 |
The present invention relates to the mannose - receptor selective lysinylated cationic amphiphile and a process for preparation thereof. The compounds of the present invention can target DNA vaccines to antigen presenting cells (APCs) su...
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WO/2014/104668A1 |
The present invention provides a novel hydroxylaminobenzene mutase, a gene coding same, and a method for preparing various aminophenol derivatives using said hydroxylaminobenzene mutase. The hydroxylaminobenzene mutase, according to the ...
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WO/2014/101690A1 |
The present invention relates to the field of pharmaceutical synthesis, and specifically, to a method for preparing an Ezetimibe chiral intermediate. The method is as follows: a method for preparing a compound with a formula (b) structur...
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WO/2014/095999A1 |
The invention relates to a continuous method for separating out a solid, saline phase containing alkaline and/or alkaline earth acetates from the product mixture of the production of N,N-dimethylacetamide (DMAc) by reacting methyl acetat...
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WO/2014/099214A1 |
The present invention relates to a process for purification of iodinated X-ray contrast agents and in particular to purification of crude dimeric contrast agents, such as Iodixanol and Ioforminol. More particularly, the invention relates...
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WO/2014/068333A2 |
There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I : according to the methods defined in the application.
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WO/2014/069875A2 |
The present invention relates to a novel method for preparing acetaminophen, and more specifically, to a method for preparing acetaminophen, comprising the steps of: reacting a benzene compound substituted with a specific functional grou...
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WO/2014/059516A1 |
A process for preparing an acrylamide-based crosslinking monomer comprising reacting in the presence of a catalyst an isocyanate compound containing at least two isocyanate groups with one of acrylic acid or methacrylic acid. These acryl...
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