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WO/2019/233498A1 |
Provided are a cis-para-substituted cyclohexylamino nitrile salt as shown in formula (I) and a preparation method therefor, a use of said salt as a preparation intermediate for a pesticide such as spirotetramat, and a method for using sa...
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WO/2019/228994A1 |
This invention relates to oleic acid derivative comprising a hydrophobic part C17H33 linked to a particular polar head part "A", especially for use as a medicament, for instance, for the treatment of a disorder caused by the GPR120 recep...
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WO/2019/229625A1 |
The present invention relates to a process for the preparation of Apalutamide of formula (A) Apalutamide is a latest-generation androgen receptor inhibitor, used to treat non-metastatic castration-resistant prostate cancer.
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WO/2019/229005A1 |
This invention relates to linoleic acid derivative of Formula (I) below comprising a hydrophobic part C17H 31 linked to a polar head part "A": (I) wherein said polar head part A is selected from A1 to A4 below: (ll) wherein R1 and R2 are...
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WO/2019/231871A1 |
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed h...
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WO/2019/231870A1 |
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed h...
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WO/2018/177383A9 |
The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a...
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WO/2019/224193A1 |
The invention relates to a method for preparing keto-functionalized aromatic (meth)acrylates by reacting keto-functionalized aromatic alcohols or keto-functionalized aromatic amines with (meth)acrylic anhydride having a content of (meth)...
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WO/2019/221925A1 |
Provided herein are integrated systems and processes for more efficient use of raw materials in chemical synthesis of ammonia, urea and copolymers. The systems and processes may include nutrient fermentation, carbonylation of syngas deri...
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WO/2019/216810A1 |
Compounds of the formulae wherein the bond α is a single bond, a trans double bond (E), or a triple bond; X and Y are -CH2- or on of X and Y is O and the other is CH2; R1 is phenyl unsubstituted or substituted with one, two, or three su...
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WO/2019/216415A1 |
The present disclosure addresses the problem of providing a production method for a novel fluoromethyl derivative. The problem is solved by a production method that is for a fluorinated organic compound represented by formula (1) [in the...
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WO/2019/205147A1 |
The present invention relates to an amino acetamide compound containing a benzo oxygen-containing aliphatic ring structure and a use thereof. In particular, disclosed are a compound represented by formula I or a pharmaceutically acceptab...
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WO/2019/210008A1 |
The present disclosure relates to certain amides and heterocyclic compounds. The present disclosure also relates to uses of these compounds to inhibit Rho-associated protein kinases and treat diseases including autoimmune disorders, graf...
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WO/2019/208705A1 |
A method for producing an N, N-disubstituted amide according to the present invention causes a reaction of a nitrile and an alcohol in the presence of a catalyst. This method for producing an N, N-disubstituted amide is configured such t...
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WO/2019/200450A1 |
Methods for enhancing the activity of an ion transporter in a cell and/or treating a channelopathy in a subject based on the administration or use of an effective amount of a fenretinide compound (fenretinide, a fenretinide analog, or a ...
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WO/2019/204180A1 |
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed h...
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WO/2019/197274A1 |
It is described an industrially viable and advantageous process for the preparation of mixed µOR agonist/δOR antagonists (9). The invention also discloses the intermediates obtained in the process.
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WO/2019/196945A1 |
Disclosed is a novel method for synthesizing deuterated amides and deuterated sulfonamides, the steps being as follows: (1) adding a compound M, DMAP, R3-X to a solvent to obtain a compound N after a reaction is complete; (2) adding the ...
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WO/2019/196714A1 |
An N-substituted acrylamide derivative, represented by general formula I, as a DHODH inhibitor, and preparation and use thereof. The N-substituted acrylamide derivative has excellent DHODH inhibiting activity, and thus can be used for tr...
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WO/2019/195634A1 |
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds...
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WO/2019/190823A1 |
The application relates to pharmaceutically acceptable salts of [3-(4- {2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lH-imidazol-4-yl}-p
henoxy) -propyl]-diethylamine (Azeliragon) useful in the treatment of RAGE mediated diseases such as Alzh...
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WO/2019/184663A1 |
Provided is a preparation method for herbal medicine, comprising the following steps: mixing one or more lipid components and/or with any one or more of the following: nucleic acid, compounds, and macromolecules; and performing heat trea...
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WO/2019/185877A1 |
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diast...
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WO/2019/185870A1 |
The present invention relates to novel spirocyclic compounds which act as modulators of indoleamine 2,3-dioxygenase (IDO1) and to the use of said compounds in the prophylaxis and/or treatment of diseases or conditions mediated by indolea...
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WO/2019/184991A1 |
The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and th...
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WO/2019/188508A1 |
Provided is a compound capable of thickening a fluidic organic substance to a desired viscosity, and uniformly stabilizing the compositional makeup thereof. The compound according to the present invention is represented by formula (1). I...
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WO/2019/189277A1 |
A method for producing an amide compound, said method comprising a step for contacting optionally treated microbial cells containing nitrile hydratase with a nitrile compound in an aqueous medium in a first reactor to give a liquid react...
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WO/2019/173993A1 |
Provided is a polymer blend that can be used in films, packages, and fibers. In one aspect, a polymer blend comprises an ethylene-based polymer, and one or more compounds of formula (I), wherein n is 6 to 24.
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WO/2019/175043A1 |
The present invention relates to a process for preparing 4-{[(2S)-2-{4-[5-chloro-2-(4-chloro-1H-1,2,3 -triazol-1-yl)phenyl] -5 -methoxy-2-oxopyridin-1(2H)-yl} butanoyl] amino} -2-fluorobenzamide (I) or 4-({(2S)-2-[4-{5-chioro-2-[4-(trifi...
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WO/2019/175897A1 |
The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tau...
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WO/2019/175396A1 |
Subject matter of the present invention is a white crystalline polymorph A of the Ca salt of a compound according to formula I or a solvate and/or a hydrate thereof with a molar ratio of a compound according to formula I or a solvate and...
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WO/2019/169402A1 |
Apparatus and a method for cleaning accumulated sediment from storm drain conduits and other large-diameter conduits. A nozzle assembly is arranged to deliver a high-volume flow of water at a pressure high enough to loosen sediment from ...
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WO/2019/166270A1 |
The invention relates to an organic electronic device comprising at least one electron transport, electron injection or electron generation layer comprising a compound of Formula (I) wherein all positions which are not linked to a -(A)a-...
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WO/2019/166269A1 |
The present invention relates to an organic electronic device comprising, between an anode and a cathode, at least one layer selected from an electron injection layer, an electron transport layer or an electron generation layer, the laye...
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WO/2019/166608A1 |
The presently claimed invention relates to a color developer, a process for its manufacture and its use as a component in heat sensitive recording material. The heat sensitive recording material is useful for thermographic printing.
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WO/2019/160037A1 |
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...
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WO/2019/159596A1 |
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...
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WO/2019/152536A1 |
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
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WO/2019/151241A1 |
The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt of the compound. (In the formula, X and Y may be the same or different, and each represents a hydrogen atom, a halogen atom, a C1-...
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WO/2019/150895A1 |
Provided is an electrolyte capable of improving the high-temperature storage characteristics and cycle characteristics of an electrochemical device. The electrolyte includes at least one type of compound indicated by general formula (1â€...
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WO/2019/146378A1 |
The purpose of the present invention is to provide: a composition for forming a resist underlayer film, which is capable of forming a resist underlayer film that has excellent etching resistance, heat resistance, flatness and film defect...
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WO/2019/143299A1 |
The present invention relates to hyper-branched compounds, a method of synthesizingthe hyper-branched compounds and applications of the hyper-branched compounds. Thehyper-branched compounds of the present invention include hyper-branched...
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WO/2019/140417A1 |
Amines and amine derivatives that improve the buffering range, and / or reduce the chelation and other negative interactions of the buffer and the system to be buffered. Aminopyridines channel blocking, combined with buffering and zwitte...
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WO/2019/136782A1 |
Disclosed is a tri-cationic viscoelastic surfactant, a preparation method therefor, an application thereof, and a clean fracturing fluid. The invention utilizes N,N'-dimethyl-1,3-propanediamine and epichlorohydrin to prepare an intermedi...
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WO/2019/140188A1 |
Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic disorders, where inhibition of Des1 is expected to be therapeutic to a patien...
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WO/2019/130866A1 |
Provided is an active ray- or radiation-sensitive resin composition which has excellent storage stability and can enable a pattern with excellent LWR performance to be obtained. Also provided are a resist film, a pattern forming method, ...
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WO/2019/127994A1 |
The present invention relates to a sacubitril sodium salt as represented by formula IV, a eutectic of sacubitril free acid and acetic acid, a crystal form of the eutectic and a preparation method for the crystal form, and a method for us...
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WO/2019/122606A1 |
Disclosed are a new composition of lipoamino acids and alkanediols, a process for the preparation thereof, and a cosmetic or pharmaceutical composition resulting therefrom.
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WO/2019/122601A1 |
Disclosed are a new composition of lipoamino acids and diols, a process for the preparation thereof, and a cosmetic or pharmaceutical composition resulting therefrom.
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WO/2019/125930A1 |
Disclosed is a composition including a carbonyl-substituted alkene including a dicarbonyl compound having an alkylene group between the carbonyl groups. At least one carbonyl group of the dicarbonyl compound includes an amide group. Anot...
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