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JP4676061B2 |
Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, ...
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JP2011079834A |
To provide a new iron chelator or the like exhibiting neuroprotective characteristics and good transport characteristics.The new iron chelator exhibiting neuroprotective characteristics and good transport characteristics is useful in iro...
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JP2011046714A |
To provide a lactone-containing compound such as discodermolides; a compound which mimics chemical and/or biological activity thereof; and a method and an intermediate, both of which are useful for producing the above compounds.There are...
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JP4631702B2 |
The present invention discloses a method for producing a hydroxylamine compound wherein a nitro compound is contacted with a hydrogen source or further with a poisoning agent in the presence of a platinum catalyst fixed on an ion-exchang...
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JP4625236B2 |
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels a...
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JP4617114B2 |
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JP4602671B2 |
The present invention relates to open chain alkoxyamine compounds, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one open chain alkoxyamine compound. Further aspects of the prese...
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JP2010538071A |
The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and nepri...
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JP2010265292A |
To provide new nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and methods for treating inflammation, pain and fever, for treating gastrointestinal disorders, and for facilitating wo...
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JP4554822B2 |
The present invention relates to a process for the continuous preparation of methoxyamine hydrochloride by cleavage of acetone oxime methyl ether by means of hydrogen chloride and water, wherein the cleavage is carried out in a reaction ...
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JP4542340B2 |
The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a plurality of processes for their preparation, and to their use as mic...
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JP2010189319A |
To provide an industrially advantageous method of a low environmental load producible of an aminooxy compound with a high yield and also producible of an optically active aminooxy compound of high optical purity.The method for producing ...
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JP4505698B2 |
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JP4499921B2 |
Methods and compositions for inhibiting the polymerization of ethylenically unsaturated hydrocarbons are disclosed. Combinations of aminophenol compound and either of phenylenediamine or hydroxylamine compounds are effective at inhibitin...
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JP2010519259A |
The present disclosure provides compounds that include hydroxylamines of formula I or II, pharmaceutical compositions, and methods for their use. The methods utilize hydroxylamine compounds and/or their pharmaceutical compositions for th...
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JP4472917B2 |
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JP4458853B2 |
A NK1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough:
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JP2010090138A |
To provide a novel substituted tetracycline compound useful to treat numerous tetracycline compound-responsive states such as bacterial infections and neoplasms.The compound is represented by formula (I), wherein X is CH2, CH-alkyl or th...
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JP2010510258A |
Preparation of an amino glycol (I) comprises reacting a ketoxime compound (II) with the ethylene oxide in an aqueous solution in the presence of a base to obtain 2-hydroxyethylketoxime compound (III) and further reacting (III) in the pre...
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JP4433516B2 |
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JP4423485B2 |
1,2-Bis-adducts of stable hindered nitroxide compounds with substituted ethylenes of formulas (I) & (II) are prepared by reacting two equivalents of nitroxyl compound with an ethylenically unsaturated compound such as styrene or an acryl...
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JP4424450B2 |
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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JP2010043112A |
To provide a compound useful for treating such diseases as inflammations, cardiovascular disorders and atherosclerosis as liver X receptor (LXR)-mediated diseases or symptoms.The compound is represented by formula (I) (wherein, X is brom...
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JP4406606B2 |
In a process for concentrating an at least partially crystalline solid containing at least one zeolite in a mixture comprising at least one auxiliary, for example a template compound, and said solid, the mixture is ultrafiltrated in a st...
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JP2010502581A |
A process for preparing a salt of compound of formula (I) wherein R1 and R2 are independently selected from an organic group other than hydrogen, said process comprising reacting a compound of formula (II) with water and an organic acid,...
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JP4395257B2 |
In one embodiment, the present invention relates to a method of making a catalytic film comprising: applying an electric current to an electrochemical cell comprising an anode, a cathode and a solution comprising a film forming compound ...
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JP4390424B2 |
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JP2009292719A |
To provide a method for concentrating an at least partially crystalline solid containing at least one zeolite in a mixture comprising at least one auxiliary, for example a template compound, and the solid.The production method comprises:...
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JP4383709B2 |
The invention relates to phenyl-propargylether derivatives of the general formula Iincluding the optical isomers thereof and mixtures of such isomers, whereinR1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl,R2 and R3 are ...
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JP4376970B2 |
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseas...
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JP4362388B2 |
The present invention is to provide a method for easily obtaining ±-aminooxyketone compound which is a synthetic equivalent for monosaccharide and pentoses, and a equivalent of ±-hydroxyketone compound that can be synthetic intermediat...
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JP4353633B2 |
The invention relates to a method for producing N-acylated (hetero)aromatic hydroxylamine derivatives of formula (I), wherein the substituents, the ring atom and the index have the meanings give in the Description, by hydrogenating a (he...
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JP2009242802A |
To provide a composition stabilized against early stage polymerization.The composition stabilized against the early stage polymerization comprises a stable and sterically hindered organic nitroxyl compound expressed by formulae I and II ...
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JP4350654B2 |
A high purity aqueous solution of hydroxylamine product is prepared by treating an aqueous solution of hydroxylammonium salt with a base like ammonia at low temperatures. A novel process can be carried out by separating the ammonium salt...
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JP2009155327A |
To provide a new method for producing a 2-hydroxyethyloxyamine compound.The method for producing a 2-hydroxyethyloxyamine compound represented by formula (2) uses an O-(1-(2-hydroxyethyl))oxyimine compound represented by formula (1). In ...
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JP2009137890A |
To provide a new method for producing a 4-(dioxazin-3-yl)sulfamoylpyrazole compound, and to provide an intermediate thereof.The method for producing the 4-(dioxazin-3-yl)sulfamoylpyrazole compound represented by the formula (1) (wherein,...
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JP4277331B2 |
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JP2009102379A |
To provide an improved synthetic method for preparing polyhydroxy-dienyl-lactone such as discodermolide, and to further provide a compound having the similar chemical and/or biological activity thereof.The synthetic method is the one for...
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JP4257827B2 |
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JP4238962B2 |
The invention relates to a polymerization inhibitor comprising at least one compound (a) selected from the group consisting of a compound having an NO radical in its molecule and a precursor compound capable of forming an NO radical, and...
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JP4238948B2 |
An Anti-gelling agent for a hydrocarbon mixture containing a conjugated diene, which comprises (a) at least one compound selected from the group consisting of compounds having an NO radical in the molecule, and precursor compounds capabl...
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JP4213435B2 |
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JP4212353B2 |
Disclosed is a probe for mass spectrometry of liquid samples, which may effectively ionize the sample without adding a protic solvent to the mobile phase in the ionization method in mass spectrometry of liquid samples. The probe accordin...
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JP2008273977A |
To require an improved synthetic method for preparing polyhydroxy dienyllactone such as discodermolide or the like, and further to require a compound with the same chemical and/or biological activities.A method for synthesizing the lacto...
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JP4176153B2 |
This invention is directed to polymeric hydroxylamine resin compounds and to processes for the solid-phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds useful thereof.
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JP4170073B2 |
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JP4153038B2 |
PCT No. PCT/EP96/05255 Sec. 371 Date Jun. 5, 1998 Sec. 102(e) Date Jun. 5, 1998 PCT Filed Nov. 28, 1996 PCT Pub. No. WO97/20807 PCT Pub. Date Jun. 12, 1997Herbicidally active cyclohexenone oxime ether metal salts of formula I where Ra, R...
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JP2008201783A |
To provide a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation.The active compounds are substituted triaryl methane compo...
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JP4125899B2 |
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JP4110980B2 |
To provide a secondary battery which has a high capacity and is superior in charge and discharge cycle, a polymer which is suitable for an active material of this secondary battery, and a monomer which is suitable for manufacturing this ...
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