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JPH0113705B2 |
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JPH0113463B2 |
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JPS6456657A |
PURPOSE: To obtain a compound useful as antiulcer agent using inexpensive phosphorus trichloride in simple treatment and good yield, by reacting an anthranilic acid lower alkyl ester with phosphorus trichloride and then reacting the resu...
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JPS6455187A |
PURPOSE: To obtain a secondary alcohol compound useful as an intermediate for the synthesis of a renin inhibitor in high efficiency by the enantio-selective reduction of a specific β-keto compound with a microorganism, especially a yeas...
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JPH0112746B2 |
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JPH0112748B2 |
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JPH0112747B2 |
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JPH0112744B2 |
As intermediates for the preparation of aminoalkylbenzene derivatives, compounds of the general formula II < IMAGE > in which the substituents attached to the benzene ring are in the ortho, para or meta position with respect to one anoth...
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JPS6412266B2 |
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JPS6412267B2 |
A complex compound of an acid addition salt of (2'-benzyloxycarbonyl)phenyl-trans-4- guanidinomethyl-cyclohexanecarboxylate with a cyclodextrin. Such complexes can be used in the treatment of ulcers .
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JPS6452743A |
NEW MATERIAL: The amino acid shown by the formula [X is an-amino protecting group selectively removable without changing alkoxybenzyl; (n) is 1 or 2; (m) is 0 or 1; Z is 1-10C alkyl] and protected by trialkoxybenzyl. EXAMPLE: The compd. ...
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JPS6450870A |
PURPOSE: To inexpensively and advantageously obtain the subject compd. of an intermediate for synthesis of plant hygienic and medicinal agents with a smaller number of stages by using monoacylhydrazine and phosgene as starting raw materi...
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JPS6450851A |
NEW MATERIAL: The compd. of formula I [R is 1 to 18C aliphatic hydrocarbon having valance of (m+n), 4 to 15C alicyclic hydrocarbon group, 6 to 15C arom. hydrocarbon group, etc.; R' is 1 to 18C aliphatic hydrocarbon group which can contai...
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JPS6450850A |
PURPOSE: To obtain a compd. which is useful as a plant disease control agent by bringing phenol or napthol and alkyl isocyanate into reaction in the presence of a specific catalyst with short time operation. CONSTITUTION: The phenol or t...
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JPS6450852A |
PURPOSE: To obtain the subject compd. useful as an intermediate in a good yield with a short process by bringing an amidating agent into reaction with O1-p-nitrobenzyl-N2-benzyloxycarbonyl-2,6-diaminopimelic acid of L, L, or D, D, etc. C...
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JPH01500518A |
This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tu...
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JPS6447729A |
NEW MATERIAL: The compd. of formula I [X is O, S, SO or SO2; R1 is H, alkyl, akinyl, halogen, phenoxy, OH, etc.; R2 is H, alkyl, cycloalkyl, phenyl-alkyl, pyridylmethyl, etc.; R3 is OH, OR6 or OCOR7 (R6 is alkyl, alyl, benzyl; R' is alky...
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JPS6447748A |
NEW MATERIAL: The compd. of formula I [one or two of R1 to R4 are halogen, methoxy and the others are H; R5 is H or phenyl; R6 is OR12 or NR13R14 (R12 is H, 1 to 10C alkyl, etc.; R13 is H or 1 to 4C alkyl,; R14 is H, pyridyl, etc.); R7 i...
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JPS6410054B2 |
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JPS6445354A |
NEW MATERIAL:Optically active N-carbamoyl-2-(R)-amino-4-phenylbutyric acid of formula. USE: A production precursor for angiotensinase inhibitor. PREPARATION: The objective compound of formula can be produced by using D,L-5-phenetylhydant...
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JPS6445344A |
NEW MATERIAL: Compounds represented by the formula I (wherein: (q) is 1; (k) is 0; (p) is 1; Ar is a phenyl group optionally substituted by a 1-4C alkyl group or a halogen; L is -O-; Ar' is a 1,3- or 1,4-phenylene group; Y is (E)-CH= CH-...
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JPS648613B2 |
Beta-monofluoromethyl beta- alanine, betadifluoromethyl beta- alanine and pharmaceutically acceptable esters and amides derived from the acid group, amides and urethanes derived from the amine group, lactams and salts thereof are novel c...
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JPS648616B2 |
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JPS647071B2 |
PURPOSE:To obtain a binuclear diphenylmethane dicarbamate in high yield, by carrying out the condensation reaction of an N-phenylcarbamate with a methylenation agent in two steps, and separating and recycling the unreacted materials in e...
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JPS647070B2 |
PURPOSE:To obtain the titled compound useful as a presursor for diphenylmethane diisocyanate, etc. industrially and advantageously in high selectivity, by reacting an N-phenylcarbamate with a methylating agent under specific conditions, ...
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JPS6434954A |
NEW MATERIAL:A compound shown by formula I [X and Y are halogen or lower alkyl; m and n are 0W3; A is (lower alkyl-substituted) methylene; R is group RaZ-(Ra is H or lower alkyl; Z is O or S)]. EXAMPLE: 4-Chloro-N-carboxymethoxy-N'-(2,6-...
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JPS6434952A |
NEW MATERIAL: A compd. of formula I [where Ar is naphthyl,2-pyridinyl, phenyl,2 -furanylmethyl, etc.; X is S, SO, SO2 or O; (d) is O or 1: B is carbonyl or thioxomethyl; (n), (m) and (p) are 2-6: one of Z and W is R and the other is (CH2...
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JPS646192B2 |
Diaminophenyl ureas of the formula in which R is an inert substituent, are obtained from the corresponding dinitrophenyl urea by way of reduction, especially catalytic hydrogenation. Through a cyclization process, while splitting off amm...
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JPS6429344A |
NEW MATERIAL: The compound of formula I (R1 is cycloalkyl, bicycloalkyl, adamantyl, 4-piperidinyl, 1- or 2-indanyl, etc.; R2 is H, alkyl, cycloalkyl, arylalkyl, alkanoyl, etc.; R1 and R2 together with N form pyrrolidino, piperidino, perh...
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JPS6426547A |
NEW MATERIAL: The compd. of formula I (n is 2 or 3; R1 is H or lower alkyl; R2 is H or lower alkyl; R3 is H or lower alkyl). EXAMPLE: N-methyl-N-[2-(methylamino)ethyl]carbamic acid 4-methoxyphenyl ester hydrochloric acid. USE: Useful as ...
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JPS6422851A |
PURPOSE: To produce the title compound of extremely fine particles which is used as a foaming agent simply in a shortened time, by feeding an azodicarbonamide solution in DMSO into an aromatic hydrocarbon poor solvent and separating the ...
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JPS6422834A |
NEW MATERIAL:The fluorine-containing mono- or polyalkylene glycol derivative characterized in that at least one of 2W30C fluorine-substituted hydrocarbon group bonded with ≥3 fluorine atoms is grafted to mono- or polyalkylene group in ...
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JPS6419053A |
NEW MATERIAL: The compd. of formula I [A is the acyl of formula II, etc., (R6 is 1 to 10C alkyl, etc.); B, C are a single bond, formula III (R1 is H, 1 to 5C alkyl; R11 is an amino acid side chain); D is a single bond, -O-, etc.; R2 is 1...
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JPS6419047A |
NEW MATERIAL:A compound expressed by formula I (R1 is H, lower alkyl or aryl) or salt thereof. EXAMPLE: Diethyl 2-benzoyloxy-2-ethoxycarbonyl-3-methyl-glutarate. USE: A dehydropeptidase I inhibitor administered to humans or animals requi...
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JPS643143B2 |
A process for the preparation of an aromatic urethane by the reaction in solution of an aromatic nitro compound or aromatic amine in the presence of an oxidation agent, with a hydroxyl compound and carbon monoxide in the presence of a no...
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JPS6413059A |
NEW MATERIAL:A compound expressed by formula I (X is -COCH3 or benzyl; R is benzyloxy). EXAMPLE: (R)-N-Benzyloxy-4-acetoxy-3-hydroxy-butanamide. USE: A synthetic intermediate for optically active mono-β-latam rings. The above- mentioned...
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JPS6413065A |
NEW MATERIAL: Compd. expressed by formula I, wherein X is H, a amino acid or oligopeptide residue produced by removing OH in the terminal carboxyl groups of the amino acid or oligopeptide; Y, Z are OH which may be protected, or amino aci...
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JPS6413076A |
NEW MATERIAL: Compd. expressed by formula I, its tautomers or its salts. In formula I, R is H, alkyl; R1 is alkyl, substd. or unsubstd. aryl; R2, R3 are each H, or R2 and R3 are bonded; A is a benzene ring having ≤5 substituents; X is ...
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JPS642097B2 |
Some new compounds, farnesyl farnesyl carboxylate, N-farnesyl farnesyl carboxamide and N-farnesyl farnesyl carbamate are disclosed, which are novel mucosal stabilizing agents showing anti-inflammative and anti-ulcerative activities. Thes...
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JPS642101B2 |
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JPS642103B2 |
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JPS642102B2 |
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JPS642085B2 |
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JPS649969A |
NEW MATERIAL:An N-aryloxycarbamic acid esters shown by formula I (A is =CH- or N; X and Y are H, Cl or trifluoromethyl; X and Y are not H at the same time; R is lower alkyl). EXAMPLE: N-(2,5-Dichlorophenoxy)carbamic acid methyl ester. US...
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JPS641474B2 |
Novel alpha -fluoromethyl- alpha -amino acids and esters have the following formula in which R is a substituted C1-C4-alkyl group and R1 has the meaning of H or C1-C18-alkyl. The compounds can be present as acid addition salts. The compo...
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JPS646251A |
NEW MATERIAL:The compound of formula (R1 and R2 are 1W10C alkyl or 6W10C aryl; R1 is different from R2). EXAMPLE: Ethyl-n-butylhexane-1,6-dicarbamate. USE: A substitute for wax. Useful as a component of a wax-containing material such as ...
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JPS643161A |
NEW MATERIAL: A compd. of formula I [where R is alkyl, cycloalkyl, alkenyl, alkynyl, etc.; R1 is -A-COOR2,-B-CONR3R4 or substd. alkyl; each of A and B is (substd.) alkylene; R2 is substd. alkyl; R3 is substd. alkyl, alkenyl, aryl, etc., ...
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JPS643158A |
NEW MATERIAL: A biscyanoimine of formula I (where R1 is propyl, 5-20C alkyl, 3-20C alkenyl or I and each of R2-R4 is H, Cl, Br, I, F, phenyl, 1-20C alkyl, 3-20C alkenyl or 1-8C alkoxy). EXAMPLE: 2-Dodecyl-N,N'-cyano-1,4-benzoquinonediimi...
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JPS64387B2 |
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JPS643185A |
NEW MATERIAL: The (S)-isomer of a compd. of formula I (where OH in the chain may be in the form of its o-acyl, phosphate, cyclic acetal or cyclic carbonate deriv.) or a mixture of the (S)-isomer with <45 wt.% of the corresponding (R)-iso...
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