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WO/1999/009234A2 |
In one embodiment, the present invention relates to a method of making a catalytic film comprising: applying an electric current to an electrochemical cell comprising an anode, a cathode and a solution comprising a film forming compound ...
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WO/1999/003894A1 |
A polymerizable composition, comprising a) at least one ethylenically unsaturated monomer or oligomer, and b) an initiator compound of formula (I) wherein n is 0 or 1. The compounds of formula (I) are prepared from a free radical (a) and...
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WO/1998/056753A1 |
Oxidation of secondary amines with hydrogen peroxide and sodium tungstate is reported to give good yields of nitrones. However, when using dimethylamine in this manner, a considerable amount of N,N-dimethylformamide was produced as a co-...
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WO/1998/050031A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic -L�2?-;...
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WO/1998/050029A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) lower alkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl -L�2?-, and (i) heterocyclic -L�2?...
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WO/1998/050030A1 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic-L�2?-; ...
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WO/1998/046560A1 |
The present invention discloses a method comprising the steps of: a) forming in an aqueous solution a hydroxamic acid from a hydroxylamine free base and anhydride having the formula (RCO)�2?O wherein R is H or a substituted or unsubsti...
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WO/1998/041523A1 |
Disclosed are a process and novel compounds useful for preparing compounds of formula (A) wherein R�1? and R�2? independently represent hydrogen, inorganic or optionally substituted organic substituents; R�3? is hydrogen, or an opt...
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WO/1998/037957A1 |
Compounds of the formula R?2�.[(AO)�n?.R?3�]�m?, where R?2� is a residue of a group having at least m active hydrogen atoms derived from hydroxyl and/or amino and/or amido groups, AO is alkyleneoxy, n is 2 to 200; R?3� includ...
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WO/1998/029376A1 |
This invention is directed to processes for the solid-phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds and to polymeric hydroxylamine resin compounds useful therefor.
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WO/1998/024429A1 |
Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
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WO/1998/012177A1 |
A compound of formula (I) and the salts thereof, wherein A is halo, hydroxy or the like; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar?1� is optionally su...
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WO/1998/006691A2 |
Low molecular weight dendritic polymers (dendroids) of Formula (I) or a pharmaceutically acceptable salt thereof wherein A is selected from 1,2,3,5-tetrasubstituted or 1,2,4- or 1,3,5-trisubstituted benzene; 2,3,4,5-tetrasubstituted or 2...
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WO/1998/001421A1 |
A hydrogel polymeric system for the site specific delivery of peptide and protein drugs to the colon is prepared. The hydrogel protects the drug through the acid environment of the stomach, swells at a chemically controlled rate in the h...
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WO/1997/045115A1 |
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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WO/1997/034589A1 |
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted ...
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WO/1997/020809A1 |
Compounds of formula (I) in which n, q, A, X, G, Y, Z, R, R2, R3, R4, R5, R7 and R9 are as defined in claim 1, and, where appropriate, E/Z isomers, E/Z isomer mixtures and/or tautomers thereof, in each case in the free form or in an agro...
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WO/1997/020807A1 |
The invention relates to herbicidally active cyclohexenone oxime ether metal salts of formula (I), in which Rn is C1-Cn-alkyl and Rb is the equivalent of an alkali metal, an alkaline earth metal or a transition metal. The claimed salts h...
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WO/1997/019091A1 |
The present invention relates to novel geranylgeranyl-derivatives and the pharmaceutically acceptable salts thereof having antiproliferative acitivity in eukaryotic cells with respect to the inhibition of protein geranylgeranylation. The...
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WO/1997/008133A1 |
Amide compounds represented by general formula (I), pharmaceutically acceptable acid-addition salts thereof and a drug comprising the same as the active ingredient, wherein R represents amino, etc.; A represents alkylene, etc.; X represe...
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WO/1997/002253A1 |
The invention pertains to benzylhydroxylamines of formula (I), wherein X is -N(R7)-O-; Y is O, S; R1 is halogen, CN, NO2, CF3; R2 is H, halogen; R3 is H, NH2, CH3; R4 is H, halogen, C1-C6 alkyl, C1-C6 alkyl halide, C1-C6 alkyl thio, C1-C...
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WO/1996/035671A1 |
'beta'-adrenergic agonists for the treatment of diseases/conditions such as obesity and diabetes. The compounds have formula (I), wherein R1, R2, R3, R4, R5, R6, R7, W, X, Y and Z are as defined in the specification.
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WO/1996/033968A1 |
Novel compounds represented by general formula (I), stereoisomers thereof, pharmaceutically acceptable salts, and solvates thereof, processes for the preparation thereof, a matrix metalloproteinase inhibitor comprising as the active ingr...
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WO/1996/030036A1 |
Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are pr...
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WO/1996/028761A1 |
Certain N-alkylhydroxylamine derivatives are useful as antioxidants in photographic color developer compositions. These compounds stabilize the developer compositions, are highly water soluble and are essentially odorless.
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WO/1996/022967A1 |
A process for producing aromatic or heteroaromatic hydroxylamines of the general formula (I) in which R1 is an unsubstituted or substituted aryl radical or an unsubstituted or substituted hetaryl radical from the pyridine or quinoline gr...
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WO/1996/019438A1 |
A novel process for producing chiral hydroxylamines for use as intermediates to make chiral hydroxyureas, which process comprises a tandem condensation-cyclization reaction between a dimethylsulfoxonium methylide and an appropriately sub...
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WO/1996/016030A1 |
Iminooxymethylene anilides have the formula (I), in which the substituents and indices have the following meanings: R stands for hydrogen, optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkinyl, alkylcarbo...
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WO/1996/007633A1 |
The invention pertains to phenylacetic acid alkyl esters of formula I, wherein the index and substituents are as follows: R' is formyl, alkyl carbonyl or alkyl; R'' is alkyl; U is -O-, -S-, -NH- or -NHO-; V is -O-, -S-, or -NH-; X is cya...
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WO/1996/001258A1 |
The invention concerns 2-[1',2',4'-triazol-3'-yloxymethylene]-anilides of the formula (I) in which the subscript and substituents are as follows: n stands for 0, 1, 2, 3, or 4; X stands for a direct bond, oxygen or NRa, Ra being hydrogen...
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WO/1996/001256A1 |
The invention concerns 2-[(dihydro)pyrazolyl-3'-oxymethylene]-anilides of formula (I) in which -- is a single or double bond and the subscripts and substituents are as follows: n 0, 1, 2, 3 or 4; m 0, 1 or 2; X a direct bond or CH2, oxyg...
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WO/1995/033709A1 |
The invention provides hydroxylamine derivatives of formula (I) wherein A, R1, R2 and R3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. They are therefore...
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WO/1995/032192A1 |
The present invention provides aromatic amine substituted metal chelating compounds of formula (I) in which the variables are as defined in the claims, chelates and chelate-targeting moiety conjugates formed from the chelating compounds,...
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WO/1995/030648A1 |
A process is disclosed for producing isomer mixtures from O-phenoxyalkylhydroxyl amines Ia: H2N-O-CH2-CH(R1)-O-Ar and Ib: H2N-O-CH(R1)-CH2-O-Ar (wherein R1 represents alkyl, Ar where appropriate a substituted phenyl) and the correspondin...
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WO/1995/025090A1 |
The invention relates to a method for the preparation of the new compounds cyclic N-alkenyloxyimides by treatment of a cyclic N-hydroxyimide with vinyl carboxylic acid esters or vinyl ethers in the presence of a suitable metal catalyst. ...
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WO/1995/022966A1 |
This disclosure relates to a novel class of hydroxamic and carboxylic acid based matrix metalloproteinase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of su...
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WO/1995/018787A1 |
A process and catalyst composition are provided for the highly efficient enantioselective hydrogenation of dehydroamino acid derivatives. The catalyst composition comprises rhodium or iridium and a diphosphinite carbohydrate ligand, wher...
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WO/1995/018623A1 |
Novel compounds and libraries of compounds based on nitrogen atoms that are joined together with spanner groups include "letters", i.e. functional groups, that are attached to the nitrogen atoms, to the spanner groups or to both the nitr...
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WO/1995/018788A1 |
This invention relates to a process for preparing aqueous solutions of O-alkylhydroxylamine salts. The process involves converting hydroxylamine salts to their O-alkyl derivatives without the isolation of intermediates. More specifically...
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WO/1995/004032A1 |
In order to prepare O-substituted hydroxylammonium salts having formula (I): R1-CHX-O-NH2 . HL, in which L = halogen, hydrogen sulphate; X = H, alkyl; R1 = possibly substituted phenyl, thienyl, furanyl, pyrrolyl or -CR2=CR3R4, in which R...
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WO/1995/002574A1 |
This invention relates to novel diastereoisomeric acid addition salts of homochiral hydroxylamines, to processes for obtaining such, to processes for the conversion thereof to the corresponding homochiral hydroxylamines, to certain novel...
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WO/1994/027965A1 |
The present invention relates to novel 5-HT4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C1-4)alkyloxy or phenyl(C1-4)al...
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WO/1994/025431A1 |
The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or ...
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WO/1994/024094A1 |
Compounds of formula (I) in which (a) four of the radicals R1, R2, R3, R4, R5 and R6 are hydrogen and the others independently of one another are in each case C1-C2alkyl, these groups being bonded to the same carbon atom or to two differ...
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WO/1994/024093A1 |
Compounds of the formula (I): H2N-(CH2)n-A-(CH2)m-O-NH2 and salts thereof are described in which the radical A is C3-C6cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the...
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WO/1994/020455A1 |
Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S-, or -N(R6), wherein R6 is a hydrogen atom or an optionally substituted alkyl g...
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WO/1994/014436A1 |
A retroviral protease inhibiting compound of formula (A) is disclosed.
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WO/1994/014757A1 |
In order to prepare hydroxylamine-ethers having formula (I), in which X stands for NO2, CN, halogen, alkyl and halogen alkyl; Y stands for H, NO2, CN, halogen, alkyl and halogen alkyl; n equals 0 to 2 or 1 to 4 when Y and all X's stand f...
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WO/1994/013622A1 |
The invention concerns aralkyldiamine derivatives of the general formula (I) which have an antiarrythmic action, methods of preparing them and drugs containing them. In the general formula (I), R1 is a hydrogen atom or a benzoyl group in...
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WO/1994/011334A1 |
Compounds of general formula (I) in which the index and the constituents have the meanings below: n: 0, 1, 2, 3 or 4; X: CHOCH3, CHCH3 or NOCH3; Y: O or NH; R1: nitro, cyano, halogen, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio...
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