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Matches 351 - 400 out of 4,768

Document Document Title
JP2020158452A
To provide an efficient method for producing α-(alkylidene aminooxy)carboxylic acids that are useful as a raw material for producing an aldehyde scavenger α-(aminooxy)carboxylic acid.By reacting the oxime represented by the formula (1)...  
JP2020143223A
To provide an agent that scavenges an amine quickly and continuously.An amine scavenger comprises at least one of a carboxy group-containing O-substituted monohydroxyl amine or a chemical acceptable salt thereof to an amine source.SELECT...  
JP6734294B2
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.  
JP2020521772A
The present invention relates to the compound used as an autophagy modulator, its manufacturing method, and use. In particular, the compound of a kind of an autophagy modulator and general formula (I) which is kinds of a mammals ATG8 hom...  
JP6702868B2
A non-invasive method of detecting or screening for lung cancer in a subject specimen is provided. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for...  
JP6689836B2
The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.  
JP2020512327A
Substitution aromatic compounds of formula (I) shown below:The definition of each variable of formula (I) is indicated in this specification. The medicine constituent containing one of the substitution aromatic compounds is also indicate...  
JP2020006159A
To provide an agent that quickly and persistently scavenges aldehydes.An aldehyde scavenger is used which comprises one or more selected from O-arylhydroxylamine derivatives represented by the general formula (1) in the figure and chemic...  
JP2020006364A
To provide an aldehyde-containing water-treating agent that quickly and persistently scavenges aldehydes.An aldehyde-containing water-treating agent is used which comprises one or more selected from O-substituted hydroxylamine derivative...  
JP6574572B2
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbox ylic acid amide is disclosed having...  
JP2019131540A
To provide a novel compound having an auxin biosynthesis inhibitory activity, and a novel compound having the auxin biosynthesis inhibitory activity with different mechanism of action from conventional auxin biosynthesis inhibitors.An as...  
JP2019518023A
A method including the process of being the method of cutting an amide linkage, making the molecule containing the process;b amide machine which provides the molecule containing a amide machine reacting with hydroxylamine salt, and cutti...  
JP2019081802A
To provide tetracycline derivatives for treatment of bacterial, viral and parasitic infections.The present invention pertains, at least in part, to substituted tetracycline compounds of the formula (I), where X is CHC(RY'Y), CRR, C=CRR, ...  
JP2019023214A
To provide β-substituted β-amino acids and analogs as chemotherapeutic agents.Disclosed herein are β-substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres, an...  
JP2019019091A
To provide a method for producing fluoroalkyl nitrile that makes it possible to obtain fluoroalkyl nitrile in high yields, in a conveniently and safe manner.The present invention provides a method for producing a compound represented by ...  
JPWO2017170885A1
In a powder X diffraction, it is at the degree of angle of diffraction of 3.8±0.2 degrees (2 theta), 7.7±0.2 degrees, 10.8±0.2 degrees, etc., Or 8.2±0.2 degrees, 12.4±0.2 degrees, 13.3±0.2 degrees, etc., The crystals of -2- (4- (4-...  
JP2018536643A
The present invention indicates the oily water amphiphilic Hippocrein derivative of 1 substitution or many substitution, and its manufacturing method and use. An oily water amphiphilic Hippocrein derivative including the substitution of ...  
JP2018531213A
The present invention relates to composition and application of cancer, other diseases and histone deacetylase useful for the medical treatment of an obstacle especially inhibitor of HDAC8, and the inhibitor. The present invention relate...  
JP6407950B2
Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may b...  
JP2018076361A
To provide quinone compounds for treating Ape1 mediated diseases.The present invention provides a quinone compound represented by the formula (R's are H, an alkoxy, or an optionally substituted, condensed aryl ring, where both R's are no...  
JP2018039846A
To provide tetracycline derivatives for treatment of bacterial, viral and parasitic infections.The present invention pertains, at least in part, to substituted tetracycline compounds of the formula (I), where X is CHC(RY'Y), CRR, C=CRR, ...  
JP6273551B2  
JP2018016644A
To provide β-substituted γ-amino acids and analogs as chemotherapeutic agents.Disclosed are β-substituted γ-amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their ...  
JP6272982B2
The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and pharmaceutical compositions containing them for tr...  
JP6271766B2
β-Substituted γ-amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted γ-amino acid derivatives and...  
JP6254811B2  
JP6219290B2
A direct acid catalyzed intermolecular electrocyclic rearrangement process for the preparation of linear and cyclic homoallylic ester and amides. A one step intermolecular electrocyclic rearrangement process includes the step of reacting...  
JP2017530192A
A simple organic structure, organicity / inorganic polymer, and other substrates are created, Those all have at least one existing pylori boss portion, and are low toxicity, While it is found out that the low complement activity characte...  
JP2017529318A
The present invention provides a method for stabilizing such solution by stabilizer which contains stabilization solution useful as materials and one or more Sial kill hydroxylamine, those inorganic matter, or organic acid salt in variou...  
JP2017525723A
The present invention relates to the process of manufacturing the alkanol amide which "maturing" time is reduced and the ratio to the ester of diethanolamide in a final product increases. The additive agent constituent containing the alk...  
JP2017132775A
To provide a crystalline salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7 -[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11 ,12a-octahydro-naphthacene-2-carboxylic acid amide having improved stability, and ...  
JP6164761B2  
JP6147908B2
Provided is a styrenated phenol compound represented by Formula 1 in which styrenated phenol and hydroxylamine bind to each other: In Formula 1, n is one of integers of 1 to 3, and R 1 and R 2 are each hydrogen or one of C1 to C4 alkyl g...  
JPWO2015019928A1
The present invention is the conditions which can be manufactured more safely and efficiently, and it can manufacture an optical activity binaphthyl diamine derivative useful as synthetic materials of a catalyst used for various asymmetr...  
JP6043937B2  
JP6037392B2  
JP2016196487A
To provide a novel benzoquinolone compound having a vesicle monoamine transporter 2 (VMAT2) inhibitory action, and capable of avoiding side effects accompanying oxidative metabolism observed in dihydrotetrabenazine which is an existing m...  
JP5897786B2
Described are novel monomers bearing functionalities capable of initiating control free radical reactions, and a novel process using these initiating monomers in the co-polymerization of an olefin for the formation of well-controlled pol...  
JP5851998B2  
JP5846909B2
The present invention relates to compounds defined by formula (I) wherein the group R is defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase ...  
JP2015205939A
To provide a tetracycline derivative for treatment of bacteria infection, virus infection and parasite infection.The invention at least partially relates to a substituted tetracycline compound of the formula (I), where X is CHC(RY'Y), CR...  
JP5725561B2  
JP5706109B2  
JP5685541B2
A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett ...  
JP5682767B2
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...  
JP5676409B2
Multiphasic reactions, especially those reactions using a phase transfer catalyst, are conducted in microchannel apparatus. Advantageously, these reactions can be conducted with two, planar microlayers of reactants in adjacent laminar fl...  
JP5670331B2
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases su...  
JP2014181219A
To provide a nano fine particle in which an artificial siderophore complex magnifying sensitivity of a detection method of microorganism by QCM is modified.There is provided a fine particle a surface of which an artificial siderophore co...  
JP5583411B2
The present invention relates to tetracycline derivatives, and in particular to sancycline derivatives substituted at their 7-position by a five-membered heterocyclic ring, for use in the treatment of bacterial, viral and/or parasitic in...  
JP2014150777A
To provide freeze denaturation-suppressing agents capable of exerting excellent freeze-denaturation suppressing effect on frozen materials such as proteins and cells to prevent denaturation, functional deterioration or viability reductio...  

Matches 351 - 400 out of 4,768