Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 401 - 450 out of 4,772

Document Document Title
JP5670331B2
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases su...  
JP2014181219A
To provide a nano fine particle in which an artificial siderophore complex magnifying sensitivity of a detection method of microorganism by QCM is modified.There is provided a fine particle a surface of which an artificial siderophore co...  
JP5583411B2
The present invention relates to tetracycline derivatives, and in particular to sancycline derivatives substituted at their 7-position by a five-membered heterocyclic ring, for use in the treatment of bacterial, viral and/or parasitic in...  
JP2014150777A
To provide freeze denaturation-suppressing agents capable of exerting excellent freeze-denaturation suppressing effect on frozen materials such as proteins and cells to prevent denaturation, functional deterioration or viability reductio...  
JP2014144947A
To provide a compound that can inhibit histone deacetylase (HDAC) and is suitable as a therapeutic agent for diseases associated with cell proliferation such as malignant tumors.This invention provides a novel stilbene-like compound such...  
JP5529849B2
Provided is a process for the formation of 2-nitropropane and/or 2,2-dinitropropane by the nitration of propane with dilute nitric acid.  
JP5504325B2
The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as pol...  
JP5490481B2
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2-, and (i) heterocyclic -L2-; R2 is selec...  
JP5467381B2  
JP5451746B2
A compound selected from the group consisting of formula I-1, II-1, III-1 and IV-1: or a compound selected from the group consisting of: 2-(hydroxylamino)hexane, 3-(hydroxylamino)hexane, 2-(hydroxylamino)octane, and 3-(hydroxylamino)octa...  
JP5425619B2
PROBLEM To provide a method for producing an arylhydroxylamine compound efficiently and safely under mild conditions. MEANS FOR SOLVING THE PROBLEM The present invention relates to a method for producing an arylhydroxylamine compound, wh...  
JP5409015B2
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, the...  
JP2013545728A
The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.  
JP5368275B2
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...  
JP5330324B2
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: wherein R1, R2, R3, R4, X, and Z are as defined. This invention also includes opti...  
JP2013184940A
To provide a new compound capable of improving a protein expression efficiency from exogenous genes.A new compound is an SAHA (suberoylanilide hydroxamic acid) derivative modifying SAHA which is a histone deacetylase inhibitor as shown b...  
JP5274743B2
The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as pol...  
JP5277213B2
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...  
JP5218788B2
A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds...  
JP5212109B2  
JP5210888B2
The invention relates to the use of gallium (III) complexes for the treatment of melanomas.  
JP5196448B2  
JP5170157B2
The present invention discloses a method for producing a hydroxylamine compound wherein a nitro compound is contacted with a hydrogen source or further with a poisoning agent in the presence of a platinum catalyst fixed on an ion-exchang...  
JP5147815B2
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...  
JP5139348B2  
JP5086635B2
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...  
JP5019882B2
This invention is related to hydroxylamino derivatives of the following general formula (I) wherein n is 0, 1 or 2; R<1> and R<2>, independently of each other, are H, OH or OCH3; R<3> is H or CH3; R<4> is H, C1-C3 straight or branched al...  
JP5010788B2
Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-p...  
JP4994033B2
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This spec...  
JP4989648B2
Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neo...  
JP4979583B2
New inhibitors of histone deacetylases having antitumor activity, and the process of preparation thereof are herein described. These compounds belong to the structural formula (I) where R1 is a linear or branched chain containing at leas...  
JP2012062284A
To provide O-acyl-N-aryl-N-(trifluoromethyl)hydroxylamine derivatives and a method for producing the same useful as production intermediates of medicines, pesticides and functional materials.In the method, the O-acyl-N-aryl-N-(trifluorom...  
JP4855924B2
The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates use...  
JP2011256174A
To provide a novel substituted methyleneamido derivative useful for the treatment and/or prevention of metabolic disorder due to insulin resistance or hyperglycemia.There are provided a substituted methyleneamido derivative represented b...  
JP4829447B2
The invention pertains to a compound of formula (I), (II) or (III)wherein R1 and R2 are independently of each other hydrogen, C1-C18alkyl, C3-C18alkenyl, C3-C18alkinyl or phenyl which are unsubstituted or substituted by NO2, halogen, ami...  
JP4686703B2  
JP2011098895A
To provide an industrially useful method of producing 2-hydroxyethyloxyamine compound.The method of producing a 2-hydroxyethyloxyamine compound represented by formula (3) includes reacting a 2-(2-hydroxyethoxy)isoindoline-1,3-dione compo...  
JP4676061B2
Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, ...  
JP2011079834A
To provide a new iron chelator or the like exhibiting neuroprotective characteristics and good transport characteristics.The new iron chelator exhibiting neuroprotective characteristics and good transport characteristics is useful in iro...  
JP2011046714A
To provide a lactone-containing compound such as discodermolides; a compound which mimics chemical and/or biological activity thereof; and a method and an intermediate, both of which are useful for producing the above compounds.There are...  
JP4631702B2
The present invention discloses a method for producing a hydroxylamine compound wherein a nitro compound is contacted with a hydrogen source or further with a poisoning agent in the presence of a platinum catalyst fixed on an ion-exchang...  
JP4625236B2
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels a...  
JP4617114B2  
JP4602671B2
The present invention relates to open chain alkoxyamine compounds, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one open chain alkoxyamine compound. Further aspects of the prese...  
JP2010538071A
The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and nepri...  
JP2010265292A
To provide new nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and methods for treating inflammation, pain and fever, for treating gastrointestinal disorders, and for facilitating wo...  
JP4554822B2
The present invention relates to a process for the continuous preparation of methoxyamine hydrochloride by cleavage of acetone oxime methyl ether by means of hydrogen chloride and water, wherein the cleavage is carried out in a reaction ...  
JP4542340B2
The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a plurality of processes for their preparation, and to their use as mic...  
JP2010189319A
To provide an industrially advantageous method of a low environmental load producible of an aminooxy compound with a high yield and also producible of an optically active aminooxy compound of high optical purity.The method for producing ...  
JP4505698B2  

Matches 401 - 450 out of 4,772