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JP5670331B2 |
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases su...
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JP2014181219A |
To provide a nano fine particle in which an artificial siderophore complex magnifying sensitivity of a detection method of microorganism by QCM is modified.There is provided a fine particle a surface of which an artificial siderophore co...
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JP5583411B2 |
The present invention relates to tetracycline derivatives, and in particular to sancycline derivatives substituted at their 7-position by a five-membered heterocyclic ring, for use in the treatment of bacterial, viral and/or parasitic in...
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JP2014150777A |
To provide freeze denaturation-suppressing agents capable of exerting excellent freeze-denaturation suppressing effect on frozen materials such as proteins and cells to prevent denaturation, functional deterioration or viability reductio...
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JP2014144947A |
To provide a compound that can inhibit histone deacetylase (HDAC) and is suitable as a therapeutic agent for diseases associated with cell proliferation such as malignant tumors.This invention provides a novel stilbene-like compound such...
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JP5529849B2 |
Provided is a process for the formation of 2-nitropropane and/or 2,2-dinitropropane by the nitration of propane with dilute nitric acid.
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JP5504325B2 |
The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as pol...
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JP5490481B2 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2-, and (i) heterocyclic -L2-; R2 is selec...
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JP5467381B2 |
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JP5451746B2 |
A compound selected from the group consisting of formula I-1, II-1, III-1 and IV-1: or a compound selected from the group consisting of: 2-(hydroxylamino)hexane, 3-(hydroxylamino)hexane, 2-(hydroxylamino)octane, and 3-(hydroxylamino)octa...
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JP5425619B2 |
PROBLEM To provide a method for producing an arylhydroxylamine compound efficiently and safely under mild conditions. MEANS FOR SOLVING THE PROBLEM The present invention relates to a method for producing an arylhydroxylamine compound, wh...
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JP5409015B2 |
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, the...
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JP2013545728A |
The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.
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JP5368275B2 |
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...
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JP5330324B2 |
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: wherein R1, R2, R3, R4, X, and Z are as defined. This invention also includes opti...
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JP2013184940A |
To provide a new compound capable of improving a protein expression efficiency from exogenous genes.A new compound is an SAHA (suberoylanilide hydroxamic acid) derivative modifying SAHA which is a histone deacetylase inhibitor as shown b...
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JP5274743B2 |
The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as pol...
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JP5277213B2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...
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JP5218788B2 |
A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds...
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JP5212109B2 |
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JP5210888B2 |
The invention relates to the use of gallium (III) complexes for the treatment of melanomas.
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JP5196448B2 |
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JP5170157B2 |
The present invention discloses a method for producing a hydroxylamine compound wherein a nitro compound is contacted with a hydrogen source or further with a poisoning agent in the presence of a platinum catalyst fixed on an ion-exchang...
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JP5147815B2 |
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...
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JP5139348B2 |
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JP5086635B2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...
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JP5019882B2 |
This invention is related to hydroxylamino derivatives of the following general formula (I) wherein n is 0, 1 or 2; R<1> and R<2>, independently of each other, are H, OH or OCH3; R<3> is H or CH3; R<4> is H, C1-C3 straight or branched al...
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JP5010788B2 |
Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-p...
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JP4994033B2 |
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This spec...
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JP4989648B2 |
Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neo...
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JP4979583B2 |
New inhibitors of histone deacetylases having antitumor activity, and the process of preparation thereof are herein described. These compounds belong to the structural formula (I) where R1 is a linear or branched chain containing at leas...
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JP2012062284A |
To provide O-acyl-N-aryl-N-(trifluoromethyl)hydroxylamine derivatives and a method for producing the same useful as production intermediates of medicines, pesticides and functional materials.In the method, the O-acyl-N-aryl-N-(trifluorom...
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JP4855924B2 |
The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates use...
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JP2011256174A |
To provide a novel substituted methyleneamido derivative useful for the treatment and/or prevention of metabolic disorder due to insulin resistance or hyperglycemia.There are provided a substituted methyleneamido derivative represented b...
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JP4829447B2 |
The invention pertains to a compound of formula (I), (II) or (III)wherein R1 and R2 are independently of each other hydrogen, C1-C18alkyl, C3-C18alkenyl, C3-C18alkinyl or phenyl which are unsubstituted or substituted by NO2, halogen, ami...
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JP4686703B2 |
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JP2011098895A |
To provide an industrially useful method of producing 2-hydroxyethyloxyamine compound.The method of producing a 2-hydroxyethyloxyamine compound represented by formula (3) includes reacting a 2-(2-hydroxyethoxy)isoindoline-1,3-dione compo...
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JP4676061B2 |
Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, ...
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JP2011079834A |
To provide a new iron chelator or the like exhibiting neuroprotective characteristics and good transport characteristics.The new iron chelator exhibiting neuroprotective characteristics and good transport characteristics is useful in iro...
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JP2011046714A |
To provide a lactone-containing compound such as discodermolides; a compound which mimics chemical and/or biological activity thereof; and a method and an intermediate, both of which are useful for producing the above compounds.There are...
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JP4631702B2 |
The present invention discloses a method for producing a hydroxylamine compound wherein a nitro compound is contacted with a hydrogen source or further with a poisoning agent in the presence of a platinum catalyst fixed on an ion-exchang...
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JP4625236B2 |
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels a...
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JP4617114B2 |
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JP4602671B2 |
The present invention relates to open chain alkoxyamine compounds, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one open chain alkoxyamine compound. Further aspects of the prese...
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JP2010538071A |
The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and nepri...
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JP2010265292A |
To provide new nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and methods for treating inflammation, pain and fever, for treating gastrointestinal disorders, and for facilitating wo...
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JP4554822B2 |
The present invention relates to a process for the continuous preparation of methoxyamine hydrochloride by cleavage of acetone oxime methyl ether by means of hydrogen chloride and water, wherein the cleavage is carried out in a reaction ...
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JP4542340B2 |
The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a plurality of processes for their preparation, and to their use as mic...
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JP2010189319A |
To provide an industrially advantageous method of a low environmental load producible of an aminooxy compound with a high yield and also producible of an optically active aminooxy compound of high optical purity.The method for producing ...
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JP4505698B2 |
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