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JPWO2015019928A1 |
The present invention relates to a novel synthetic method capable of producing an optically active binaphthyldiamine derivative useful as a synthetic raw material for a catalyst used for various asymmetric synthesis under conditions that...
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JP6043937B2 |
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JP6037392B2 |
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JP2016196487A |
To provide a novel benzoquinolone compound having a vesicle monoamine transporter 2 (VMAT2) inhibitory action, and capable of avoiding side effects accompanying oxidative metabolism observed in dihydrotetrabenazine which is an existing m...
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JP5897786B2 |
Described are novel monomers bearing functionalities capable of initiating control free radical reactions, and a novel process using these initiating monomers in the co-polymerization of an olefin for the formation of well-controlled pol...
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JP5851998B2 |
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JP5846909B2 |
The present invention relates to compounds defined by formula (I) wherein the group R is defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase ...
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JP2015205939A |
To provide a tetracycline derivative for treatment of bacteria infection, virus infection and parasite infection.The invention at least partially relates to a substituted tetracycline compound of the formula (I), where X is CHC(RY'Y), CR...
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JP5725561B2 |
The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and ...
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JP5706109B2 |
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JP5685541B2 |
A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett ...
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JP5682767B2 |
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...
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JP5676409B2 |
Multiphasic reactions, especially those reactions using a phase transfer catalyst, are conducted in microchannel apparatus. Advantageously, these reactions can be conducted with two, planar microlayers of reactants in adjacent laminar fl...
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JP5670331B2 |
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases su...
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JP2014181219A |
To provide a nano fine particle in which an artificial siderophore complex magnifying sensitivity of a detection method of microorganism by QCM is modified.There is provided a fine particle a surface of which an artificial siderophore co...
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JP5583411B2 |
The present invention relates to tetracycline derivatives, and in particular to sancycline derivatives substituted at their 7-position by a five-membered heterocyclic ring, for use in the treatment of bacterial, viral and/or parasitic in...
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JP2014150777A |
To provide freeze denaturation-suppressing agents capable of exerting excellent freeze-denaturation suppressing effect on frozen materials such as proteins and cells to prevent denaturation, functional deterioration or viability reductio...
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JP2014144947A |
To provide a compound that can inhibit histone deacetylase (HDAC) and is suitable as a therapeutic agent for diseases associated with cell proliferation such as malignant tumors.This invention provides a novel stilbene-like compound such...
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JP5529849B2 |
Provided is a process for the formation of 2-nitropropane and/or 2,2-dinitropropane by the nitration of propane with dilute nitric acid.
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JP5504325B2 |
The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as pol...
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JP5490481B2 |
Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2-, and (i) heterocyclic -L2-; R2 is selec...
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JP5467381B2 |
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JP5451746B2 |
A compound selected from the group consisting of formula I-1, II-1, III-1 and IV-1: or a compound selected from the group consisting of: 2-(hydroxylamino)hexane, 3-(hydroxylamino)hexane, 2-(hydroxylamino)octane, and 3-(hydroxylamino)octa...
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JP5425619B2 |
PROBLEM To provide a method for producing an arylhydroxylamine compound efficiently and safely under mild conditions. MEANS FOR SOLVING THE PROBLEM The present invention relates to a method for producing an arylhydroxylamine compound, wh...
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JP5409015B2 |
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, the...
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JP2013545728A |
The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.
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JP5368275B2 |
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...
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JP5330324B2 |
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: wherein R1, R2, R3, R4, X, and Z are as defined. This invention also includes opti...
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JP2013184940A |
To provide a new compound capable of improving a protein expression efficiency from exogenous genes.A new compound is an SAHA (suberoylanilide hydroxamic acid) derivative modifying SAHA which is a histone deacetylase inhibitor as shown b...
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JP5274743B2 |
The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as pol...
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JP5277213B2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...
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JP5218788B2 |
A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds...
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JP5212109B2 |
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JP5210888B2 |
The invention relates to the use of gallium (III) complexes for the treatment of melanomas.
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JP5196448B2 |
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JP5170157B2 |
The present invention discloses a method for producing a hydroxylamine compound wherein a nitro compound is contacted with a hydrogen source or further with a poisoning agent in the presence of a platinum catalyst fixed on an ion-exchang...
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JP5147815B2 |
The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance i...
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JP5139348B2 |
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JP5086635B2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...
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JP5019882B2 |
This invention is related to hydroxylamino derivatives of the following general formula (I) wherein n is 0, 1 or 2; R<1> and R<2>, independently of each other, are H, OH or OCH3; R<3> is H or CH3; R<4> is H, C1-C3 straight or branched al...
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JP5010788B2 |
Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-p...
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JP4994033B2 |
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This spec...
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JP4989648B2 |
Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neo...
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JP4979583B2 |
New inhibitors of histone deacetylases having antitumor activity, and the process of preparation thereof are herein described. These compounds belong to the structural formula (I) where R1 is a linear or branched chain containing at leas...
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JP2012062284A |
To provide O-acyl-N-aryl-N-(trifluoromethyl)hydroxylamine derivatives and a method for producing the same useful as production intermediates of medicines, pesticides and functional materials.In the method, the O-acyl-N-aryl-N-(trifluorom...
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JP4855924B2 |
The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates use...
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JP2011256174A |
To provide a novel substituted methyleneamido derivative useful for the treatment and/or prevention of metabolic disorder due to insulin resistance or hyperglycemia.There are provided a substituted methyleneamido derivative represented b...
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JP4829447B2 |
The invention pertains to a compound of formula (I), (II) or (III)wherein R1 and R2 are independently of each other hydrogen, C1-C18alkyl, C3-C18alkenyl, C3-C18alkinyl or phenyl which are unsubstituted or substituted by NO2, halogen, ami...
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JP4686703B2 |
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JP2011098895A |
To provide an industrially useful method of producing 2-hydroxyethyloxyamine compound.The method of producing a 2-hydroxyethyloxyamine compound represented by formula (3) includes reacting a 2-(2-hydroxyethoxy)isoindoline-1,3-dione compo...
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