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WO/2024/034642A1 |
Provided is an azobenzene derivative represented by formula (1). (In formula (1), R1 represents a C1-18 alkoxy group, R2 each independently represent a hydrogen atom or a C1-4 alkyl group, R3 represents a hydrogen atom, a C1-4 alkyl grou...
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WO/2023/208233A1 |
Provided are a diazo compound, a preparation method therefor, and a use thereof. The diazo compound has a structure as shown in formula (I), wherein R1 represents H, an alkyl, a halogen, an alkoxy or an alkylamino; and R2 represents an a...
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WO/2023/202651A1 |
Provided herein are new polymorph forms of the compound of Formula (I), pharmaceutical composition thereof, and methods of preparing them and using them.
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WO/2023/155247A1 |
Provided are a single-molecular-weight amphiphilic fluorene-azobenzene oligomer, a self-assembled fiber, and a preparation method. The present invention diversifies and expands the studies of molecules having a backbone containing fluori...
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WO/2023/114963A1 |
This disclosure relates to compositions and methods for selective labeling of aliphatic or aromatic secondary amines. In certain embodiments, the secondary amines are N-methyl lysine, N-terminal proline, N-alkyl lysine, N-alkyl adenosine...
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WO/2023/095166A1 |
The present invention relates to substituted-diazenylanilines of the formula I and their nucleotide conjugates, complexes, salts which may be used potentially as fluorescent quenchers in chemical and biological sciences such as cell imag...
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WO/2023/081832A1 |
Provided are glutamine antagonists and prodrugs of glutamine analogs having formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R2', and X are as defined as set forth in the specification, for use in preventing an...
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WO/2023/043197A1 |
The present invention provides a cannabidiol derivative, a method for preparing same, and a composition for cognitive function improvement comprising same. The novel cannabidiol derivative of the present invention has been confirmed to e...
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WO/2023/023500A1 |
Disclosed herein include methods, compositions, reaction mixtures, kits and systems for identification of methylated cytosines in nucleic acids using a bisulfite-free, one-step chemoenzymatic modification of methylated cytosines.
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WO/2023/276667A1 |
This composition includes a compound represented by formula (1) and a liquid crystal compound. In the formula, n is 1 or 2. Ar1, Ar2, and Ar3 represent 1,4-phenylene groups or the like, where at least one thereof has a hydroxyl group tha...
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WO/2023/276668A1 |
Provided is a composition comprising a compound represented by formula (1) and a liquid crystal compound. (In the formula , n is 1 or 2. Ar1, Ar2, and Ar3 each represent a 1,4-phenylene group or the like, and at least one of these has a ...
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WO/2022/264172A1 |
The present invention relates to a process for the preparation of 2-chloro-4-fluorotoluene of formula I from diazotization of 2-chloro-4-aminotoluene of formula III.
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WO/2022/232565A1 |
The present disclosure provides prodrugs of 6-diazo-5-oxo-L-norleucine (DON) for use in treating or preventing a disease, disorder, or condition in which the inhibition of glutamineutilizing enzymes provides a benefit.
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WO/2022/198124A1 |
Provided are photoswitchable glycerophospholipids having a photoswitchable group having the following structure: or The photoswitchable glycerophospholipids can be isomerized by red spectral light. Also disclosed are nanovesicles (e.g., ...
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WO/2022/170704A1 |
Disclosed in the embodiments of the present application are a green-light sacrificial layer, and a preparation method for a touch-control display panel. The green-light sacrificial layer is made of a green-light sacrificial layer materia...
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WO/2022/163736A1 |
[Problem] To provide an azo iron complex dye which does not contain harmful heavy metals, exhibits sufficient solubility in organic solvents for practical use, and exhibits a good black color. [Solution] This azo iron complex dye contain...
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WO/2022/072820A1 |
The present disclosure provides lyophilates comprising (S)-isopropyl 2-((S)-2- acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoa
te: for subcutaneous administration to a subject, and pharmaceutical compositions, pharmaceutical...
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WO/2022/061920A1 |
A method for preparing 3',5'-dichloro-2,2,2-trifluoroacetophenone. The method comprises subjecting 3'-chloro-2,2,2-trifluoroacetophenone as a raw material to four steps, i.e. nitrification, reduction, chlorination and deamination, so as ...
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WO/2022/061918A1 |
The present application relates to the technical field of chemical pharmacy, and in particular, to a preparation method for 3,5-dihalobenzotrifluoride, comprising: using 3,5-dihalo-4-aminotrifluorotoluene as a raw material, and subjectin...
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WO/2022/061914A1 |
The present application relates to the technical field of chemical pharmacy, and in particular, to a method for preparing 3,5-dihalotrifluoroacetophenone and a derivative thereof. 3-halogen-4-nitrotrifluoroacetophenone is used as a raw m...
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WO/2022/044038A1 |
An automated apparatus (Diazo-M-pen and Diazo-M-cube) for production, utilization and quenching of highly toxic diazomethane comprising of integrated pumps, tubular flow reactor, liquid-liquid micro-separator, solid MOF quencher etc.
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WO/2022/027769A1 |
An azobenzene derivative, a preparation method therefor, an azophenyl light-controlled reversible adhesive, and a method for using same. The azobenzene derivative has a structure represented by P1 and P2. The preparation method therefor ...
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WO/2021/239049A1 |
A novel glutamine analogs shown as the formula (I), a composition containing the glutamine analogs and the use thereof.
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WO/2021/181416A1 |
The present invention relates to a process for the preparation of l-bromo-2,4,5-trifluorobenzene from 2,4,5-trifhioroaniline or sulfate salt thereof. The present invention also relates to a process for the preparation of 1,2,4-trifluorob...
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WO/2021/175251A1 |
The present disclosure provides a quantum dot ligand and a preparation method therefor, a light-emitting device and a preparation method therefor, and a display device. The quantum dot ligand is an azobenzene compound represented by form...
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WO/2021/160654A1 |
This invention concerns a versatile and simple one-pot method to prepare nanomaterials, and in particular nanoparticles, grafted with an ultra-thin layer of calixarenes by placing at 5 least one oxidized metal with at least one calix[n]a...
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WO/2021/158638A1 |
The present invention relates to a compound of Formula (I): wherein R1, R2, m, n, p, Q, X, Y, W, and "A" are as described herein. The present invention also relates to a process for preparation of a compound of Formula (I). Also disclose...
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WO/2021/095059A1 |
The present disclosure provides a continuous process for the synthesis coupled compounds of diazonium salts including azo dyes involving in-situ generation of diazonium salts. It further discloses a set up to carry out the process for th...
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WO/2021/039929A1 |
An ionic metal complex which contains a metal complex cation and at least one anion (A) that is selected from the group consisting of a dye anion, a metal complex anion and a metal salt anion.
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WO/2021/022984A1 |
A pharmaceutical composition comprising an azo calixarene supramolecular compound of formula (I) as a targeted pharmaceutical adjuvant for hypoxia response, and pharmaceutical use of the azo calixarene supramolecular compound.
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WO/2021/000248A1 |
Disclosed in the present invention are a method and an apparatus for continuous synthesis of cyclopropane compounds. The method comprises the following steps: the synthesis reaction of a diazomethane precursor is carried out continuously...
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WO/2019/234567A9 |
The present patent application relates to compounds of formula (1) wherein Y and Z are independently O, N, P; R, R1, R2, R3, where present, are independently H, optionally substituted C1-C12 alkyl, O, or R and R1 and/or R2 and R3 form, t...
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WO/2020/246342A1 |
Provided are: an ink composition containing a colorant comprising an azo compound represented by formula (1) or a slat thereof, etc.; an ink-jet recording method including using the ink composition; and a recorded material obtained by ad...
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WO/2020/232625A1 |
The present invention provides a process of preparing diazomethane. The process comprises: step S1, using N-methylurea as a raw material to continuously prepare a first product system containing N-methyl-N-nitrosourea in a continuous rea...
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WO/2020/175711A1 |
This compound is represented by formula (1). L1 and L2 each independently denote an alkyl group having 1-20 carbon atoms, an alkoxy group having 1-20 carbon atoms, NH2, NHR3, NR3R4, an ester group, a carboxyl group, an amide group, a cya...
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WO/2020/167829A1 |
The present disclosure provides a method of preparing a compound of Formula I, wherein R1 is C1-C4 alkyl; R2 is C1-C4 alkyl; and R3 is selected from the group consisting of C1-C6 alkyl, (aryl)alkyl, and (heteroaryl)alkyl in >95% chemical...
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WO/2020/167831A1 |
The present disclosure provides methods of preparing a compound of Formula (1): wherein R1, R2, and R3 are as defined as set forth in the application. In one embodiment, a compound of Formula (1) is prepared in >95% chemical purity and >...
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WO/2020/121304A1 |
Provided herein is a class of anti-cancer conjugates designed to cross the blood-brain barrier (BBB) and thereby deliver a methylation agent into cancerous tumor cells, wherein the conjugate comprises a BBB-shuttle moiety that allows the...
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WO/2020/065318A1 |
A composition comprising a compound of formula (I): wherein R1 and R2 may be the same or different, and are independently selected from hydrogen; halogen; hydroxyl; C1-18 alkoxy; C1-18 alkyl; C1-18 cycloalkyl; a primary, secondary or ter...
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WO/2020/065119A1 |
The invention relates to a group of compounds with a structural nucleus of acylhydrazone, which are capable of modulating the interaction between the proteins NCS-1 and Ric8a involved in the process of regulating the number of synapses a...
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WO/2020/048018A1 |
Disclosed are a reactive disperse dye dedicated for water-free dyeing of a natural fiber in supercritical CO 2 fluid, and an intermediate thereof. A long alkane chain bridge group is comprised between a dye parent chromophore of the reac...
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WO/2020/044348A1 |
Compositions comprising a tetraaryl ammonium salt, a tetraaryl ammonium salt covalently bound to a polymer and methods for manufacturing the same are disclosed. The disclosed compositions are useful e.g., for an anion exchange membrane, ...
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WO/2020/043997A1 |
The present invention relates to 1,4-dimethyltetrazenes of formula (la), (Ib) and (le): R1-CH2-N(CH3)-N=N-N(CH3)-CH2-R2 (la) R3-CH2-CH2-N(CH3)-N=N-N(CH3)-CH2-CH2-R4 (Ib) R5-CHOH-CH2-N(CH3)-N=N-N(CH3)-CH2-CHOH-R5 (lc), in which RI, R2, R3...
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WO/2019/182137A1 |
The present invention addresses the problem of providing a metal-organic framework production method capable of producing metal-organic frameworks which exhibit excellent gas adsorbability and durability.　This metal-organic framework p...
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WO/2019/181784A1 |
Provided are a photoresponsive compound, composition, and polymer compound. A photoresponsive polymer compound according to the present invention contains an azo compound-based repeating unit represented by formula (B). (In formula (B), ...
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WO/2019/139009A1 |
The present invention addresses the problem of providing a technology whereby a detection object can be detected with high sensitivity. The present invention provides a linker compound represented by formula (1). (In formula (1), A repre...
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WO/2019/132739A1 |
The present invention relates to the field of organic chemistry and pharmacology and describes novel asymmetric derivatives of polyphenols of the dinaphthalene series of general Formula (I) or general Formula (II), a process of preparing...
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WO/2019/115646A1 |
The invention relates to the use of a metal complex, which has at least one ligand of the formula R1-N3-R2, wherein R1 and R2 are hydrocarbon moieties, for depositing the metal or a compound of the metal from the gas phase. The invention...
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WO/2019/060785A1 |
The present disclosure provides a conjugate comprising: a) an affinity agent that specifically binds a target ligand-binding polypeptide; and b) a photoisomerizable regulator comprising: i) a photoisomerizable moiety; and ii) a ligand th...
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WO/2018/217689A1 |
Described herein are genetically engineered template-independent DNA polymerases, specifically terminal deoxynucleotidyl transferases, and methods of using these polymerases to control DNA synthesis by adding a single nucleotide (mononuc...
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