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WO/1995/001970A1 |
Described is a process for converting an alcohol to an azide with SN2 inversion using a phosphoryl azide, e.g. diphenylphosphoryl azide (DPPA). Good yields of azide in high enantiomeric excess can be achieved specifically for benzylic al...
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WO/1994/029255A1 |
Compounds of general formula (I), stereoisomers and pharmaceutically acceptable salts thereof, wherein each of Z and Z' are independently H or F; Q is (a), CH(OH), (b); X is H, Br, Cl, F or CF3; Y is H, Br, Cl, F, OH, OR5, OC(O)R4, N3, C...
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WO/1994/017096A1 |
Compounds of formula (I), wherein Ar, W, Z, Q, R1, U, and L are as set forth herein, are described. These compounds are active as agents against HIV and inhibit renin and therefore are also active against hypertension. Similar retrovirus...
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WO/1994/014436A1 |
A retroviral protease inhibiting compound of formula (A) is disclosed.
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WO/1994/006433A1 |
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, ether or thioether groups, e.g...
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WO/1994/005643A1 |
This invention relates to novel neopentyl difluoroamino compounds which are useful as plasticizers and oxidizers in energetic formulations, such as propellants, explosives, and gasifiers. These neopentyl difluoroamino compounds can be pr...
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WO/1993/023383A1 |
A compound of formula (I) wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is...
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WO/1993/013051A1 |
This invention relates to energetic binders, and, more specifically, a class of nitramine-containing polyether polymers characterized by favorable viscosity and glass transition temperature, as well as resistance to hydrolysis are prepar...
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WO/1993/012165A1 |
Composition capable of being transformed into a foam comprising a polymeric resin-based blend and an effective quantity of blowing agent in relation to said resin. The agent comprises at least one alpha, beta hydroxylated hydrocarbon nit...
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WO/1993/012055A2 |
Photocurable cyclobutarene compositions having a low dielectric constant, low moisture uptake, enhanced oxidative stability, good processability, good planarization, and a long shelf life are disclosed. These polymer compositions are use...
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WO/1992/021657A1 |
Omega-deoxy-azapyranose compounds, processes of making and using the same are disclosed, as are a process of making omega-deoxy-azafuranose compounds.
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WO/1992/017176A1 |
Compounds are disclosed which are retroviral protease inhibitors. Also disclosed are methods of using the compounds and compositions for inhibiting a retroviral protease and for treating an HIV infection.
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WO/1992/002484A1 |
Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes, aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class and from polyacetates, diaminobe...
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WO/1992/000750A1 |
Compounds useful as inhibitors of retroviral proteases characterized by structures (I) and (II) wherein the X1 and X2 groups may consist of 0 to 2 alpha-amino acid groups terminally substituted by hydrogen or one of a number of end group...
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WO/1992/000275A1 |
The description relates to a process for producing enantiomer-pure $g(a)-hydroxypropionoaldehyde derivatives of the general formula (I) in which: R¿1? is the substituent Q which may be a hydrocarbon radical interrupted by oxygen atoms, ...
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WO/1991/018890A1 |
A compound of general formula I(a) and/or I(b) and/or I(c), in which R1 represents a methyl group or a group of the general formula -CH2.SO2.R2 or -CH2.SO2.NR2R3, in which each of R2 and R3 independently represents an alkyl, cycloalkyl o...
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WO/1991/013054A1 |
Compounds of formula (I), wherein A completes a 5 or 6 membered carbocyclic ring which may be saturated or monounsaturated; Y is an alkylene group of from 1 to 9 carbon atoms; R1 is H or (C1-C4)alkyl; R and R4 are H, (C1-C6)alkyl, (C3-C7...
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WO/1991/003227A1 |
Topical polyethylene glycol based formulations for the delivery of 2-substituted-1-naphthols and indoles and particularly, 2-phenylmethyl-1-naphthol are provided. Said topical formulations exert excellent localized antiinflammatory activ...
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WO/1991/002084A1 |
A method for the detection of multiple drug-resistant tumor cells is described which comprises the admixture of a sample of mammalian tumor cellular material with an effective binding amount of a labeled colchicine derivative to form a c...
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WO/1990/008539A1 |
The present invention relates to a method for inhibiting the phosphatidylinositol cycle in a cell by contacting the cell with certain myo-inositol analogs. Such myo-inositol analogs can also be utilized to treat phosphatidylinositol cycl...
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WO/1989/011478A1 |
A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles ...
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WO/1989/009542A1 |
The invention is directed to azido-substituted octopamine agonists and the radiolabeled derivatives thereof. The invention also relates to pest controlling compositions comprising the azido-substituted octopamine agonists of the inventio...
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WO/1989/007098A1 |
The present invention concerns a compound having structure (I), wherein R1 is a branched- or unbranched-chain alkylamine having from 2 to 20 atoms in the chain and wherein each of R2, R3 and R4 is the same or different and is hydrogen or...
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WO/1989/001470A1 |
The invention concerns a process for producing E/Z mixtures of 2-(bicyclo[3.3.0]octane-3-ylidene) acetic acid derivatives of formula (I) in which either the E or the Z moiety predominates.
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WO/1989/000990A1 |
The invention concerns carbacycline derivatives of formula (I), where Y1 is the residue -CH2-X-(CH2)n-R1 or the residue (a), n = 1 or 3, R1 is the residue (b), the residue (c), -COCH3, COOR2, where R2 is hydrogen or possibly alkyl with 1...
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WO/1988/007521A1 |
Compounds having the general formula (I), where n and m each denote the figures 0, 1, 2, 3 and 4, X denotes a hydrogen atom and/or a metallic ion equivalent of an element of the ordinal numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83, R...
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WO/1988/007514A1 |
Tolanes having the formula (I): R1-(A1-Z1)m-A3-C=C-A4-(A2)n-R2, in which R1, A1, Z1, m, A3, A4, A2, n and R2 are as given in claim (1), and application of said tolanes as components of liquid crystal phases, particularly as components of...
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WO/1988/003567A1 |
Process for the production of optically active (+)-bicyclo[3.3.0]octanol derivatives of formula (+)-I, in which R1 and R2 represent jointly an oxygen atom or the double-bond residue -O-X-O-, with X as a straight or branched-chain alkylen...
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WO/1987/006929A1 |
A new chiral reagent of formula (I), wherein X is halogen, an azide group or a succinimidyl group and wherein R is an alkyl group or a trifluormethyl group. The invention further relates to a method for derivatization, determination and ...
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WO/1986/005487A1 |
A new process for the manufacture of benzoyl urea with formula (I) (the symbols are defined in the description) starts from benzoyl derivates of the formula Q - COF which, by way of the appropriate azides are transformed into the isocyan...
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WO/1986/001799A1 |
A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols. Preparation of D-(threo)-1-Aryl-2-acylamido-...
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JP7427242B2 |
To provide a novel optically active azide ester and a method for producing the same.The present invention discloses a series of methods whereby: a zinc binuclear complex catalyst composed of a 3,3'-amino imino binaphthol ligand and a zin...
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JP2024015264A |
The present invention provides photoactivatable compounds and methods for their use to determine binding sites and other structural information about RNA transcripts. The present invention also provides methods for identifying RNA transc...
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JP2023184620A |
To provide methods for site-selectively crosslinking payloads to antibodies and other proteins.The foregoing problem is solved by using traceless affinity labels designed to label target proteins with bio-orthogonally reactive entities (...
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JP2023179471A |
To provide a novel alginic acid derivative or a novel crosslinked alginic acid, and production methods therefor.The present invention provides alginic acid derivatives represented by formula (I) and formula (II), and a novel crosslinked ...
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JP2023535295A |
The present invention is a functionalized thermoplastic polyurethane containing a novel chain extender having a functionality capable of chemically bonding to a prepolymer polymerized by reacting a polyol (P) and a diisocyanate (R). , fu...
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JP7326395B2 |
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions fu...
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JP2023013561A |
To provide means excellent in radiation (particularly EUV) absorption properties and enabling improvement of properties, such as sensitivity, developability and resolution.Ionic salt is provided, consisting of a multivalent ion (a) havin...
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JP7161776B2 |
Disclosed herein are compositions for use in an energy providing devices and methods of preparing such devices. Also included herein is energy providing devices that comprise a charged compound modified substrate or zwitterion-modified s...
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JP7137590B2 |
A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
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JP2022538253A |
Bis(2-haloacetamide) compounds for use as linkers to chemically cross-link multiple thiol groups, particularly but not limited to the thiol groups of cysteine amino acids in peptide chains, and also as linking agents and resulting produc...
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JP7034461B2 |
To provide a botryococcene derivative.The present invention provides a botryococcene derivative in which at least one double bond of botryococcene is replaced by one of the following formulae (each arrows denotes a bond to an adjacent at...
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JP6968809B2 |
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...
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JP2021523133A |
Aspects allow rapid and reversible labeling of single-stranded nucleic acids in living cells, N.3-Intended for kethoxal reagents and their derivatives, as well as related methods. As an example, one aspect aims at a process for the rever...
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JPWO2020004043A1 |
Provided is a method capable of producing an α-azidoaniline derivative or an α, α'-diazide derivative using an aniline derivative as a starting material. In the present invention, the aniline derivative represented by the formula (1) ...
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JPWO2019235493A1 |
Provided is a method capable of producing a diaminobenzoic acid ester and a benzimidazole derivative more easily by using a cheaper material. The present invention produces an azide form of the anthranilic acid ester represented by the f...
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JP2021509115A |
The present invention relates to the fields of organic chemistry and pharmacology, a novel asymmetric derivative of the dinaphthalene series polyphenols of general formula (I) or general formula (II), a method for producing the same, and...
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JP6833764B2 |
Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent bindin...
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JP6826367B2 |
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified...
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JP2021502418A |
The present disclosure provides a method for site-selectively cross-linking a payload to antibodies and other proteins. This is achieved using traceless affinity labeling designed to label the target protein with a bioorthogonal reactive...
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