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JP2013104100A |
To provide a method for depositing a metallic thin film, whereby a low substrate temperature can be achieved and the deposition rate can be improved, and a raw material for depositing the metallic thin film.The method for depositing the ...
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JP5190366B2 |
Pharmaceutical compositions comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-
dioxo-1 (2H)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of ...
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JP5140854B2 |
The present invention relates to a medicine, and more particularly to novel arylamidrazone derivatives having an antagonistic action against S1P 3 receptors and a medicine containing thereof as an active ingredient. The present invention...
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JP5128341B2 |
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JP5117377B2 |
Chemical compounds identified by in silico molecular modelling, and having an structure that allows the blocking of the phosphorylation event, through the interaction of such compounds with the phosphorylation domain or its milieu in the...
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JP5116207B2 |
The invention describes compounds represented by the general formula (I) given below: in which: n is an integer between 1 and 4; R1 and R2 are chosen independently from hydrogen and a methyl group; R3 is chosen independently from a linea...
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JP2012527435A |
A compound of formula (I) wherein R1 to R15, P1, P2, A, B and Q are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as matriptase inhibitors a...
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JP5064872B2 |
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JP5064125B2 |
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JP5063860B2 |
Diamidine derivatives of formula (I) and their salts are new. Amidine derivatives of formula (I) and their salts are new. [Image] X : a group of formula (ii) or R 4; Z : -(CH 2) m-; m : 8 - 21; n : 0 or 1; Y : R 3 or a group of formula (...
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JP2012207034A |
To provide: a 3-iminopropene compound represented by formula (I) or its salt; a pesticide composition containing the same; a noxious organism-controlling agent containing the same; and a method of controlling noxious organisms, character...
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JP2012524769A |
Processes for the preparation of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbam
oylmethyl)piperidin-4-yl]oxy}quinazoline, salts thereof, and the intermediates used in the process are described.
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JP5049946B2 |
An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at atypical beta-adrenoceptors (also known as beta-3-adrenoceptors).
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JP5042548B2 |
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JP5016178B2 |
The present invention relates to compounds of the of the formula I, in which R<1>, R<2>, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a st...
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JP5009480B2 |
The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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JP5004643B2 |
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JP2012153902A |
To provide an improved curative capable of being more easily dispersed in a perfluoroelastomer, particularly a cyano curable perfluoroelastomer and more rapidly curing the perfluoroelastomer, particularly cyano curable perfluoro elastome...
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JP2012518030A |
The present invention relates to a process for preparing 2-aminobiphenyls of the formula I in which n is 0, 1, 2 or 3, R1 is hydrogen, cyano or fluorine, and each R2 is independently selected from cyano, fluorine, C1-C4-alkyl, C1-C4-fluo...
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JP2012149049A |
To provide a compound having excellent plant disease controlling effect.The amidine compound represented by formula (1) (wherein R1 represents a C1-C11 fluoroalkyl group, a C3-C11 fluoroalkenyl group or a C3-C11 fluoroalkynyl group; R2 r...
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JP4991037B2 |
This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed
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JP2012140438A |
To provide 7-substituted tetracycline compounds used for treatment of numerous tetracycline compound-responsive states such as bacterial infections and neoplasms, as well as for other known applications for minocycline and tetracycline c...
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JP4954864B2 |
This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed
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JP4954409B2 |
A process is described for preparing 1-aryltriazolinones of formula I useful in the production of commercial herbicides: by (i) carbonylating an amidrazone of formula (A) with one or more carbonylating agent, or by (ii) condensing a hydr...
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JP4937506B2 |
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JP4927108B2 |
Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
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JP4910695B2 |
Disclosed is a contrast medium for thrombus which comprises, as an active substance, a substance obtained by labeling a compound capable of binding to glycoprotein IIb/IIIa or a physiologically acceptable salt thereof with a positron emi...
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JP4900238B2 |
The present invention relates to a novel compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof. wherein each symbol is as defined in the specification. According to the present invention, an acti...
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JP4894110B2 |
A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used...
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JP4887782B2 |
The present invention relates to a process for producing an N -aryl-2,2,2-trifluoroacetimidoyl chloride represented by Formula (2): the process comprising the step of reacting in an organic solvent a tertiary amine, a 2,2,2-trifluoro- N ...
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JP4861835B2 |
A method for producing an imide ether compound in high yield is provided. The method is characterized in that a nitrile compound, an alcohol and a hydrogen halide are continuously introduced into a flow reaction apparatus comprising a mi...
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JP4855368B2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
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JP4836396B2 |
The invention relates to novel naphthalene derivatives of formula (I) and their use as cannabinoid receptor agonists wherein X, R 1 , R 2 and R 3 are as defined in the description, processes for their production, their use as pharmaceuti...
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JP4838396B2 |
This invention concerns HIV replication inhibitors of formulathe N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a1=a2-a3=a4- a...
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JP2011529135A |
Methods and compositions for depositing a film on one or more substrates include providing a reactor with at least one substrate disposed in the reactor. At least one metal precursor are provided and at least partially deposited onto the...
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JP4824740B2 |
The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen o...
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JP4823401B2 |
Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
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JP4805916B2 |
Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
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JP4795242B2 |
Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neut...
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JP4790901B2 |
To provide a method for easily and efficiently producing a 4-amino-5- cyanoimidazole derivative and the corresponding intermediate. This method for producing a 4-amino-5-cyanoimidazole derivative of formula (III) and the corresponding in...
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JP4778181B2 |
The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalanin
amides of the formula I, in which the anions X are physiologically acceptable anions, and their analogs, which...
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JP2011173907A |
To provide a safe and efficient method of manufacturing 1-aryl-5-(trifluoromethyl)-1H-tetrazole and its production intermediate, N-aryl-2,2,2-trifluoroacetoimidoyl chloride.There are disclosed a method for manufacturing N-aryl-2,2,2-trif...
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JP4768109B2 |
To provide a new method for efficiently producing a 1H-2- substituted-4(5)-amino-5(4)-carboxamide-imidazole being an intermediate for an agrochemical and a medicine. A nitrile derivative of general formula (I) R1CN (I) (R1 is a 1-10C alk...
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JP4743673B2 |
Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. A...
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JP4708024B2 |
(2S,5Z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid is crystallized as an anhydrous, stoichiometric 1.5 HCl salt and a scaleable crystallization method is disclosed. The salt form was characterized and the absolute configurat...
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JP4683675B2 |
Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
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JP2011084586A |
To develop novel polyamine analogues for various applications.The present invention provides novel polyamine analogues, compositions comprising these polyamine analogues, and methods of using the analogues and the compositions. In one em...
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JP2011057678A |
To provide a novel agricultural and horticultural fungicide.N-phenylamidine derivatives expressed by general formula (I) are provided. (In the formula, R1 represents alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl or H; R2 and R3 repr...
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JP4639686B2 |
A chemical vapor deposition material comprising a ruthenium compound having a ligand represented by the following formula: wherein R1, R2 and R3 are each independently a hydrogen atom, fluorine atom, trifluoromethyl group or hydrocarbon ...
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JP4588951B2 |
Method of producing compounds of formula (I), wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical -N(R3)R4; or R2 and R6 together are -CH2-CH2-S-; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-...
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