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Document Title |
JP3558295B2 |
PCT No. PCT/GB93/02442 Sec. 371 Date Aug. 25, 1995 Sec. 102(e) Date Aug. 25, 1995 PCT Filed Nov. 26, 1993 PCT Pub. No. WO94/12654 PCT Pub. Date Jun. 9, 1994A process for preparing clavulanic acid and other clavam derivatives using an enz...
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JP2004525119A |
Compounds of the formula (I) in which R<1 >is CN, or C(=NH)-NH2, CON(R<3>)2 or [C(R<4>)2]nN(R<3>)2, each of which is unsubstituted or monosubstituted by C(=O)R<3>, COOR<3>, or<3 >or by a conventional amino-protecting group, or W is -NR<3...
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JP2004522759A |
The invention relates to anti-thrombotic compounds of general formula (I), where R1 to R4, Ar, A, m and n are as defined in claim 1, the tautomers, stereoisomers, mixtures, pro-drugs and salts thereof which have worthwhile properties. Co...
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JP2004166714A |
To provide a new clavulanic acid intermediate by an enzyme reaction and a reaction process in its conversion to clavulanic acid.An enzyme having amidinohydrolase activity is obtained by centrifugation and ultrasonication of Streptomyces ...
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JP2004517060A |
Compounds of formula I and II,or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is a linker, and R1-...
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JP2004516339A |
Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising one or two nitrogen donor atom or atoms i...
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JPWO2002060861A1 |
In the following formula (I) [in the formula, R is an unsubstituted or substituted phenyl group present at the ortho-position, meta-position, or para-position, or an unsubstituted or substituted alkyl group of C1 to C10. , An unsubstitut...
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JP2004514669A |
Compounds having the formula (I),are useful as serine protease inhibitors, more particularly inhibitors of Factors VIIa, IXa, Xa, and/or XIa, wherein ring B is phenyl or pyridyl, W is preferably C(=O)NR4R5, L is a linker group, X2 compri...
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JP2004513136A |
Conjugates in which polyamine analogs are conjugated to an amino acid are provided, as well as compositions comprising these conjugates. Methods of using these conjugates as anticancer treatments are also provided.
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JP2004107344A |
To improve a yield in synthesizing an α-amino-N-allylamidinonitrobenzene compound.In a method for producing the compound, an N-allyiminonitrobenzene compound is reacted with a diamono dinucleophile to form the α-amino-N-allylamidinonit...
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JP3516095B2 |
PURPOSE: To safely obtain an azoimino ether compound from an inexpensive raw material in a short time in high yield by successively reacting a hydrazonitrile compound with bromine, chlorine and anhydrous hydrochloric acid in the presence...
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JP3510663B2 |
PURPOSE: To provide a method for producing the spherical granules of a water-soluble azo compound, capable of safely obtaining the spherical water-soluble azo compound substantially not generating dust. CONSTITUTION: A method for produci...
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JP2004509097A |
The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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JP2004509096A |
The present invention relates to 2-amino-2-alkyl-3 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors
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JP2004509095A |
The present invention relates to 2-amino-2-alkyl-4 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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JP2004509098A |
The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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JP2004508373A |
Disclosed are cyclic and acyclic amidines, pharmaceutical compositions containing such amidines, and their use in treating or preventing progesterone receptor mediated diseases or conditions, such as osteopenia and osteoporosis.
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JP3507067B2 |
To provide an intermediate and a reaction in the process of converting it to clavulanic acid. This method for producing clavulanic acid is a method for β-hydroxylating a compound having an amino, guanidino or amidino group in the side c...
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JP3505179B2 |
PCT No. PCT/EP93/03257 Sec. 371 Date May 26, 1995 Sec. 102(e) Date May 26, 1995 PCT Filed Nov. 19, 1993 PCT Pub. No. WO94/12492 PCT Pub. Date Jun. 9, 1994Disclosed herein is a process for preparing a compound of structure (I): (I) which ...
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JP2004051614A |
To provide a new vermin-controlling agent, especially an insecticide or acaricide.This vermin-controlling agent contains a substituted amide compound expressed by general formula (1) [wherein, A is carbon atom or the like; G is G-1 or G-...
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JP2004505106A |
Novel compounds of the formula I, in which R, R<1 >and R<2 >are as defined in patent claim 1, are inhibitors of coagulation factor Xa and VIIa and can be employed for the treatment of thromboses, myocardial infarction, arteriosclerosis, ...
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JP2004503465A |
A novel process for producing unsubstituted and substituted meta- and para-cyanobenzoic acid compounds, salts and derivatives thereof, and intermediates therefor, which are useful as intermediates for producing platelet aggregation inhib...
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JP2004503563A |
The invention relates to derivatives of amidino-benzylamine, especially derivatives of 4-amidino-benzylamine, with two bonded amino acids. These derivatives represent a novel group of highly active and very selective F Xa-inhibitors for ...
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JP2004018480A |
To provide a 5-substituted-1,2,4-triazole-3-carboxylic acid ester derivative and an acylamidrazone derivative which are useful intermediates for producing pharmaceuticals, and to provide their production methods.A compound represented by...
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JP3487851B2 |
Amidine derivs. of formula (I), in the form of their racemates, enantiomer pure or enriched forms, diastereomer pairs, cis- and trans-isomers, free bases or salts (pref. with physiologically acceptable acids) are new. In (I), R1 and R2 a...
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JP2004501077A |
The invention relates to polycyclic aryl and heteroaryl substituted 1,4-quinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treat...
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JP2004501136A |
A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, i...
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JP2004500338A |
The invention relates to compounds of the formula (I), wherein X, R<1>, R<2>, R<3>, R<4> and R<5> have the meaning indicated in claim 1. The inventive compounds represent inhibitors of the subtype 3 sodium/proton exchanger (NHE-3).
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JP2003535856A |
Disclosed are processes for coupling amino substituted 2-chromanyl derivatives and benzoyl derivatives via an amide bond, and intermediates for producing platelet aggregation inhibitors and for producing potent platelet aggregation inhib...
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JP2003321431A |
To provide a method for efficiently producing imidoyl halides from amides.The method for producing the imidoyl halide represented by formula (1) comprises steps converting a compound represented by formula (II) to the compound represente...
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JP2003532702A |
The present invention relates to a process for the preparation of both the phenyl pyrazine derivative 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine and an intermediate in the synthesis of 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine, 2-...
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JP2003531934A |
Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N-pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or...
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JP3461441B2 |
To subject new compound which possesses potent FXa inhibitory activity and is useful as a protective and therapeutic medicine for various diseases caused by thrombus and embolus. The compound of formula I [R1-R4 are each H and the like; ...
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JP2003531132A |
The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
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JP2003530435A |
The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
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JP2003530412A |
The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
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JP2003528077A |
Amidino-aryl substituted biphenyl derivatives and analogs (I) are new. Amidino-aryl substituted biphenyl derivatives of formula (I), their salts or solvates, are new. [Image] R1phenyl or naphthyl, both (i) substituted by -C(=NH)NH2 (opti...
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JP2003527332A |
This invention relates to novel substituted succinic acid metallo-beta-lactamase inhibitors which are useful potentiators of beta-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections i...
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JP2003246779A |
To provide a method for manufacturing a compound shown in general formula (V) at a high purity by continuous reaction without inserting a purification process on the way in the process (1) to (3) shown below and to provide a manufacturin...
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JP2003524001A |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula 1, wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated...
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JP2003523356A |
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a phar...
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JP2003522733A |
Alkenyl and alkynyl compounds as potent and highly selective inhibitors of factor Xa isolated or assembled in the prothrombinase complex and compositions containing such alkenyl and alkynyl compounds are described. Such compounds show se...
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JP2003520843A |
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...
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JP2003517033A |
The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising themSubstituted norbornylamino derivatives having exo-configured nitro...
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JP2003514792A |
The invention relates to bis-basic compounds of the general formula (I): B<1>-Ar<1>-X<1>-Ar<2>-X<2>-A-X<3>-Ar<3>-X<4>-Ar<4>-B<2>, wherein the groups B<1>, B<2>, Ar<1>, Ar<2>, Ar<3>, Ar<4>, X<1>, X<2>, X<3>, X<4> and A have the meaning in...
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JP2003113151A |
To provide a method for producing an N-unsubstituted imidic acid ester alkylsulfate and an N-unsubstituted amidinium alkylsulfate by which an additional neutralization step or isolation of a slightly soluble intermediate of an imidic aci...
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JP2003096042A |
To provide a method in which an α-cyanocarbonyl compound represented by general formula (II) is produced from a compound represented by general formula (I).The production method of the compound represented by general formula (II) (where...
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JP2003507450A |
The present invention relates to compounds of the Formula or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of tryptase and for the treatment and/or prevention ...
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JP2003505365A |
Diacylhydrazine derivatives of general formula (I)wherein X, Y, Z, R<1>, <2 >and R<3 >are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to combat thromboses, my...
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JP3370998B2 |
The invention relates to the compounds of the formula and pharmaceutically acceptable salts thereof, in which: R1 is amino which is mono- or disubstituted by a substituent selected from an aliphatic hydrocarbon radical, an araliphatic hy...
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