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WO/1999/046316A2 |
The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicab...
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WO/1999/041214A1 |
A halogenating agent represented by general formula (1) and a process for halogenating a hydroxyl group therewith. In said formula R?1¿ and R?2¿ are the same or different and each represents ethyl, propyl, isopropyl, butyl, isobutyl or...
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WO/1999/041231A1 |
Novel amidino derivatives represented by general formula (I) which have an inhibitory effect on blood coagulation factor VIIa and are useful as preventives and/or remedies for various vascular lesions associating accelerated coagulation ...
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WO/1999/038841A1 |
A compound of formula (1), wherein R¿1?, R¿2?, R¿3?, R¿4? and R¿5? are independently selected from hydrogen, alkyl and aryl; and prodrugs thereof; and pharmaceutically acceptable salts thereof; and use of the compounds in therapy, p...
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WO/1999/032105A1 |
The present invention provides CLA esters and uses thereof. More particularly, the present invention provides a composition for topical use comprising CLA esters and a topical carrier. In addition, the present invention specifically prov...
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WO/1999/031051A1 |
Use of a compound of the formula (1), wherein X is an alkylene chain comprising 0, 1, 2, 3 or 4 carbon atoms; R?1¿, R?2¿ and R?3¿ are independently selected from hydrogen, alkyl and aryl; R?4¿, R?5¿ and R?6¿ are independently selec...
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WO/1999/031092A1 |
The invention relates to novel compounds of formula (1) wherein X, Y, W, R?1¿, R?2¿, R?3¿ and R?4¿ have the meaning cited in Claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in prophylaxis and/...
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WO/1999/031049A1 |
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN-, (where X and Y are hydrogen or various groups); R?a¿ represents alkylene; R?b¿ and R?c¿ each represents alkylene, the total num...
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WO/1999/030695A1 |
Use in medicaments for the treatment of chronic obstructive pulmonary disease of compounds of formula (I) wherein the C(=NH)-NHR¿3? group may be in tautomeric or isomeric form, or a pharmaceutically acceptable salt thereof, in which: RÂ...
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WO/1999/029670A2 |
The present invention relates to bicyclene of general formula (I) substituted by an aminocarbonyl radical, wherein R¿1?-R¿6?, X¿1?-X¿3?, Y¿1?-Y¿2? are defined as in claim 1 and the tautomers, stereoisomers, mixtures and salts there...
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WO/1999/028284A1 |
The invention referres to dibenzosuberone derivatives and to the procedures of their preparation. According to this invention, conditions for a regioselective bromination of dibenzosuberone have been found, as well as for the isolation o...
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WO/1999/026919A1 |
Biphenylamidine derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof, both being novel compounds functioning as clinically applicable Fxa inhibitors.
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WO/1999/026918A1 |
Biphenylamidine derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof, both being novel compounds functioning as clinically applicable Fxa inhibitors.
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WO/1999/024407A1 |
The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediat...
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WO/1999/024395A1 |
The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediat...
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WO/1999/022707A1 |
The invention concerns a composition for topical application on the skin and/or its appendages comprising, in a cosmetically and/or dermatologically acceptable medium, at least a compound containing an iminophenol fragment, and the use o...
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WO/1999/010316A1 |
3-Amidinoaniline derivatives represented by general formula (I) which have potent and selective activity of inhibiting activated blood coagulation factor X and are useful as activated blood coagulation factor X inhibitors, or pharmacolog...
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WO/1999/005096A2 |
Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
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WO/1999/004778A1 |
The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using...
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WO/1999/000127A1 |
This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of ...
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WO/1999/000356A1 |
This invention relates to compounds of formula (I) which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ame...
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WO/1999/000121A1 |
This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of ...
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WO/1998/058905A1 |
Amidrazone derivatives of formula (I) useful for prevention or treatment of lupus mycosis attributable to fungi, such as Candida, Aspergillus, and Cryptococcus, pharmaceutically acceptable salts thereof, and pharmaceutical compositions t...
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WO/1998/050344A1 |
Substituted cyanoenamines of general formula (I) wherein Z, R?1�, R?2� and R?3� are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment o...
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WO/1998/047933A1 |
Provided are certain transition metal complexes which are useful as catalysts in the polymerization of olefinic monomers. In particular, the invention provides complexes of certain bidentate ligands bonded to Ni, Pd, Co, or Fe, and optio...
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WO/1998/047894A1 |
3-(Substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and ...
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WO/1998/045259A2 |
The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.
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WO/1998/043973A1 |
The invention relates to a new method for the production of a compound having formula (I) or one of its salts. In this formula, the radicals have the meanings given in the description. This method relates to a new intermediary compound h...
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WO/1998/040370A1 |
The present invention provides compounds having the structure: Ar�1?-Q-Ar�2?-O-(CH�2?)�n?-Z and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are media...
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WO/1998/040420A2 |
The present invention includes novel ligands which may be utilized as part of a catalyst system. A catalyst system of the present invention is a transition metal-ligand complex. In particular, the catalyst system includes a transition me...
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WO/1998/040374A2 |
Methods for preparing olefin polymers, or oligomers catalysts for preparing olefin polymers and bidentate ligand used for preparing these catalysts are disclosed. The polymers can be prepared containing the corresponding monomers with a ...
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WO/1998/034898A1 |
The invention relates to phenoxyacetic acid derivatives of formula (I), wherein R�1?, R�2?, Xn and A are as defined in the description, A represents a halogen atom, hydroxy, OR�3?, S(O)�k?R�3?, or a group of formula (A-1) or (A...
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WO/1998/031661A1 |
Benzamidine derivatives involving compounds represented by formulae (a) and (b) and analogs thereof or pharmaceutically acceptable salts thereof. These compounds show anticoagulant effects based on their excellent effects of inhibiting a...
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WO/1998/031660A1 |
The present invention provides novel indane-like compounds which can be useful for treating conditions associated with the modulation of a muscarinic receptor. The invention provides novel processes and intermediates for preparing the no...
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WO/1998/029399A1 |
The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention includes an anionic portion combined with at least one cationic portion M?+m� in sufficient numbers to ensur...
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WO/1998/029388A1 |
The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention is comprised of an amide or one of its salts, including an anionic portion combined with at least one cationic...
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WO/1998/029384A1 |
The invention concerns 2-benzoyl-cyclohexan-1,3-diones of formula (I), in which R?1�, R?2� stand for hydrogen, nitro, halogen, cyano, rhodano, alkyl, halogen alkyl, alkoxyalkyl, alkenyl, alkinyl, -OR?5�, -OCOR?6�, -OSO�2?R?6�...
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WO/1998/029877A1 |
Disclosed is a proton conductor in liquid form, comprised of a mixture of the following components: (a) a salt combined with a nitrogenated base along with an acid, according to formula (I), wherein Z�1?, Z�2?, Z�3?, and Z�4?, wh...
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WO/1998/029389A1 |
The invention is related to ionic compounds, derivatives of malononitrile, in which the anionic load has been displaced. An ionic compound disclosed by the invention includes an anionic portion combined with at least one cationic portion...
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WO/1998/029396A1 |
The invention relates to ionic compounds in which the anionic load has been displaced, and the uses of these compounds. A compound disclosed by the invention comprises an anionic portion combined with at least one cationic portion M?+mï¿...
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WO/1998/029358A2 |
Disclosed is a method for grafting a polymer onto the surface of a carbonate material with carboxyl, amine, and/or hydroxyl functions on its surface. Said material is placed in suspension in a solution including the polymer to be grafted...
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WO/1998/017626A2 |
This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides. In one embodiment, the invention relates to non-natural amino acids that closely replicate the natural ...
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WO/1998/016506A1 |
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-$g(a) converting enzyme (TACE, tumor necrosis fa...
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WO/1998/015512A2 |
The invention concerns fungicidal compounds, and compositions containing them, of general formula (I) in which G is selected from the groups G1 to G9: (a) in which the different symbols represent various organic groups. The invention als...
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WO/1998/010763A1 |
A compound which inhibits human thrombin and which has general structure (I) such as formula (a).
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WO/1998/011062A1 |
The current invention relates to new benzamidine derivatives, a process for the manufacture and the use thereof as medicaments. The new benzamidine derivatives have the general formula (1).
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WO/1998/009950A1 |
The invention concerns a process for preparing amidines and their salts with inorganic or organic acids. According to this process, the corresponding nitrile is reacted with ammonia, a C�1?-C�6? alkylamine or hydrazine in the presenc...
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WO/1998/008799A1 |
The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glyc...
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WO/1998/006691A2 |
Low molecular weight dendritic polymers (dendroids) of Formula (I) or a pharmaceutically acceptable salt thereof wherein A is selected from 1,2,3,5-tetrasubstituted or 1,2,4- or 1,3,5-trisubstituted benzene; 2,3,4,5-tetrasubstituted or 2...
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WO/1998/003475A1 |
A composition, which comprises at least one compound of formula (I), in which A�1?, A�2?, R�1? and R�2? are as defined in claim 1, or, if appropriate, an E/Z isomer, an E/Z isomer mixture and/or a tautomer thereof, in each case i...
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