Acyclic or Carbocyclic Compounds

Matches 401 - 450 out of 1,375	< 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >

Document	Document Title
WO/1995/034534A1	ENZYME INHIBITORS A compound of formula (I), wherein R1 is a C1-6 straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6alkynyl group, a C3-6cycloalkyl group or a C3-6cycloalkyl C1-6alkyl group, each optionally substituted by one to three gro...
WO/1995/032710A1	COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION Compounds of the following general structure: X-Y-Z-Aryl-A-B, for example (I), which inhibit osteoclast-mediated bone resorption.
WO/1995/031445A1	PROCESS FOR PRODUCING TETRAZOLE COMPOUND AND INTERMEDIATE THEREFOR A process for producing a tetrazole compound represented by general formula (1) in an industrially advantageous manner, which comprises either reacting a nitride represented by general formula (2): R1CN, with hydrazine or a salt therof i...
WO/1995/029889A1	PERHALOALKOXYBENZENOPHENONE HYDRAZONES AND THEIR USE AS PESTICIDES Compounds of formula (I) in which X is (a) or (b), n is 0, 1, 2, 3, 4 or 5, where if n is greater than 1, the radicals R2 are identical or different; o is 0, 1, 2, 3 or 4, where if o is greater than 1, the radicals R3 are identical or di...
WO/1995/027693A1	'alpha'-SUBSTITUTED PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL BACTERICIDE CONTAINING THE SAME An 'alpha'-substituted phenylacetic acid derivative useful as an agricultural bactericide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricu...
WO/1995/025717A1	AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS There is disclosed amidino derivatives of formula (I), pharmaceutical compositions containing these derivatives, and their use in therapy, in particular their use as nitric oxide synthase inhibitors wherein: X is alkyl, alkenyl, alkynyl,...
WO/1995/024381A1	CYANO COMPOUNDS AND PREPARATIONS THEREOF This invention relates to compounds of formula (I) which are useful as PDE IV inhibitors and for treating diseases related thereto.
WO/1995/024382A1	L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS There is disclosed a novel amino glycol derivatives of L-N6-(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.
WO/1995/023609A1	ANTITHROMBOTIC AGENTS This invention relates to thrombin inhibiting compounds having the formula (I): X-Y-NH-(CH2)r-G where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods...
WO/1995/019769A1	COMBINATIONS OF A CREATINE COMPOUND WITH A HYPERPLASTIC INHIBITORY AGENT FOR INHIBITING UNDESIRABLE CELL GROWTH The present invention provides for the use of creatine compounds and hyperplastic inhibitory agents for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The present invention provides methods of using c...
WO/1995/018111A1	COMPOUNDS CONTAINING BASIC AND ACIDIC TERMINI USEFUL AS FIBRINOGEN RECEPTOR ANTAGONISTS This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combinatio...
WO/1995/017378A1	COMPOUND CAPABLE OF INTRODUCING AT LEAST ONE MOLECULE INTO A CELL The present invention relates to a compound capable of introducing at least one molecule into a cell and of formula (I) in which: A is chosen from the group consisting of the radicals comprising a hydrophilic group or a CH2 group and a h...
WO/1995/017378A2	COMPOUND CAPABLE OF INTRODUCING AT LEAST ONE MOLECULE INTO A CELL The present invention relates to a compound capable of introducing at least one molecule into a cell and of formula (I) in which: A is chosen from the group consisting of the radicals comprising a hydrophilic group or a CH2 group and a h...
WO/1995/013262A1	SUBSTITUTED PHENYL COMPOUNDS Compounds of formula (I) are described wherein R1 is hydrogen, -(lower alkyl)q(CO2R6 or OH), -CN, -C(R7)=NOR8, NO2, -O(lower alkyl)R9, -CC-R10, -CR11=C(R12)(R13), -C(=O)CH2C(=O)CO2H, -CO(R14), alkylthio, alkylsulphinyl, alkylsulphonyl, c...
WO/1995/011014A1	AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The current invention discloses amidino derivatives useful as nitric oxide synthase inhibitors.
WO/1995/005363A1	AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES Compounds of formula (I) wherein D represents phenyl, pyridinyl or a 5-membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, S and N, which three groups are optionally substituted by one or more groups select...
WO/1995/001168A2	PHARMACEUTICAL PREPARATIONS WITH AN ACTIVE PRINCIPLE CONTAINING MODIFIED AMIDIN GROUPS A novel pharmaceutical preparation contains an active principle with at least one pharmaceutically active amidin group which may be orally absorbed. The amidin group is a compound selected from the group (a), (b) and (c), in which R7 sta...
WO/1995/000505A1	AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS Compounds of formula (I) and salts, esters and amides thereof, wherein R1 is a C1-6 straight or branched chain alkyl group, a C3-6 cycloalkyl group, a thiol group optionally substituted by a C1-6 alkyl group, or an amino group optionally...
WO/1995/000480A1	NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R1 represents hydrogen or...
WO/1995/000472A1	1,2 DIACYLATED HYDRAZINE DERIVATIVES AND THEIR USE AS ALL ADHESION INHIBITORS The invention concerns acid derivatives of the formula (I): R1-CON(R2)-N(R3)CO-X1-Q-X2-G, and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof; wherein R1 represents...
WO/1994/029336A1	NEW PEPTIDE DERIVATIVES The invention relates to new competitive inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, antic...
WO/1994/026700A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES Compounds of formula (I) in which Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group (a) or (b) and R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4-alkynyl, C3-C6cycloalkyl, phenyl which is unsubs...
WO/1994/021599A1	NOVEL COMPOUND WITH PLATELET AGGREGATION INHIBITOR ACTIVITY A compound with a platelet aggregation inhibitor activity, represented by the following general formula (I), and pharmacologically acceptable salt and solvate thereof. Examples of the compound are as in (II).
WO/1994/020457A1	N-ACYL BETA AMINO ACID DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS Novel N-acyl beta amino acid derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
WO/1994/017035A1	AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME New aminoacid derivates have the general formula: T-Z-NR1-(R2CR3)-CO-Y-(CH2)n-R, in which R, R1 to R3, T, Z, Y and n are defined as in the first claim. They represent valuable NPY-antagonistic active substances. Also disclosed are their ...
WO/1994/015923A2	IN VIVO METHOD OF OBTAINING CELL COMPONENTS Described is an in vivo method of obtaining cell components, the cells concerned being suddenly changed from a first state, in which essentially constant conditions exist between the cell and the surrounding medium, to a second state, th...
WO/1994/014758A1	ARYL IMIDATE ACTIVATED POLYALKYLENE OXIDES Water-soluble aryl imidate activated polyalkylene oxides having improved hydrolytic stability and conjugates of the aryl imidate activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of preparing the ...
WO/1994/012469A1	N-ARYLOXYACYL-N-PHENYLTETRAHYDROPHTHALAMIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT An N-aryloxyacyl-N-phenyltetrahydrophthalamic acid derivative represented by general formula (I), a process for producing the same, and a herbicide containing the same as the active ingredient, which is very useful as a herbicide because...
WO/1994/012654A1	PROCESS FOR PREPARING CLAVULANIC ACID A process for preparing clavulanic acid and other clavam derivatives from any one of S-arginine, compounds of formula (I), wherein R1 is (a) or (b), wherein R2 = H or C1-6alkyl; compounds of formula (II), wherein R1 is (c) or (d), where ...
WO/1994/012492A1	PROCESS FOR PREPARING BENZOPYRAN COMPOUNDS A process for preparing substituted benzopyran derivatives which comprises a final step cyclisation of the corresponding open-chain intermediates.
WO/1994/011341A1	SUBSTITUTED AMIDINO COMPOUNDS, THEIR MANUFACTURE AND METHODS OF TREATMENT The invention relates to the compounds of formula (I) wherein the C( = NH)-NHR3 group may be in tautomeric or isomeric form, and pharmaceutically acceptable salts thereof, in which: R1 is amino which is mono- or disubstituted by a substi...
WO/1994/011340A1	HYDRAZONE DERIVATIVE A compound representd by general formula (I), a salt thereof, and a pest control agent, wherein: X represents halogen, alkyl, alkoxy, cycloalkyloxy, alkylsulfonyloxy, alkylthio or alkylsulfonyl; R1 represents hydrogen or alkyl; R2 repres...
WO/1994/005335A1	NEW ORGANIC CONTRAST AGENT ANALOG AND METHOD OF MAKING SAME An organic contrast agent analog is derived to contain fluorine moieties. A method for making the organic contrast agent analog includes the steps of fluorinating the contrast agent analog for increasing the acidity of the analog to incr...
WO/1994/000424A1	PHENYL AMIDINE ALKANOIC ACIDS AND LACTONES USEFUL AS PLATELET AGGREGATION INHIBITORS This invention relates to phenyl amidine alkanoic acids and lactones having formula (I) or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compo...
WO/1993/021146A1	COMPOUNDS HAVING SELECTIVITY FOR RETINOID X RECEPTORS Compounds, compositions, and method for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to member...
WO/1993/018058A1	PEPTIDES MIMICS USEFUL AS PLATELET AGGREGATION INHIBITORS This invention relates to compounds having formula (I) or pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a me...
WO/1993/016036A1	NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDIAMENTS WITH LTB-4 ANTAGONISTIC EFFECT Compounds of formula (I), which are defined in more detail in the description, can be prepared by conventional methods and are used for therapeutic purposes in the usual galenical preparations.
WO/1993/013055A1	AMIDINO DERIVATIVES AND THEIR USE AS NITRIC OXIDE SYNTHASE INHIBITORS Amidino derivatives of formula (I) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R1 is a C1-6 straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6alkynyl group, a C3-6cycloalkyl group or a...
WO/1993/012781A2	CREATINE ANALOGS HAVING ANTIVIRAL ACTIVITY The present invention relates to the use of creatine and suitable creatine analogs, such as cyclocreatine, as antiviral agents. These compounds can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such ...
WO/1993/012074A1	PEPTIDE MIMETIC COMPOUNDS USEFUL AS PLATELET AGGREGATION INHIBITORS This invention relates to compounds having formula (I) or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions - of such phenyl amidines...
WO/1993/007867A1	SUBSTITUTED $g(b)-AMINO ACID DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS Novel substituted beta-amino acid derivatives having general formula (I), are provided, in which e.g. R?2¿ is selected from the group consisting of hydrogen, lower alkyl radicals, lower alkenyl radicals, lower alkynyl radicals, alicycli...
WO/1993/004032A1	NOVEL AMINE DERIVATIVE, PRODUCTION THEREOF, AND INSECTICIDE A compound having a high insecticidal activity, represented by general formula (I), or a salt thereof wherein R¿1? represents optionally substituted alkyl; R¿2? represents hydrogen, optionally substituted alkyl or COR¿3? wherein R¿3?...
WO/1992/020705A1	PEPTIDE MIMETIC COMPOUNDS USEFUL AS PLATELET AGGREGATION INHIBITORS This invention relates to a compound having formula (I) or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl a...
WO/1992/019588A1	NEW AMIDRAZONE DERIVATES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS LIPOXYGENASE INHIBITORS New amidrazone derivates having general formula (I), a process for producing the same and their use as lipoxygenase inhibitors are disclosed. In order to synthesize the compounds having general formula (I), 1,3 cyclohexandione is reacted...
WO/1992/015607A2	PHENYL AMIDINES DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS This invention relates to phenyl amidines derivatives having formula (I) or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such...
WO/1992/004054A1	SUBSTITUTED AMIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF N,N'-disubstituted-amidines, e.g., of formula (I), wherein R, R' and R" are substituted or unsubstituted hydrocarbon and/or heterocyclic groups. Methods are provided for the treatment or prophylaxis of anxiety in an animal, for treating ...
WO/1992/004317A2	NOVEL IMIDATE INSECTICIDES Novel insecticides have formula (I) in which R¿1? is hydrogen, halogen, C¿1?-C¿4? alkoxy, C¿1?-C¿4? haloalkyl, C¿1?-C¿4? haloalkoxy or C¿1?-C¿4? haloalkylthio; R¿2? is hydrogen, halogen, C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy, C...
WO/1992/003407A1	N-ACYL-N-PHENYLTETRAHYDROPHTHALAMIC ACID DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT An N-acyl-N-phenyltetrahydrophthalamic acid derivative represented by general formula (I), a process for producing the same, and a herbicide containing the same as the active ingredient: wherein X and Y represent each independently hydro...
WO/1992/000273A1	ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM Compounds of formula (I) and their salts in which R1 is optionally substituted phenyl, R2 is alkyl, cycloalkyl or optionally substituted amino, or R2 and R3 together with the nitrogen and carbon atoms to which they are attached form an o...
WO/1991/018866A2	1,4-DIAMINO-2,3-DIHYDROXYBUTANES There are provided novel 1,4-diamine-2,3-dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.

Matches 401 - 450 out of 1,375	< 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >