Acyclic or Carbocyclic Compounds

Matches 501 - 550 out of 1,858	< 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >

Document	Document Title
WO/1998/015525A1	HYDROXAMIC ACIDS Hydroxamic acid derivatives represented by the following general formula and useful as a matrix metalloprotease inhibitor: R-X-B-N(R?1�)-A-CO-NHOH, wherein R is an optionally substituted cyclic hydrocarbon group or the like; X is optio...
WO/1998/015512A2	FUNGICIDES WITH HYDROXIMIC AND HYDRAZONIC GROUPS The invention concerns fungicidal compounds, and compositions containing them, of general formula (I) in which G is selected from the groups G1 to G9: (a) in which the different symbols represent various organic groups. The invention als...
WO/1998/014424A1	HYDROXAMIC ACID DERIVATIVES Hydroxamic compounds belonging to the family of 3-imino-4-oxo-1,7-dioic acid (7-N-hydroxy) diamides characterised by the presence of an oxymethyl group on the 6-position are disclosed. Preferred compounds have formula (I), wherein R�1?...
WO/1998/013055A1	ANTIOXIDIZING COMPOSITION FOR SCAVENGING FREE RADICALS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND PROCESS FOR PREPARING THE SAME An antioxidizing composition for scavenging free radicals, comprising at least one essential oil component containing a number of fat-soluble, low-molecular compounds, a pharmaceutical composition comprising the above composition, and a ...
WO/1998/011063A1	CYTOSTATIC HYDROXAMIC ACID DERIVATIVES Compounds of formula (1) wherein R�4? is an ester or thioester group, and R, R�1?, R�2? and R�3? are as defined in the specification are inhibitors of rapidly dividing tumour cells.
WO/1998/005627A1	BORONIC COMPOUND COMPLEXING REAGENTS AND HIGHLY STABLE COMPLEXES Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, afte...
WO/1998/005629A1	BORONIC COMPOUND COMPLEXING REAGENTS AND COMPLEXES Boron compound complexing reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, after further reactions described herein, to ...
WO/1998/004509A1	2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF 2,3-Dihalogeno-6-trifluoromethylbenzaldehydes of general formula (I) useful as intermediates for the preparation of fungicides for agricultural and horticultural use; a process for the preparation of the same; and a process for preparing...
WO/1998/004520A1	FUNGICIDES A fungicidal compound of formula (I): or a stereoisomer thereof, wherein A is CH or N, B is OCH�3? or NHCH�3?, E is -NR?1�-C(CH�3?)=N- or -N=C(CH�3?)-NR?1�-, R?1� is H, C�1-4? alkyl, C�2-4? alkenyl, C�2-4? alkynyl or ...
WO/1997/049674A1	MATRIX METALLOPROTEINASE INHIBITORS Succinic amide derivatives of formula (I), wherein W is a -CO2H or -CONHOH group; R, R1 and R2 are each hydrogen or an organic residue, R3 is the residue of an alpha-aminoacid and R4 is an organic group, are inhibitors of matrix metallop...
WO/1997/049667A1	INHIBITORS OF OLEAMIDE HYDROLASE Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of...
WO/1997/044480A1	ENZYMATIC SYNTHESIS OF OPTICALLY ACTIVE HYDROXAMIC ACIDS AND THEIR CONVERSION INTO OPTICALLY ACTIVE PRIMARY AMINES BY LOSSEN TRANSPOSITION The description relates to a process for producing optically active hydroxamic acids of the general formula (I) in which R1, R2 and R3 are different and represent a cyclic or linear, aliphatic or aromatic, substituted or unsubstituted hy...
WO/1997/043249A1	INHIBITORS OF THE PRODUCTION OF s-CD23 AND THE SECRETION OF TNF Compounds of formula (I) wherein: R is hydroxy, hydrogen, alkyl, alkenyl, alkynyl or aryl; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or ary...
WO/1997/043251A1	COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES Compounds of formula (I), wherein R' is hydrogen or alkyl; A is adamantyl or a mono-, bi- or tricyclic residue optionally unsaturated, a heterocyclic residue and/or substituted by hydroxy, alkanoyloxy, amino, aminoalkyl, halogen, alkyl, ...
WO/1997/038705A1	N-FORMYL HYDROXYLAMINE CONTAINING COMPOUNDS USEFUL AS ACE INHIBITORS AND/OR NEP INHIBITORS N-formyl hydroxylamines are provided which have structure (I) wherein R and R1 are as defined herein and A is a dipeptide derived from an amino acid or is a conformationally restricted dipeptide mimic.
WO/1997/037970A1	PHENYLALKYLCARBOXYLIC ACID DERIVATIVES Phenylalkylcarboxylic acid derivatives represented by general formula (I) and pharmacologically acceptable salts and esters thereof (wherein R1 represents alkyl, etc.; R2 represents alkylene; R3 represents hydrogen, etc.; X represents (u...
WO/1997/036480A1	COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
WO/1997/036862A1	META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS The present invention relates to a class of compounds represented by Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting o...
WO/1997/036859A1	PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS The present invention relates to a class of compounds represented by Formula (I) or a phramaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of Formula (I), and methods of selectively inhibiting or anta...
WO/1997/034589A1	TRIARYL METHANE COMPOUNDS FOR SICKLE CELL DISEASE The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted ...
WO/1997/032844A1	HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
WO/1997/032842A1	DIPHENYLETHERS, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, AND THEIR USE The invention concerns diphenylethers of formula (I) and their salts and N-oxides, the substituents and indices in the formula having the following meanings: Q is C(CO2CH3)=CHCH3, C(CO2CH3)=CHOCH3, C(CONH2)=CHOCH3, C(CO2CH3)=NOCH3, C(CON...
WO/1997/031892A1	HYDROXAMIC ACID DERIVATIVES Compounds represented by general formula (1), which have excellent inhibitory activities on matrix metaproteinases and are useful as a cancerous metastasis inhibitor, etc.; wherein R1 represents optionally substituted C1-15 alkyl; R2 rep...
WO/1997/030047A1	FUNGICIDAL 1,2,4-OXADIAZOLES AND ANALOGUES Compounds of formula (I), where W is H or halogen, and R is alkyl or trifluoromethyl and compounds of formula (II), where X is O or S; Y is alkyl, cycloalkyl, cycloalkenyl, alkenyl or alkynyl, each of which is optionally substituted, hyd...
WO/1997/026257A1	HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS Compounds of formula (I) wherein R and R3 are each independently hydrogen, alkyl, alkenyl, alkynyl or aryl; R1 is arylmethyl; and R2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl, and pharmaceutically acceptable derivatives thereof...
WO/1997/026240A1	CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable sa...
WO/1997/024118A1	SUBSTITUTED N-[(AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula (I) herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical co...
WO/1997/024117A1	SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS This invention is directed to compounds of formula (I), wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are e...
WO/1997/019917A1	METHOD FOR PREPARING (+)COMPACTIN AND (+)MEVINOLIN ANALOG COMPOUNDS HAVING A 'beta'-HYDROXY-'delta'-LACTONE GROUPING A novel method for preparing (+)compactin and (+)mevinolin analog compounds having a 'beta'-hydroxy-'delta'-lactone grouping is disclosed. The method for preparing said compounds uses novel reaction intermediates. Said reaction intermedi...
WO/1997/019051A1	FLUOROBUTENOYLOXYACETAMIDES The invention concerns fluorobutenoyloxyacetamides of formula (I), in which R1, R2, R3 and R4 are as defined in the description, methods of preparing them and their use in the control of animal pests.
WO/1997/019050A1	SYNTHESIS OF CARBOXYLIC ACID DERIVATIVES Compounds of formula (I) wherein R1, R2, R3, R4, X are as defined in the specification and are prepared by elimination of one of the groups X1 and X2 from a compound of formula (II) wherein X1 and X2 each independently represent a carbox...
WO/1997/019053A1	METALLOPROTEINASE INHIBITORS Compounds of general formula (I) wherein X ia a -CO2H, -NH(OH)CHO or -CONHOH group; R1 is a cylcoalkyl, cycloalkenyl or non-aromatic heterocyclic ring containing up to 3 heteroatoms, any of which may be (i) substituted by one ore more su...
WO/1997/017949A1	BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is...
WO/1997/018188A1	BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES Compounds of formula (I), or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF'alpha' secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinas...
WO/1997/018187A1	AZINOOXIMETHERS, PROCESSES AND INTERMEDIATE PRODUCTS FOR MANUFACTURING SAME, AND THE USES THEREOF IN COMBATING HARMFUL FUNGI AND PESTS Disclosed are azinooximethers of formula (I) in which X stands for NOCH3, CHOCH3, CHCH3, Y stands for O, NZ, Z being H or alkyl, R1 stands for H, alkyl, R2 stands for cyano, nitro, trifluoromethyl, halogen, alkyl, alkoxy, m is 0, 1 or 2,...
WO/1997/018183A1	PREPARATION OF ALLYL SUCCINATE DERIVATIVES AND STARTING MATERIALS THEREFOR A process for the preparation of a compound of formula (I) wherein R2 is a (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, cycloalkyl(C1-C6)alkyl or cycloalkenyl(C1-C6)alkyl group, any one of whi...
WO/1997/016415A1	PHENYLCARBAMATES, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES AND FUNGICIDES The invention concerns phenylcarbamates of formula (I) in which the substituents and the index have the following meanings: R = cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy; m = 0, 1 or 2; R1 = alkyl, alkenyl, alkinyl, cycloal...
WO/1997/016439A1	HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces ...
WO/1997/015550A1	FLUORO-SUBSTITUTED BENZOYLPROPIONIC ACID DERIVATIVES A fluoro-substituted benzoyl propionic acid derivative of formula (I) either as single isomer or as mixture of isomers, wherein R is hydroxy, amino, hydroxylamine, -OR', -NHR', N(R')2 or -NHOR' in which R' is C1-C6 alkyl or benzyl, or a ...
WO/1997/015280A1	USE OF AT LEAST ONE NO SYNTHASE INHIBITOR FOR TREATING SENSITIVE SKIN The use of at least one NO synthase inhibitor as the active principle in a cosmetic composition for treating and/or preventing sensitive skin is disclosed. The use of at least one NO synthase inhibitor for preparing a pharmaceutical and ...
WO/1997/015552A1	PHENYLACETIC ACID DERIVATIVES, PROCESS AND INTERMEDIATE PRODUCTS FOR USE IN PRODUCING THEM AND AGENTS CONTAINING THEM Disclosed are phenylacetic acid derivatives of formula (I) in which the substituents and the index have the following meanings: X is NOCH3, CHOCH3, CHCH3; Y is O or NR; R1, R independently of one another stand for hydrogen or C1-C4 alkyl...
WO/1997/015553A1	HYROXAMIC ACID DERIVATIVES Hydroxamic acid derivatives represented by general formula (1) or pharmacologically acceptable salts thereof which are excellent in the inhibitory activity on matrix metaproteinase and useful as a preventive and remedy for metastatic inf...
WO/1997/013747A1	OXYAMINO OXIME ETHERS, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, AND AGENTS CONTAINING THEM AND USED FOR CONTROLLING HARMFUL FUNGI AND PESTS The disclosure concerns oxyamino oxime ethers of formula (I), wherein: X is NOCH3, CHOCH3, CHCH3; Y is O or NZ, Z being H or alkyl; R1 is H or alkyl; R2 is cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy, m = 0, 1 or 2 and the gr...
WO/1997/010205A1	A NEW FAMILY OF COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-VIRAL ACTIVITY AND COMPOSITIONS OF THESE, ALONE AND IN COMBINATION WITH REVERSE TRANSCRIPTASE INHIBITORS, FOR INHIBITING, PREVENTING OR ELIMINATING VIRAL REPLICATION AND METHODS OF USING SAME A new family of compounds having anti-inflammatory, anti-viral, and broncho-dilating activity having linear formula (I) and cyclic formula (II), and compositions of these, which alone, and in combination with reverse transcriptase inhibi...
WO/1997/010195A1	SYNTHESIS OF 'alpha'-CHLORO OR FLUORO KETONES A simple, high yielding synthesis of 'alpha'-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-M-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N...
WO/1997/009066A1	Fas LIGAND SOLUBILIZATION INHIBITOR A Fas ligand solubilization inhibitor which comprises as the active ingredient a compound represented by general formula (I) having a matrix metalloprotease inhibitory activity or a pharmaceutically acceptable salt thereof. This drug is ...
WO/1997/009301A1	2-ACYLAMINOBENZAMIDE DERIVATIVES AND PREVENTIVE AND REMEDY FOR DISEASES CAUSED BY THE SUPERMULTIPLICATION OF VASCULAR INTIMAL CELLS 2-Acylbenzamide derivatives represented by general formula (I), (wherein R1, R2, R3, R4 and R5 represent each hydrogen, etc.; X represents vinylene, etc.; and B represents -N(R6) (R7) (wherein R6 and R7 represent each hydrogen, etc.), -N...
WO/1997/008133A1	AMIDE COMPOUNDS AND USE OF THE SAME Amide compounds represented by general formula (I), pharmaceutically acceptable acid-addition salts thereof and a drug comprising the same as the active ingredient, wherein R represents amino, etc.; A represents alkylene, etc.; X represe...
WO/1997/005865A1	C-PROTEINASE INHIBITORS FOR THE TREATMENT OF DISORDERS RELATED TO THE OVERPRODUCTION OF COLLAGEN The present invention relates to the novel use of organic molecules capable of inhibiting C-proteinase activity in order to regulate, modulate and/or inhibit abnormal collagen formation.
WO/1997/006242A1	RECOMBINANT C-PROTEINASE AND PROCESSES, METHODS AND USES THEREOF The present invention is directed to the isolation and identification of the nucleic acid sequence encoding C-proteinase, the recognition of such protein's activity and applications, and tools, processes, and methods of use thereof.

Matches 501 - 550 out of 1,858	< 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >