Acyclic or Carbocyclic Compounds

Matches 601 - 650 out of 1,858	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >

Document	Document Title
WO/1995/022966A1	HYDROXAMIC ACID AND CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF This disclosure relates to a novel class of hydroxamic and carboxylic acid based matrix metalloproteinase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of su...
WO/1995/022520A1	SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS A compound of structure (I), wherein, when R8 = H: R1 = alkyl, cycloalkyl, arylalkyl, aryl; R2 = cycloalkyl, aryl, C3-C10 alkyl; X, Y = O, S(O)n, NH; Z = CH2OH, NHSO2R3, CHO, CO2R3, CONHR4R5, CN, COR6, H, halo, NHCN, NHCONR4R5, CONR4OR5,...
WO/1995/021153A1	PHENYL ACETIC ACID DERIVATIVES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND AGENTS CONTAINING THEM Phenyl acetic acid derivatives of formula (I) in which the components and index have the following meanings: X is NOCH3, CHOCH3 CHCH3 and CHCH2CH3; R1 is hydrogen and alkyl; R2 is cyano, nitro, trifluoro methyl, halogen, alkyl and alkoxy...
WO/1995/021174A1	PHENYLIMINO-THIADIAZABICYCLOALKANE DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES Compounds of formula (I): wherein R is C1-C6alkyl, C1-C6haloalkyl, C3-C6alkenyl, C3-C6alkynyl, C1-C4alkoxy or C3-C6cycloalkyl; R1 is halogen; R2 and R3 are each independently of the other C1-C4alkyl; R4 is halogen or a group of the formu...
WO/1995/020570A1	HYDROXAMIC-ACID DERIVATIVES, METHOD OF PREPARING THEM AND THEIR USE AS FUNGICIDES The invention concerns hydroxamic-acid derivatives of general formula (I) in which A is hydrogen or a grouping which can be easily splitt off, A1 is hydrogen or alkyl, Ar is an optionally substituted arylene or hetero-arylene group, E is...
WO/1995/019957A1	HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS The following compounds: 2S-Hydroxy-3R-[1S-(tert-butylcarbamoyl)-2,2-dimethyl-propylc arbamoyl]-5-methyl-hexanohydroxamic acid, 2S-Hydroxy-3R-[1S-(N,N-dimethylcarbamoyl)-2,2-dimethyl-propy l-carbamoyl]-5-methyl-hexanohydroxamic acid, 2S-...
WO/1995/019956A1	METALLOPROTEINASE INHIBITORS Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a -CO2H or -CONHOH group; R4 is a phenyl or 5- or 6-membered heteroaryl ring wherein any ring nitrogen atom may be oxidised as an N-oxide, which may be optionally...
WO/1995/019965A1	SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, ke...
WO/1995/019961A1	METALLOPROTEINASE INHIBITORS Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a -CO2H or -CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption.
WO/1995/017376A1	ARYL ACETIC ACID DERIVATIVES The invention relates to novel aryl acetic acid derivatives of formula (I) in which Ar, E, G, Q1, Q2 and Z have the meanings given in the description, processes for their production and their use as fungicides.
WO/1995/016667A1	PROCESS FOR THE PREPARATION OF N-ALKYL-N,O-DIACETYL HYDROXYLAMINE Process for the preparation of N-alkyl-N,O-diacetyl hydroxylamine, for instance N-methyl-N,O-diacetyl hydroxylamine, by catalytic reduction of a nitroalkane, for instance nitromethane, in the presence of acetic anhydride. As catalyst pre...
WO/1995/013264A1	HYDROXAMIC ACID DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME A hydroxamic acid derivative represented by general formula (1) and a medicinal preparation containing the same, having the effect of suppressing smooth muscle fiber growth and being usable as a vascular wall thickening preventive, a pos...
WO/1995/012572A1	CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disor...
WO/1995/012603A1	MATRIX METALLOPROTEASE INHIBITORS________________________________ This invention is directed to compounds of formula (I): wherein R1 is mercapto, acetylthio, carboxy, hydroxycarbamoyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, benzyloxycarbamoyl or (i) (where R6 is optionally substituted aryl,...
WO/1995/010503A1	AMIDOXIME DERIVATIVE AND FLOWERING ACCELERATOR Amidoxime derivatives represented by general formula [I] and a flowering accelerator containing at least one of them as the active ingredient, wherein R1 represents halogen, alkynyloxy, haloalkyl, alkoxy, alkyl or methylenedioxy, and n r...
WO/1995/007076A1	INCLUSION COMPLEXES OF RACEMIC IBUPROXAM AND OF OPTICALLY ACTIVE IBUPROXAM WITH CYCLODEXTRIN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THESE INCLUSION COMPLEXES OR CONTAINING OPTICALLY ACTIVE S-(+)-IBUPROXAM, AND USE THEREOF There are disclosed novel inclusion complexes of racemic ibuproxam and of optically active S-(+)-ibuproxam with hydrophilic and hydrophobic cyclodextrin derivatives and, in the case of optically active S-(+)-ibuproxam, also with 'beta'-c...
WO/1995/006031A1	INHIBITORS OF TNF-ALPHA SECRETION Compounds and methods are disclosed that are useful in inhibiting the TNF-'alpha' converting enzyme (TACE) responsible for cleavage of TNF-'alpha' precursor to provide biologically active TNF-'alpha'. The compounds employed in the invent...
WO/1995/005358A1	USE OF PHENOLS AND PHENOL DERIVATES AS MEDICAMENTS WITH FIBRINOGEN-REDUCING EFFECT Phenols and phenol derivatives having the general structural formula (I) are used to produce medicaments with fibrinogen-reducing effect. Also disclosed are new phenols and phenol derivatives, a process for producing the same and medicam...
WO/1995/004715A1	ACYLPHENYLGLYCINE DERIVATIVE AND PREVENTIVE AND REMEDY FOR DISEASES CAUSED BY INCREASED COLLAGENASE ACTIVITY CONTAINING SAID COMPOUND AS ACTIVE INGREDIENT An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for diseases caused by an increased collagenase activity containing the same as the active ingr...
WO/1995/004033A1	SUCCINAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS GELATINASE AND COLLAGENASE INHIBITORS Compounds of formula (1) are described, wherein R1 represents (a), where R3 is a hydrogen or halogen atom or a methyl, trifluoromethyl or methoxy group; R2 represents a hydrogen atom or a methyl group; and the salts, solvates, hydrates a...
WO/1995/003271A1	2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY Use in the prevention and/or in the treatment of neurodegenerative diseases of 2-amino-4-phenyl-4-oxobutyric acid derivatives (I) which act as kynureninase enzyme inhibitors and/or kynurenine-3-hydroxylase enzyme inhibitors. In formula (...
WO/1995/002575A1	5-LIPOXYGENASE INHIBITORS Hydroxyurea compounds comprising halo substituted 1, 2, 3, 4-tetrahydronaphthalene, and indane derivatives, pharmaceutical compositions and their use as OPUFA and 5-lipoxygenase pathway inhibitors.
WO/1995/001168A2	PHARMACEUTICAL PREPARATIONS WITH AN ACTIVE PRINCIPLE CONTAINING MODIFIED AMIDIN GROUPS A novel pharmaceutical preparation contains an active principle with at least one pharmaceutically active amidin group which may be orally absorbed. The amidin group is a compound selected from the group (a), (b) and (c), in which R7 sta...
WO/1995/000480A1	NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R1 represents hydrogen or...
WO/1995/000140A1	GALLIUM COMPLEXES FOR THE TREATMENT OF FREE RADICAL-INDUCED DISEASES A pharmaceutical composition comprises a gallium complex of desferrioxamine or penicillamine as active ingredient therein, in combination with a pharmacologically acceptable carrier. The gallium desferrioxamine or gallium penicillamine c...
WO/1994/027965A1	NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS The present invention relates to novel 5-HT4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C1-4)alkyloxy or phenyl(C1-4)al...
WO/1994/027947A1	PHENYLCYCLOPROPANE COMPOUNDS AND THEIR USE AS cAMP AND TNF INHIBITORS This invention relates to substituted phenylcyclopropane derivatives, which carry various substituents on the cyclopropane ring, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for their...
WO/1994/027955A1	INTERMEDIATES AND PROCESS OF MAKING DIPEPTIDE ISOSTERES Intermediates and a stereoselective process for preparing hydroxyethylene dipeptide isosteres and lactone compounds which process comprises, as an essential step, the stereoselective reduction of the keto group in a 5S-4-keto-5-dibenzyla...
WO/1994/026693A1	BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS Novel compounds of formula (I) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.
WO/1994/026700A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES Compounds of formula (I) in which Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group (a) or (b) and R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4-alkynyl, C3-C6cycloalkyl, phenyl which is unsubs...
WO/1994/026692A1	BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS The present invention relates to amide and thioamide compounds of formula (I), synthesis thereof, intermediates, salts, solvates and physiologically functional derivatives thereof, pharmaceutical compositions containing them and to the u...
WO/1994/025435A1	PEPTIDYL DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITORS Compounds of formula (1), wherein R represents a -CONHOR6 [where R6 is a hydrogen atom or an acyl group], carboxyl (-CO2H), esterified carboxyl, -SR6 or -P(O)(X1R7)-X2R8 group, where X1 and X2, which may be the same or different, is each...
WO/1994/025434A1	PEPTIDYL DERIVATIVES AS METALLOPROTEINASE INHIBITORS Compounds of formula (1) are described where R represents a -CONHOR6 [where R6 is a hydrogen atom or an acyl group], carboxyl (-CO2H), esterified carboxyl, -SR6 or -P(O)(X1R7)- -X2R8 group, where X1 and X2, which may be the same or diffe...
WO/1994/025430A1	CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or ...
WO/1994/025431A1	CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING N(3-BIPHENYLYL-1(S)-METHYL-2-PROPENYL) ACETOHYDROXAMIC ACID DERIVATIVES The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or ...
WO/1994/024095A1	IMMUNOSUPPRESSIVE AGENTS Compounds having a formula selected from the group consisting of (I), (a) and (III) and the respective pharmaceutically acceptable salts, esters and prodrugs thereof, wherein E is selected from the group consisting of -R14, -NR14R15, -SR...
WO/1994/024096A1	HYDROXAMIC ACIDS AND HYDROXAMIC ACID ETHERS AND THEIR USE AS COMPLEXING AGENTS Hydroxamic acids and hydroxamic acid ethers have formulae (I) and (II), in which Z1 and Z2 stand for the groups -NH-OY, -NR1-OY or -OX, at least one of the residues Z1 or Z2 in (I) or the residue Z1 in (II) being -NH-OY or -NR1-OY; R1 st...
WO/1994/022309A1	SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF Methods and compositions are disclosed that are useful for treating or preventing diseases wherein said diseases include skin disorders, keratoconus, restenosis, and wounds and the compositions include synthetic mammalian matrix metallop...
WO/1994/021625A1	HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS Compounds of formula (I), wherein R2 represents a C2-C6 alkyl group which may contain an ether or thioether linkage; R3 represents (a) the side chain of a naturally occurring alpha-amino acid in which any carboxylic acid group may be est...
WO/1994/018158A1	SPIROALKYLHYDROXYUREAS FOR USE AS LIPOXYGENASE INHIBITORS The present invention provides novel N-hydroxyurea and hydroxamic acid derivatives of chemical formula (I), wherein R is C1-C4 alkyl or -NR1R2; R1 and R2 are each, independently, hydrogen or C1-C4 alkyl; M is hydrogen or pharmaceutically...
WO/1994/017035A1	AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME New aminoacid derivates have the general formula: T-Z-NR1-(R2CR3)-CO-Y-(CH2)n-R, in which R, R1 to R3, T, Z, Y and n are defined as in the first claim. They represent valuable NPY-antagonistic active substances. Also disclosed are their ...
WO/1994/015908A1	PROPIONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF A propionamide derivative represented by general formula (I) and a salt thereof, wherein R1 and R2 represent each hydrogen, etc.; R3 and R4 are combined together to represent optionally substituted C2-C7 alkylene, etc.; R5 represents hyd...
WO/1994/014322A1	ARYLAMINO-ALKOXIMINO DERIVATIVES AND THEIR USE AS FUNGICIDES A compound having formula (I) wherein R1 is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, aryl or aryl(C1-4)alkyl; R2 is hydrogen, C1-4 alkyl, C1-4 haloalkyl or C3-6 cycloalkyl; W is CH3O.CH = CCO2CH3...
WO/1994/014755A1	AMINO ACID DERIVATIVE AND ANTI-ACTIVE-OXYGEN AGENT A novel anti-active-oxygen agent which inhibits the generation of active oxygen species, is highly safe, can be preparated at a rather low cost, and contains an amino acid derivative represented by general formula (I) or a salt thereof a...
WO/1994/014757A1	PROCESS AND INTERMEDIATE PRODUCTS FOR PREPARING HYDROXYLAMINE-ETHERS AND THEIR SALTS In order to prepare hydroxylamine-ethers having formula (I), in which X stands for NO2, CN, halogen, alkyl and halogen alkyl; Y stands for H, NO2, CN, halogen, alkyl and halogen alkyl; n equals 0 to 2 or 1 to 4 when Y and all X's stand f...
WO/1994/014761A1	ARALKYLOXY- AND ARALKYLTHIO ALKOXIMINO DERIVATIVES AND THEIR USE AS FUNGICIDES A compound having general formula (I), wherein R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, aryl or aryl(C1-4)alkyl; R3 is hydrogen, C1-4 alkyl, C1-4 haloalkyl or C3-6 cyc...
WO/1994/012461A1	CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDEIV and in the treatment of AIDS, ast...
WO/1994/011339A1	SUBSTITUTED CYCLOPENTANE COMPOUNDS FOR USE AS CHELATING AGENTS The invention provides as new compounds cis-cis-cis-tetrasubstituted cyclopentane compounds which are expected to be useful as chelating agents for alkaline earths, transition, lanthanide and actinide metal ions. The compounds have formu...
WO/1994/011334A1	SUBSTITUTED ORTHO-ETHENYL-PHENYL ACETIC ACID DERIVATIVES Compounds of general formula (I) in which the index and the constituents have the meanings below: n: 0, 1, 2, 3 or 4; X: CHOCH3, CHCH3 or NOCH3; Y: O or NH; R1: nitro, cyano, halogen, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio...
WO/1994/010148A1	ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein W is selected from optionally substituted pyridyl, naphthyl, and quinolyl; which inhibits lipoxygenase enzyme activity and l...

Matches 601 - 650 out of 1,858	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >