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WO/1994/005627A1 |
The present disclosure details the preparation of hydroxamic-acid based bifunctional chelators and their use in conjugating metal ions to proteins and nucleic acids for tumor or tissue imaging or therapy purposes. Some preferred aspects ...
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WO/1994/005153A1 |
Herbicidal compositions and method of use involving effective amounts of substituted benzene compounds to control the growth of undesired vegetation.
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WO/1994/002448A1 |
The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the treatment of a clinical condition for which an inhibitor of the lipoxygenase or cyclooxygenase...
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WO/1994/002447A1 |
Compounds of formula (I) have matrix metalloproteinase inhibitory activity, wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may...
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WO/1994/002446A1 |
Compounds of Formula (I) wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R6 represent...
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WO/1994/000422A2 |
A fungicidal compound having formula (I), wherein either: A and B are both fluoro; W is oxygen; Z is NR\'R\'\'; R\' is C1-4 alkyl; R\'\' is C1-4 alkyl, C1-4 alkoxy or C1-4 haloalkyl; and R3 is C(CH3)2F; provided that when R\' is methyl t...
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WO/1993/025519A1 |
The invention concerns copolymerizable oxime ethers of generale formula (I), in which A is a bivalent link group; R?1¿ is a hydrogen atom or a C¿1? to C¿4? alkyl group; and R?2¿ and R?3¿, independently of each other, may be a hydrog...
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WO/1993/024451A1 |
A salt of formula (I) where X denotes a group of formula (II), Y denotes a group of formula (III) and R denotes the residue of an aliphatic or cycloaliphatic sulphonic acid having at least 3 carbon atoms after removal of an -SO3H group t...
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WO/1993/024449A1 |
Compounds of formula (1) are described wherein R represents a -CONHOH, carboxyl (-CO2H), esterified carboxyl or -P(O)(X1R8)X2R9 group, where X1 and X2, which may be the same or different is each an oxygen or a sulphur atom, and R8 and R9...
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WO/1993/024475A1 |
Compounds of formula (1) are described wherein R represents a -CONHOH, carboxyl (-CO2H), esterified carboxyl or -P(O)(X1R8)X2R9 group, where X1 and X2, which may be the same or different is each an oxygen or a sulphur atom, and R8 and R9...
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WO/1993/019749A1 |
Novel compounds of formula (I) are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the presen...
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WO/1993/016986A1 |
Azo oxime ethers of general formula (I), in which X is CH or N, R1 is hydrogen, C1-C3alkyl, trifluoromethyl or cylclopropyl and R2 is aryl or heteroaryl, have an activity against phytopathogenic fungi. They can be used in the form of for...
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WO/1993/015046A1 |
Carbamate having the formula (I), its plant-compatible acid addition and basic addition products, and fungicides containing the same are disclosed.
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WO/1993/015093A1 |
A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which a...
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WO/1993/013741A2 |
Synthetic mammalian matrix metalloprotease inhibitors are useful in controlling angiogenesis. These compounds are thus useful in controlling the growth of tumors and in controlling neovascular glaucomas.
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WO/1993/013056A1 |
The novel salts of (+)-(1S,2R)-2-[[N-(2-hydroxylamino-2-oxoethyl)-N-methyl-amin
o]carbonyl]cyclohexane-1-carboxylic acid with metals and organic bases, represented by general formula (I) wherein R and R' if taken together represent a biv...
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WO/1993/012075A1 |
A novel hydroxamic acid derivative containing a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, which has activities of inhibiting cell growth, vascularization, etc.. It...
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WO/1993/012077A1 |
Compounds of formula (I) wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or (II), R' is hydrogen or C2 to C8 alkylthioalkyl, n is an integer of from 1 to 4 and p is an integer of from 2 t...
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WO/1993/011154A1 |
Novel and known compounds are described which inhibit endothelin converting enzyme (ECE), thereby preventing the conversion of Big Endothelin (BET) to Endothelin (ET). Pharmaceutical usefulness and preparations are described.
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WO/1993/009090A1 |
A compound represented by general formula (I), a pharmaceutical composition containing same, a process for the production thereof, and an intermediate therefor. In formula (I) R1 represents lower alkyl which may be substituted by a subst...
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WO/1993/009088A1 |
Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. T...
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WO/1993/007867A1 |
Novel substituted beta-amino acid derivatives having general formula (I), are provided, in which e.g. R?2¿ is selected from the group consisting of hydrogen, lower alkyl radicals, lower alkenyl radicals, lower alkynyl radicals, alicycli...
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WO/1993/007148A1 |
The present invention provides the compound having structure (I), wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloa...
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WO/1993/003045A1 |
The present invention describes a synthesis and purification of novel organic chelate metal ion (II) or (III) complexes. These processes are useful specifically for producing purer complexes for magnetic resonance imaging (MRI) contrast ...
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WO/1993/002047A1 |
N-ethyl alkanohydroxamic acids, where said alkyl group is a straight chain alkyl group of 8 to 10 carbon atoms, or a branched alkyl group of 8 to 18 carbon atoms, provided said alkyl group is not cyclic, useful as metal chelants for use ...
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WO/1993/002045A1 |
The present invention provides a compound of formula (I): A[X(CR1R2)n]mXA or a chelate complex of salt thereof, for use as therapeutic or diagnostic agent wherein in formula (I), each of the groups R1 and R2 may independently represent a...
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WO/1993/000327A1 |
Linear hydroxamate derivatives of the formula (I): R1R2N-X1-CONR3-X2-CONR4-X3-R5 wherein X1, X2 and X3 are the same or different moiety of the formula -CHR6-(CH2)m-(CHR7)8-CONOH-(CH2)n- and the -N-CHR6-(CH2)m-CO- moiety is preferably der...
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WO/1993/000082A1 |
Pharmaceutical compositions comprising compounds of the formula: R2C{CH2O(CH2)nCO[NR3CHR(CH2)mCO]qNOHR1}3, wherein R is hydrogen, alkyl optionally substituted by OR5, SR5, NR5R6, COR6, COOR6, CONR5R6, -NHC(NR5R6)=NR7, aryl, aralkyl or he...
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WO/1992/022523A2 |
This invention is directed to a collagenase inhibitor of formula (1).
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WO/1992/021648A1 |
The present invention relates to compounds of formula (I).
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WO/1992/020227A1 |
Compounds are described of general formula (I), wherein R1 is acyl of the formula -C(=O)-R5; R2, R3, R4, R6, R7 and R8 are each selected from the group consisting of hydrogen and acyl of the formula -C(=O)-R5, wherein R5 is selected from...
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WO/1992/018487A1 |
Compounds having formula (I), wherein A is hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy or cyano; and one of R1 and R2 is methyl and the other is pyridyl or pyrimidinyl substituted by one or more s...
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WO/1992/015555A2 |
Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are pa...
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WO/1992/013831A1 |
Compounds of general formula (I): wherein R1 is hydrogen, C1-C6 alkyl, phenyl, substituted phenyl, phenyl(C1-C6 alkyl), or heterocyclyl; or R1 is ASOnR7 wherein A represents a C1-C6 hydrocarbon chain, optionally substituted with one or m...
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WO/1992/010469A1 |
Certain novel hydroxamic acid derivatives having structure (I) inhibit the enzyme lipoxygenase. These compounds, and the pharmaceutically acceptable salts thereof, are useful in the treatment or alleviation of inflammatory diseases, alle...
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WO/1992/009567A1 |
The present invention is concerned with compounds of formula (I), wherein m is 0 or 1; n is an integer of from 1 to 6 and p is an integer of from 0 to 3 with the proviso that n+p does not exceed 6; Ar is a mono-, bi-, or tricyclic aromat...
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WO/1992/009282A1 |
Compounds of formulae (1) or (2) wherein R1 is H and R2 is alkyl (3-8C) or wherein R1 and R2 taken together are -(CH2)n- wherein n = 3-5; R3 is H or alkyl (1-4C); R4 is a substituted or unsubstituted fused or conjugated bicycloaryl methy...
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WO/1992/009566A1 |
Certain novel hydroxamic acid derivatives having structure (I), inhibit the enzyme lipoxygenase. These compounds, and the pharmaceutically acceptable salts thereof, are useful in the treatment or alleviation of inflammatory diseases, all...
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WO/1992/009556A1 |
Compounds of formulas (1) or (2) wherein each R?1¿ is independently H or alkyl (1-8C) and R?2¿ is alkyl (1-8C) or wherein the proximal R?1¿ and R?2¿ taken together are -(CH¿2?)¿p?- wherein p = 3-5; R?3¿ is H or alkyl (1-4C); R?4¿...
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WO/1992/009563A1 |
Compounds of formulas (1) or (2), wherein each R?1¿ is independently H or alkyl (1-8C) and R?2¿ is alkyl (1-8C) or wherein the proximal R?1¿ and R?2¿ taken together are -(CH¿2?)¿p?- wherein p = 3-5; R?3¿ is H or alkyl (1-4C); R?4Â...
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WO/1992/009564A1 |
Compounds of formula (I) are described wherein R represents a -CONHOH, carboxyl (-CO2H) or esterified carboxyl group; R1 represents an optionally substituted alkyl, alkenyl, aryl, aralkyl, heteroaralkyl or heteroarylthioalkyl group; R2 r...
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WO/1992/009565A1 |
Compounds of formula (I) are described wherein R represents a -CONHOH, carboxyl (-CO2H) or esterified carboxyl group; R1 represents an optionally substituted alkyl, alkenyl, aryl, aralkyl, heteroaralkyl or heteroarylthioalkyl group; R2 r...
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WO/1992/008453A1 |
Compounds of formula (I) in which R and R' are each separately selected from aliphatic hydrocarbon groups, aryl groups and aliphatic hydrocarbon groups substituted by an aryl group, are of value for use in medicaments for the control of ...
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WO/1992/007822A1 |
Compounds of formula (I), which are intermediates in the preparation of 4,5-difluoroanthranilic acid, an intermediate itself in the synthesis of quinolone antibacterials, and methods of preparing these intermediates.
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WO/1992/004318A1 |
Selected oxime carbonates of formula (I), and their geometric and stereoisomers, agricultural compositions containing such compounds and their use as fungicides. In formula (I) Y is Cl or SO2R4; R1 is (a),(b), (c), or (d) wherein the aro...
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WO/1992/004321A1 |
The invention relates to bicyclic aryl compounds having selective LTB4 antagonist properties and comprising an amido substituent , a substituent group having a terminal carboxylic acid or derivative thereof and a lipophilic substituent, ...
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WO/1992/002491A1 |
Fungicidally active compounds of formula (I) are disclosed.
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WO/1992/000968A1 |
Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors...
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WO/1992/000957A1 |
A method for preparing deferoxamine and a composition of formula (I): X-Ph-CH¿2?-O-C(O)-NH-(CH¿2?)¿4?-CH=NOR, wherein X is a C¿1?-C¿4? alkyl, -O(C¿1?-C¿4? alkyl), a halogen or hydrogen; R is X-Ph-CH¿2?- or hydrogen for preparing ...
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WO/1991/016298A1 |
Compounds having structure (I) wherein X is nitrogen, oxygen, sulfur or a bond and Z is oxygen or sulfur have been synthesized. These compounds are lipoxygenase inhibitors and are useful as the active agent in pharmaceutical compositions...
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