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WO/2018/007919A1 |
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...
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WO/2017/214539A1 |
The application relates to 2-amino-4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2/3 potassium channel modulators, and methods of their uses.
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WO/2017/211145A1 |
The present invention discloses a micro/nanomaterial, a product thereof with a surface covalently modified with a hydrophilic material, and a manufacturing method. The surface of the micro/nanomaterial comprises a carboxyl group or poten...
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WO/2017/206692A1 |
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions and/or organic amine B cations; m ...
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WO/2017/206693A1 |
An organic amine salt compound having the general formula (I): An-[Bm+]p. In the formula, An- is anions having -n valence serving as CO2 donors, wherein n = 1, 2, or 3; Bm+ is or contains: ammonium ions, hydrazine ions and/or organic ami...
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WO/2017/204144A1 |
Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal o...
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WO/2017/195147A1 |
The present invention relates to process for preparation of ledipasvir of formula (1) and its novel intermediates. The process involves reacting a compound of formula (4) with compound of formula (5) to yield a compound of formula (3), d...
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WO/2017/175238A1 |
: The invention discloses a novel process for highly chemoselective reactions of substituted anilines without any detectable reaction at aromatic amino group. The invention also relates to a novel process for preparation of neostigmine m...
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WO/2017/170934A1 |
The present invention pertains to an acetylacetone derivative which is useful in trapping metal elements by complex formation, and a simple and highly versatile synthesis method therefor. More specifically, the present invention pertains...
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WO/2017/155120A1 |
The present invention addresses the problem of providing a long life catalyst which can be produced simply and inexpensively, which exhibits high activity, and in which metal leakage is suppressed. Provided is a catalyst according to sev...
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WO/2017/137343A1 |
A method for the production of carbamate compounds comprises the steps of: A) reacting an organic primary amine with an organic halogen compound in the presence of a quaternary organic ammonium carbonate and/or bicarbonate, thereby obtai...
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WO/2017/133620A1 |
The present invention relates to a synthesis process of suvorexant, and a preparation method of novel compounds represented by formulas II, III, IV or V, or a salt or intermediate thereof for preparing the suvorexant. The preparation met...
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WO/2017/100750A1 |
An adhesive comprising an allyl (urethane) silane, where the allyl (urethane) silane comprises at least one allyl-functional group and one silane-functional group connected through a urethane linkage. Preferably, the allyl(urethane) sila...
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WO/2017/098975A1 |
A method for producing methyl (2Z)-3-(1,1'-biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]- prop-2-enoate, comprising the steps of: reacting 4-phenylbenzaldehyde with glycine in the presence of sodium hydroxide or potassium hydroxide to pr...
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WO/2017/070418A1 |
Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.
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WO/2017/059759A1 |
A process is provided for preparation of (R)-N-Boc biphenyl alaninol.It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 ...
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WO/2017/043626A1 |
Provided is a method for producing an optically active 4-carbamoyl-2,6-dimethylphenylalanine derivative, which is a compound useful as an intermediate for a medicine, in a simple manner and with high efficiency. 4-carbamoyl-2,6-dimethylb...
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WO/2017/020835A1 |
An antibiotic for inhibiting a drug-resistant microorganism. The antibiotic is Fmoc-Ala-OPfp, which is not toxic to human cells and can effectively inhibit a drug-resistant microorganism.
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WO/2017/019791A1 |
Provided is a process for preparing (S)-Pregabalin
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WO/2016/199688A1 |
Tert-Butyl[(2R)-1-(biphenyl-4-yl)-3-hydroxypropan-2-yl]carba
mate can be produced by a step for obtaining a protic acid salt of a compound shown by formula [C]: by reacting a compound shown by formula [A]: with an alcohol shown by formul...
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WO/2016/192150A1 |
A class of propyl cationic peptide lipids is propyl cationic peptide lipid compounds having a general formula structure as follows. After the propyl cationic peptide lipids are dispersed in water, a cationic liposome with a particle size...
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WO/2016/193474A1 |
Reaction product containing amidoamine groups, containing one or more species of the general formula (I) (R1-X)p-Z1-(XH)y where p + y = w and w is an integer from 1 to 10, p is an integer from 1 to 10, y is an integer from 0 to 9, and X ...
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WO/2016/184160A1 |
The present invention relates to a chiral spiro phosphorus-nitrogen-sulphur (P-N-S) tridentate ligand, and a preparation method and application thereof. The P-N-S tridentate ligand is a compound represented by formula I or formula II, a ...
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WO/2016/180275A1 |
Disclosed are AHU-377 intermediates and a method for preparing AHU-377 and AHU-377 intermediates. The above-mentioned method for preparing AHU-377 uses a chiral glycidyl benzyl ether as the starting raw material. Intermediate compound (3...
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WO/2016/177761A1 |
The present invention relates to a process for the preparation of an isocyanate compound comprising the steps of: a) Reacting an amine compound A having at least one primary amino group with CO2 and an organotin compound S having at leas...
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WO/2016/176636A1 |
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
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WO/2016/150823A1 |
Described is a method of preparing a carbamate-functional material. The method comprises reacting a carbamate compound with a hydroxy-functional material using a zinc catalyst. Also described are carbamate-functional materials prepared b...
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WO/2016/150953A1 |
The present invention relates to a process for synthesis of 4,5,6,7- tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to ob...
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WO/2016/147204A1 |
The present invention discloses an improved catalyst free process for synthesis of alkyl carbamates in an integrated system comprising a tubular reactor and a striper. The process comprises reacting urea and an alcohol in said tubular re...
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WO/2016/140189A1 |
The purpose of the present invention is to provide a novel method for producing an optically active α-fluoro amino acid compound or a salt thereof. More specifically, the purpose is to produce an α-fluoro amino acid compound or a salt ...
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WO/2016/123707A1 |
The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in par...
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WO/2016/119757A1 |
The present invention relates to a method for preparing a 2-[1-cycloalkylethyl] phenol derivative, i.e. a method for preparing a compound as shown in formula (I) and an isomer thereof, and an intermediate, and the method has the advantag...
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WO/2016/114670A1 |
The invention pertains to the synthesis of carbamate and urea compounds. In particular the invention is directed to the synthesis of carbamate and urea compounds which may be used in the production of compounds that are used to stabilize...
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WO/2016/083475A1 |
The invention relates to an electrochemical process for preparing bis-O-alkyl-carbamates from primary amines with C02 as carbonyl source and at least one alkyl halide with at least 3 C-atoms in the alkyl group as alkylating agent.
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WO/2016/075605A1 |
The present invention provides a process for the preparation of crystalline anhydrous compound of Formula (X), Further, the present invention relates to the use of compound of Formula (X) preparation of Raltegravir (I) or its pharmaceuti...
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WO/2016/055015A1 |
Disclosed is a method for synthesizing a sitagliptin intermediate, the method comprising: under the existence of transition metal catalyst of chiral phosphine ligand and hydrogen, conducting asymmetrical reduction ammonification reaction...
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WO/2016/047644A1 |
Provided is a production method for an optically active α-trifluormethyl-β-amino acid derivative whereby: a compound indicated by general formula (1) and a compound indicated by general formula (2) are reacted in the presence of a copp...
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WO/2016/026459A1 |
The present invention relates to an isopropyl phenol derivative and a preparation method thereof, and in particular relates to a method for preparing compounds shown by formulae (I) and (IV), and their intermediates, and to their interme...
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WO/2016/019630A1 |
Disclosed is a method for synthesizing 1,3-disubstituted allene with high optical activity, namely a method for preparing 1,3-disubstituted allene with high optical activity in one step of functionalizing terminal alkyne, aldehyde and ch...
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WO/2016/015596A1 |
A process of preparing 2, 3-disubstituted-5-oxopyran compounds, comprising cyclizing a compound in the presence of a base and an organic solvent is provided.
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WO/2016/002918A1 |
Provided is a novel method for producing an indole compound or salt thereof having an ITK-inhibiting effect and being useful in the treatment or prevention of inflammatory diseases and the like. A method for producing N-[2-(6,6-dimethyl-...
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WO/2015/190118A1 |
The present invention relates to an onium salt, an acrylic acid copolymer containing the onium salt, and an antistatic agent containing the onium salt or the acrylic acid copolymer. The present invention provides an onium salt capable ...
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WO/2015/169550A1 |
A carbamate-functional material is prepared by reacting a carbamate compound with a hydroxy-functional material using zirconium acetylacetonateas catalyst.
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WO/2015/169545A1 |
A carbamate-functional material is prepared by reacting a carbamate compound with a hydroxy-functional material using titanium (IV) alkoxide as catalyst.
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WO/2015/168465A1 |
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
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WO/2015/165352A1 |
The present invention provides a compound with a structure represented by general formula I or a pharmaceutically acceptable salt thereof, a preparation method for the compound or the salt, and a use of the compound or the pharmaceutical...
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WO/2015/158799A1 |
The invention relates to a process for preparing alkylaryl carbamates from alkyl formates and at least one amino aryl compound in the presence of a metal-based catalyst. The alkylaryl carbamates can be used for the preparation of isocyan...
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WO/2015/151885A1 |
Provided is a fluorine-containing monomer, which can be solubilized in a hydrocarbon solvent and also has excellent water and oil repellence, and a manufacturing method therefor. A carboxylic ester / carbamate compound, which is represen...
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WO/2015/146905A1 |
[Problem] To provide: an acrylic or methacrylic compound having an N-alkoxyalkyl group; and a method for producing the acrylic or methacrylic compound. [Solution] An acrylic or methacrylic compound which is represented by formula (1) and...
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WO/2015/135176A1 |
Methods, systems and kits for preparing carbamates as well as catalysts for preparing the carbamates, are disclosed. The methods for preparing carbamate can include providing a catalyst comprising cerium oxide (Ce02) and at least one met...
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