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WO/2023/175492A1 |
The present invention relates to novel intermediate of formula (V) and formula (VI) and preparation thereof. The present invention further relates to an industrially feasible and commercially viable process for preparation of sitagliptin...
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WO/2023/168889A1 |
Disclosed herein are a preparation method for an alicyclic carbamate and the use thereof. The preparation method comprises the following steps: mixing a carbamate containing an aromatic ring, a catalyst and a solvent, and then introducin...
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WO/2023/164889A1 |
Disclosed are a method for preparing codeine and a derivative and intermediate thereof. Simple, cheap and easily-available commercially available compounds are used as starting materials in the present invention, various intermediates th...
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WO/2023/158634A1 |
Described herein are crystalline forms of a prostacyclin (IP) receptor agonist compound, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatm...
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WO/2023/143158A1 |
The present invention relates to a phenol derivative, a crystal form thereof, and a preparation method therefor, in particular to a solid intermediate used for preparing the phenol derivative, and specifically provides a compound shown i...
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WO/2023/134673A1 |
A high-selectivity KCNQ4 potassium channel agonist of formula I, a preparation method therefor and the use thereof. The compound further improves the KCNQ4 agonistic activity, and is still free of KCNQ2 agonistic activity, thus having ex...
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WO/2023/123747A1 |
The present invention relates to the technical field of photoinitiator synthesis, and in particular relates to a hydrogen abstraction photoinitiator, a preparation method therefor, and a use thereof. The hydrogen abstraction photoinitiat...
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WO/2023/106377A1 |
Provided is a method for producing a blocked isocyanate compound, the method comprising a reaction step of reacting a primary amine compound, a carbonic acid derivative, and a blocking agent by means of heat treatment in the presence of ...
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WO/2023/080257A1 |
The method for producing isocyanate compounds comprises: a step (1) for obtaining an N-substituted carbamate compound by reacting a primary amine compound and a carbonate derivative, while removing by-product compounds that have a boilin...
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WO/2023/080258A1 |
The present invention provides a carbonyl compound represented by general formula (I) (wherein R11 is an (n11+n12)-valent organic group, R12 is a monovalent organic group, n11 is an integer of 1-8, n12 is an integer of 0-7, and the sum o...
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WO/2023/071328A1 |
Disclosed is a method for synthesizing 8-amino-1-{[2-(trimethylsilyl)ethoxy]methoxy}octane-3-one, which belongs to the technical field of pharmaceutical chemical synthesis. The method comprises the steps of: firstly, protecting diphenylm...
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WO/2023/073606A1 |
The present invention relates to an industrially feasible and economically viable process for preparation of Edoxaban key intermediate viz. compound of formula (1) which is shown below:
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WO/2023/072143A1 |
Disclosed in the present invention are a camptothecin derivative intermediate, and a preparation method therefor and the use thereof. The structural formula of the camptothecin derivative intermediate of the present invention is as shown...
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WO/2023/065610A1 |
The present invention relates to the field of drug synthesis. Disclosed is a preparation method for halofuginone intermediate trans-N-benzyloxycarbonyl-(3-hydroxy-2-piperidinyl)-2-aceton
e. The preparation method of the present invention...
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WO/2023/029235A1 |
The present invention belongs to the technical field of chemical synthesis and discloses a method for preparing a sacubitril intermediate. A key aza-tricyclic compound 5 is generated by using starting materials, chloramine-T trihydrate (...
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WO/2023/033015A1 |
Provided is a method for producing a Fmoc-protected amino group-containing compound, wherein a raw material amino group-containing compound is not wasted, by-production of Fmoc-β-Ala-OH is suppressed, and the purification of a target su...
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WO/2023/017474A1 |
This invention provides a flow synthesis process for producing sulfonylurea compounds of formula (1), including gliclazide, chlorpropamide and tolbutamide, and pharmaceutically acceptable salts thereof.
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WO/2023/014160A1 |
The present invention relates to a crystalline form of a phenyl carbamate derivative compound and uses thereof, and more specifically, the present invention relates to a pattern 1 crystalline form, which is a thermodynamically more stabl...
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WO/2023/004687A1 |
Provided by the present invention is an unnatural amino acid, which is a compound having a structure as shown in formula (I) or an enantiomer thereof. Further provided by the present invention is an application of the unnatural amino aci...
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WO/2023/286053A1 |
The present invention pertains to a process for preparing of methyl chloroformyl[4-(trifluoromethoxy)phenyl]carbamate of formula I as intermediate in the preparation of arthropodicidal indoxacarb, comprising reaction of compound of formu...
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WO/2023/285310A1 |
The invention relates to novel carbodiimides, to a process for the preparation and use thereof as a stabilizer in ester-based polyols, in polyethylene terephthalate (PET), in polybutylene terephthalate (PBT), in polytrimethylene terephth...
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WO/2023/280638A1 |
The application relates to vinyl thianthrenium compounds Vinyl- TT+X" of the Formula (I), a process for preparing the same and the use thereof for vinylating organic compounds.
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WO/2022/264168A1 |
The present invention provides a process for preparation of compound of formula (I), a key intermediate in synthesis of L-glufosinate or its salt. wherein P2 is an amino-protecting group; R1 is hydrogen, substituted or unsubstituted C 1 ...
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WO/2022/246929A1 |
The present invention relates to the technical field of drug synthesis, and provides a preparation method for an ABT-737 key intermediate and a preparation method for ABT-737. A compound having a structure as represented by formula I is ...
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WO/2022/041171A9 |
The present application relates to a compound having the effects of being an antidepressant, narcotizing, alleviating pain, improving cognitive functions, protecting lungs, preventing or treating amyotrophic lateral sclerosis, or prevent...
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WO/2022/201155A1 |
The present invention relates to a novel nitration process of 2- chloro -4- fluorobenzoic acid to 2-chloro-4- fluoro-5-nitrobenzoic acid, 2-chloro-4- f luoro-3 -nitrobenzoic acid and 3, 5-dinitro-2-chloro-4- fluorobenzoic acid; purifying...
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WO/2022/197182A1 |
The present invention pertains to improved methods for preparing cyclooctenes and conjugates thereof. In particular, methods for regioselective modification and/or enantiomerically enriching compounds are disclosed. In addition, compound...
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WO/2022/190486A1 |
The present invention provides, as a novel compound that can be utilized for efficient synthesis or the like of a polypeptide comprising various amino acids, a silane-containing condensed cyclic dipeptide compound represented by formula ...
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WO/2022/169729A1 |
A crosslinkable coating composition comprising: ingredient A that has at least two protons that can be activated to form a Michael carb anion donor, wherein ingredient A is selected from the group consisting of an acetoacetate group cont...
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WO/2022/148585A1 |
The present invention relates to a method for producing materials having at least one carbamate functionality, to carbamate-functional materials obtained from the inventive process, coating compositions comprising said carbamate-function...
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WO/2022/138891A1 |
The present invention addresses the problem of providing a method for producing a high-purity peptide compound with high efficiency and high yield. It is found that the problem can be solved by supporting a peptide on a resin for solid-p...
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WO/2022/138605A1 |
The present invention addresses the problem of providing a method for efficiently producing a peptide having a high purity, a reagent for forming a protective group having excellent deprotection properties, and a novel fused polycyclic c...
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WO/2022/134297A1 |
The present invention relates to a preparation method for a carboxylate ester compound, comprising: under the catalysis of a nitrite ester, reacting carboxylic acid and methanol in air, so as to obtain an ester compound. The preparation ...
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WO/2022/112868A1 |
The subject matter of the invention is a method for the preparation of oligocarbamates with a defined monomeric sequence of the general formula (I) characterised in that the multistage synthesis is performed in one reaction pot without t...
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WO/2022/084834A1 |
The present invention concerns a novel process for preparing solriamfetol hydrochloride.
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WO/2022/052683A1 |
The present invention provides a method for preparing a water-soluble magnolol derivative and a honokiol derivative, methods for preparing intermediates of a water-soluble magnolol derivative and a honokiol derivative, and a related mono...
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WO/2022/048930A1 |
The invention relates to a process for producing isocyanates by reacting the corresponding amines with phosgene in the liquid phase, comprising: (a) mixing an amine comprising feed stream, a phosgene comprising feed stream and optionally...
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WO/2022/041502A1 |
Disclosed herein is a method for preparing 1,5-pentane diisocyanate, comprising the following steps: (1) mixing 1,5-pentanediamine, a carbonylation agent, a first solvent and a catalyst for a carbonylation reaction, performing solid-liqu...
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WO/2022/021859A1 |
Disclosed are a carisoprodol antigen, a preparation method therefor, and an application thereof. Carboxyl is derived from carisoprodol N by succinic anhydride; the carboxyl is coupled with a protein to obtain the carisoprodol antigen.
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WO/2022/023626A1 |
The invention relates to a rheology-modifying difunctional compound. The invention also provides an aqueous composition containing a difunctional compound according to the invention and a method for controlling the viscosity of an aqueou...
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WO/2022/020385A1 |
A dispenser comprising a dispensing device containing a dispensing device solution, the dispensing device solution comprising C20H29NO7Si, the dispensing device solution having antiviral properties and emitting or reflecting UV light, wh...
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WO/2021/250067A2 |
The present invention relates to a process for the purification of (R)-2-amino-3-phenylpropyl carbamate in perspective of the subsequent conversion in the corresponding HCl salt (SOLRIAMFETOL). The invention further relates to the proces...
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WO/2021/248770A1 |
A genetically encoded formaldehyde reactive unnatural amino acid. Specifically, the present invention relates to a genetically encoded formaldehyde reactive unnatural amino acid PrAK, a preparation method and an application thereof in de...
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WO/2021/246485A1 |
Provided is a carbamate production method characterized by bringing a carbon dioxide-containing mixed gas in which the partial pressure of carbon dioxide is 0.001 atm or greater but less than 1 atm, into contact with an amino group-conta...
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WO/2021/234697A1 |
The present invention pertains to compositions and methods for treating inflammation in a subject in need thereof using hydroxynorketamine (HNK), a salt thereof, a stereoisomer thereof, or a combination thereof.
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WO/2021/233976A1 |
The synthesis of omega-hydroxyalkyl-urethanes, and of alfa-omega-diurethanes is reported which includes the reaction of diols with urea in presence of catalysts based on Ce at temperatures between 125 and 170°C over 4-8 h reaction time....
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WO/2021/223301A1 |
Provided is a preparation method for water-soluble Florfenicol amino acid ester salt, the method comprising the steps of: using Florfenicol and N-Cbz-amino acid as starting raw materials, and subjecting same to acyl chlorination, esterif...
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WO/2021/212762A1 |
A three-dimensional molding material, comprising the following components by mass fraction: 5-50% of a monofunctional polyurethane oligomer, 35-85% of a monofunctional monomer, 0-30% of a polyfunctional compound, 0.5-8% of a photoinitiat...
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WO/2021/196323A1 |
The present invention provides a light-emitting layer material and a manufacturing method therefor, and an electroluminescent device. The light-emitting layer material comprises a spiral nanotube structure and light-emitting particles, a...
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WO/2021/195671A1 |
The present invention relates to a process for preparing trientine dihydrochloride as an active pharmaceutical ingredient (API). The present invention relates to a process for the preparation of trientine dihydrochloride with a pharmaceu...
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