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Matches 801 - 850 out of 6,258

Document Document Title
WO/2003/089404A1
The present invention relates to naphthylamide compounds and their ability to act as potassium channel openers.  
WO/2003/089615A2
Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a com...  
WO/2003/089405A1
The present invention relates to derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition, more particularly the compounds of the present invention specifically inhibit the activation of T lymphoc...  
WO/2003/088915A2
The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/o...  
WO/2003/087045A1
Novel compounds of Formula (I) which modulate MCH activity are disclosed, in which A is a linker; Ar1 is an aryl or heteroaryl group; R1 is a lower alkoxy group; R2 is an R1 group or hydrogen, an OH or an NH2 group, Q together with the c...  
WO2003055848A3
This invention relates to urea derivatives of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: (I) wherein Y is R<1>- R<6> and X have the same meanings given in the description, which is useful as an active ingr...  
WO/2003/087044A2
Novel compounds of formula (I) which modulate MCH activity are disclosed, in which A is a linker; B is a connecting moiety; Ar1 and Ar2 are aryl or heteroaryl groups; R1 and R2 are hydrogen, halogen atoms, CF3, OCF3, SCF3, SCH3, nitrile,...  
WO/2003/087046A1
Novel compounds of formula (I) which modulate MCH activity are disclosed in which A is a linker; Ar1 is an aryl or heteroaryl group; R1 and R2 are hydrogen, straight or branched alkyl, alkenyl or alkynyl groups, cycloalkyl groups, alkylc...  
WO/2003/084997A1
Aspects of the present invention include probes, methods, systems that have stand alone utility and may comprise features of a drug discovery system or method. The present invention also includes pharmaceutical compositions. In more deta...  
WO2003048108A3
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model ...  
WO/2003/084922A1
The invention relates to acyl-4-carboxyphenylurea derivatives, the physiologically-acceptable salts, physiologically-functional derivatives thereof and compounds of formula (I), where the groups have the given meanings, the physiological...  
WO/2003/084923A1
The invention relates to acyl-3-carboxyphenylurea derivatives, physiologically-acceptable salts, physiologically-functional derivatives thereof and compounds of formula (I), where the groups have the given meanings, the physiologically-a...  
WO/2003/082205A2
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and so...  
WO2002083627A3
The invention relates to the novel biphenyl derivatives of the general formula (I), wherein R<1>, R<1>', R<1>'', R<2> and n are defined as in claim 1. The invention also relates to the stereoisomers and the physiologically acceptable sal...  
WO/2003/082777A2
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as glucocorticoid receptor modulators. The compounds of the instant invention are ligands for glucocorticoid receptors and as such may be ...  
WO/2003/079984A2
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...  
WO/2003/080554A2
A compound represented by the following general formula (IA) or a salt thereof: wherein Ar¿1? represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar¿2? represents an aryl group having at least on...  
WO/2003/077847A2
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...  
WO/2003/078376A1
A NK1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough.  
WO2003029199A9
Novel benzene derivatives represented by the general formula (||), which exhibit vanilloid receptor agonism and are useful as preventive and therapeutic drugs for pollakisuria and urinary incontinence, analgesic, or the like: (||) wherei...  
WO/2003/076397A1
The present invention relates to a compound formula [I] wherein R1 and R5 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, x is bond,-o-o,-O-CH2-, etc., y is in which Z is bond, -0...  
WO/2003/075857A2
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.  
WO/2003/075853A2
The present application describes modulators of MCP-1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, restinosis, organ tra...  
WO/2003/072537A2
Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the ...  
WO/2003/072539A1
The present invention relates to novel compounds of formula (I),to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of ...  
WO/2003/070692A1
A compound represented by the following formula (1): (1) (wherein R1 represents C1-12 alkyl, phenyl, 1-naphthyl, etc.; R2 represents C2-12 alkyl; (R3)b represent zero to four substituents, e.g., halogeno; R4 represents lower alkyl; R5 re...  
WO2002072534A3
The invention relates novel butane acid derivatives containing a cyanide group, pharmaceutical compositions containing butane acid derivatives and the use of said butane acid derivatives in the production of pharmaceutical compositions f...  
WO2002002512A3
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.  
WO/2003/066579A2
The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical c...  
WO/2003/066581A1
The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of ...  
WO/2003/066889A2
This invention is directed to a continuous method for measuring the activity of an enzyme that catalyzes the addition of an acetyl group to a residue capable of being acetylated or an enzyme that catalyzes the removal of an acetyl group ...  
WO2003024955A3
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provi...  
WO2002062762A3
Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.  
WO/2003/062192A1
Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the ...  
WO/2003/060523A1
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NA...  
WO/2003/057169A2
The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infect...  
WO/2003/055848A2
This invention relates to urea derivatives of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: (I) wherein Y is R1- R6 and X have the same meanings given in the description, which is useful as an active ingredie...  
WO2001096297A3
Compounds of the formula (I), where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions ...  
WO/2003/051841A2
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...  
WO/2003/051842A2
Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasm...  
WO/2003/051276A2
Compounds of formula (I) or (II) wherein R1 , R2 , R3 , R4 , W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are usefu...  
WO/2003/050066A1
This invention is directed to functionalized higher diamondoids having at least one functional group. These derivatives have a higher diamondoid nucleus and up to six independently selected functional groups. The functionalized higher di...  
WO/2003/048115A1
Compounds of formula (I) are antibacterial agents: wherein: Z is −N(OH)CH(=O) or −C(=O)NH(OH)&semi R1 represents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula −N(OH)CH(=O), a hydroxy, halo or amino g...  
WO2002017712A3
Compounds of formula (I): wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amount of a compou...  
WO/2003/048108A2
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine−mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal mode...  
WO/2003/047568A1
The present invention discloses compounds of the formula I which, are novel antagonists for melanin−concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceut...  
WO2000037429A3
The present invention relates to small molecules according to formula (I) which are potent inhibitors of a alpha 4 beta 1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing alpha 4 beta 1 adhesion m...  
WO2003005965A3
The present invention relates to compounds which can be used as inhibitors of mitochondrial ceramidase, in particular human mitochondrial ceramidase. The invention also relates to methods of designing and making the compounds, as well as...  
WO2002100836A3
Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease; are provided. The methods involve administering to a subject in need thereof a pharmaceutical ...  
WO/2003/037865A1
The present invention relates to compounds of formula (I): (I) their pharmacologically acceptable salts, or solvates and hydrates, and their prodrugs, respectively, and to pharmaceutical compositions containing the same as active ingredi...  

Matches 801 - 850 out of 6,258