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Patent Searching and Data


Matches 951 - 1,000 out of 6,256

Document Document Title
WO2002030874A3
The present invention relates to compounds of the general formula (I), (I)processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatme...  
WO2001040188A9
The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF3; Z is H, OH, OR1, halogen, or CF3; X1 and X2 are independently C or N; and A is as defined in the application; exhibiting anti-tumor and anti-ang...  
WO/2002/053523A1
A tropolone derivative represented by the formula (I) which has retinoid activity and is useful as an active ingredient for medicines [R?1¿ to R?4¿ each represents hydrogen, alkyl, or alkoxy; ring Ar represents an aryl ring or heteroar...  
WO2000064911A9
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...  
WO/2002/053534A1
Compounds represented by the general formula (I) or salts thereof, and medicines containing the same: (I) [wherein W is W?A¿-A?1¿-W?B¿- (wherein W?A¿ is optionally substituted aryl or the like; A?1¿ is -NR?1¿-, a single bond, -C(O)...  
WO2000073263A9
A composition is provided comprising a novel cationic lipid compound having hydrophobic tails and two quaternary ammonium headgroups bridged by a linker. The composition is useful as a cytofectin for facilitating delivery and transfectio...  
WO/2002/051810A2
The invention relates to novel compounds, to the use thereof as the ligands of integrin receptors, especially for the use as the ligands of the $g(a)¿v?$g(b)¿3? integrin receptor, as well as to pharmaceutical preparations that contain ...  
WO2002022627A3
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...  
WO/2002/051799A1
Biphenyl derivatives represented by the general formula (1) or salts thereof; and ACAT inhibitors or medicines containing the same as the active ingredient: (1) [wherein R?1¿ is C¿5-7? alkyl; R?2¿ is optionally substituted aromatic hy...  
WO2001092213A3
Compounds of the formula (I) in which: R<1> is (CH2)nY; n is 1 or 2; Y is NHSO2R<2> or X<1>-W-X<2>-R<3>; X<1> is O or NH; W is C=O, C=S, C=NH, or SO2; X<2> is O or NH, provided that X<1> and X<2> are not both O; R<2> is C1-10 alkyl; C2-1...  
WO/2002/050052A1
The invention relates to compounds of formula (I), wherein R¿1? is aryl unsubstituted or mono- to penta-substituted by R¿7? or is heteroaryl unsubstituted or mono- to tetra-substituted by R¿7? it being possible for the substituents in...  
WO2002018323A3
Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are dis...  
WO/2002/050019A2
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.  
WO2002022592A3
Compounds represented by structural formula (I) including its N-oxides wherein Y is (a) or (b); R<1> is H or (C1-C6)alkyl; R<2> is H,(C1-C6)alkyl,(C3-C9)cycloalkyl or (C3-C7)cycloalkyl(C1-C6)alkyl; R<3> is (c), (d), (e), (f), (g), (h) or...  
WO2002024613A3
The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.  
WO2002012243A3
A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl -1-H-imidazo[1,2-a]imidazol-2-one (1). This compound is useful as an intermediate in the preparation of certain small molecules that are ...  
WO/2002/048099A1
The invention relates to compounds of formula (I), wherein the variables have the following meanings: D means a phenyl or a pyridyl which is unsubstituted or is mono- or polysubstituted by Hal, A, OR?2¿, N(R?2¿)¿2?, NO¿2?, CN, COOR2 ...  
WO/2002/046141A2
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO1999059957A9
Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparatio...  
WO/2002/046172A2
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO/2002/046181A2
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO/2002/046146A1
Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor a (PPARa) as a ligand thereof and activate the same to thereby exert a lipid-lowering effect, an arteriosclerosis-preventing eff...  
WO2001085681A3
1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provid...  
WO2002004406A3
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...  
WO/2002/044126A2
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached ...  
WO2001021160B1
The present invention relates to the use of carboxamide compounds as selective inhibitors of pathogens, particularly viruses and, more particularly, herpesviridae. Surprisingly, these compounds show reduced side effects in comparison wit...  
WO/2002/042248A2
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...  
WO2002014264A3
Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid- beta peptide. Met...  
WO/2002/042257A1
The invention relates to substituted cyclohexane derivates of formula (I), a method for the production thereof and the use thereof in medicaments, particularly for preventing and/or treating cardiovascular diseases, diseases of the uroge...  
WO2001098235A3
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...  
WO/2002/040446A1
A novel class of compounds of the general formula (I): wherein Z is arylene or a divalent radical derived from a 5 or 6 membered heteroaromatic ring E is which act to antagonize the action of the glucagon hormone on the glucagon receptor...  
WO/2002/040444A1
Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any di...  
WO/2002/040445A1
A novel class of compounds of the general formula (I): wherein B is (1), (2), (3) or (4), Z is arylene or a divalent radical derived from a 5 or 6 membered heteroaromaic ring containing 1 or 2 heteroatoms selected from nitrogen, oxygen a...  
WO/2002/039967A1
Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R?5¿SO¿4?, R, R?1¿, R?2¿ and R?5¿ are each individually selected from C¿1? to C¿22? alky...  
WO/2002/038534A2
The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions con...  
WO/2002/036553A2
The invention is directed to physiologically active compounds of general formula (1): wherein:- A?1¿ represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a satu...  
WO2001081298A3
The present invention relates to compounds of general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of i...  
WO2002003995A3
The present invention relates to the use of neutral endopeptidase inhibitors (NEPi) and a combination of NEPi and phosphodiesterase type (PDE5) inhibitor for the treatment of male sexual dysfunction, in particular MED.  
WO/2002/030876A2
The present invention relates to compounds of the general formula (I), process for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of...  
WO/2002/030915A2
A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resista...  
WO/2002/030875A1
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment ...  
WO/2002/030874A2
The present invention relates to compounds of the general formula (I), (I)processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatme...  
WO/2002/028820A1
The present invention relates to a compound of formula (I) in which X, A, T, Y, G and R are as defined in Claim (1).  
WO/2002/028824A1
The present invention relates to compounds named Citrullimycines which are obtainable by cultivation of Streptomyces sp. ST 101396(DSM 13309), and to their pharmaceutically acceptable salts. The present invention further relates to a pro...  
WO2001045678A3
The invention relates to a composition which comprises as its constituents (a) a local anaesthetic and (b) an anti-inflammatory compound and/or an immunostimulant compound and/or a compound which acts as a supporting material for the loc...  
WO/2002/026701A2
Ionic compounds with a freezing point of up to 100 °C are formed by the reaction of an one amine salt of formula (I) R?1¿ R?2¿ R?3¿ R?4¿ N?+¿ X?-¿, such as choline chloride with an organic compound (II) capable of forming a hydrog...  
WO2001094301A3
The present invention relates to compounds of formula (I), in which R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, A, X, m and n have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compo...  
WO2002004407A3
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplas...  
WO/2002/024635A2
The present invention relates to a compound formula (I) wherein X¿1? is bond or -O-CH¿2?-, (II) or (III) R?1¿ is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or t...  
WO/2002/024613A2
The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.  

Matches 951 - 1,000 out of 6,256