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Patent Searching and Data


Matches 1,001 - 1,050 out of 6,256

Document Document Title
WO/2002/022563A1
A novel urea derivative and a medicinal application thereof, especially as an adhesive-molecule inhibitor useful for the treatment of inflammatory diseases. The urea derivative, for example, has the chemical structure represented by the ...  
WO/2002/022592A2
Compounds represented by structural formula (I) including its N-oxides wherein Y is (a) or (b); R?1¿ is H or (C¿1?-C¿6?)alkyl; R?2¿ is H,(C¿1?-C¿6?)alkyl,(C¿3?-C¿9?)cycloalkyl or (C¿3?-C¿7?)cycloalkyl(C¿1?-C¿6?)alkyl; R?3¿ i...  
WO2001055081A3
Esters derived from fatty acids and juvenoid alcohols of the general formula (I), in which X means the oxygen atom or the NH group, Y means the NH group or the oxygen atom, R means methyl, ethyl, 1-propyl, 2-methylethyl or propargyl and ...  
WO/2002/022844A1
(R)-N-(aminocarbonyl)fluorophenylalanine; and a process for producing (R)-N-(aminocarbonyl)fluorophenylalanine, characterized by treating 5-(fluorobenzyl)hydantoin with either an enzyme having the ability to selectively hydrolyze the (R)...  
WO/2002/022627A2
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...  
WO/2002/020472A1
The invention relates to substituted phenylcyclohexane carboxylic acid amides of formula (I), a method for the production thereof and the use thereof in medicaments, especially in the prevention and/or treatment of cardiovascular diseases.  
WO/2002/018326A1
Propenohydroxamic acid derivatives represented by the following general formula (1) or salts thereof and drugs containing the same: (1) wherein R?1¿ represents hydrogen, alkyl or halogeno; R?2 ¿represents cycloalkyl, aryl, heteroaryl, ...  
WO/2002/018323A2
Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are dis...  
WO/2002/017712A2
Compounds of formula (I): wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amount of a compou...  
WO2001070684A3
One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands - agonists or antagonists - for various cellular ...  
WO2000067746A8
A method for the inhibition of the binding of alpha 4 beta 1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions com...  
WO/2002/016318A1
The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pa...  
WO/2002/014265A1
Urea derivatives represented by the following general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein each symbol is as defined in the description. Because of having a C5a receptor antagonism, these compounds are us...  
WO/2002/014261A2
Compounds of general formula (I), in which: X represents a bond, O, S, SO or SO¿2?; and R?1¿ represents a (1-10C)alkyl, (2-10C)alkenyl, (2-10C)alkynyl, (4-10C)alkadienyl, carboxamido(1-8C)alkyl or aminocarbonyl(1-8C)alkyl group which i...  
WO/2002/014267A1
The present invention relates to compounds of formula (I) wherein U, V, W, A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically accep...  
WO/2002/014264A2
Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-$g(b) peptide. Met...  
WO/2002/012169A1
The invention relates to novel amino diphenyl ethers and amido diphenyl ethers, to methods for the production thereof, and to their use in medicaments, especially for the indications of arteriosclerosis and hypercholesterolemia.  
WO/2002/012168A1
A compound having general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.  
WO/2002/012534A2
The present invention relates to compounds made by a subset of modules from one or more polyketide synthase ('PKS') genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring p...  
WO/2002/012243A2
A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl -1-H-imidazo[1,2-a]imidazol-2-one (1). This compound is useful as an intermediate in the preparation of certain small molecules that are ...  
WO2001030333A3
The invention includes tissue factor (TF) blocking compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such compounds. Compounds of the invention are particularly useful for treating...  
WO/2002/008209A1
Compounds fo the formula (I) wherein R?1¿ and R?2¿ are independently hydrogen or substituents; R?3¿ is lower alkyl having from 2 to 4 carbon atoms or a 5 to 7-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having...  
WO/2002/008174A1
Novel mono- and dihydroxy phenylethylamine derivatives useful in treating melanoma are provided having the formulae (Ia, Ib or Ic). In the above formulae, R?a¿ is hydrogen or -COOR?b¿, R?b¿ is hydrogen or C¿1-6? alkyl; R?e¿ and R?e...  
WO2001014328A3
Compounds of Formula (I) are antagonists of VLA-4 and/or alpha 4 beta 7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutica...  
WO2001021160A3
The present invention relates to the use of carboxamide compounds as selective inhibitors of pathogens, particularly viruses and, more particularly, herpesviridae. Surprisingly, these compounds show reduced side effects in comparison wit...  
WO/2002/006189A2
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associa...  
WO/2002/003995A2
The present invention relates to the use of neutral endopeptidase inhibitors (NEPi) and a combination of NEPi and phosphodiesterase type (PDE5) inhibitor for the treatment of male sexual dysfunction, in particular MED.  
WO/2002/004406A2
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...  
WO/2002/004407A2
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplas...  
WO/2002/002520A2
The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.  
WO2001042192A3
Compounds of formula (I) wherein Ar is carbocyclic or heterocyclic aryl, or biaryl; Q is O, S or N-CN; X is arylene; V is NH, O, NHOH, CH2 or a direct bond; W is NH, O, NHOH, CH2 or a direct bond; Alk is C2-C7-alkylene or C2-C7-alkylene ...  
WO/2002/002506A2
The present invention is substituted amines of formula (XV) useful in treating Alzheimer's disease and other similar diseases.  
WO/2002/002518A2
The present invention is disubstituted amines of formula (I) and disbustituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.  
WO/2002/002512A2
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.  
WO/2002/002505A2
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.  
WO/2002/002513A1
The invention provides compounds of formula I wherein R?1¿ is optionally substituted C¿1?-¿6?alkyl, optionally substituted C¿3-7? cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; n is 0, 1 or 2; and Y i...  
WO2001052900A3
Polyazacarboxylates and their peptide conjugates which are useful for imaging, diagnosis and therapy are disclosed. Particularly, this invention relates to compositions of two or more peptides that are conjugated to a molecule of polyaza...  
WO/2002/000612A1
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or preventio...  
WO/2001/098256A1
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor $g(b), to methods of preparing such compounds and to methods for using such compound...  
WO/2001/098235A2
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...  
WO2001051456A3
Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.  
WO/2001/096297A2
Compounds of the formula (I), where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions ...  
WO/2001/094301A2
The present invention relates to compounds of formula (I), in which R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, A, X, m and n have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active...  
WO/2001/094300A1
The invention relates to acylphenyl urea derivatives and the physiologically compatible salts and physiologically functional derivatives thereof. Such compounds correspond to the formula (I) wherein the radicals have the cited meanings. ...  
WO/2001/094357A1
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO¿2?R', NO¿2?, NH¿2?, NHR', N(R')¿2?, CN, halogen, C(=O)H, C(=O)CH¿3?,...  
WO/2001/092213A2
Compounds of the formula (I) in which: R?1¿ is (CH¿2?)¿n?Y; n is 1 or 2; Y is NHSO¿2?R?2¿ or X?1¿-W-X?2¿-R?3¿; X?1¿ is O or NH; W is C=O, C=S, C=NH, or SO¿2?; X?2¿ is O or NH, provided that X?1¿ and X?2¿ are not both O; R?2...  
WO/2001/092210A1
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...  
WO/2001/092229A1
The invention provides TNF-$g(a) production inhibitors useful as remedies for autoimmune diseases such as rheumatoid arthritis. Novel compounds of the general formula [1] or salts thereof exhibit excellent TNF-a production inhibiting act...  
WO/2001/092218A2
Novel 'bispolyamine' inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...  
WO/2001/090051A1
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula (I) wherein X and R?1¿ to R?5¿ are as defined in the description and in the claims, as well as hydrates or solvates and/or physiologica...  

Matches 1,001 - 1,050 out of 6,256