Acyclic or Carbocyclic Compounds

Matches 1,201 - 1,250 out of 4,696	< 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 >

Document	Document Title
WO/1995/031977A1	NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHODS OF USE THEREOF The present invention provides the compound having structure (I), wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloa...
WO/1995/032184A1	SYSTEMATIC MODULAR PRODUCTION OF AMINIMIDE- AND OXAZOLONE- BASED MOLECULES HAVING AT LEAST TWO STRUCTURAL DIVERSITY ELEMENTS Aminimide- and oxazolone-based molecules, and arrays thereof, having at least two structural diversity elements are made via systematic modular production. A combinatorial library of aminimide- and oxazolone-based molecules is made via s...
WO/1995/029154A1	NOVEL BENZYLAMINE DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Novel compounds of general formula (I) wherein R1-R7 denote, in particular, a straight or branched hydrocarbon radical comprising 1-6 carbon atoms, Z is a straight or branched hydroxycarbon radical comprising 2-6 carbon atoms, a triple b...
WO/1995/029155A1	NOVEL ANTITUMOUR COMPOUNDS WITH ANTIMITOTIC ACTIVITY Novel N-acyl-aminoalkyl phenyl ether compounds having general formula (I), wherein A is an aromatic ring such as phenyl, thienyl, furyl, pyridyl; R1, R2 and R3 are selected from H, alkyl, halogen, electron acceptors and electron donors; ...
WO/1995/026951A1	TERTIARY AMINOUREA COMPOSITIONS AND THEIR USE AS CATALYSTS IN CURABLE COMPOSITIONS A composition which is the reaction product of (i) a material having the structure (I) where R1 is an organic radical having 6 to 25 carbon atoms; R2 is alkylene having 1 to 4 carbon atoms; R3 and R4 are independently alkyl having 1 to 4...
WO/1995/026360A1	ANTAGONISTS OF ENDOTHELIN RECEPTORS The present invention provides novel compounds having pharmacological properties represented by general formula (I) wherein Ar represents a direct bond or arylene; processes for the manufacture, pharmaceutical compositions and the use of...
WO/1995/026328A1	BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which R1 is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6...
WO/1995/024126A1	FUNGICIDAL TOXINS FROM BIOCONTROL BACTERIA A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previous...
WO/1995/022520A1	SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS A compound of structure (I), wherein, when R8 = H: R1 = alkyl, cycloalkyl, arylalkyl, aryl; R2 = cycloalkyl, aryl, C3-C10 alkyl; X, Y = O, S(O)n, NH; Z = CH2OH, NHSO2R3, CHO, CO2R3, CONHR4R5, CN, COR6, H, halo, NHCN, NHCONR4R5, CONR4OR5,...
WO/1995/021856A1	CARBAMOYLMETHYLUREA DERIVATIVE A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, having a strong affinity for gastrin receptors and/or CCK-B receptors but not for CCK-A receptors and hence being useful for curing diseases rel...
WO/1995/020578A1	SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS This invention is directed to compounds of formula (I), wherein R1 is an optionally substituted lower alkyl group; R2 is an optionally substituted oxaaliphatic group; R3 is an optionally substituted aryl group or an optionally substitute...
WO/1995/020574A1	PROCESS FOR PREPARING 2-OXINDOLE-1-CARBOXAMIDES The present invention provides a process for preparing 2-oxindole-1-carboxamides, comprising reacting N-acyl 2-oxindole-1-carboxamides with alcohols in the presence of aprotic weak Lewis acid catalysts. In certain processes of the presen...
WO/1995/020570A1	HYDROXAMIC-ACID DERIVATIVES, METHOD OF PREPARING THEM AND THEIR USE AS FUNGICIDES The invention concerns hydroxamic-acid derivatives of general formula (I) in which A is hydrogen or a grouping which can be easily splitt off, A1 is hydrogen or alkyl, Ar is an optionally substituted arylene or hetero-arylene group, E is...
WO/1995/019767A1	GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS This invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More par...
WO/1995/019959A1	AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS The present invention relates to a novel fatty acid derivative of formula (I) wherein R1 is acyl group, etc.; R2 is acyl(lower)alkyl; R3 is lower alkyl, etc.; R4 is hydrogen, etc.; and X is -O-, etc.; and a pharmaceutically acceptable sa...
WO/1995/016668A1	UREA AND URETHANE MONOMERS FOR CONTACT LENS MATERIALS Urea- and urethane-containing monomers selected from compounds of general formula (I) or (II), wherein each X is independently -O- or -NH-, for contact lens materials are disclosed.
WO/1995/015306A1	ARYL HALIDE SUBSTITUTED METALLIC COMPLEXES, PHARMACEUTICALS CONTAINING THESE COMPLEXES, THEIR USE FOR DIAGNOSTIC PURPOSES, AND METHODS FOR PREPARING THE COMPLEXES AND PHARMACEUTICALS The invention pertains to new metallic complexes containing an ion of an element of atomic number 12, 13, 20-31, 39-42, 44-50 or 57-83 and a halogenated complexing ligand of formula (I), where R1, R2, R3, Z1, Z2, Z3, U1, U2, V1, V2 or V3...
WO/1995/014653A1	METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide of cyanohydrin from a...
WO/1995/012572A1	CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disor...
WO/1995/009619A2	SUBSTITUTED UREA AND ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS The use of an N-substituted urea derivative for the manufacture of a medicament for the treatment of a condition where there is an advantage in inhibiting the NO synthase enzyme, in particular cerebral ischemia, and pharmaceutical formul...
WO/1995/008529A1	CHIRAL SURFACTANTS AND METHODS FOR THEIR USE IN CHIRAL SEPARATIONS Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using micellar capillary electrophoresis is disclosed. A chiral surfactant having general formula (I) is described. R1 is th...
WO/1995/007258A1	CYCLOHEXANEDIUREA DERIVATIVE AND PROCESS FOR PRODUCING THE SAME A cyclohexanediurea derivative represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate therefor, medicinal applications thereof, method of treatment therewith, and use thereof, wherein R1 a...
WO/1995/005408A1	POLYMER SURFACE COATINGS New polymers formed from ethylenically unsaturated monomers having pendant zwitterionic groups and pendant urethane units are used to increase the biocompatibility, especially hemocompatibility, of polymeric, especially polyurethane, sub...
WO/1995/005386A1	PHENETHYLAMINE COMPOUNDS Substituted phenethylamines of formula (I) useful for treating phosphodiesterase IV related disease states are disclosed herein.
WO/1995/005360A1	PHENOXYPHENYL CYCLOPENTENYL HYDROXYUREAS Certain novel phenylsubstituted cyclopentenylhydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and being the dextrorotatory isomers of the compounds having formula (II) and the pharmaceutically acceptable salt...
WO/1995/004034A1	(THIO)CARBIMIDINIC ACID DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME New medicaments containing (thio)carbamidinic acid derivatives having formula (I) are disclosed, as well as new (thio)carbamidinic acid derivatives, a process for preparing the same and medicaments containing these compounds. Medicaments...
WO/1995/002575A1	5-LIPOXYGENASE INHIBITORS Hydroxyurea compounds comprising halo substituted 1, 2, 3, 4-tetrahydronaphthalene, and indane derivatives, pharmaceutical compositions and their use as OPUFA and 5-lipoxygenase pathway inhibitors.
WO/1995/001327A1	THERMOTROPIC POLYUREAS AND USE THEREOF FOR DYEING AND MECHANICALLY AND THERMALLY STRENGTHENING POLYMERS Thermotropic polyreas produced by the (poly)addition of at least one polyisocyanate with at least one thermotropic aromatic diamine including imine junctions and having general formula H2N - R1 - N = CH - R2 - CH = N - R3 - NH2 wherein e...
WO/1995/001326A1	ANTI-ATHEROSCLEROTIC DIARYL COMPOUNDS The present invention is concerned with diaryl compounds of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of a clinical condition for which an ACAT inhibitor is indicated, such as hyperlipidae...
WO/1995/000535A1	OPTICALLY PURE CALPAIN INHIBITOR COMPOUNDS Optically pure alpha-ketoamide compounds, and use therefor in treating neurodegenerative pathologies having enhanced Calpain activity, are disclosed. These compounds comprise optically pure alpha-ketoamides, and physiologically acceptabl...
WO/1994/029335A1	NEW PEPTIDES DERIVATIVES A compound of the general formula (I): A1 - A2 -NH-(CH2)n - NH-C(NH)-NH2, wherein n is an integer 2, 3, 4, 5, or 6; preferably 3 or 4; A1 represents a structural fragment of formulae (IIa), (IIb), (IIc), (IId) or (IIe); A2 represents a s...
WO/1994/027947A1	PHENYLCYCLOPROPANE COMPOUNDS AND THEIR USE AS cAMP AND TNF INHIBITORS This invention relates to substituted phenylcyclopropane derivatives, which carry various substituents on the cyclopropane ring, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for their...
WO/1994/025430A1	CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or ...
WO/1994/025431A1	CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING N(3-BIPHENYLYL-1(S)-METHYL-2-PROPENYL) ACETOHYDROXAMIC ACID DERIVATIVES The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or ...
WO/1994/022907A1	NEW UREA DERIVATES, THEIR PREPARATION AND THEIR USE Urea derivates are disclosed having the general formula (I), in which A, B, W, Z, R, R1, R2, R3 and r have the meaning given in the description, as well as a process for preparing the same and their use as inhibitors of thrombocyte aggre...
WO/1994/022814A1	CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS The present invention provides a novel N-hydroxyurea compound of chemical formula (I) wherein R1 and R2 are each independently hydrogen or C1-C4 alkyl; Ar is phenyl or mono-, di- or trisubstituted phenyl; A is a valence bond or a C1-C6 a...
WO/1994/022807A1	UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS A compound having formula (I) or a pharmaceutically acceptable salt thereof, wherein X and Z each independently are NH or CH2, at least one of X and Z being NH; Y is O, S, NCN, or NH; B, D, E and F each independently are C or N, at least...
WO/1994/018158A1	SPIROALKYLHYDROXYUREAS FOR USE AS LIPOXYGENASE INHIBITORS The present invention provides novel N-hydroxyurea and hydroxamic acid derivatives of chemical formula (I), wherein R is C1-C4 alkyl or -NR1R2; R1 and R2 are each, independently, hydrogen or C1-C4 alkyl; M is hydrogen or pharmaceutically...
WO/1994/017034A1	SUBSTITUTED AMINO COMPOUNDS, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THROMBOCYTE AGGREGATION Compounds are disclosed having the general formula (I) R1-(A)a-(B)b-(D)c-(CH2)m-N(R2)-(CH2)n-R3, in which A, B, D, R1 to R3 and a, b, c, m and n have the definitions given in the description, as well as a process for preparing the same a...
WO/1994/017052A1	C2 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Taxane derivatives having alternative C2 substituent which is -OCOR31 wherein R31 is substituted phenyl and the substituent is selected from the group consisting of alkanoxy, protected hydroxy, halogen, alkyl, aryl, alkenyl, acyl, acylox...
WO/1994/017051A1	PROCESS FOR THE PREPARATION OF BACCATIN III ANALOGS BEARING NEW C2 AND C4 FUNCTIONAL GROUPS Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 ...
WO/1994/017041A1	AMIDINOPHENYL SUBSTITUTED UREA, THIOUREA OR GUANIDINO DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS The present invention relates to a class of compounds represented by formula (I) which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives. In said formula, R is...
WO/1994/017050A1	C7 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Taxane derivatives having alternative C7 substituents wherein the substituents are independently selected from the group consisting of hydrogen and acyloxy. The derivatives are valuable antileukemia and antitumor agents.
WO/1994/017035A1	AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME New aminoacid derivates have the general formula: T-Z-NR1-(R2CR3)-CO-Y-(CH2)n-R, in which R, R1 to R3, T, Z, Y and n are defined as in the first claim. They represent valuable NPY-antagonistic active substances. Also disclosed are their ...
WO/1994/015599A1	C10 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS Taxane derivatives substituted on the C10 position with novel substituents are disclosed. The novel compounds have utility as antileukemia and antitumor agents.
WO/1994/014864A1	AMINOPLAST ANCHORED ANTIOXIDANTS This invention provides novel aminoplast anchored, hindered phenolic antioxidants which are useful as stabilizers for coatings and polymers such as polyethylene, polypropylene, and the like to extend their useful life. The aminoplast anc...
WO/1994/014436A1	RETROVIRAL PROTEASE INHIBITING COMPOUNDS A retroviral protease inhibiting compound of formula (A) is disclosed.
WO/1994/014742A1	TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally s...
WO/1994/014762A1	OXIME ETHER DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY The present invention provides certain substituted oxime ether compounds which inhibit lipoxygenase enzyme activity and are useful in the treatment of allergic and inflammatory disease states. The compounds of this invention have structu...
WO/1994/013712A1	MONOMER PRESENTING AT LEAST ONE ISOCYANATE FUNCTION AND AN INSATURATION, SYNTHESIS PROCESS AND (CO)POLYMERS DERIVED THEREFROM The monomer is characterized by the general formula (1) [(R1)(R2)C = C(R3)-CO-L-]q A(NCObloc)p wherein R1, R2 and R3 similar or different, represent a hydrogen or a group selected among the hydrocarbon chains having from 1 to 12 carbon a...

Matches 1,201 - 1,250 out of 4,696	< 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 >