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WO/2010/004231A2 |
The invention relates to novel compounds having the following formula (I) in which: n is an integer from 1 to 12, in particular from 1 to 8, m and m' are, independently of one another, integers from 0 to 8, - q and q' are, independently ...
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WO/2009/132786A1 |
A granulated dicyandiamide material having a high abrasion resistance and good solids flow and having a) an average primary crystallite size of from 0.01 to 1 mm and b) an average agglomerate size of from 0.2 to 20 mm is described. The g...
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WO/2009/100267A1 |
The present invention provides methods to produce arginine bicarbonate more rapidly and efficiently than conventional methods.
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WO/2009/059934A1 |
A method for producing salts of the formula (I) (B+)n x Ay-, wherein B denotes a cation, which contains at least one nitrogen atom, A denotes an anion, and n denotes an integer between 1 and 3, x and y each denote an integer between 1 an...
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WO/2008/082701A1 |
Disclosed herein is a method comprising: (a) adding an aqueous solution comprising a quaternary ammonium salt to an organic solvent in a vessel under an inert atmosphere, thereby forming a first mixture comprising the quaternary ammonium...
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WO/2008/061456A1 |
The present invention discloses a new biguanidine compound, i.e. folacin-metformin, and its manufacture with inorganic salt of metformin as raw material. Compared with metformin, the compound has the same clinic curative effect, such as ...
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WO/2008/031456A1 |
The present invention is directed to a process for preparing hexamethylenebiscyanoguanidine. This compound is used as an intermediate to prepare chlorhexidine. The formation of the hexamethylenebiscyanoguanidine proceeds under base catal...
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WO/2008/026757A1 |
The present invention provides a process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof, the process comprising reacting 1-cyano-3-octylguanidine or a salt thereof, with 3,4-dichlorobenzylamine or a salt thereof,...
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WO/2008/019594A1 |
Agmatine sulfate dihydrate represented by formula (I), its crystal form and pharmaceutical composition, use for treating drug abuse, antiinflammatory, lowering blood glucose levels and prevention and/or treatment of diseases caused by ag...
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WO/2007/115799A1 |
A process is proposed for preparing creatine, creatine monohydrate or guanidinoacetic acid, wherein N-methylethanolamine or ethanolamine is first catalytically dehydrogenated, in each case in alkaline solution, and the sarcosinate or gly...
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WO/2006/136846A1 |
The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R1 is hydrogen or C1-4alkyl; R2 and R4 are each independently selected from C1-4 alkyl, [11C] C1 4alkyl, and [18F]-C1-4 fluoroalkyl provided that at...
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WO/2006/108643A1 |
The invention describes novel pharmaceutically acceptable salt forms of camostat, processes for lyophilisation, taste-masked formulations, nebulised formulations and the use of each of the fore-going in the treatment of respiratory disea...
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WO/2006/108643A2 |
The invention describes novel pharmaceutically acceptable salt forms of camostat, processes for lyophilisation, taste-masked formulations, nebulised formulations and the use of each of the fore-going in the treatment of respiratory disea...
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WO/2006/097015A1 |
Agmatines labeled by deuterium and tritium and their preparation methods are disclosed. The uses of said compounds and related intermediates in the research of biochemical mechanism and medicines are also described.
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WO/2006/074501A1 |
The present invention provides a compound of formula (I), (II), (III) and (IV) as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in...
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WO/2006/000904A2 |
Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
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WO/2005/100306A1 |
The present invention provides procedures for preparation of N, N', N''-tris-(3-dimethylaminopropyl)-guanidine by addition of 3-dimethylaminopropylamine to N1, N3-bis-(3-dimethylaminopropyl)-carbodiimide. The latter compound was prepared...
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WO/2005/097713A1 |
A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent.
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WO/2005/075413A1 |
The invention relates to a two-stage method for producing guanidinium salts of formula (1), wherein the substituents R have the designation cited in patent claim 1, and A- is a sulfonate, an alkyl or aryl sulfate, a hydrogen sulfate, a i...
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WO/2005/066118A1 |
Disclosed is a method for removing a neutral or an ionic guanidine compound from an aqueous media optionally comprising an alkali metal halide, wherein the method is selected from the group consisting of (a) adsorption onto a carbonaceou...
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WO/2005/040092A1 |
The present invention relates to a method for synthesis of an acrylamide derivative, starting with dissolving a salt of a nucleophilic amine in water to form an aqueous solution and desalting said solution with a base, comprising the fol...
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WO/2005/016994A1 |
A method for preparing polyalkylenebiguanidine salt, which does not require a high-viscosity reactor and a toxic solvent, and is capable of producing various polyalkylenebiguanidine salt, is disclosed. The method comprises the steps of: ...
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WO/2004/106288A2 |
The invention relates to salts containing guanidinium cations, to a method for their production and to their use as ionic liquids.
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WO/2004/099125A1 |
The invention relates to a method for crystallizing compounds of formula (I) or the acid addition salts thereof, R1, R2, and R3 having the meaning indicated in claim 1.
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WO/2004/031133A1 |
The invention pertains to a process for the synthesis of guanidine derivatives of Formula (I) wherein X is selected from OH, OM wherein M is an alkali or earth alkali metal ion, and NR1R2 wherein R1 and R2 are independently H, C1-C6 alky...
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WO/2003/055603A1 |
The invention relates to a method for separating and recycling catalyst components of a chemical reaction mixture involving oxidative direct carbonylation.
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WO/2003/055849A1 |
The invention relates to a method for the production of solutions a quaternary cation and an anion from a deprotonated hydroxy aromatic in an organic solvent by a reactive extraction of a quaternary salt in the presence of an aqueous hyd...
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WO/2003/024945A2 |
The invention relates to a simple, cost-effective method for producing polyphosphates of organic bases. According to said method, a mixture of phosphorus pentaoxide and at least one organic nitrogen base is reacted with at least one comp...
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WO/2003/014076A2 |
Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of $g(v)-amino groups to the corresponding gua...
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WO/2002/085838A1 |
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...
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WO/2001/094292A1 |
The invention concerns the preparation of cationic surfactants derived from the condensation of an acid, preferably a fatty acid or a hydroxy acid with a number of carbon atoms of 8 - 14 with esterified amino acids, preferably basic-type...
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WO/2001/092207A1 |
A process of reacting a compound having an NH group with a thiocyanate, a cyanamide, a nitrile, or an ester in the presence of a silylating agent to thereby obtain the corresponding nitrogen-containing addition or substitution product. T...
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WO/2001/092210A1 |
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...
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WO/2001/085676A1 |
The invention relates to biocidal polymers with a guanidine salt base, characterised in that they are representatives of the series of polyoxyalkylene guanidines and their salts and in that they represent a product of the polycondensatio...
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WO/2001/062735A1 |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula (I), wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicat...
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WO/2001/055099A1 |
The invention relates to a method for producing 1-methyl-3-nitroguanidine. According to said method, nitroguanidine is reacted with methylamine and/or a methylammonium salt in an aqueous solution, at temperatures of 30 to 60 °C and at a...
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WO/2001/051458A1 |
The invention relates to a novel method for producing N-methyl-N'-nitroguanidine by reacting nitroguanidine with an aqueous methylamine solution that has been buffered by adding inorganic or organic acids.
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WO/2001/046129A2 |
The invention relates to a method for producing nitroguanidine. According to the inventive method, guanidine nitrate or guanidine carbonate a dehydrated in a first step with high concentration nitric acid (> 85 %). The nitroguanidine nit...
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WO/2001/032611A1 |
The present invention relates to compounds of formula (I), in which A, L, Y and k have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithro...
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WO/2001/014323A1 |
The invention relates to a method for producing 1-methyl-3-nitroguanidine, comprising the following steps: a) reacting chlorine cyanide or bromine cyanide with methylamine in the presence of an inert organic solvent at temperatures of -3...
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WO/2001/009091A1 |
The invention relates to a novel method for converting carboxylic acids into protected acyl guanidines. The invention specifically relates to a novel method for continuously carrying out Mukaiyama reactions in a microreactor.
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WO/2001/005753A1 |
Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R?1¿, R?2¿ and R?3¿ have the meanings cited in Claim 1, and the physiologically acceptable salts or solvates thereof, which are integrin inhibitors and can be used to...
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WO/2001/005752A1 |
The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine hydrate in the presence of CO¿2?. The invention is characterised in that it consists in pro...
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WO/2001/000558A1 |
The invention relates to methods for preparing substituted cyclopentene compounds, their intermediates and use as neuraminidase inhibitors.
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WO/2001/000623A1 |
Method of producing compounds of formula (I), wherein R¿1? is hydrogen or C¿1?-C¿4?-alkyl; R¿2? is hydrogen, C¿1?-C¿8?-alkyl, C¿3?-C¿6?-cycloalkyl, or a radical -N(R¿3?)R¿4?; or R¿2? and R¿6? together are -CH¿2?-CH¿2?-S-; R...
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WO/2001/000571A1 |
The invention relates to a process for preparing substituted cyclopentane derivatives represented by formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿, X and Y are as described in the specification, and pharmaceutically acceptable salts the...
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WO/2000/042001A1 |
The invention relates to a pharmaceutical composition comprising as active principle a compound of general formula (I), in which R¿1?, R¿2?, R¿3? and A are as defined in Claim 1. These compositions can be used in the treatment of path...
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WO/2000/040549A1 |
The invention relates to a novel method for producing robenidine or derivatives thereof of general formula (I) wherein X means a halogen atom, using hydrazine hydrate and a cyanogen compound as the starting materials. The two educts are ...
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WO/2000/040548A1 |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to arylalkanoyl derivatives of formula (I), wherein R(1), R(2), R(3), R(4), R(5), R(6a) and R(6b) have the meanings indi...
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WO/2000/035860A2 |
The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that converts the carboxy to an acyl halide, foll...
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