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JP3718250B2 |
PURPOSE: To provide a novel phenyl-substd. alkylcarboguanidide having a perfluoroalkyl group suppressing an Na+/H+ exchange mechanism of cells and effective against all of diseases developed by ischemia. CONSTITUTION: This compd. is repr...
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JP3718257B2 |
PURPOSE: To obtain the subject new compound having excellent antiarrhythmic properties and strongly inhibiting actions on proliferation of fibroblast and proliferation of smooth muscle fiber, useful as a therapeutic agent for arrhythmia,...
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JP2005526707A |
A process for the preparation of a solution of a quaternary cation and an anion from a deprotonated hydroxy aromatic in an organic solvent by means of a reactive extraction of a quaternary salt in the presence of an aqueous hydroxide sol...
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JP3662925B2 |
PCT No. PCT/SE94/00517 Sec. 371 Date Jun. 28, 1994 Sec. 102(e) Date Jun. 28, 1994 PCT Filed Jun. 1, 1994 PCT Pub. No. WO94/29269 PCT Pub. Date Dec. 22, 1994A process for the production of guanidino protected omega -aminoalkyl guanidines ...
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JP3647901B2 |
PURPOSE: To provide the titled novel compound useful as an antiarrhythmic agent for the treatment of infarction and angina pectoris and as a remedy for the treatment of heart arrhythmia caused by ischemia, which is obtained by reacting a...
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JP2005512806A |
A process for the removal and recovery of quaternary salt (A) and base (D) from a reaction mixture is disclosed. The reaction mixture resulting from oxidative direct carbonylation contains in addition to (A) and (D), at least one hydroxy...
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JP3617091B2 |
This method results in a purified basic amino acid which does not cause problems in filterability even when a neutral or acidic aqueous solution containing the basic amino acid is processed by filtration. A method for the purification of...
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JP2004537596A |
Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of omega-amino groups to the corresponding gua...
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JP3563106B2 |
PURPOSE: To provide the new substituted benzoylguanidines useful for treating and preventing arrhythmia, myocardial infarction, angina pectoris and various ischemic conditions as well as conditions of shock. CONSTITUTION: The benzoylguan...
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JP3554352B2 |
There are described benzoylguanidines of the formula I where R(1) to R(3) are H, Hal, (cyclo)alkyl, N3, CN, or OH, alkyloxy, phenyl, phenoxy or benzoyl, and their pharmacologically acceptable salts, but with the exception of the compound...
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JP3536217B2 |
PURPOSE: To produce a guanidine derivative economically, acceptably to the environment, in a high yield and with high purity, by greatly reducing the waste water. CONSTITUTION: Aqueous cyanamide solution is allowed to react with aniline ...
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JP2004075616A |
To provide a method for producing a 4-hydroxy-2-(4-fluorophenylamino)-5,6-dimethylpyrimidine useful as a medicine technical product in short processes and a simple operation without requiring a specific reagent and apparatus.This method ...
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JP2004075647A |
To provide a method for producing a triarylguanidine compound simply and industrially advantageously.This method for producing the triarylguanidine compound is characterized by heating an aromatic isocyanate compound in the presence of a...
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JP3490739B2 |
PURPOSE: To obtain new benzoylguanidines or their pharmaceutically tolerable salts useful as drugs for arrhythmia, myocardial infarction, stenocardia, ischemic heart disease, etc., and as anti-atherosclerotic drugs. CONSTITUTION: The ben...
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JP2003530306A |
The invention relates to methods for preparing substituted cyclopentene compounds, their intermediates and use as neuraminidase inhibitors.
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JP2003524001A |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula 1, wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated...
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JP3423357B2 |
PURPOSE: To provide a contact lens care product fit for all sorts of contact lenses including hard and soft contact lenses and a flexible or high gas permeable contact lens by incorporating aminopropylbiguanide or its salt and tromethamo...
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JP2003513066A5 |
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JP2003506351A |
(57) [Summary] The present invention relates to a novel method for converting a carboxylic acid to a protective acylguanidine. The present invention particularly relates to a novel method for continuously carrying out the Mukaiyama react...
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JP2003040853A |
To provide a method for producing a guanidine derivative containing an amido group or salt thereof industrially advantageously and simply. In this method for producing a guanidine derivative containing an amido group represented by gener...
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JP2003505365A |
Diacylhydrazine derivatives of general formula (I)wherein X, Y, Z, R<1>, <2 >and R<3 >are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to combat thromboses, my...
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JP2002348264A |
To provide a new hydroxy aliphatic acid analogue which has strong algicide effect especially against dinoflagellates and is expected for use as an inhibitor as well as its chemical synthesizing method. The hydroxy aliphatic acid analogue...
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JP2002534408A |
The present invention is directed to new compounds for the inhibition of blood clotting proteins and factor Xa activity, and more particularly, to arylalkanoyl derivatives of the formula (I):wherein R(1), R(2), R(3), R(4), R(5), R(6a), a...
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JP2002532466A |
Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) ...
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JP2002532461A |
The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that converts the carboxy to an acyl halide, foll...
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JP3326700B2 |
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JP2002530367A |
The invention relates to a method of producing N-alkyl-N'-nitroguanidine. According to said method, an alkyl amine solution is added to a nitroguanidine or nitroguanidine nitrate suspension at temperatures of >60° C. and the ammonia for...
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JP3300405B2 |
PURPOSE: To produce the subject compound of high purity, useful. as a raw material of silicon nitride, a binder and an adhesive with a simple operation in a relatively short time by reacting a guanidine compound with an organosilicon com...
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JP3276405B2 |
PURPOSE: To obtain the compound in a high purity by adding an equivalent water to a guanidine compound and an organoboron compound such as an alkoxyboron in an organic solvent and reacting these components in a nonaqueous solution system...
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JP3268461B2 |
There is proposed a novel process for the preparation of 1,3-disubstituted 2-nitroguanidines of the formula I in which R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl or a radical -CH2B; A is an aromati...
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JP3263428B2 |
PURPOSE: To produce the subject compound of high purity, useful as a raw material of aluminum nitride with a simple operation in a relatively short time by reacting a guanidine compound with an aluminum alcoholate. CONSTITUTION: The subj...
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JP3263422B2 |
PURPOSE: To obtain a guanidine aluminate at a low cost in a short time by reacting an aqueous solution of a guanidine compound with metal aluminum in an inert gas atmosphere. CONSTITUTION: A guanidine compound of the formula (R1 to R4 ar...
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JP2002506099A |
The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicab...
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JP3250825B2 |
PURPOSE: To provide the new substituted nitroguanidine derivative low in the toxicity to human bodies, fishes and natural enemies and having good safety and excellent control effects against insect pests. CONSTITUTION: A compound of form...
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JP3232586B2 |
PURPOSE: To obtain a new organic compound having excellent insecticidal effects not only on insect pests of susceptibility group but insect pests of resistance group against organic phosphorous agent and carbamate agent. CONSTITUTION: A ...
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JP2001316350A |
To provide a hydroxyguanidine carbonic acid ester compound useful as a synthetic intermediate of a dyestuff or coupler for photography and an industrially advantageous method for producing the same compound.This method for producing the ...
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JP2001233845A |
To provide a purifying method by which the high-quality objective substance can economically be obtained in a method for producing a di- substituted nitroguanidine derivative represented by formula (2).This method for purifying a di-subs...
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JP2001512443A |
PCT No. PCT/US98/02443 Sec. 371 Date Dec. 13, 1999 Sec. 102(e) Date Dec. 13, 1999 PCT Filed Feb. 11, 1998 PCT Pub. No. WO98/34647 PCT Pub. Date Aug. 13, 1998The present invention is directed to an arginine-silicate complex and its use in...
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JP2001187775A |
To provide a method for stably producing a high-purity amide group- containing guanidine derivative having excellent solution stability even in the presence of a surfactant and an electrolyte or its salt. This method for producing the am...
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JP2001181254A |
To provide a method for providing creatine having purity as high as possible in a simple way. A method for purifying creatine is to introduce creatine to be purified and not containing water of crystallization into a saturated aqueous so...
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JP2001114746A |
To provide an industrial method for producing an N-(2,2-dialkoxyethyl) guanidine or a salt thereof, useful as an intermediate for synthesizing a medicine, an agrochemical or the like without accompanying the generation of a harmful mater...
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JP2001114747A |
To obtain a water-soluble solder flux composition not greatly affecting insulation reliability even if the composition remains in electric/electronic instruments. This water-soluble solder flux contains a compound (especially [N-(2,3-dih...
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JP2001114745A |
To provide an industrial method for producing a salt of an N-(2,2- dialkoxyethyl)guanidine useful as an intermediate for synthesizing a medicine, an agrochemical or the like by a simple operation in good yield. This method for producing ...
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JP3110050B2 |
The invention is directed to a method for preventing or treating the symptoms associated with sensitive skin by applying an effective amount of at least one nitric oxide synthase inhibitor to treat or prevent the symptoms associated with...
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JP3090960B2 |
Creatine pyruvates are described which have the general formula (I)wherex=1 to 100y=1 to 10 andn=0 to 10These creatine pyruvates, which are produced by way of the relatively simple reaction of creatine with pyruvic acid, can be used to e...
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JP2000511180A |
Process for the preparation of 2,2'-(1-methyl-1,2-ethanediylidene)bisÄhydrazine carboximidamideÜ by a) removing impurities from aminoguanidine bicarbonate ; b) reacting the aminoguanidine bicarbonate with methylglyoxal dimethyl acetal ...
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JP2000229936A |
To easily and continuously produce a guanidine derivative in a high purity and in a high yield by continuously reacting a cyanamide derivative with an amine in the presence of the seed crystals of the guanidine derivative. This method fo...
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JP2000212155A |
To provide a practical method for producing 1,1,3,3- tetramethylguanidine and dimethylcyanamide. This method for producing 1,1,3,3-tetramethylguanidine and/or its hydrochloride is composed of reacting cyanogen chloride with dimethylamine...
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JP2000191625A |
To readily obtain a guanidine derivative in a high purity, high yield and narrow particle size distribution by reacting O-alkyl isourea salt with a specific amine in the presence of a seed crystal of a guanidine derivative. This guanidin...
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JP3056416B2 |
Prepn. of creatine or creatine monohydrate comprises reaction of the sodium or potassium salt of sarcosine with cyanamide in water or a mixture of water and organic solvent at 20-150 degrees C and at pH 7.0-14.0. Reaction temp. is 50-100...
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