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WO/2024/074779A1 |
The present invention relates to a method for granulating an azo compound, comprising the following steps: a) a step of granulating by agitating an aqueous suspension of said azo compound, in the presence of an organic binder; b) an opti...
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WO/2024/017150A1 |
Provided in the present application is a method for synthesizing deucravacitinib. The method comprises: subjecting the compound of formula (I) to chlorination and to electrophilic substitution with the compound of formula (VI) to synthes...
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WO/2023/107909A1 |
A carbazate-functional compound includes a plurality of groups having the following structure: [formula (I)] where X forms at least a portion of: a urethane linkage, an ester linkage, or an ether linkage. At least one R1 from the plurali...
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WO/2023/000616A1 |
The present invention relates to the technical field of synthesis of pesticides and intermediates, and in particular to a method for preparing bifenazate. The preparation method comprises taking a compound as represented by formula (I) a...
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WO/2022/102569A1 |
The present invention provides a semicarbazide composition or the like containing a semicarbazide compound (S) derived from hydrazine and an isocyanate compound (N). The semicarbazide compound (S) includes a hydrophilic functional group ...
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WO/2022/088244A1 |
A method for performing Mitsunobu reaction between an alcoholic hydroxyl group donor and an active hydrogen donor, comprising the following steps: reacting the alcoholic hydroxyl group donor and the active hydrogen donor with a trihydroc...
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WO/2021/209859A1 |
Monomers, polymers formed from such monomers, and articles for biomaterial capture including such polymers, wherein the monomer is represented by the following general Formula (I): CH2=CR1-C(=O)-X-R2-Z-X3-NR3-C(=X2)-X1-R4, wherein: R1 is...
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WO/2021/105337A1 |
The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and tr...
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WO/2021/012138A1 |
Disclosed is a use of a diaminoguanidine derivative and a feed composition thereof in the preparation of a veterinary drug. Particularly, disclosed is a use of a diaminoguanidine derivative having a structure of formula (I), or a stereoi...
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WO/2020/215043A1 |
In various aspects and embodiments the invention provides compositions and methods for removing glucosepane from one or more proteins in a subject. In certain embodiments, the method comprises administering to the subject an effective am...
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WO/2020/201326A1 |
The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions compris...
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WO/2019/240141A1 |
Provided is a method for producing a high-purity, high-quality semicarbazide compound at a high yield by a simple method. The semicarbazide compound is recrystallized by a solvent containing a halogenated hydrocarbon. Dichloromethane is ...
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WO/2019/235569A1 |
The present invention addresses the problem of providing: a novel kinase inhibitor and others; and a therapeutic agent for a disease, a drug discovery screening method and others, each utilizing the inhibitor and others. A compound repre...
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WO/2019/117262A1 |
The present invention provides a composition for promoting cell adhesion containing a compound represented by general formula (I) or a salt thereof. {In the formula, each symbol is as defined in the description.}
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WO/2019/088642A1 |
The present invention relates to a novel glutamic acid derivative exhibiting an excellent antioxidizing effect, or an antioxidant composition including same. A composition according to the present invention may be used to provide an anti...
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WO/2018/164994A1 |
A self-assembled active agent may be formed by a process including covalently bonding at least a first component molecule and a second component molecule, the two component molecules displaying synergy such that the effective amount of t...
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WO/2018/133473A1 |
Provided in the present invention is a direct oxidation method for a saturated carbon hydrogen bond in an organic compound, comprising: under conditions of visible light irradiation, reacting the organic compound with an oxidising reagen...
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WO/2018/095458A1 |
The invention relates to a method for storing energy in the form of hydrazine carbonate and subsequent reconversion of the hydrazine carbonate into reusable energy, in which sea water is first used in an electrolysis method to produce hy...
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WO/2018/085753A1 |
Provided herein are substituted hydrazone compounds useful as inhibitors of DEPTOR. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted hyd...
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WO/2018/043399A1 |
[Problem] To provide a novel therapeutic agent for diabetes which can be less apt to produce side effects such as persistent hypoglycemia. [Solution] A compound characterized by containing a derivative of 1,1-diphenylsemicarbazide or 1,1...
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WO/2017/214680A1 |
The present invention relates to new multi-functional compounds that are useful in the treatment of neurodegenerative diseases, such as Alzheimer's disease, to the preparation of the compounds, and to compositions including the compounds...
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WO/2017/133675A1 |
The present invention relates to a method for preparing a high-purity cyclohexenone long-chain alcohol represented by formula I. The compound represented by formula I is prepared by using metal-mediated Barbier reaction. The method of th...
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WO/2017/100602A1 |
Disclosed herein are methods of preparing an aminimide. An epoxy compound is reacted with a hydrazine compound comprising a trivalent nitrogen, and an anhydride functional material or a cyclic compound containing a carbonyl group and at ...
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WO/2017/053776A1 |
Glucosepane is a structurally complex protein post-translational modification (PTM) believed to exist in all living organisms. Research in humans suggests that glucosepane plays a critical role in the pathophysiology of both diabetes and...
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WO/2016/171038A1 |
This gas-generating agent comprises a compound represented by the following general formula (1).
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WO/2016/162688A1 |
The present invention discloses a method to discover selective inhibitors of phosphatases. Thus the invention provides a method for screening a test compound to determine whether the compound binds a holophosphatase selectively or non-se...
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WO/2016/162689A1 |
The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated ...
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WO/2016/131201A1 |
Isopropoxy-benzoguanamine series salt as shown by the formula (I) and an application thereof in preparing a growth promoter for animal feed, wherein R is DL-lactic acid, methanesulfonic acid, 2-isethionic acid, citric acid, tartaric acid...
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WO/2016/108045A2 |
The invention discloses compounds of the formula wherein A, B, X, Y and Z are defined. The compounds of the invention show activity against a range of bacteria, and are useful in the treatment or prophylaxis of a bacterial infection in a...
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WO/2016/039466A1 |
Provided is an economical, safe, and more environmentally-friendly production method for azodicarbonamide. According to the present invention, in a homogeneous system or heterogeneous miscible system of water or an organic solvent or a...
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WO/2016/039274A1 |
The present invention provides a compound represented by formula (1) or formula (2). (In formula (1), X is an acid that forms a salt with a guanidine moiety, and the R1 and R2 moieties are each independently at least one type selected fr...
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WO/2016/033635A1 |
The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in ...
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WO/2016/013033A1 |
The present invention discloses a novel vinylic 3-amino-1,2 diol compounds of formula (I) and a one pot cost-effective process for the synthesis of vinylic-3-amino-1,2-diols of formula (I) which comprises tandem α-amination-benzoyloxyal...
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WO/2016/001390A1 |
The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof Formula (I), and its uses to treat a disorder associated with protein misfolding stress and in particular with an...
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WO/2015/198343A1 |
The present invention relates to novel ortho alkynyl anilines of formula (I) which are useful in synthesis of drug intermediates and natural products and process for preparation of these ortho alkynyl anilines of formula (I) via copper c...
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WO/2015/190504A1 |
Provided is a compound represented by formula (1). (In the formula, X is an acid that forms a salt with a guanidine region, R1 and R2 are each independently any moiety selected from the group consisting of C1-18 alkyl groups, cycloalkyl ...
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WO/2015/113321A1 |
A diamino guanidine derivative as represented by formula I, wherein R1 represents methyl, ethyl, isopropyl, n-butyl, n-propyl, n-pentyl, n-octyl, n-tetradecyl, secbutyl, 3-pentyl, cyclopentyl or benzyl. When first using the compound in f...
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WO/2014/202703A1 |
The present invention relates to novel strobilurine type compounds I, processes for preparing these compounds, a use of compounds of the formula I and/or their agriculturally useful salts for controlling phytopathogenic fungi, to composi...
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WO/2014/176636A9 |
The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufactur...
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WO/2014/147568A1 |
S-adenosyl methionine, and the salts and complexes thereof, in the form of a spray-dried sterile powder which has a pharmacologically active enantiomer content exceeding 70% and a water residue below 2.5% by weight.
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WO/2014/108520A1 |
The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof, wherein:R1 is alkyl, Cl, F or Br; R2 is H or F; R3 is selected from H and alkyl; R4 is selected from H and C(O)R...
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WO/2014/077363A1 |
A semicarbazide composition which comprises a semicarbazide compound (A) having an amino group and a semicarbazide group, a semicarbazide compound (B-1) in which the amino group of the semicarbazide compound (A) has been substituted by a...
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WO/2014/027009A1 |
The present invention relates to a novel process for the preparation of a pyrazole carboxylic acid derivative of the formula (I) wherein R1 is C1-7-alkyl and R3 is C1-7-alkyl which is optionally substituted with halogen or C1-4-alkoxy. T...
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WO/2014/019044A1 |
The invention relates to hydrazide-N-acylhydrazone compounds, to a method for producing hydrazide-N-acylhydrazone compounds, to the use of intermediate compounds for producing hydrazide-N-acylhydrazones for the treatment of leishmaniasis...
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WO/2013/045487A1 |
The present application relates to azo compounds and also to use thereof as a mediator in a diagnostic method. In addition, the present application relates to detection reagents, kits and test elements which comprise such azo compounds.
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WO/2013/024720A1 |
This catalyst is composed of a peptide and a carrier, said peptide containing an amino acid represented by formula (SAA)-(AA)-(AA2) or (SAA1)-(SAA)- (AA)- (AA2) at the N-terminus thereof. (In the formula, SAA, SAA1 independently represen...
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WO/2012/165650A1 |
A new method for manufacturing an isoxazoline compound represented in formula (9) (in the formula, R1 represents a C1-C12 alkyl group optionally having one or more halogen atoms, or a C3-C12 cycloalkyl group optionally having one or more...
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WO/2012/130884A1 |
The invention relates to a rubber composition for tyres, comprising at least a diene elastomer, an inorganic reinforcing filler, and a coupling agent linking the inorganic filler and the diene elastomer. The composition is characterised ...
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WO/2012/130885A1 |
The invention relates to a rubber composition for tyres, comprising at least a diene elastomer, an inorganic reinforcing filler, and a coupling agent linking the inorganic filler and the diene elastomer. The composition is characterised ...
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WO/2012/093064A1 |
The present invention relates to a conjugate of the formula A−R1−N (H) −N (CH2−C (=O) −R2−B) 2, in which A is a functional entity, B is a targeting entity, and R1 and R2 are identical or different and each represent a bond or...
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