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WO/2000/044709A2 |
Compound of the formula (B) are useful in treating disease conditions mediated by TNF-$g(a), such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage l...
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WO/2000/044711A1 |
The invention discloses hydroxamide acids of formula (B) which are useful in treating disease conditions mediated by TNF-$g(a), such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's d...
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WO/2000/041997A1 |
3 process for the preparation of optically active $g(b)-amino alcohols represented by the general formula (2): Ra-C*H(OH)-C*H(Rb)-Rc, [wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, or the like; Rb is on...
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WO/2000/040529A1 |
The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C=NOH, or -CH(R?7¿)- wherein R?7¿ is hydrogen, hydroxy, C¿1-7?alkoxy, -OR?8¿ or -NR?8¿R?9¿ (wherein R?8¿ is a group -Y?1¿R?10¿ (wherein ...
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WO/2000/040551A1 |
The present invention relates to a process for forming a linear alkyl benzene sulfonate surfactant containing the steps of providing a linear alkyl benzene, providing an effective amount of an added hydrotrope precursor, combining the li...
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WO/2000/040571A1 |
The present invention relates to new compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of formula (I), wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated i...
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WO/2000/038813A1 |
Described are methods for dehydrating a hydrous substrate by combining the hydrous substrate with a hydrofluorocarbon, such as a hydrofluoroether. The process can include the step of removing water from the combined substrate and hydrofl...
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WO/2000/035863A1 |
The present invention relates to a surfactant for general use in agricultural compositions, including, but not limited to herbicidal, fungicidal and insecticidal formulations comprised of two components: an alkoxylated tristyrylphenol ac...
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WO/2000/035442A1 |
The invention relates to novel hydroxy diphenylurea sulfonamides, compositions and intermediates thereof. The hydroxy diphenylurea sulfonamides are useful in the treatment of disease states mediated by the chemokine, Interleukin-8.
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WO/2000/035864A1 |
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the tre...
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WO/2000/034233A1 |
Amidoalkanesulfonic acids are prepared by reacting a molar excess of an unsaturated nitrile, a source of SO¿3?, and an olefin, in a substantially non-aqueous medium, and transferring the crude reaction product containing amidoalkanesulf...
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WO/2000/032569A2 |
The invention relates to $g(a)-sulfin- and $g(a)-sulfonamimo acid amides of general formula(I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R¿1? is C¿1?-C¿12?alkyl, C¿1?-C¿12...
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WO/2000/032552A1 |
The present invention relates to a novel process for the preparation of functionalized chiral cyclopentanes comprising the steps of transforming an azanorbornyl derivative into a substituted enantiomerically pure cyclopentane. Furthermor...
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WO/2000/032568A2 |
(57) Abstract The invention relates to $g(a)-sulfin- and $g(a)-sulfonamino acid amides of general formula (I), including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R¿8? is C¿1?-C¿6?alk...
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WO/2000/032570A1 |
Hydrazine derivatives of formula (I) wherein R?1¿ represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl, R?2¿ represents heterocyclyl or NR?5¿R?6¿, R?3¿ represents hydrogen, ...
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WO/2000/031029A1 |
The invention relates to a method of producing organic disulfides by oxidizing mercaptans with sulfur which is dissolved in an organic disulfide and using an amine as the catalyst. Said mercaptans are used as 'crude mercaptan flow' from ...
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WO/2000/031028A2 |
The present invention relates to an improved process for synthesizing organic compounds for use as bleach activators.
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WO/2000/031027A1 |
The invention relates to a method of producing alkane sulfonic acid, comprising the following steps: (a) oxidizing alkyl mercaptans and/or dialkyldisulfides and/or dialkylpolysulfides having three to nine sulfur atoms with nitric acid to...
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WO/2000/027808A1 |
The invention relates to compounds of formula (I) and/or a stereoisomeric form of the compound of formula (I) and/or a physiologically acceptable salt of the compound of formula (I) which are suitable for producing medicaments for the th...
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WO/2000/026161A1 |
The invention concerns a method and a reagent useful for the synthesis of perhalogenated sulphanilide on the carbon borne by the sulphur atom of the sulphanilide function. Said perfluoroalkane sulphonylation method is characterised in th...
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WO/2000/024704A1 |
A process for producing peptidyl aldehyde derivatives represented by general formula (I), wherein A represents amino acid-origin acyl; and R¿1? and R¿2? are different and one represents hydrogen while the other represents optionally su...
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WO/2000/024709A2 |
Disclosed fluoro-olefins bearing an ionic functionality or a precursor thereto, a process for the production thereof, and polymers, especially ionomers, formed therefrom, and their application for electrochemical uses.
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WO/2000/023548A1 |
Modified alkylbenzene sulfonate surfactant mixtures comprise a mixture of specific branched and non-branched alkylbenzene sulfonate compounds, and are further characterised by a 2/3-phenyl index of 160-275. Detergent and cleaning product...
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WO/2000/022012A1 |
This invention concerns terminally unsaturated olefins of formula (III) wherein R is oxygen or an alkylene or alkylene ether group wherein one or more of the hydrogens may be substituted by halogen, and R¿f? is a radical of formula (II)...
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WO/2000/021920A1 |
Compounds of the formula (1a), wherein R1 is a group of the formula (2) where R1, R2, A, B, U, V, W, X, Y, Z, k and n have the significance given in the specification, are useful to treat rheumatoid arthritis, psoriasis, multiple scleros...
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WO/2000/020389A1 |
A compound having formula (I) wherein R?1¿ is oxo, -OR?a¿, -OC(=O)R?b¿; or (A); R?2¿ is H; or R?1¿ is -OR?c¿ and R?2¿ is -OR?d¿; or R?1¿ and R?2¿ together form -O(CH¿2?)¿m?O-; and any pharmaceutically-acceptable salt thereof ...
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WO/2000/020384A1 |
A description is given of diphenyl compounds of formula (1) wherein R is a camphor or hydantoin derivative; and R¿1? is hydrogen; or C¿1?-C¿5?alkyl. These compounds are suitable as light stabilisers in cosmetic, pharmaceutical and vet...
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WO/2000/015607A1 |
The present invention is a process for the preparation of calcium hydroxy alkane sulphonates from a mixture comprising at least 20 % by weight paraffins and at least 10 % by weight olefins, comprising reacting the mixture with a sulphona...
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WO/2000/012451A1 |
Processes for making particularly branched, especially monomethyl-branched or nongeminal dimethyl-branched surfactants used in cleaning products; preferred processes comprising particular combinations of two or more adsorptive separation...
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WO/2000/012077A1 |
Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have structure (I) where A, B, D, Q, X?1¿, R, R?1¿, X?2¿ and R?2¿ are as defined herein. These compounds are useful as antiarrhythmi...
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WO/2000/010968A2 |
The present invention relates to novel aryl sulphonamide amino acid esters and analogues, methods for the production and use thereof in the prophylaxis and treatment of neurodegenerative diseases, especially in the treatment of apoplexia...
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WO/2000/010966A1 |
The present invention relates to a method for the production of compounds of general formula (I) from compounds of general formula (II) and sulfite salts with subsequent halogenation. The solvent used in halogenation is an organic solven...
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WO/2000/008025A1 |
Novel intermediates and improvements in the synthesis of acyclic guanine nucleoside prodrugs of the formula (R)-9-[(2-alkanoylmethyl)-4-(aminoacyloxy)butyl]guanine (for example valtamociclovir stearate), including purine salts amenable t...
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WO/2000/006538A1 |
Provided are methods of purification of an organic lithium salt comprising the steps of: (a) dissolving an impure organic lithium salt in a solution comprising an organic complexing solvent; (b) crystallizing from said solution a solid s...
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WO/1999/065870A2 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural an...
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WO/1999/062872A1 |
A novel 3-aryl-2-hydroxypropionic acid derivative, having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediate for its manufacture, pharmaceutical preparations containing ...
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WO/1999/062871A1 |
Novel 3-aryl proprionic acid derivatives and analogs, having general formula (I) and stereo- and optical isomers and racemates thereof as well as pharmaceutically acceptable salts, solvates and crystalline forms thereof, process for thei...
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WO/1999/062864A1 |
A process is described for the stereoselective synthesis of R-(-)-carnitine in which the characterising step is condensation of glycerol with an amine of (-)camphorsulphonic acid.
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WO/1999/061415A1 |
An improved process for sulphonation of organic compounds, notably hydroxybenzene and alkylbenzene compounds, comprises reacting them with sulphuric acid or oleum in the presence of an organic solvent, notably an n-alkane or a cycloalkan...
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WO/1999/058630A1 |
The invention relates to a method for producing low-odour alkyl sulfate granulates and to their use for producing laundry and dishwashing detergents, cleaning products and cleansing cosmetics.
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WO/1999/055666A1 |
The present invention provides a method of converting a hydroxy group in alcohols containing an electron withdrawing group into perfluoroalkanesulphonate and fluorosulphonate esters, which are good leaving groups, with inversion of confi...
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WO/1999/054292A1 |
The invention concerns novel sulphonated and oxy- or polyalkylene diphenol derivatives and their corresponding salts corresponding to general formulae (Ia and Ib) wherein Y¿1? and Y¿2? are such as defined in Claim 1.
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WO/1999/052862A1 |
The present invention relates to a process for the preparation of compounds of formula (b), in which a compound of formula (V) is reacted with a compound of formula (VI). The resulting compound of formula (IV) is reduced to a compound of...
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WO/1999/047488A1 |
A process for producing L-valine benzyl ester p-toluenesulfonate which involves the steps of reacting L-valine with benzyl alcohol in at least one aromatic solvent selected from among toluene, monochlorobenzene and xylene in the presence...
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WO/1999/047495A1 |
A process for the preparation of sulphonated distyryl-biphenyl compounds of formula (1), in which R¿1? and R¿2?, independently, are hydrogen, C¿1?-C¿5?-alkyl, C¿1?-C¿5?-alkoxy or halogen, and M represents Li, K, an alkaline earth m...
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WO/1999/046242A1 |
Compounds represented by formula (1a) or salts thereof, which are preventives/remedies for heart diseases, autoimmune diseases, inflammatory diseases, septic shock, etc., wherein R represents an optionally substituted aliphatic hydrocarb...
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WO/1999/043285A2 |
The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them.
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WO1998022435A9 |
The invention concerns a reagent and a family of compounds. The reagent contains by successive or simultaneous addition: a material of formula RfH, a silicophilic base, a trivalent nitrogenous derivative containing no hydrogen and at lea...
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WO/1999/040096A1 |
A method for the synthesis of certain N-silylated cyclopentaphenanthrene (Group IV metal) complexes is disclosed.
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WO/1999/038828A1 |
A process for producing a butanetriol derivative represented by formula (1) useful as a material for medicines, characterized by reacting a compound represented by formula (3), wherein R?1¿ and R?2¿ represent different protecting group...
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