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WO/2002/014287A1 |
New sulfamide compounds and methods of forming those compounds are provided. The inventive methods comprise subjecting a template opened-ring sulfamide compound to a ring-closing metathesis reaction in the presence of a Grubbs catalyst t...
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WO/2002/006189A2 |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associa...
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WO/2002/004410A1 |
A process for producing a sulfamate compound which comprises reacting a hydroxylated compound with sulfamoyl chloride, characterized in that the reaction is conducted in the presence of a compound such as N,N-dimethylacetamide or 1-methy...
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WO/2001/096298A2 |
The present invention provides compounds of formula (I) wherein R, Z, Y, W, R¿5?, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to th...
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WO/2001/081561A1 |
Compounds of the general formula (I) are provided, and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R¿i? capable of binding at a primary specificity site of a protease; Y is a chemical species reactive ...
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WO/2001/079161A1 |
The invention relates to novel pesticidally active $g(a)-sulfin- and $g(a)-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one, R¿1? - ...
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WO/2001/079160A1 |
The invention relates to novel pesticidally active $g(a)-sulfin and $g(a)-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R¿1?, RÂ...
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WO/2001/079159A1 |
The invention relates to novel pesticidally active $g(a)-sulfin- and $g(a)-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R¿1? - ...
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WO/2001/076393A1 |
Salts of L-carnitine and lower alkanoyl L-carnitines with aspartame, cyclamic acid and saccharine are stable and non-hygroscopic and find utilization as sweeteners, particularly for coffee and tea.
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WO/2001/064165A2 |
This invention relates to the novel use of diphenyl sulfamido in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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WO/2001/046124A1 |
Aromatic diamide derivatives of general formula (I) or salts thereof; chemicals for agricultural or horticultural use; and usage thereof [wherein A?1¿ is optionally substituted C¿1-8? alkylene, C¿3-8? alkenylene, or the like; B is O- ...
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WO/2001/042203A1 |
The present invention provides certain cyclopentyl sulfonamide derivatives of formula (I): useful for potentiating glutamate receptor function in a mammal. It also relates to novel cyclopentyl sulfonamide derivatives, to processes for th...
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WO/2001/036375A1 |
This invention relates to new aminoalcohol derivatives or salts thereof represented by formula (I): wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pan...
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WO/2001/036383A1 |
A process for the production of an aryl sulfamide having formula (I), in which R?1¿, R?2¿ and R?3¿ are each hydrogen, alkyl, cycloalkyl or aryl, provided that at least one of R?1¿, R?2¿ and R¿3? is aryl,which comprises reacting a c...
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WO/2001/015683A1 |
The invention relates to tramadol forms of administration whose action is delayed by means of a coating and which contain the active agent tramadol in the form of tramadol saccharinate and optionally, other adjuvants.
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WO/2001/015682A1 |
The invention relates to pharmaceutical salts consisting of the active agent tramadol and at least one sugar substitute. The invention also relates to medicaments containing these salts, to the use of these salts for producing medicament...
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WO/2001/015667A1 |
The invention relates to oral dosage forms with controlled total-release of an active substance. Said active substance is present in the form of at least two different salts that are present in the dosage form in a solid state of aggrega...
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WO/2001/004086A1 |
Non-steroidal sulphamate compounds of formula (A), such as (B), which inhibit oestrone sulphatase and dehydroepiandrosterone sulphatase and are thus useful in treating sulphatase-associated conditions such as breast cancer.
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WO/2001/002349A1 |
Phenyl sulfamate derivatives of general formula (I) or salts thereof, exhibiting an excellent steroid sulfatase inhibitory activity and being therefore effective in the prevention or treatment of diseases related to steroids including es...
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WO/2000/066522A1 |
The present invention provides non-steroidal compounds of formula (I) which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides p...
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WO/2000/066546A2 |
The present invention provides monofluoroalkyl derivatives of the formula (I) wherein: A represents SO¿2?, CO¿2? or CONH; R?a¿ represents (1-6C)alkyl, (2-6C)alkenyl, -(1-4C)alkyl(3-8C)cycloalkyl, or (1-4C)alkylaromatic; R?b¿ represen...
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WO/2000/054759A2 |
The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The c...
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WO/2000/051972A1 |
The invention provides compounds of formula (I), wherein R?1¿ and R?2¿ independently represent H or C¿1-6? alkyl; R?3¿ represents phenyl substituted by at least one group selected form halo, CF¿3?, OCF¿3?, CN, OH, C¿1-6? alkyl and...
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WO/2000/040529A1 |
The invention relates to the use of compounds of formula (I): wherein X is -C(O)-, -C(S)-, -C=NOH, or -CH(R?7¿)- wherein R?7¿ is hydrogen, hydroxy, C¿1-7?alkoxy, -OR?8¿ or -NR?8¿R?9¿ (wherein R?8¿ is a group -Y?1¿R?10¿ (wherein ...
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WO/2000/039077A2 |
New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R¿1? is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R¿2? and R¿3? are the same o...
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WO/2000/032569A2 |
The invention relates to $g(a)-sulfin- and $g(a)-sulfonamimo acid amides of general formula(I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R¿1? is C¿1?-C¿12?alkyl, C¿1?-C¿12...
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WO/2000/032568A2 |
(57) Abstract The invention relates to $g(a)-sulfin- and $g(a)-sulfonamino acid amides of general formula (I), including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R¿8? is C¿1?-C¿6?alk...
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WO/2000/018397A1 |
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. M...
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WO/2000/010969A1 |
Novel sulfonylimide and sulfonylmethide compounds are described which are useful as conductive salts. Also described is the use of the above compounds in salt form in battery electrolytes, particular salts having mixed perfluorocarbon an...
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WO/2000/006537A1 |
The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurolo...
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WO/2000/005198A1 |
Anthranilic acid derivatives represented by general formulae (1) or (2) (wherein Y?1¿ and Y?2¿ are each a group represented by general formula (3)-1, (3)-2 or the like; X?1¿ is O, S or the like; X?2¿ is O or S; and R?1¿ to R?4¿ are...
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WO/2000/005201A1 |
A compound of formula (I) or a pharmaceutically acceptable salt thereof; or an enantiomer thereof. Compounds of formula (I) are useful as inhibitors or microsomal triglyceride transfer protein (MTP) and apolipoprotein B (ApoB) secretion ...
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WO/1999/058478A1 |
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the inv...
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WO/1999/055666A1 |
The present invention provides a method of converting a hydroxy group in alcohols containing an electron withdrawing group into perfluoroalkanesulphonate and fluorosulphonate esters, which are good leaving groups, with inversion of confi...
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WO/1999/051564A1 |
This invention relates to new propanolamine derivatives or salts thereof represented by general formula (I), wherein each symbol is as defined in the specification or salts thereof which are $g(b)¿3? adrergenic receptor agonists and the...
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WO/1999/043644A1 |
Novel $g(a)-amino acid amides of formula (I) as well as possible isomers and mixtures of isomers thereof, wherein the substituents are defined as follows: n is the number zero or one; R¿1? is optionally substituted alkyl, alkenyl, alkyn...
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WO/1999/019291A1 |
Compounds represented by general formula (I) or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 5 carbon atoms, a cyclopentyl group, a cyclohexyl group or the ...
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WO/1999/007674A2 |
The invention relates to novel pesticidally active compounds of general formula (I) as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R¿1? is C¿1?-C¿12?alkyl that is unsubstituted or m...
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WO/1999/002166A1 |
Colchinol derivatives of formula (I) wherein R¿1?, R¿2?, R¿3? and R¿6? are each independently H, optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, alkanoyl, PO¿3?H¿2?; X is carbonyl (CO), thiocarbonyl (CS), methy...
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WO/1999/000121A1 |
This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of ...
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WO/1998/038160A1 |
$g(a)-Amino acid amides of formula (I) wherein the substituents are defined as follows: n is a number zero or one; R�1? to R�7? are as defined herein; R�8? is C�1?-C�6?alkyl, C�3?-C�6?alkenyl or C�3?-C�6?alkynyl; R�9?...
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WO/1998/038161A1 |
The invention relates to novel pesticidally active compounds of general formula (I) as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and R�1? is C�1?-C�12?alkyl that is unsubstituted or ...
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WO/1998/037061A1 |
The present invention relates to novel aryl sulfonamides and analogues thereof, methods for producing same and their use in the treatment of neurodegenerative diseases, in particular the prophylaxis and treatment of neurodegenerative dis...
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WO/1998/035935A1 |
Novel compounds useful as active ingredients of pesticides are disclosed. Acrylonitrile compounds of formula (I) or their salts, wherein Q is Qa, Qb, Qc or Qd, Y is =C(R�4?)- or =N-, R�1? is alkyl, haloalkyl, etc., each of R�2? and...
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WO/1998/033496A1 |
Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula (I): R?1�-L-NHSO�2?R?2�, in which R?1� represents an unsubstituted or substituted aromatic or heteroaromatic group; R?2...
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WO/1998/032748A1 |
This invention relates to sulfamides of formula (I) wherein R?1�, R?2�, R?3�, R?10�, R?20�, R?21� are as defined in the specifications and the claims that are inhibitors of metalloproteases, pharmaceutical compositions contai...
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WO/1998/028280A1 |
Herbicidal compounds having structure (a) are disclosed, in which: X and Y are independently selected from hydrogen, halogen, and alkyl; R is alkyl or amino; R?1� is hydrogen, alkyl, cyanoalkylsulfonyl, acyl, acyloxyacyl, alkoxycarbony...
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WO/1998/011064A1 |
This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to ...
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WO/1998/005659A1 |
Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R?1� is vinyl or ethyl; and R?2� is a group R?3�, R?4�CH�2?-, or R?5�R?6�C=CH-; wherein each of R?3� and R?4� is an azabi...
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WO1998004508A1 |
Selective IgE production inhibitors which contain substances inhibiting the production of IgE in the process of the differentiation of matured B cells into antibody-producing cells and the production of the antibody thereby while not or ...
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