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JP4145320B2 |
Use of a sulfamide derivative (I) or its salts, solvates or isomers, for the nontherapeutic care of skin. Use of a sulfamide derivative (I) of formula (R 3>)(R 4>)N-S(=O)(=O)(N)(R 1>)(R 2>) or its salts, solvates or isomers, for the nont...
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JP2008528691A |
1-Acylamino-2-hydroxy-3-amino-omega-arylalkanes of formula I. and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients.
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JPWO2006001318A1 |
Formula (I): [Chemical formula 1] (In the formula, R1 is an amino which may be substituted with ethyl or lower alkyl which may be substituted with halogen, and R2 and R3 are independently hydrogen or lower alkyl, respectively. X is a cyc...
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JPWO2006070878A1 |
Provided is a compound which has an anticoagulant action based on the inhibition of activated blood coagulation factor VII and is useful as a blood coagulation inhibitor or a prophylactic / therapeutic agent for a disease caused by throm...
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JP4097294B2 |
The present invention describes a method for treating neuropathic pain comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of formula (I), wherei...
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JP4094057B2 |
There are disclosed novel sulfamate compounds containing N-substituted carbamoyl group including their racemates and (R)- and (S)-optical isomers represented by Formulas (I), (II) and (III), pharmaceutically useful for the prophylaxis an...
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JP4094955B2 |
The present invention provides a compound of the formula (I): wherein R<1a>, R<1b>, R<1c> and R<1d> are each independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkylsulfonyl or cycloalkyl and the like, R<4> to R<15>...
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JP2008512374A |
The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering...
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JPWO2005097738A1 |
Equation (1): [In the equation, m, n, and p independently represent integers 0 to 4. However, 3 m + n 8. X is a group represented by the formula: NR4, R1, R3 and R4 are substituted or unsubstituted aryl groups, etc., R2 is a hydrogen ato...
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JP2008007510A |
To provide a new compound useful in treating certain metabolic diseases and diseases modulated by the inhibition of an enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD).The new compound has a specific structure, be...
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JP2008001719A |
To provide methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD).The invention relates to methods for the pro...
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JP4008498B2 |
The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the productio...
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JP4005911B2 |
The present invention relates to compounds of formula (I)wherein U, Y, V, W, L, X, A<1>, A<2>, A<3>, A<4>, A<5 >and A<6 >are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptabl...
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JP4004867B2 |
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JP2007528362A |
A compound represented by the formula (I): [In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting c...
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JP3988963B2 |
Ionic compound is claimed which contains at least one A<+>X<-> group in which A<+> is cation selected from biaryliodonium, arylsulphonium, arylacylsulphonium, diazonium, and organometallic cations containing transition metal complexed by...
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JP2007520492A |
One aspect of the present invention relates to ionic liquids comprising an anionic sweetener. Another aspect of the present invention relates to the use of an ionic liquid of the present invention comprising a pendant Bronsted-acidic gro...
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JPWO2005063222A1 |
Provided is an Hsp90 family protein inhibitor containing a benzene derivative represented by the general formula (I), a prodrug thereof, or a pharmacologically acceptable salt thereof as an active ingredient.
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JP2007516938A |
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
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JP2007516207A |
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease....
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JP2007516228A |
The present invention relates to compounds according to the structure (I): Where R is -CH3 or -CH2CH2Cl; R' is C1-C7 alkyl or -CH2CH2Cl; R2 or R4 is OP03H2, N02, OCO(Glu-OH), NHCO(Glu-OH), NHR7 and unassigned groups of R2, R3, R4, R5 and...
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JP3929702B2 |
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the inv...
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JP2007509852A |
Compounds of formula (I): and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective beta2-adrenoreceptor agonist is indicated, for examp...
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JP2007509044A |
The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subc...
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JP3901945B2 |
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides phar...
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JP2007505160A |
Compounds having the general formula I are useful for inhibiting serine protease enzymes, such as Tissue Factor VIIa, factor Xa, thrombin and kallikrein and have improved permeability properties. These compounds may be used in methods of...
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JP3880051B2 |
Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.
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JP3878206B2 |
The invention relates to an ionically conductive material, to its preparation and to its uses.The material includes at least one ionic compound in solution in an aprotic solvent, chosen from the compounds (1/mM)+[(ZY)2N]-, (1/mM)+[(ZY)3C...
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JP3856465B2 |
Tri-substituted phenyl derivatives and processes for their preparation. In a preferred embodiment, the compounds have the general formula (1) wherein L may be -OR; Z may be -C(R3)(R4)-C(R5)(R6)(R7); R may be an optionally substituted cyc...
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JP3838578B2 |
This invention discloses compounds useful as non-steroidal sulfatase inhibitors. The compounds comprise the formula (1) (1) wherein (a) R1 is selected from the group consisting of hydrogen and a lower alkyl group, (b) R2 is selected from...
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JP2006523669A |
Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic...
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JP2006210331A |
To provide an ionic conductive material showing good corrosion resistance as well as remarkable conductivity and stable quality.The material contains at least one ion compound in a solution of an aprotic solvent selected from compounds: ...
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JP3798458B2 |
To obtain a new oxime sulfonate useful as an acid generating agent for resist capable of providing a resist pattern high in generation efficiency of an acid, excellent in pattern shape, dimensional fidelity, exposure margin, heat resista...
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JP3795339B2 |
To obtain a matrix metalloproteinase inhibitor contributing to an amelioration or a prevention of a progress of osteoarthritis, articular rheumatism, corneal ulcer, periodontal disease, the transition or invasion of ulcer, or viral disea...
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JP2006083133A |
To provide a medicine containing a sulfamide derivative exhibiting excellent MEK-inhibiting activity and useful as an antitumor agent or its pharmacologically acceptable salt as an active ingredient.The medicine comprises a sulfamide der...
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JP2006028127A |
To provide an efficient method for producing an aromatic amine compound with a simple process in high yield, and to obtain a new amination agent for an aromatic compound.The method for producing the aromatic amine compound expressed by f...
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JP2001513529A5 |
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JP3716217B2 |
To provide a sulfamide compound acting as a selective β3 agonist and a pharmaceutical composition comprising the sulfamide compound. This sulfamide compound is represented by the formula (I) (wherein, e.g. R0, R1, R4 and R5 are each hyd...
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JP3711581B2 |
PURPOSE: To obtain a new semicarbazone derivative, having excellent insecticidal and acaricidal activities against agricultural insect pests and tetranychids in a small dose, hardly exerting adverse influences upon mammals, fishes and be...
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JP3704149B2 |
The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, I wherein X and Y are oxygen, sulfur, or (CR'R'')n wherein n is 1 to 4;...
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JP2005523920A |
The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use i...
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JP2005200359A |
To provide a salt melting at normal temperature, exhibiting a low-viscosity liquid shape at room temperature, having sufficiently high electroconductivity, and useful as an electrolyte or electrolysis solution for an electrochemical devi...
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JP2005522525A |
This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
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JP3671110B2 |
To obtain the subject new compound useful as an active ingredient for pest-controlling agents such as insecticides, acaricides and nematicides. An acrylonitrile compound of formula I {Q is a group of formula II-V [R3 groups are each a ha...
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JP2005170948A |
To provide a new compound having pesticidal activity, to provide a method for producing the compound, and to provide applications of the compound.The pest control agent includes a compound represented by formula (I) [wherein, Q is a grou...
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JP2005162727A |
To provide a sulfamide derivative which shows good MEK inhibitory activity and is useful as an antineoplastic agent or pharmacologically acceptable salts thereof, and to provide a medicinal preparation having good cell proliferation-cont...
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JP2005518377A |
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hor...
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JP2005518376A |
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hor...
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JP2005517705A |
The invention provides compounds of formula (I) wherein A and B represent the groups CH2)m- and CH2)n- respectively; R1 represents hydrogen or C1-4alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoro...
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JP3621125B2 |
The invention relates to novel substituted triazolinones of the general formula (I) in which R<1> represents hydrogen, halogen, cyano, hydroxyl, or one of the radicals -R<6>, -O-R<6>, -O-NR<6>R<7>, -S-R<6>, -S(O)-R<6> or -SO2-R<6>, R<2> ...
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