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WO/2005/075623A1 |
The present invention provides acylalkylisethionate esters useful in consumer products. The acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates unde...
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WO/2005/075651A1 |
A low-cost and efficient industrial process for producing (S)-2-pentanol, (S)-2-hexanol, 1-methylalkylmalonic acid and 3-methylcarboxylic acid with high optical purity. There is provided a process for producing (S)-2-pentanol and (S)-2-h...
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WO/2005/073216A2 |
Compounds of the formula (F) where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those ...
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WO/2005/073182A1 |
A method for producing a fluorine-containing unsaturated sulfonyl fluoride represented by the chemical formula: RfSO2F (wherein Rf is as defined below) is characterized in that a fluorine-containing unsaturated sulfonyl chloride represen...
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WO/2005/073388A1 |
A process for producing an optically active 1,4-pentanediol which comprises asymmetrically reducing 5-hydroxy-2-pentanone, which is easily available at low cost. Also provided is a process for producing an optically active 1-substituted ...
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WO/2005/073195A2 |
Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocycli...
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WO/2005/069751A2 |
Radicals with unpaired electrons are used to initiate a chain reaction that converts small hydrocarbons such as methane into oxygenated liquids. An initiator such as Marshall's acid is used to create methyl radicals. These radicals combi...
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WO/2005/068405A1 |
A process for producing phenyl-alkanes by paraffin dehydrogenation followed by olefin isomerization and then by alkylation of a phenyl compound by a lightly branched olefin is disclosed. An effluent of the alkylation section comprises pa...
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WO/2005/068418A1 |
The invention encompasses novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose...
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WO/2005/068412A1 |
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders c...
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WO/2005/063700A1 |
The invention relates to a process for catalyzing the preparation of directly esterified fatty acid isethionate (DEFI) reaction using group 4 metal based catalyst (according to IUPAC). Directly esterified fatty acyl isethionate (DEFI) is...
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WO/2005/063707A1 |
A novel, improved, and enantiospecific process for the preparation of (-)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperid
ine of formula-(I), an advanced intermediate in the manufacture of antidepressant drug paroxetine is discl...
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WO/2005/063701A1 |
The present invention relates to a new process for the preparation of optically pure (R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.
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WO/2005/063729A1 |
The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40 receptor function modulating action, whic...
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WO/2005/063689A1 |
A compound which has high angiogenesis inhibitory activity and is useful in therapeutic and preventive drugs which are effective in diseases accompanied by diseased angiogenesis, e.g., cancers and the metastasis of cancers; a process for...
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WO/2005/064336A1 |
The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of c...
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WO/2005/063222A1 |
An Hsp90 family protein inhibitor which contains as an active ingredient a benzene derivative represented by the following general formula (I), a prodrug thereof, or a pharmacologically acceptable salt of either.
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WO/2005/061443A2 |
The invention relates to benzoyl-substituted phenylalanine amides of formula (I), wherein the variables R1 to R15 have the meanings indicated in the description, the agriculturally useful salts thereof, methods and intermediate products ...
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WO/2005/061447A2 |
The production of alkylaryl compounds comprises the following stages: a) reaction of a C4/C5 olefin mixture on a metathesis catalyst to produce a C4-8 olefin mixture containing 2-pentene and the optional isolation of the C4-8 olefin mixt...
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WO/2005/058807A1 |
A compound of Formula (1) and salts thereof; wherein: Q is an optionally substituted aryl ring; Y is C02H, S03H or P03H2; R and X are substituents; m is 0 to 3; n is 0 to 6; and q is 0 to 6. Also compositions comprising these compounds, ...
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WO/2005/057714A1 |
It is aimed to obtain a lithium secondary battery with excellent characteristics such as energy density and electromotive force, which is also excellent in cycle life and shelf life stability. Disclosed is an electrolyte solution for sec...
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WO/2005/055286A2 |
Zwitterionic compounds, photovoltaic cell charge carrier layers (140) containing such compounds, photovoltaic cells (100) including such charge carrier layers (140), and related methods are disclosed.
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WO/2005/054276A1 |
The invention relates to a method for synthesis of perindopril of formula (I) and the pharmaceutically-acceptable salts thereof.
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WO/2005/051898A2 |
The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1&agr ,25 dihydroxy vitamin D3. These com...
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WO/2005/049556A2 |
The subject matter of the invention is a process for the production of metal salts of trifluoromethane sulphonic acid by reacting trifluoromethane sulphonic acid with a metal alcoholate and the use thereof as esterification catalyst and/...
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WO/2005/047263A1 |
The invention relates to a method for producing cyclic, N-substituted alpha-iminocarboxylic acids of formula (I). According to said method, biphenyl-4-yl-carbamic acid esters are converted into 4'-carbamic acid ester-biphenyl-4-sulphonic...
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WO/2005/042514A2 |
This invention provides naphthalene-1,5-disulfonic acid salts of 4-{N-[7-(3-(S)-1-carbamoyl-1,1-diphenylmethyl)pyrrolidin-1-y
l)hept-1-yl]-N-(isopropyl)amino}-1-(4-methoxypyrid-3-ylmethy
l)piperidine, which salts are useful as muscarinic...
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WO/2005/042471A1 |
The present invention relates to novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cel...
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WO/2005/040104A1 |
The present invention relates to novel hypolipidemic, antiobesity, hypocholesterolemic and antidiabetic compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their stereoi...
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WO/2005/040127A1 |
The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPAR&gammad ) and alpha (PPAR&agr ), processes of preparing the same, and pharmaceutical compositions contain...
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WO/2005/040102A2 |
The present invention relates to novel compounds of formula (I) and their pharmaceutically acceptable salts, wherein ring “Ar1” represents a monocyclic or polycyclic aromatic or partially saturated aromatic polycyclic, which may opti...
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WO/2005/037774A1 |
This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention ...
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WO/2005/037775A1 |
The present invention is related to compound having general formula Z-OC (C Rn1Rn2) -CO-Z wherein Z &equals OH or NH2 and n1 &equals n2 &equals 1 to useful for modulation of immune response by inducing differentiation of dendritic cells ...
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WO/2005/037269A1 |
A compound represented by the following formula (1), a prodrug thereof, or a pharmaceutically acceptable salt of either. They are effective in enhancing LDL receptor manifestation and are useful as a therapeutic agent for hyperlipemia, a...
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WO/2005/037776A1 |
The present invention is related to compound having general formula Z-OC (C Rn1Rn2) -CO-Z wherein Z = OH or NH2 and n1 = n2 = 1 to 8 for modulation of immune response by inducing differentiation of dendritic cells consisting novel class ...
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WO/2005/037205A2 |
The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating...
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WO/2005/037206A2 |
The present invention relates to a novel class of anti-cancer compounds which selectively target androgen receptor (AR)-expressing cancer, cells, such as prostate cancer cells and breast cancer cells, These agents comprise an androgen re...
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WO/2005/033082A2 |
Compounds resulting from the administration of torcetrapib to a mammal, and the use of such compounds as an indicator or biomarker to the presence or exposure of torcetrapib in the plasma of a mammal including humans. The invention is al...
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WO/2005/030699A1 |
A novel agricultural chemical, especially an insecticide or acaricide. It is a pest control agent containing either a substituted benzanilide compound represented by the general formula (1): [wherein W1 and W2 each represents oxygen, etc...
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WO/2005/029631A1 |
[PROBLEMS] The present invention provides a lithium secondary battery which is improved particularly in cycle characteristics. [MEANS FOR SOLVING PROBLEMS] Disclosed is a lithium secondary battery which uses a nonaqueous electrolyte solu...
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WO/2005/028425A2 |
Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neut...
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WO/2005/029508A1 |
A sulfonated amorphous carbon characterized in that chemical shifts of sulfonated condensed aromatic carbon 6-membered ring and condensed aromatic carbon 6-membered ring are detected in a 13C nuclear magnetic resonance spectrum and at le...
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WO/2005/025554A2 |
A compound of the formula [I] wherein each symbol is as defined in the specification, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof or a solvate thereof show a DPP-IV inhibitory activity and are novel compounds ef...
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WO/2005/021489A2 |
Hydroxamic acids having the formula (B) are useful in treating disease conditions mediated by TNF-(x, euch as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart hHure,...
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WO/2005/020896A2 |
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This spec...
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WO/2005/018300A2 |
The present invention is directed to alkylxylene sulfonate for enhanced oil recovery processes. The alkylxylene moiety in the alkylxylene sulfonate contains a high percentage of the 4-alkyl-1,2-dimethyl benzene isomer and a high percenta...
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WO/2005/016862A1 |
A compound represented by the formula (I)[In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting car...
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WO/2005/012239A1 |
Provided are ionically dissociative functional molecules which are thermally and chemically stable under the conditions required for electrochemical equipment and useful as the material of protonic conductors of fuel cells; processes for...
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WO/2005/009927A2 |
Acetyl anhydrides such as acetyl sulfate are produced by a process for comprising contacting methane and carbon dioxide in an anhydrous environment in the presence of effective amounts of a transition metal catalyst and a reaction promot...
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WO/2005/010011A2 |
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in...
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