| Document |
Document Title |
|
WO/1999/062871A1 |
Novel 3-aryl proprionic acid derivatives and analogs, having general formula (I) and stereo- and optical isomers and racemates thereof as well as pharmaceutically acceptable salts, solvates and crystalline forms thereof, process for thei...
|
|
WO/1999/059941A1 |
The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amoun...
|
|
WO/1999/048851A2 |
The invention relates to processes for the preparation of compounds of formula (I), wherein R?1¿ and R?2¿ are as defined in the description.
|
|
WO/1999/040065A1 |
A process for producing a purified aryl vinyl sulfone solution, characterized by crystallizing an aryl vinyl sulfone from a crude organic solvent solution of the sulfone, removing the solution from the resultant mixture to obtain a wet a...
|
|
WO/1999/028282A1 |
A process for preparing a compound of Formula (I); where Q completes an optionally substituted 5- or 6-member saturated carbocyclic ring and R is optionally substituted phenyl or optionally substituted C¿3?-C¿6? cycloalkyl which proces...
|
|
WO/1999/015503A2 |
The invention encompasses a process for making compounds of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases.
|
|
WO/1999/015481A1 |
A process for the preparation of an enantioenriched sulphone of formula (1), comprises asymmetric hydrogenation of a vinyl sulphone of formula (2) wherein R?1¿, R?2¿ and R?3¿ are each independently a hydrocarbon group of less than 20 ...
|
|
WO/1999/010357A1 |
The subject invention provides a binuclear metal complex having structure (I) wherein M¿1?, and M¿2? are independently selected from the group consisting of Fe, Co, Mn and Ru; wherein $i(m) and $i(n) are independently +2 or +3; wherein...
|
|
WO/1999/006363A1 |
The invention relates to a method for sulfochlorinating acetanilide, characterised in that the acetanilide is introduced into a reaction vessel in fused form and then reacted with chlorosulfonic acid and thionyl chloride. The intermediat...
|
|
WO/1999/003802A1 |
The present invention provides a method of substituting a carbonyl compound with fluorine at the $g(a)-position, comprising reacting the carbonyl compound with a fluorinating agent in the present of a metal-containing catalyst. The react...
|
|
WO/1998/058907A1 |
The invention relates to a method for producing 4,4'-dihalogendiphenylsulfone by reacting halogenated benzene with 4-halogenphenylsulfonyl chloride in a liquid phase at high temperature, in the presence of a solid catalyst having acid ce...
|
|
WO/1998/042677A1 |
Herbicidal 1-alkyl-4-(2-chloro-3-alkoxy-4-alkylsulfonylbenzoyl)-5-hydro
xypyrazole compounds, as well as 1-halo-2-chloro-3-alkoxy-4-alkylsulfonylbenzene compounds and 2-chloro-3-alkoxy-4-alkylsulfonylbenzoic acid compounds, were prepared...
|
|
WO/1998/040339A1 |
The invention concerns a method for the acylation or sulphonation of an aromatic compound. More particularly, the invention concerns a method for the acylation or sulphonation of an activated or deactivated aromatic compound and is usefu...
|
|
WO/1998/037058A1 |
The invention relates to an advantageous method for producing aromatic nitriles from chloroaromates with alkali cyanides in the presence of nickel catalysts by working in the presence of a possibly cyclic ketone having at least 4 carbon ...
|
|
WO/1998/029376A1 |
This invention is directed to processes for the solid-phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds and to polymeric hydroxylamine resin compounds useful therefor.
|
|
WO/1998/017640A1 |
Hydrogen peroxide adducts of phosphine oxides and equivalents for As, Sb and Bi and or phosphonates and phosphinates. Methods of preparation of said adducts by reaction of hydrogen peroxide on the phosphine oxides, equivalents for As, Sb...
|
|
WO/1998/017638A1 |
Protected amino acid derivatives of general formula (I) wherein R�1? represent hydrogen atom, and R�2? may represent hydroxymethyl, 1-hydroxyethyl, 4-hydroxybenzyl, imidazolyl-2-methyl, benzyloxymethyl, 1-benzyloxyethyl, 4-benzyloxyb...
|
|
WO/1997/045420A1 |
The invention encompasses a process for making compounds of formula (I) or (Ia) useful in the treatment of cyclooxygenase-2 mediated diseases.
|
|
WO/1997/034867A1 |
A process is disclosed for making a compound having a sulfoxide group comprising providing a first compound having a sulfide group and contacting said first compound with an oxidizing agent in the presence of silica and a carboxylic acid...
|
|
WO/1997/019918A1 |
Novel 2,3,5-trimethyl-4-hydroxy anilide derivatives of general formula 1, wherein, in particular, R1 is phenyl, R2 is H, R3 is C12H25 and A is a sulphur atom, are disclosed. A method for preparing said derivatives, pharmaceutical composi...
|
|
WO/1997/019917A1 |
A novel method for preparing (+)compactin and (+)mevinolin analog compounds having a 'beta'-hydroxy-'delta'-lactone grouping is disclosed. The method for preparing said compounds uses novel reaction intermediates. Said reaction intermedi...
|
|
WO/1997/019057A1 |
A method for purifying dimethyl sulphoxide (DMSO), wherein the liquid DMSO with a low water content is contacted with an ion exchange resin in the form of -SO3H, and the liquid is separated from the resin. The resulting DMSO has an iron ...
|
|
WO/1996/040693A1 |
The present invention is directed to novel vinyl sulfenic acid derivatives, and to a new process for the synthesis of novel vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particula...
|
|
WO/1996/040691A1 |
The present invention is directed to new diarylvinyl sulfoxides and to a new process for their synthesis.
|
|
WO/1996/033167A1 |
A process for preparing an aromatic or heteroaromatic sulfonyl halide of the general formula (3): Ar-(-SO2Y)n by halogenating an aromatic or heteroaromatic methyl sulfide of the general formula (1): Ar-(-SCH3-mXm)n or an aromatic or hete...
|
|
WO/1996/033168A1 |
The present invention presents a benzylsulfide derivative of formula (I) or its salt: wherein R1 is a C1-6 alkyl group, a C1-6 haloalkyl group, a C2-4 alkenyl group, a cyano group, etc., and each of R2 and R3 is a hydrogen atom, a haloge...
|
|
WO/1996/025394A1 |
Protected amino acid derivatives of general formula (I) wherein R1 represents hydrogen atom, and R2 represents hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, tert-butoxymethyl, 1-tert-butoxyethyl, 2-methylthioethyl, benzyl,...
|
|
WO/1996/022957A1 |
A process for preparing a compound of formula (I), where R1, R2, R3, R4, R5 and R6 are independently hydrogen or C1-6 alkyl; R7 is halogen, cyano, NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or RaS in which Ra is C1-4 alkyl; R8, R9 and ...
|
|
WO/1996/022958A1 |
A process for preparing a compound of formula (I), where R1, R2, R3, R4, R5 and R6 are independently hydrogen or C1-6 alkyl; R7 is halogen, cyano, NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or RaS in which Ra is C1-4 alkyl; R8, R9 and ...
|
|
WO/1996/021452A1 |
This invention relates to certain 5-(optionally substituted aryl or heteroaryl)-4-(optionally substituted heteroaryl)-1-(optionally substituted heterocyclyl or heterocyclylalkyl) or 1- optionally substituted alkyl or alkenyl -imidazoles ...
|
|
WO/1996/002515A1 |
The disclosure herein relates to the title compounds of formula (I) and salts and esters thereof, wherein X is halogen, C1-6 polyhaloalkyl, C6-10 aryloxy, C1-6 alkoxy or alkylsulfonyl, C4-10 tert-alkyl, NO2 or CN; n is 0-4 and Z is an (u...
|
|
WO/1995/034534A1 |
A compound of formula (I), wherein R1 is a C1-6 straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6alkynyl group, a C3-6cycloalkyl group or a C3-6cycloalkyl C1-6alkyl group, each optionally substituted by one to three gro...
|
|
WO/1995/030672A1 |
Novel N-sulfinyl-2-carboxyaziridine compounds and novel N-hydrogen-2-hydroxymethylaziridine compounds are provided. The asymmetric synthesis of N-sulfinylaziridines is readily accomplished in high diastereomeric purity and good yield by ...
|
|
WO/1995/028384A1 |
The invention provides for diazo-phenanthrenone compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-'alpha' reductase. The invention also provides processes for pr...
|
|
WO/1995/023134A1 |
Arylthiobenzonitrile compounds of formula (I) wherein, R is hydrogen, nitro, trifluoromethyl, halogen, carboxy, C1-4 carboxyamido, nitrile, C1-4 alkanoyl, C1-4 alkylsulfonyl, C1-4 alkylsulfinyl, trifluoromethylsulfonyl, trifluoromethylsu...
|
|
WO/1995/023133A1 |
Arylthiobenzonitrile compounds of formula (I) wherein: R is hydrogen, C1-4 alkyl, C1-4 alkoxy, hydroxyl, mercapto, NR1aR2a or SR1a (wherein R1a and R2a, which may be the same or different are, hydrogen, C1-4 alkyl or phenyl C1-4 alkyl); ...
|
|
WO/1995/018018A1 |
A method of preventing hydration of 4-hydroxy-4'-isopropoxydiphenyl sulfone characterized by wet pulverizing the sulfone in water in the presence of a diphenyl sulfone derivative represented by general formula (I): (wherein R1 represents...
|
|
WO/1995/016786A1 |
Process for the preparation of a threo-phenylserine amide of general formula (2) in which glycine amide is contacted with the corresponding substituted benzaldehyde of formula (3) in an excess relative to the amount of glycine amide, thi...
|
|
WO/1995/013265A1 |
This invention relates to an improved process for preparing a herbicidal intermediate compound having structural formula (I), wherein groups X are independently selected from C1-6 alkyl, halo C1-6 alkyl, CN, halogen, C1-6 alkoxy, nitro, ...
|
|
WO/1995/011230A1 |
A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I) wherein, X is oxygen, NR4 or CHR5; R1 is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R2 is hydrogen, alkyl, aryl, heteroaromatic...
|
|
WO/1995/009841A1 |
Compounds of formula (I), wherein: R1 represents hydrogen or a (C1-C6)alkyl, (C1-C6)alkoxycarbonyl(C1-C6)alkyl, phenyl, substituted phenyl, phenyl (C1-C6)alkyl, heterocyclyl, (C1-C6)alkylcarbonyl, phenacyl or substituted phenacyl group; ...
|
|
WO/1995/007885A1 |
Compounds of formula (I), wherein R is a hydrogen atom or an OY group; R1 is a hydrogen atom or an OY' group; R2 is a hydrogen atom or an OY'' group; provided that at least one among R, R1 and R2 is hydrogen but R, R1 and R2 are not cont...
|
|
WO/1995/004716A1 |
The invention relates to oxime derivatives of formula (I) whereinR1 is alkyl, haloalkyl or optionally substituted cycloalkyl; R2 is optionally halogen-substituted alkyl, alkenyl or alkynyl; alkyl substituted by -OR6; a group selected fro...
|
|
WO/1995/004026A1 |
Compounds of general formula (I) characterised in that R1 and R2 are independently selected from the group consisting of COOR, CN, aryl, substituted aryl, COOH, halogen, C(O)NHR4, C(O)NR5R6; X and Y are independently selected from the gr...
|
|
WO/1995/004109A1 |
Aqueous dispersions which are particularly well suited for use as aqueous ink jet ink compositions having an aqueous carrier medium which comprises water or a mixture of water and at least one organic solvent; a particulate solid, prefer...
|
|
WO/1995/002591A1 |
This invention relates to a novel group of imidazole compounds, processes for the preparation thereof, the use thereof in treating cytokine mediated diseases, and pharmaceutical compositions for use in such therapy.
|
|
WO/1995/001333A1 |
The present invention relates to compounds of formula (I) wherein R1 is selected from H and 3-chloro; R2 is selected from a phenyl group and a pyridyl group; R3 and R4 are selected independently of each other from H and methyl; R5 and R6...
|
|
WO/1994/027959A1 |
A process for preparing a compound of formula (I), where R1 is optionally substituted alkyl or phenyl, R2 is COOH, and R3 and R4 are independently selected from hydrogen, halo, haloalkyl, nitro, hydroxy, alkoxy, haloalkoxy or alkoxyalkox...
|
|
WO/1994/025435A1 |
Compounds of formula (1), wherein R represents a -CONHOR6 [where R6 is a hydrogen atom or an acyl group], carboxyl (-CO2H), esterified carboxyl, -SR6 or -P(O)(X1R7)-X2R8 group, where X1 and X2, which may be the same or different, is each...
|
|
WO/1994/021603A1 |
Certain sulfides can be converted to sulfoxides or sulfones using oxone in 12.5 % aqueous acetone and buffered to pH 7.5 - 8.0 with sodium bicarbonate.
|
