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WO/2016/161996A1 |
The present invention provides a method of chiral resolution of racemic amines of the benzyl type by means of salts formed with tartaric acid of formula (3) and intermediate of formula (2), and their use in the synthesis of Apremilast of...
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WO/2016/146607A1 |
The invention relates to a novel and improved method for producing (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo
-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile of formula (I), and to the produc...
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WO/2016/145236A1 |
Chemical compounds that modulate HIF-2α activity, their polymorphs, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with HIF-2α, are described herein.
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WO/2016/144825A1 |
Aromatic entities that modulate HIF-2α activity, pharmaceutical compositions containing the aromatic entities, and methods of using these chemical entities for treating proliferative diseases and conditions associated with HIF-2α activ...
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WO/2016/122287A1 |
The present description relates to a compound comprising an aromatic ring, a polymer electrolyte membrane comprising same, a membrane electrode assembly comprising the polymer electrolyte membrane, a fuel cell comprising the membrane ele...
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WO/2016/119643A1 |
Disclosed are a compound as shown by the following formula 1, and a pharmaceutically acceptable salt, an ester, a hydrate and an organic solvate thereof. In the formula (1), the groups R1 to R17 are independently selected from the group ...
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WO/2016/099050A1 |
The present specification relates to a novel compound, a polymer electrolyte membrane comprising same, a membrane-electrode assembly comprising the polymer electrolyte membrane, a fuel cell comprising the membrane-electrode assembly, and...
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WO/2016/086710A1 |
Disclosed is a carboxylic acid preparation method. The method is characterized in that: a compound (II) reacts in the presence of hydrogen peroxide and a base to produce a target product (I) represented by the following equation: R1 is a...
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WO/2016/076160A1 |
[Problem] To provide a method for producing an industrially preferred optically active sulfoxide derivative. [Solution] A method for producing an optically active sulfoxide derivative represented by general formula (1), the method charac...
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WO/2016/071088A1 |
A poly(arylether sulfone)polymer[(t-PAES)polymer], wherein more than 70% moles of the recurring units are recurring units (Rt) of formula (St): -E-Ar1-SO2-[Ar2-(T-Ar3)n-SO2]m-Ar4- (formula St) wherein: n and m, equal to or different from...
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WO/2016/069358A1 |
A synthesis process for making a benzoxazine compound containing at least one benzoxazine unit from aromatic amine containing at least one primary amino group, at least one phenolic compound with at least one ortho-hydrogen, and alkyl fo...
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WO/2016/066574A1 |
Disclosed are compounds of formula (I) which possess anthelminthic properties wherein the structural elements have the meaning as indicated in the description. Further disclosed are such compounds for the control, treatment and/or preven...
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WO/2016/068605A1 |
The present description relates to a fluorine-based compound for a brancher, polymer using same, a polymer electrolyte membrane using same, a fuel cell using same, and a redox flow battery comprising same.
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WO/2016/062597A1 |
The present invention relates to a method for the manufacture of a poly(aryl ether) such as a poly(aryl ethersulfone) or a poly(aryl ether ketone) including the use of an organic base having a pKa of at least 10.
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WO/2016/058082A1 |
Compounds having a structure of Formula I: (I) or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R1, R2, R3, R4, Z, X and n are as defined herein, and wherein the compound comprises at least one 18F moiety, are provi...
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WO/2016/044331A1 |
Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
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WO/2016/039691A1 |
Compounds of formula (I): wherein R and A- are defined herein as a catalyst for making chiral heterocyclic sulfoxides and a method of producing enantioenriched sulfoxide in the presence of the said compounds.
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WO/2016/032120A1 |
The present invention relates to: a novel amino-phenyl-sulfonyl-acetate derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating diabetes, containing the same as an active ingr...
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WO/2016/031831A1 |
In order to achieve excellent mechanical strength of cured products, and excellent handling properties at low viscosity even in a room temperature environment, a polymerizable monomer represented by general formula (1) is provided, as we...
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WO/2016/028959A1 |
Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V) and/or a salt thereof, wherein R1 is OH or OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as ...
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WO/2016/024434A1 |
The present invention relates to the following: a compound represented by formula [1] or a salt thereof; a fungicidal composition comprising the compound or salt thereof; a method for eliminating plant diseases brought on by plant pathog...
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WO/2016/013633A1 |
A compound represented by formula (I) or a salt thereof has an excellent noxious organism control activity, particularly an excellent miticidal activity and/or an excellent insecticidal activity, is highly safe, and can be synthesized in...
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WO/2016/005318A1 |
The present invention provides novel amino lipids and a method for synthesizing these compounds. According to the invention, the amino lipids have a structure of the following formula (I) wherein Z is either hydrogen or -X1 R1, R1 and R2...
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WO/2016/001073A1 |
The invention relates to benzoic acid amides of general formula (I) as herbicides. In formula (I) X, Z and R represent radicals such as alkyl and cycloalkyl. Q represents a 5-membered heterocycle.
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WO/2016/001075A1 |
The invention relates to N-(1-methyltetrazol-5-yl)benzoic acid amides of the general formula (I) as herbicides. In formula (I) X, Z and R represent radicals such as alkyl and cycloalkyl.
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WO/2016/001390A1 |
The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof Formula (I), and its uses to treat a disorder associated with protein misfolding stress and in particular with an...
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WO/2016/001074A1 |
The invention relates to benzoic acid amides of general formula (I) as herbicides. In formula (I) X, Z and R represent radicals such as alkyl and cycloalkyl. Q represents a 5-membered heterocycle.
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WO/2015/198850A1 |
Provided is a method for producing a compound represented by formula (2-b), which is useful as an intermediate for producing agricultural chemicals. The method includes a step for obtaining a compound represented by formula (2-a) by oxid...
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WO/2015/194293A1 |
This lubricant contains a protic ionic liquid having a conjugate acid (B+) and a conjugate base (X-), the ionic liquid is represented by general formula (1), and the conjugate base is one of the conjugate base of sulfonic acid, the conju...
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WO/2015/181249A1 |
The present invention relates to processes for preparing β-aminosulfone compounds. The provided compounds are useful intermediates in the preparation of sulfone group containing isoindoline-based compounds, in particular apremilast.
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WO/2015/157927A1 |
Disclosed is a new florfenicol synthesizing method. The method synthesizes florfenicol products meeting requirements of the Drug Administration by a series of combinations of cyclization, selective reduction, fluorinated open ring, depro...
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WO/2015/157313A1 |
Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
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WO/2015/145371A1 |
The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparati...
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WO/2015/131200A1 |
Small molecule xanthine oxidase inhibitors, speifically substituted benzaldehydes including dihydroxy and trihydroxy benzaldehydes having therapeutic utility in the treatment of gout and hyperuricemia are provided. Pharmaceutical composi...
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WO/2015/104343A1 |
It relates to spirocyclic compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or any stereoisomers either of the compounds of formula (I) or of their pharmaceutically or veterinary acceptable salts, wher...
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WO/2015/103507A1 |
Described are RORϒ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions ...
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WO/2015/103508A1 |
Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions ...
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WO/2015/100225A1 |
The present invention provides sulfur- or selenium-containing compounds comprising hydrophobic moieties and ethoxylated ester or ethoxylated amide moieties such that the compounds have surfactant properties. Also provided are methods for...
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WO/2015/096226A1 |
A thermally activated delayed fluorescence material, synthetic process thereof and OLED device using same. The structure of the thermal activation delayed fluorescence material is represented by formula (1), wherein Ar1 is the same as or...
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WO/2015/087352A1 |
The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted aryl sulfones starting from aryl substrates.
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WO/2015/087834A1 |
The objective of the present invention is to provide a polyester resin composition which is free from the generation of an irritating gas in the production processes, and which is not increased in the viscosity of a polyester resin even ...
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WO/2015/082533A1 |
The present invention relates to compounds according to Formula I: Wherein: A11 - A14 are N or CR11, CR12, CR13, CR14, respectively, with the proviso that no more than two of the four positions A can be simultaneously N; R1 is C(1-6)alky...
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WO/2015/078802A1 |
The present invention relates to compounds of general formula (I), wherein the groups R1, R2, R3, X, m and n are defined as in claim 1, wich have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate ...
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WO/2015/081188A1 |
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an omega-(arylsulfonyl)alkylnitrile compound, or a pharmaceutically acceptable salt thereof. The present invention is ...
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WO/2015/080217A1 |
A purpose of the present invention is to provide a coloring resin composition which has high color purity and satisfactory light resistance, and which develops a high contrast. Another purpose of the present invention is to provide: a co...
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WO/2015/076395A1 |
The present invention addresses the problem of providing: an acid- and radical-generating agent which has high sensitivity to an active energy ray having a wavelength of about 300 to 450 nm, can exhibit both high acid-generating ability ...
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WO/2015/074281A1 |
The present application relates to rigosertib salt and a crystal form thereof. Compared with existing rigosertib salt, the rigosertib salt and the crystal form thereof in the present application has advantages on crystallinity, crystal h...
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WO/2015/072463A1 |
In the production of crops in agriculture, horticulture, and the like, damage by destructive insects is still great, and the development of novel agricultural/horticultural insecticides is desired due to the occurrence of destructive ins...
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WO/2015/064584A1 |
The present invention produces various triarylmethane compounds at a high yield and by means of few steps by means of reacting a diaryl methyl aryl sulfone compound represented by the formula CHAr1Ar2SO2Ar (where Ar1, Ar2, and Ar are sub...
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WO/2015/062103A1 |
Disclosed are a refining method for 2-nitro-4-methylsulfonyl benzoic acid and an intermediate thereof. The method comprises the following steps of: synthesizing an intermediate organic ammonium salt (III) in an organic solvent using a cr...
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