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Matches 1 - 50 out of 11,033

Document Document Title
WO/2021/069927A1
The disclosures herein relate to novel compounds of formula (1): (1) and salts thereof, wherein A, X, R1, R2, R3, R4, R10 and R11 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk o...  
WO/2021/069567A1
The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositio...  
WO/2021/071372A1
The invention relates to an improved process of vitamin K2 derivatives preparation via the alkylation of the menadione-cyclopentadiene adduct.  
WO/2021/067799A1
The present application provides methods and compounds of modulating Nrf2 pathway. Methods for treating cancer and neurodegenerative conditions are also provided.  
WO/2021/060517A1
The present invention provides a novel method for producing a derivative of an organic substance that contains one or more groups selected from the group consisting of a sulfanyl group, a selanyl group and a sulfino group. A method for p...  
WO/2021/037683A1
The invention relates to a process for purifying 4,4'-dichlorodiphenyl sulfone comprising: (a) providing a suspension comprising particulate 4,4'-dichlorodiphenyl sulfone in carboxylic acid, (b) carrying out a solid-liquid separation of ...  
WO/2021/037677A1
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfone comprising reacting a solution comprising 4,4'-dichlorodiphenyl sulfoxide and at least one linear C6-C10 carboxylic acid as solvent with an oxidizing agent to...  
WO/2021/037672A1
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfone, comprising: (a) reacting 4,4'-dichlorodiphenyl sulfoxide and an oxidizing agent in at least one carboxylic acid as solvent to obtain a reaction mixture compr...  
WO/2021/037675A1
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfone, comprising: (I) reacting thionyl chloride, chlorobenzene and aluminum chloride forming an intermediate reaction product and hydrogen chloride; (II) mixing aq...  
WO/2021/037682A1
The invention relates to a process for purifying crude 4,4'-dichlorodiphenyl sulfone comprising: (a) dissolving the crude 4,4'-dichlorodiphenyl sulfone which may contain water in an organic solvent in which 4,4'-dichlorodiphenyl sulfone ...  
WO/2021/036845A1
Provided is a substituted benzoyl compound and an application thereof; specifically, provided is a compound represented by formula (I), a preparation method therefor and a use thereof as an herbicide. Q is optionally substituted oxocyclo...  
WO/2021/037680A1
The invention relates to a process for obtaining 4,4'-dichlorodiphenyl sulfone from an organic mixture comprising 4,4'-dichlorodiphenyl sulfone and a linear C6 to C10 carboxylic acid as organic solvent, comprising: (a) cooling the organi...  
WO/2021/037797A1
The invention relates to crystals (C) consisting of at least 98 % by weight of 4,4'- dichlorodiphenylsulfone, 0 to 2 % by weight of impurities and 0 to 2 % by weight of at least one solvent (c). Moreover, the present invention relates to...  
WO/2021/020429A1
The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.  
WO/2021/012014A1
The present invention relates to methods for preparing a variety of difluorohaloallylamine derivatives. The present invention also relates to novel difluorohaloallylamine derivatives that are capable of inhibiting certain amine oxidase e...  
WO/2021/007840A1
Provided is a carbamate-substituted styryl sulfone compound, a preparation method, and an application thereof. The carbamate-substituted styryl sulfone compound has a structure represented by general formula I. The carbamate-substituted ...  
WO/2021/007663A1
This disclosure relates to cannabinoid derivatives of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor ...  
WO/2021/007478A1
Provided herein are sulfone compounds, for example, a compound of Formula A, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant there...  
WO/2020/257573A1
The invention provides crystalline salt and cocrystal forms of bempedoic acid. Also provided are compositions and pharmaceutical materials including a crystalline salt or cocrystal form of bempedoic acid as well as methods of treating va...  
WO/2020/257571A1
The invention provides methods of preparing 8-hy droxy-2,2, 14,14- tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hy droxy-2,2, 14, 14-tetramethylpentadecanedioic acid. ...  
WO/2020/257093A1
The present invention is directed to a method for treating Asthma. The method comprises administering to a subject in need thereof 3-methanesulfonylpropionitrile (dapansutrile), or a pharmaceutically acceptable solvate thereof, in an eff...  
WO/2020/251012A1
Provided is are an agricultural and horticultural agent, in particular a compound which is useful as the active ingredient of an agricultural and horticultural pest control agent, a mite control agent, a nematode control agent or a disea...  
WO/2020/239568A1
There is disclosed a salt of Formula III, a method for manufacturing thereof as well as uses thereof. ( Formula III ), wherein X is H or OH, Y is H or a cation selected from the group consisting of Li, Na and K, is a single bond or a dou...  
WO/2020/238779A1
The present invention relates to a method for synthesizing florfenicol. The method comprises the steps of: using sulfuryl fluoride as a fluorinating reagent to fluorinate compound I to obtain a product, and then performing a ring opening...  
WO/2020/229685A1
A pharmaceutical composition or combination product comprising certain polyunsaturated long-chain ketones in combination with certain protein kinase inhibitors, in particular phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors (PI3...  
WO/2020/221960A1
The present invention relates to a stable formulation comprising at least one organic solvent selected from a group consisting of aliphatic esters and cyclic esters, and a compound of Formula (I).  
WO/2020/212543A1
The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalm...  
WO/2020/207929A1
The invention relates to a process for working up a composition comprising solid 4,4'- dichlorodiphenyl sulfoxide and a solvent, wherein the amount of solvent in the composition is in the range between 5 and 25 wt% based on the total mas...  
WO/2020/186632A1
The present application relates to a benzidine compound and an application thereof, the benzidine compound having the structure as shown in formula I below. Further provided in the present application are a pharmaceutically acceptable sa...  
WO/2020/187795A1
The invention relates to an anionic surfactant of general formula (I) or general formula (II) or mixtures thereof, in which R represents hydrogen or a linear or branched alkyl, alkenyl, alkyl-aryl or alkenyl-aryl group with 5 to 25 C ato...  
WO/2020/142764A4
The present application relates to new HtrA inhibitors and use thereof. Additionally, the present application also relates to new peptides for inhibiting CagA and use thereof.  
WO/2020/161225A1
The invention relates to a process for purifying 4,4'-dichlorodiphenyl sulfoxide comprising: (a) providing a suspension comprising particulate 4,4'-dichlorodiphenyl sulfoxide in monochlorobenzene, (b) solid-liquid separation of the suspe...  
WO/2020/161228A1
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfoxide comprising: (I) reacting thionyl chloride, chlorobenzene and aluminum chloride in a molar ratio of thionyl chloride : chlorobenzene : aluminum chloride of 1...  
WO/2020/161226A1
The invention relates to a process for obtaining 4,4'-dichlorodiphenyl sulfoxide from a liquid mixture comprising 4,4'-dichlorodiphenyl sulfoxide and a solvent, comprising: (a) cooling the liquid mixture to a temperature below the satura...  
WO/2020/102901A8
Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium...  
WO/2020/142764A1
The present application relates to new HtrA inhibitors and use thereof. Additionally, the present application also relates to new peptides for inhibiting CagA and use thereof.  
WO/2020/135000A1
Disclosed is a preparation method for 3-phenyl-L-serine or derivatives thereof, comprising the following steps: a. obtaining 3-phenyl-L-serine or derivatives thereof on the basis of the reaction formula represented by Formula I, wherein ...  
WO/2020/127960A1
The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.  
WO/2020/127675A1
Described are colour developers of formula (I) Ar1-SO2-NH-C6H4-SO2-C6H4-NH-CO-NH-Ar2 (I), a heat-sensitive recording material, comprising a base substrate and also a heat-sensitive, colour-forming layer comprising at least one colour for...  
WO/2020/102901A1
Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium...  
WO/2020/094917A1
The present invention relates to a process for the preparation of arylsulfonylpro- penenitriles. The reaction starting from arylsulfonyl halides is catalyzed by a cat- alyst compound comprising a transition metal. The process is scalable...  
WO/2020/086789A1
The present disclosure encompasses crystalline polymorphs of Rigosertib Sodium, processes for preparation thereof, and pharmaceutical compositions thereof.  
WO/2020/074964A1
The present disclosure relates to compounds of the general formula (I): wherein R1, R2, R3, R4, R5, R6, and R7 may be chosen from different substituents; n is 0, 1, or 2; and X is a hydroxymethyl or a carboxylic acid or a derivative ther...  
WO/2020/063821A1
A polypeptide conjugate of ODN or a derivative thereof, and a preparation method therefor, the conjugate is a compound represented by formula (I): (I) the compound has the characteristics of good targeting, strong biological activity, lo...  
WO/2020/024017A9
The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human sub...  
WO/2020/046975A1
Described herein are methods of treating or preventing an ASK1 or DYRK1A associated disease, disorder, or condition comprising administering to a subject in need thereof a dual inhibitor of ASK1 and DYRK1A; including administering pharma...  
WO/2020/035560A1
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl...  
WO/2020/024017A1
The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human sub...  
WO/2020/011750A1
The invention relates to the field of biological fungicides with a broad range of antifungal activity coming from plant extracts from the order of Brassicales or molecules revealing similar chemical structure. In particular, Applicants s...  
WO/2020/006778A1
The invention belongs to the field of chemical synthesis and discloses a new crystal form of tembotrione, which is a herbicide, a preparation method thereof, and an application thereof as a preparation for plant protection. The present i...  

Matches 1 - 50 out of 11,033