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WO/1992/003050A1 |
Fungicidally effective compounds of formula (I) are disclosed.
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WO/1992/002487A1 |
Diamine compounds represented by general formula (I) and acid addition salts thereof, and a brain protecting agent containing the same, wherein R1 to R6 may be the same or different from one another and each represents hydrogen, halogen,...
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WO/1992/002481A1 |
Novel arylcycloalkanepolyalkylamines useful as anti-psychotic, anti-ischemia, anti-stroke, anti-dementia and anti-convulsant agents. These arylcycloalkanepolyalkylamines are selective high-affinity ligands to the sigma binding-sites cont...
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WO/1992/000952A1 |
A compound for use as a medicine having formula (I), a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R?1¿ and R?2¿ each independently are hydrogen, C¿1-6?alkyl or C¿3-6?cyclo...
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WO/1991/016299A1 |
A method for control of plant disease, especially fungus, using compounds of formula (I) and novel compounds within the class, wherein: A is C(=O)R, C(=O)OR1, C(=O)SR1, P(=O)QR2Q1R3; C(=O)NHR, SO2R5, SO2NR6R7; Q and Q1 are independently ...
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WO/1991/013055A2 |
Aryl- and heteroarylethenylene derivatives of formula (I) wherein Y is a mono- or bicyclic ring system chosen from (A), (B), (C), (D), (E), (F) and (G); R is a group of formula (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j) in which ...
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WO/1991/012227A1 |
An aromatic oligomer comprising repeating structural units of formula (I) and having a number-average degree of polymerization of 2 to 10 and a flow temperature of 100 to 400 �C, wherein X is selected between O and S; Ar is selected fr...
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WO/1991/010652A1 |
Thioformamide derivatives of formula (I), in which R represents alkyl, Y represents methylene, ethylene or a direct bond, A represents optionally substituted phenyl or heterocyclyl and: R1 represents hydrogen, and R2 represents an N-alky...
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WO/1991/009840A1 |
Mercaptocycloacyl aminoacid inhibitors of endopeptidase of formula (I) or a pharmaceutically acceptable salt thereof, wherein -A- is a 4-, 5- or 6-membered optionally substituted alkylene chain; a 4-, 5- or 6-membered optionally substitu...
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WO/1991/005761A1 |
A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of com...
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WO/1991/004246A1 |
Amino acid drivatives, enkephalinase and ACE inhibitors, of the formula (Ia) and (Ib), wherein R1 represents a biphenyl group or one of the groups (a), wherein Z, Y and n have the meanings (b) or (c), wherein R'1, represents a hydrogen a...
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WO/1991/003544A1 |
The present invention provides novel hydrolytic enzyme inhibitors (inactivators) and substrates that have three functional parts: 1) a moiety that is specifically cleavable upon contact of the compound with a specific hydrolytic enzyme w...
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WO/1991/002716A2 |
Compounds of general formula (I) wherein R1 represents a hydrogen atom or a C1-C6 alkyl, C1-C6 alkenyl, phenyl, phenyl(C1-C6)alkyl, C1-C6 alkylthiomethyl, phenylthiomethyl, substituted phenylthiomethyl, phenyl(C1-C6)alkylthiomethyl or he...
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WO/1991/001297A1 |
The invention relates to new 2-amino-7-carbamoyl-1,2,3,4-tetrahydronaphthalenes, a process for preparing them and their use as drugs.
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WO/1991/000725A2 |
A CCK antagonist compound of formula (I) wherein G is (1) NH2 or (2) substituted amino; R9 is (1) hydrogen, (2) loweralkyl, (3) carboxy-substituted alkyl or (4) carboxyester-substituted alkyl; R10 is (1) hydrogen, (2) loweralkyl, (3) fun...
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WO/1990/015047A1 |
This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of formula (I). These compounds are useful to treat central nervous system disorders, hypertension, diabetes, sexual im...
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WO/1990/012784A1 |
A method for control of plant disease, especially fungus, using compounds of formula (I) and novel compounds within the class (I), wherein: A is C(=O)R, C(=O)OR?1¿, C(=O)SR?1¿, P(=O)QR?2¿Q?1¿R?3¿; C(=O)NHR, SO¿2?R?5¿, SO¿2?NR?6¿...
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WO/1990/012003A1 |
Novel mercapto-acylamino acids of the formula (I), wherein Q is hydrogen or R7CO-; R1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R2 is hydrogen; lower alkyl; cyclolower alkyl; lower alkyl substituted with hydroxy, lower alkoxy...
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WO/1990/006911A1 |
Process for the preparation of acetoacetates and other beta-ketoesters is provided, involving reaction of nitrogen, oxygen or sulfur nucleophiles with a tertiaryalkyl acetoacetate or tertiaryalkyl beta-ketoester.
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WO/1990/005719A1 |
Compounds of general formula (I), wherein R1 represents hydrogen or an alkyl, phenyl, thiophenyl, substituted phenyl, phenylalkyl, heterocyclyl, alkylcarbonyl phenacyl or substituted phenacyl group; or, when n = 0, R1 represents SRX, whe...
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WO/1990/004587A1 |
4,4'-Bis(methacryloylthio)diphenyl sulfide represented by formula (I) and two curable compositions containing same are disclosed. One composition comprises (A) the sulfide of formula (I) and (B) at least one compound selected from the gr...
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WO/1990/003364A1 |
Novel mercapto-acylamino acids of formula (I), wherein R1 is H or R5CO-; R2 is Y-C6H4-, Y-C6H4S-, Y-C6H4O-, Y-C6H4CH2S-, Y-C6H4CH2O-, naphthyl, furyl, thienyl, benzofuryl, benzothienyl, diphenylmethyl or (a); R3 is -OR6, -NR6R7 or (b); R...
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WO/1990/000543A1 |
The present invention relates to an aminoacetonitrile derivative or salts thereof, having formula (I), wherein R represents an alkyl group which may be substituted by phenyl groups (which may be substituted by halogen atoms or C1-3 alkyl...
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WO/1989/012624A2 |
This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second group reactive toward nucleophiles such ...
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WO/1989/012625A1 |
A bifunctional coupling agent for joining a sulfhydryl-containing protein or peptide and a metallic radionuclide comprising a sulfhydryl selective electrophile, a chelator containing at least one protected thiol and an organic linking ra...
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WO/1989/012085A1 |
Molecular building beams, liquid crystals, and surfactants in the form of compounds based on [1.1.1]propellane, including poly[1.1.1]propellanes. Molecular building beams having a telomeric or polymeric chain staff, and linking groups fu...
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WO/1989/010917A2 |
Compound of formula (I), wherein R1, W, R2, Z, A and B have the meaning given in claim 1, process for producing it, and its use as a renin inhibitor in the treatment of hypertension and chronic cardiac insufficiency and in the treatment ...
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WO/1989/009765A1 |
This invention relates to novel compositions of matter and their methods of preparation, which compositions are esters with enhanced water solubility, for use in aqueous enzymatic resolution reactions of racemic mixtures of these esters....
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WO/1989/007890A1 |
Useful as antimicrobial agents are beta-substituted alpha-halo-acrylonitriles of formula (I), wherein X represents chlorine, bromine or iodine and R represents a lower alkyl, aryl, aralkyl, heterocyclyl, or thiocarbonyl group. These comp...
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WO/1989/008096A1 |
The invention relates to compounds having the formula (I) wherein the radical A is represented by the formula (II) wherein D is hydrogen, halogen, alkoxyl, G is oxygen or sulphur, J is alkyl, aryl or a heterocycle optionally substituted,...
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WO/1989/005796A1 |
Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension are disclosed.
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WO/1989/005791A1 |
Disclosed herein are N-naphthoylglycines and methods of their preparation. The N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
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WO/1989/003177A1 |
This invention relates to condensation polymers of thiolactic and thioglycolic acids. These polymers, as well as thiolactic acid, 2,2'-dithiobisacetic acid, and 2,2'-dithiobispropanoic acid, increase both the rate of plant growth and the...
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WO/1989/003416A1 |
Compounds having the formula (I): R1-(CO)m-S-aryl-Z1-(A1-Z2)n-A2-R2, in which R1, R2, aryl, Z1, Z2, A1, A2, m and n have the meaning defined in claim 1 are used as components of ferroelectric liquid crystalline phases. The invention also...
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WO/1989/002450A1 |
This invention relates to novel polymeric polyamines containing internal urea, biuret, thiourea, dithiobiuret, and/or thioamide moieties, and to polymers prepared therefrom. This invention also relates to novel isocyanate-functional prep...
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WO/1989/000427A1 |
The invention concerns the pharmaceutical therapeutic use of a thiol derivative of glutathione having the formula (I). Glutathione therapy permits the correction of numerous abnormalities of cellular metabolism, and hence the cure of num...
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WO/1988/007514A1 |
Tolanes having the formula (I): R1-(A1-Z1)m-A3-C=C-A4-(A2)n-R2, in which R1, A1, Z1, m, A3, A4, A2, n and R2 are as given in claim (1), and application of said tolanes as components of liquid crystal phases, particularly as components of...
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WO/1988/007582A1 |
This invention relates to the resolution of racemic mixtures of optically active compounds, including but not limited to the stereochemical purification of chiral organic esters, amides, carboxylic acids, alcohols, and amines. Novel meth...
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WO/1988/006154A1 |
Molecular systems formed from ordered heterometallic chains containing A and B ions with different spins, connected by bis-bidentate ligands which, due to their substituent (s), are capable of creating a strong steric hindrance around th...
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WO/1988/005050A1 |
A renin inhibiting compound of formula (I), wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl-m...
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WO/1988/002363A1 |
The derivatives have the general formula (I) wherein R1 is an optionally mono or polyhalogenated aliphatic acyl group, a benzoyl or phenacetyl group which may carry on the phenyl residue one to three halogeno or alkyl substituents, an al...
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WO/1988/000227A2 |
Polymerizable liquid crystal materials and polymer materials displaying liquid crystal phases, which have mesogenous groups linked directly or via a spacer, which groups contain at least one transversely polarizing structural element of ...
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WO/1987/005781A2 |
Synergistic plant growth regulator compositions containing (i) an ethylene response or ethylene-type response inducing agent and (ii) a malonic acid derivative compound. This invention also relates to the use of said compositions for ind...
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WO/1987/005898A2 |
Method for retarding plant growth by applying to the plant an effective amount of a malonic acid derivative compound. This invention also relates to novel malonic acid derivative compounds and processes for the preparation thereof.
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WO/1987/005897A2 |
Malonic acid derivative compounds, processes for their preparation and their use for increasing crop yield.
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WO/1987/005014A1 |
Compounds represented by general formula (I), (wherein Y-Z represents (II), -CH=CH- or -CH2CH2-, R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents hydrogen, alkyl, optionally substituted alke...
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WO/1987/004427A2 |
A process for the preparation of a compound of formula (I), wherein X and X' each represents hydrogen or together represent a bridging group -CH2-, -CH2-CH2- or -O-; R1 is a 6-carboxyhex-2-enyl group or a modification thereof in which th...
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WO/1987/004155A1 |
Hexasubstituted cyclokexane compounds have the formula (I), in which Z1 is -CO-X1-, -X1-CO-, -CH2-X2-, -X2-CH2- or -CH2- or - CH2-CH2-, Z2 has one of the meanings of Z1 or is a simple bond, Z3 is -X1-CO- or -X2-CH2- X1 is O, S or Se, X2 ...
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WO/1986/002639A2 |
The drug comprises a preparation of sodium diethyldithiocarbamate purified by dissolution in water.
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WO/1986/002348A1 |
A method for the preparation of monomers, especially aromatic ester monomers, which comprises reacting a stannylated compound generally of formula (I) or formula (II), where A1 is usually an aromatic group and A3 is usually an aromatic g...
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