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WO/1985/000167A1 |
The present invention relates particularly to chemical compounds having the formula (I), R1-CO-NR3- ADA BD-S-R2 wherein R1 is a radical corresponding to an amino acid R1-COOH, ADA BD is an alkylene radical at C2 or C3 which may be substi...
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WO/1984/000875A1 |
Methods for the treatment of physiological disorders, including protozoal infections in mammalian and avian species and gastrointestinal and cardiovascular disorders in mammalian species by administering a class of aralkyl- and aralkenyl...
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WO/1984/000032A1 |
1-amino-4-oxy-3-(mercapto-alkyl)-(unbranched chain)-benzenes, having particularly the formula (I) wherein R and R2 are hydrogen or an alkyl residue with 1 to 6 atoms of carbon, R' is hydrogen, an alkyl residue with 1 to 6 atoms of carbon...
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WO/1983/001617A1 |
A composition of matter comprising an acrylamido-acyl or methacrylamido-acyl oligomer derived from at least one nucleophilic oligomer having at least one amino-, hydroxyl-, or thiol-substituted polyoxyalkylene, polyalkyleneimine, polyest...
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WO/1980/000964A1 |
New compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of producing said compounds and compositions, the no...
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WO/1980/000023A1 |
Compounds of formula: (FORMULA) wherein R1 is an optionally substituted alkoxy, alkanyloxy, phenoxy, alkylthio, phenylthio or amino group and R2 is a chloro and/or trifluoromethyl-substituted phenyl or phenoxyphenyl group. A typical exam...
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JP2024010532A |
An object of the present invention is to provide a compound intermediate that exhibits excellent reactivity with a substance that has affinity for antibodies. [Solution] The following formula (1): [In the formula, F represents a fluorine...
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JP2023184620A |
To provide methods for site-selectively crosslinking payloads to antibodies and other proteins.The foregoing problem is solved by using traceless affinity labels designed to label target proteins with bio-orthogonally reactive entities (...
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JP7082861B6 |
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr...
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JP7402467B2 |
The purpose in one embodiment of the present invention is to provide a therapeutic for Parkinson's disease, etc. A compound represented by formulas (1), (2), or (8) or a pharmacologically acceptable salt thereof can be used in the treatm...
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JP2023551653A |
The present invention relates to compounds of formula I or salts or solvates thereof, combinations containing the same, uses and methods thereof, and kits containing the same. [Formula 1] [Selection diagram] None
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JP2023164361A |
To provide: ionizable lipid compounds or pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof; nanoparticle pharmaceutical compositions comprising the compounds; and application of the compounds and th...
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JP7375685B2 |
A chemically amplified resist composition comprising a quencher containing an ammonium salt of a carboxylic acid having an iodized or brominated hydrocarbyl group exclusive of an iodized or brominated aromatic ring and an acid generator ...
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JP2023543442A |
The present disclosure generally relates to novel sulfur-containing glycerol monoester derivatives and methods useful for treating Gram-positive, Gram-negative, fungal and enveloped viral infections in patients.
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JP2023145722A |
To provide molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and pr...
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JP2023126883A |
To provide novel thiol compounds and applications thereof, and specifically, novel thiol compounds, methods for synthesizing the thiol compounds, curing agents containing the thiol compounds, resin compositions containing the curing agen...
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JP2023538768A |
The present invention provides compounds of general formula (Ia) and Pseudomonas aeruginosa (P.aeruginosa) concerning its use as an inhibitor of the virulence factor LasB. These compounds are useful in treating bacterial infections, part...
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JP7338711B2 |
An object of the present invention is to provide a DP receptor antagonist. A compound represented by general formula (I):(wherein all symbols are as shown in the specification) and a pharmaceutically acceptable salt thereof have DP recep...
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JP2023070184A |
To provide a novel thioester derivative and a method for producing the same, a novel ketone derivative and a method for producing the same, a novel method for producing a C-arylhydroxyglucoside derivative, and a novel method for producin...
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JP2023066301A |
To provide a novel compound derived from botryococcene or squalene having antioxidant activity, a method for producing the same, and an antioxidative composition comprising such a novel compound as an active ingredient.This invention has...
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JP2023063361A |
To provide lipid-therapeutic nucleic acid compositions that are suitable for general therapeutic use.The invention provides a lipid having a structure represented by formula XXXIII or XXXVIII, or a salt or isomer thereof.SELECTED DRAWING...
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JP2023518205A |
The present invention relates to the treatment of disorders associated with oxidative stress, including neuropathic pain, and to small synthetically derived compounds for treating such disorders. [Selection drawing] Fig. 1a
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JP2023514711A |
An isotopically modified polyunsaturated lipid containing a 1,4-diene system comprising selective isotopic modification of one or more bis-allyl positions of the polyunsaturated lipid in the presence of a transition metal catalyst. Metho...
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JP7229189B2 |
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr...
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JP2023008839A |
To provide a novel compound, a flavor imparting composition and consumable, a method of imparting flavor to a perfume composition, and a method of imparting flavor to consumable.Provided are a compound represented by the following formul...
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JP2022186263A |
To provide a method for producing a carboxylic thioester that can be produced by a simple operation, allows reduction in the amount of waste, and has sustainability.A method for producing a carboxylic thioester includes reacting a carbox...
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JP7179431B2 |
To provide a novel sulfur-containing compound and flavoring agent; consumer goods, a method for improving flavor of the perfume composition, and a method for improving flavor of the consumer goods.This invention provides: a sulfur-contai...
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JP2022548312A |
The present application relates to lipids of formula (A-1) and compositions therewith. Lipid nanoparticles (eg, empty LNPs or loaded LNPs) include such lipids as well as additional lipids such as phospholipids, structured lipids, PEG lip...
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JP7168656B2 |
A method for producing an organic mercapto compound or an intermediate thereof according to the present invention has a reaction step of reacting an alcohol compound including a sulfur atom with a thioamide compound having a structure in...
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JP2022163090A |
To provide: novel cationic (amino) lipids and lipid particles comprising these lipids, which are advantageous for the in vivo delivery of effective components, such as nucleic acids; nucleic acid-lipid particle compositions suitable for ...
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JP2022542607A |
The present invention relates to novel amino ester compounds or pharmaceutically acceptable salts or optical isomers, racemates, diastereomers, enantiomers or tautomers thereof. The invention also relates to processes for their preparati...
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JP2022137128A |
To provide small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on...
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JP2022538009A |
The present invention is a novel isolated succinic acid as a free compound or a salt, hydrate, solvate or complex thereof that is cell permeable and intended to increase mitochondrial ATP production. Offer prodrugs. The compounds are use...
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JP7112464B2 |
where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
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JP7105916B2 |
Disclosed are a glycerol derivative that is useful for improving, preventing or treating inflammation-related diseases by inhibiting overexpression of various inflammatory cytokines such as IL-4, IL-6 and so on, or chemokine CXCL8 and re...
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JP2022101520A |
To provide a pharmaceutical composition that is useful for the prevention and/or treatment of diseases caused by activation of EP2 receptor.Since the compound represented by the general formula (I-A) (all symbols in the formula have the ...
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JP2022091500A |
To provide: a highly safe and industrially usable thionizing agent; and a method for manufacturing a sulfur-containing compound by using the thionizing agent.A thionizing agent is composed of a reaction liquid between phosphorus sulfide ...
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JP2022080772A |
To provide a thioester derivative and a ketone derivative which are novel compounds, and production methods of the compounds.A thioester derivative represented by the following formula (II) is provided. In the formula (II), R1, R2, and R...
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JP7052195B2 |
According to the present invention, there is provided a method for producing carboxylic acid thioester, comprising reacting a compound represented by the following formula (I), carboxylic acid and thiol in the presence of a catalyst incl...
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JP2022520518A |
The present disclosure relates to compounds of formula (I), (II), or (II'), [Chemical 1] Or the pharmaceutically acceptable salt or solvate thereof. The present disclosure also relates to pharmaceutical compositions containing compounds,...
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JP2022520458A |
Equation (X) A method for synthesizing a compound of the above is provided. R2Is -H, -C1-C4-Alkyl, -C2-C4-Alkenyl and C1-C4-Selected from aryl; R3Is -C (O) H and -C (O) C1-C4-Selected from alkyl; A is a pharmaceutically acceptable anion ...
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JP2022029075A |
To provide a method for efficiently producing a thioester derivative.The production method includes: in the presence of at least one of an alkyl magnesium halide and an aryl magnesium halide, bringing a lactone derivative represented by ...
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JP2022029068A |
To provide a method for efficiently producing a thioester derivative.The production method includes: in the presence of a dialkyl aluminum hydride, bringing a lactone derivative represented by formula (1) into contact with a thiol repres...
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JP2022029051A |
To provide a method for efficiently producing a thioester derivative.The production method includes: in the presence of a dialkyl aluminum halide, bringing a lactone derivative represented by formula (1) into contact with a thiol represe...
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JP6998864B2 |
The present invention relates to an industrial process for the preparation of (5S,10S)-10- benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trith
ia-12-azahenicosan-5-aminium (E)-3-carboxyacrylate salt of following formula (I) : wh...
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JP2022507020A |
A pharmaceutical composition comprising a compound useful for treating cancer and the above-mentioned compound is provided herein. Certain cancers include those mediated by YAP / TAZ or regulated by the interaction between YAP / TAZ and ...
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JP2021525240A |
Cationic lipids that are compounds of formula (I), (II), (III), (IV), (V), or (VI) are disclosed. The cationic lipids provided herein can be useful for the delivery and expression of mRNA and encoded proteins, for example as components o...
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JP6923534B2 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing suc...
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JP6923539B2 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing suc...
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JP6895187B2 |
An object of the present invention is to provide a benzylamide compound or a salt thereof that controls a mite. The present invention provides a benzylamide compound represented by Formula (1): or a salt thereof, wherein R1 represents C1...
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