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WO/2010/094992A1 |
The invention pertains to the field of life necessities and more particularly relates to the cosmetic and/or dermatological fields, in particular the field of weight loss. The invention more particularly relates to esters or amides of co...
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WO/2010/086429A2 |
(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pa...
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WO/2010/083307A2 |
The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.
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WO/2010/070132A1 |
The present invention relates to thioic acids according to formula (II) suitable as building block for polythioesters; Wherein X is O, N or S and whereby R1 is chosen from (-CH2-)2, -CH2-O-CH2- or (-CH2-)3, R2 is preferably chosen from a...
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WO/2010/069859A1 |
The invention is concerned with novel compound of formula (I) wherein R, R2 and Q are as defined in the description and in the claims, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceu...
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WO/2010/065512A2 |
The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex...
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WO/2010/048284A1 |
The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I):,...
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WO/2010/048191A1 |
The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia): wherein, R3, R4, R5, R6, R7, P, Q, T, V, W, X, Y, Z, a, m and n are as defined in the description, compositions thereof, processes for their pr...
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WO/2010/048293A1 |
The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): ...
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WO/2010/037271A1 |
A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have inhibiting the c...
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WO/2010/036147A1 |
The invention relates to new biologically active compounds which can be used for suppressing pathogenic bacteria, in particular for acting on the type III secretion system in pathogens. The biologically active compounds are in the form o...
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WO/2010/011284A2 |
The invention relates to the compositions of synthetic oligo-β-(l →6)-2-amino-2- deoxy-D-glucopyranosides conjugated to carriers, and methods for making and use same.
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WO/2009/153181A1 |
The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutical active compounds.
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WO/2009/147682A1 |
The present invention provides new tyrphostin derivatives acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including suc...
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WO/2009/132832A2 |
The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.
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WO/2009/121789A1 |
A process for the preparation of a compound of Formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
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WO/2009/123704A2 |
Disclosed herein are methods of preparing a bis(thio-hydrazide amides) compounds of the following structural formula: wherein R1, R2, R3, R4, R5, R6 and R13 are defined herein.
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WO/2009/107799A1 |
Disclosed is a novel process for producing a 2-aryl-3-hydroxy-4-substituted-carbonylthiophene compound, which is a compound useful as an intermediate for the production of a pharmaceutical agent or an agricultural agent or an intermediat...
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WO/2009/105257A1 |
Disclosed are compounds of Formula (I) and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural ...
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WO/2009/100431A1 |
The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and c...
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WO/2009/073148A2 |
At least 70% by weight of Compound 1 is the single crystalline form, Form A, Form C, or Form D, of the compound. A pharmaceutical composition comprises a pharmaceutically acceptable carrier or diluent, and compound 1, wherein at least 70...
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WO/2009/073147A2 |
Disclosed herein are methods of preparing a bis(thio-hydrazide amides) compounds of the following structural formula (I): wherein R1, R3 and Y are defined herein.
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WO/2009/064031A1 |
There is provided a compound having an excellent controlling effect on pests, represented by the formula (I): wherein, A and E independently represent a -R1 group, a -L1-R1 group, etc.; G represents a -L2-R1 group, a -S(O)2-R4 group, etc...
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WO/2009/052148A1 |
A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided. The methods may be used to make functional...
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WO/2009/026701A1 |
This invention relates to compounds and methods for the inhibition of sirtuin enzymatic activity. More particularly, the invention provides for compounds of formula (I), Y__L__Z__D, and N-oxides, hydrates, solvates, pharmaceutically acce...
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WO/2009/020631A2 |
Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer inductio...
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WO/2009/014267A2 |
There is provided a compound having an excellent controlling effect on arthropod pests represented by the formula (I-1): wherein Z represents an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; G ...
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WO/2008/149962A1 |
The present invention provides a thioimidate compound having an excellent control efficacy against pests, which is represented by the formula (I): wherein R represents a C6-12 bicycloalkyl group or a C1-3 alkyl group substituted with a C...
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WO/2008/130571A1 |
The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention a...
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WO/2008/108735A1 |
The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl) propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl) propionic acid derivatives, benzoic acid derivatives, and d...
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WO/2008/096509A1 |
Disclosed is a polymerizable optically-active compound represented by the general formula (1). The polymerizable optically-active compound has a high helix-inducing ability and therefore, when added to a liquid crystal composition, can a...
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WO/2008/077170A2 |
The invention relates to the use of a compound of general formula (I), wherein Y is selected from among the group comprising thienyl, pyridyl, and formula (a), wherein each radical R represents hydrogen or a substituent selected from amo...
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WO/2008/074677A1 |
The present invention relates to a process for the preparation of 1 -(2-cthyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of, pharmaceutical active compounds, comprising reacting cyclohexanecar...
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WO/2008/067713A1 |
Compounds having substituted cyclopentane structure represented by formulas I-IV, their preparation methods, and useful as glucagon like peptide-1 receptor regulator for prevention and/or treatment of metabolic disorders (including, but ...
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WO/2008/068751A1 |
The present invention provides new tyrphostin derivatives acting as substrate competitive protein tyrosine kinase (PTK) inhibitors and receptor tyrosine kinase (RTK) inhibitors, methods of their preparation, pharmaceutical compositions i...
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WO/2008/033494A2 |
Disclosed herein is a method for the purification of bis(thiohydrazide amide) compounds of formula I, wherein R1, R2, R3, R4, R7, R8, Z and Y are defined herein, by dissolving the compound in a solvent selected from the group consisting ...
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WO/2008/024302A2 |
Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer inductio...
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WO/2008/024303A2 |
Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variabables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a prolifer...
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WO/2008/009118A1 |
Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enh...
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WO/2008/009127A1 |
The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatize...
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WO/2007/140611A1 |
Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are partic...
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WO/2007/126812A2 |
A process for the synthesis of bisfuran intermediates of formula (0) useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed. Furthermore disclosed is a HIV protease inhibitor of formula (IV) as well as variou...
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WO/2007/125196A1 |
This invention relates to compounds with the formula (I) given below or one of their pharmaceutically acceptable salts, as a medicine; Formula (I) of pharmaceutical compositions comprising one or more compounds with Formula (I) as active...
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WO/2007/118010A1 |
The present invention is directed (i) to a method for the preparation of a compound of formula (8) by condensing the compound of formula (7) with acetone and (ii) to a method for the preparation of a compound of formula (13) by alkylatin...
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WO/2007/112828A1 |
The invention relates to associations of xanthogenates and cyclodextrins, to pharmaceutical formulations thereof and to medicaments comprising these formulations for the treatment of Alzheimer's, viral diseases, tumour diseases, cardiova...
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WO/2007/113644A2 |
The present invention relates to novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, ph...
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WO/2007/105668A1 |
The invention provides a novel immobilized Lewis acid catalyst which exhibits high catalytic activity in an aqueous solution and which permits recovery and reuse or long-term continuous use. The invention relates to an immobilized Lewis ...
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WO/2007/096034A1 |
A process for preparing 3,4-disubstituted phenylacetic acids of the formula (I) in which X is fluorine, chlorine, bromine or iodine and R is C1-C4-alkylthio, C1-C4-alkylsulfonyl or C1-C4-alkylsulfoxide, starting from a 2-halo-C1-C4-alkyl...
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WO/2007/093530A1 |
The present invention relates to thioamide compounds of the general formula (I) and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the thioamide compound...
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WO/2007/095584A2 |
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, the...
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