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WO/2004/080938A1 |
A method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting a precursor thiol reagent with trichloroacetyl chloride to produce an S-alkyl and S-aryl trichloroacetyl thioester intermediate, which is reacted with an amine ...
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WO/2004/078706A1 |
The invention relates to a method for the production of an thioacetic acid and salts thereof of formulae (I) and (II), wherein Mn+ represents ammonium or an alkali metal cation, alkaline earth metal cation, aluminium cation or titanium c...
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WO/2004/074239A1 |
The invention relates to acylated aminopropanediols and the nitrogen and sulphur analogues thereof, having general formula (I), wherein R, R1, R2, R3, G2 and G3 are defined as in the claims. The invention also relates to pharmaceutical c...
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WO/2004/069241A1 |
The invention relates to the use of acylglycerols and the nitrogen- and sulphur-containing analogues thereof in therapy, particularly for the treatment of cerebral ischemia. The invention further relates to methods for preparation of sai...
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WO/2004/061094A1 |
Water-soluble thioester and selenoester compounds, their generators, as well as methods for making and using the same, are provided. The subject thioester and selenoester compounds are characterized by including an amino acid synthon hav...
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WO/2004/058174A2 |
This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in p...
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WO/2004/052872A1 |
ABSTRACT A novel haloalkene compound represented by the formula (I), useful as an active ingredient of a pesticide, is presented: wherein each of X¿1? and X¿2? is halogen, Y is a hydrogen atom, halogen, alkyl or the like, n is from 0 t...
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WO/2004/035533A1 |
The present invention relates to novel n-hydroxythiourea, urea and amide compounds as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to ...
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WO/2004/033414A1 |
Peptidomimetic compounds derived from aralkyl substitued 8-amino-3,7- or 3,6-dihydroxy alkenoic or alkanoic acids and compositions including those compounds, as well as methods of using and making the compounds are herein described. The ...
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WO/2004/024081A2 |
Disclosed are compounds of the formula: (I) where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's dis...
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WO/2004/024681A2 |
The invention relates to compounds having general formula (I), the preparation method thereof and the use of same in radical organic synthesis. The invention also relates to compounds having formula (II), the preparation method thereof a...
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WO/2004/022766A1 |
A process for easily producing an L-&agr -methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethy...
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WO/2004/020399A1 |
The present invention relates to a novel malononitrile compound represented by the formula (A): wherein, R¿1? represents C1 to C6 alkyl that may be substituted with halogen, C2 to C6 alkenyl that may be substituted with halogen, etc; RÂ...
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WO/2004/009533A1 |
Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by mo...
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WO/2004/007575A1 |
The invention relates to a method for producing a highly transparent plastic, obtained by the free radical copolymerisation of a blend containing compounds of formulae (I) and (II), in which the respective R1 variables independently of o...
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WO/2004/004648A2 |
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound ...
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WO/2003/104181A2 |
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and ...
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WO/2003/103651A1 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2003/099789A1 |
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-chalcogenmethylcarbonyl group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone ...
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WO2002044124A9 |
A three-dimensional molecular array on one of a conductor and semiconductor surface is disclosed. The array comprises at least one columnar stack comprising a plurality of substituted aromatic rings, wherein the aromatic rings of each co...
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WO/2003/093226A1 |
A process for synthesizing pharmaceutically active disulfides, particularly Dimesna and certain derivatives thereof. The process includes reacting an alkylene salt with a sulfurating reagent, then alkalizing the intermediate and flowing ...
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WO/2003/089405A1 |
The present invention relates to derivatives of hydroxyphenyl, a method for preparing thereof and their pharmaceutical composition, more particularly the compounds of the present invention specifically inhibit the activation of T lymphoc...
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WO/2003/084938A2 |
AbstractThe present invention relates to novel pyrimidone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their phar...
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WO/2003/084936A2 |
The present invention relates to novel amino substituted pyrimidinone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates...
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WO/2003/084935A2 |
The present invention relates to novel diaryl pyrimidinedione derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their ...
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WO/2003/084937A2 |
The present invention relates to novel pyrimidinedione derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmac...
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WO/2003/080631A2 |
Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using th...
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WO/2003/081295A1 |
The invention relates to an optical material suitable for lenses of eyeglasses and so on, which exhibits a high refractive index, a high Abbe number, and excellent heat resistance and is excellent in workability to generate little uncomf...
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WO/2003/078390A1 |
A novel phenolic compound; and a recording material containing the compound and having excellent storage stability. The phenolic compound is represented by the formula (I): (I) wherein m is an integer of 0 to 2; R1 and R2 each independen...
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WO/2003/078382A1 |
N-Biphenylamides represented by the general formula (1) have excellent control activities against plant diseases: (1) wherein R1, R2, R3, R4, and R5 are each independently hydrogen, halogeno, or the like; R6 is C1-6 alkyl or the like; R7...
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WO/2003/076072A1 |
A practical chiral zirconium catalyst, characterized in that a chiral zirconium catalyst is fixed on a zeolite. The practical chiral zirconium catalyst can maintain high catalyst activity after the storage for a long period of time, is s...
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WO/2003/076404A1 |
A chain oligolactic acid thioester having a thioester group at an end is produced as a single compound and isolated. It is a compound represented by the general formula (1) or a salt thereof: (1) wherein X represents hydrogen or a hydrox...
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WO/2003/070714A1 |
The present invention relates to a method for the synthesis of highly fluorinated compounds and to novel highly fluorinated compounds. In particular, the present invention relates to the synthesis of highly fluorinated acetals and ketals...
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WO/2003/066685A2 |
Polymers and copolymers synthesized by means that yield a narrow range of molecular weights can have different properties than polymers synthesized by conventional means. In order to obtain such polymers, however, polymerization must be ...
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WO/2003/062280A2 |
Disclosed are water soluble dithioesters capable of acting as chain transfer agents in preparing a vinyl-based polymer to control molecular weight and molecular weight distribution thereof as well as being capable of living polymerizatio...
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WO/2003/059869A1 |
A process for easily and industrially advantageously producing a high-purity 2-aralkyl-3-acetylthiopropionic acid and a high-purity 2-aralkylpropionic acid having a leaving group in the 3-position from easily available compounds. A 2-ara...
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WO/2003/059873A1 |
This invention relates to novel compounds characterized by the general Formula (I) any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof, or an N-oxide thereof, useful as potassium channe...
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WO/2003/055919A1 |
The invention provides a method for preparing an aqueous dispersion of polymer particles comprising the following steps: (i) preparing a dispersion having a continuous aqueous phase, a dispersed organic phase comprising one or more ethyl...
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WO/2003/051824A1 |
&agr -Cyanoacrylates of the formula (I), where: R1 is ORa wherein Ra is hydrogen, substituted alkyl, branched alkyl, branched alkenyl, cycloloalkyl, heterocyclyl, aryl, phenylalkyl or alkylÂimino; is NRbRc wherein Rb is hydrogen, alkyl ...
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WO/2003/051827A1 |
The invention relates to a process for the preparation of an enantiomerically enriched compound of formula (1) or a salt thereof, in which R?1¿ and R?2¿ each independently represent an (hetero)alkyl or (hetero)aryl group, wherein R?1¿...
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WO/2003/042168A1 |
The invention relates to &agr -oxygenated or &agr -thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitute...
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WO/2003/042167A1 |
The invention relates to $g(a)-oxygenated or $g(a)-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitu...
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WO/2003/037855A1 |
A high−purity thiocarboxylic acid or a salt thereof can be obtained by: reacting an acid halide or acid anhydride with a metal salt of hydrogen sulfide in the presence of a base&semi and&sol or adding an organic solvent having a relati...
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WO/2003/020690A1 |
Aryl sulfamate derivatives represented by the general formula (&Verbar ) or pharmacologically acceptable salts thereof: (&Verbar ) wherein Rr and Rs are each independently hydrogen or lower alkyl&semi R1, R2, R3, and R4 are each independ...
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WO/2003/014073A1 |
The invention concerns novel molecules, their preparation and their uses, in particular in the field of human and veterinary medicine and in cosmetics. The inventive compounds are partly fatty acid derivatives and exhibit advantageous ph...
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WO/2003/006428A1 |
One embodiment of the present invention is a compound represented by Structural Formula (I) wherein Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z ...
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WO/2003/006429A1 |
Disclosed is a method of preparing a thiohydrazide compound a formula (II) from a hydrazide starting compound of formula (I). The method comprises reacting the starting compound of formula (I) with a thionylating reagent. The thiohydrazi...
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WO/2003/006430A1 |
Disclosed is a compound represented by the Structural Formula (I); Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both $m(g)C=Z groups to ...
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WO/2003/005959A2 |
The present invention provides polymeric compounds that can form micelles in solutions. These compounds have a hydrophobic, core that is coupled to a plurality of hydrophilic moieties.
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WO/2003/002491A2 |
Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of $g(a), $g(b)-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) or are acid...
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