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WO/2003/000643A1 |
Nitrooxyderivative compounds or salts thereof having the following general formula (I): A-(B)¿b0?-(C)¿co?-NO¿2? (I) wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A = R-T¿1?-, wherein R is the radical of for...
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WO/2002/103103A2 |
Provided are fluorine-containing compounds, and polymers derived therefrom, for use in compositions used for treating textile subtrates. The present invention further provides methods of making fluorine-containing compounds and polymers ...
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WO/2002/102758A1 |
Provided are fluorine-containing compounds, and polymers derived therefrom, for use in compositions used for treating textile substrates. Also provided are methods of making fluorine-containing compounds and polymers derived therefrom, c...
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WO/2002/098849A2 |
Disclosed are compounds of formula X, where R¿n?, R¿20?, R¿1?, R¿2?, R¿3?, and R¿c? are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising c...
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WO/2002/098841A1 |
The present invention provides N-biphenylthiohydrazone derivatives of formula (I) and compositions and methods for the use thereof in the control of insect and acarid pests and for the protection of crops therefrom.
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WO/2002/098241A1 |
Flavour and fragrance compositions comprising 1-mercapto-1-arylalkanes or derivatives thereof according to formula (I).
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WO/2002/097393A2 |
Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
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WO2002060340A9 |
This invention relates to a method for identifying maxi-K channel blockers comprising using HEK-293 cells that have been stably transfected with both alpha and beta l subunits of the maxi-K channel and incubated with potassium channel bl...
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WO/2002/088061A1 |
A novel compound which is highly effective in ameliorating the cellular disorders caused by radicals and in inhibiting the neurotoxicity induced by excitatory neurotransmitters such as glutamic acid. It is a compound represented by the f...
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WO/2002/081437A2 |
The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R¿1? is hydrogen, alkyl, cycloalkyl or optionally...
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WO/2002/074298A1 |
IL-6 production inhibitors containing as the active ingredient hydroxamic acid derivatives represented by the following general formula (I) or equivalents thereto, non-toxic salts thereof or prodrugs of the same, (I) wherein each symbol ...
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WO/2002/074724A1 |
A method for an aldol reaction in water, characterized in that an aldehyde and an silyl enol ether is reacted in water as a medium in the presence of a boronic acid represented by the general formula (1): R?1¿R?2¿BOH (1) wherein R?1¿ ...
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WO/2002/068592A2 |
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners ther...
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WO/2002/064551A1 |
A compound selected from the group consisting of a compound of formula I or formula II: (I) (II) wherein n is 3 or 4 wherein Cx is selected from the group consisting of -COOM, COOR¿6?, -CHO, -CH¿2?OR¿7?, -CH¿2?OCOR¿8?, -CONHR¿9? an...
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WO/2002/064583A2 |
The invention relates to bis(alkylthio)carbenium salts of formula (I) wherein R?1¿, R?2¿, R?3¿ and Y?-¿ have the cited designations, and a method for the production of the same. The inventive compounds are advantageously suitable as ...
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WO/2002/064554A1 |
A thioacetamide compound represented by the formula (1) (1) which is useful as an intermediate for an acrylonitrile derivative serving as an active ingredient for medicines and agricultural chemicals, especially insecticides/acaricides; ...
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WO/2002/060863A1 |
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also ...
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WO/2002/048073A1 |
The invention relates to a method for producing compounds having at least one -CF¿2?-O bridge per molecule, according to which: a) an acid is added to at least one ketene dithioketal; b) the obtained bis(alkylthio)carbenium salt is reac...
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WO/2002/046141A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/046172A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/046181A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/042256A2 |
The present invention relates to N-alkylated GABA (Gamma-aminobutyric acid) compounds of Formula I, to processes for their preparation, to their use in therapy and to pharmaceutical compositions containing them. More particularly these c...
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WO/2002/036538A1 |
A process for producing an esterificated condensate, wherein a monomeric ester or thioester, or a polyester or polythioester is produced by carrying out a direct condensation reaction from a carboxylic acid and an equimolar amount of an ...
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WO/2002/030880A2 |
The invention relates to compounds of formula (I) wherein the substituents R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, X, Y, U, V and W have the designation cited in patent claim 1. The compounds are suitable for producing pharmaceuticals for fig...
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WO/2002/030867A2 |
Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B)¿b0?-(C)¿c0?-NO¿2? wherein A contains the radical of a drug having an antiiflammatory or analgesic activity, B is a bivalent ...
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WO/2002/030866A1 |
Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X¿1?-L-(W)¿p?-NO¿2? wherein A contains the radical of a drug, X¿1? and W are bivalent radicals,...
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WO/2002/028809A2 |
Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, whe...
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WO/2002/024335A2 |
A strong-acid cation exchange resin in acid form is contacted with an alkylcarbamoyl alkylthioester in the presence of water for producing a strong-acid cation exchange resin comprising a plurality of acid groups being partially neutrali...
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WO/2002/022556A1 |
Amide derivatives represented by the following general formula (1) which have a C5$g(a) receptor antagonism, wherein each symbol has the meaning as defined in the description. These amide derivatives, optically active isomers thereof or ...
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WO/2002/022849A2 |
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer, (I), wherein Ar is C¿6? or C¿10? aromatic group that can be substituted with H, C¿1? to C¿6? alkyl, trifluoromethyl or hal...
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WO/2002/019967A2 |
A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulatio...
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WO/2002/016317A1 |
The present invention relates to an antagonist against vanilloid receptor and the pharmaceutical compositions containing the same.As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic...
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WO/2002/014263A1 |
Acylacetonitriles represented by the general formula (1): (1) [wherein R?1¿ is C(O)ZR?2¿; R?2¿ is C¿1-6? alkyl, C¿1-4? haloalkyl, or the like; Z is oxygen or sulfur; X and Y are each halogeno, C¿1-6? alkyl, or C¿1-4? haloalkyl; an...
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WO/2002/010127A1 |
The invention relates to novel compounds of formula (I) wherein R, R?1¿ and R?2¿ have the designation cited in patent claim 1. Said compounds are inhibitors of the coagulation factors Xa and VIIa, and can be used to treat thromboses, m...
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WO/2002/000607A1 |
Amide compounds represented by the following general formula; and microbicides containing the same as the active ingredient: wherein R?1¿ is C¿1-10? haloalkyl or the like; R?2¿ is hydrogen or the like; X is oxygen or sulfur; Y is oxyg...
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WO/2001/098235A2 |
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...
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WO/2001/092220A1 |
The invention concerns novel aminothiolester compounds of general formula (I), the method for preparing them, and their use in pharmaceutical compositions for use in human or veterinary medicine (cancers and precancerous conditions, derm...
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WO/2001/092218A2 |
Novel 'bispolyamine' inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...
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WO/2001/090114A1 |
The invention concerns radiopharmaceutical products suitable for the selective labeling of lymphomas containing a metal complex with the formula: [m(R1CS2) (R1CS3)], in which M is chosen from among ?99m¿Tc, ?186¿Re and ?188¿Re, and R?...
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WO/2001/085673A1 |
The invention relates to novel phenyl-substituted 2-enamino-keto nitriles of formula (I), wherein Ar, X, Z, Y and K have the meanings as cited in the description. The invention also relates to several methods for producing said phenyl-su...
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WO/2001/083426A1 |
A 2-fluoroalkanamide compound represented by the formula (I) wherein R represents C¿1-6? alkyl or phenyl; X represents oxygen or sulfur; Y represents a single bond, CH¿2?CH¿2?, or CH¿2?CH¿2?O; and Q represents any one of Q1 to Q12 a...
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WO/2001/081300A1 |
An industrial process for recovering and purifying 2-acetylthio-3-phenylpropionic acid, particularly optically active one, in the form of free acid. 2-Acetylthio-3-phenylpropionic acid is recovered and purified in the form of crystals of...
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WO/2001/079158A2 |
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (I).
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WO/2001/077096A2 |
This invention relates to a process for the preparation of thioacetates addition of thioacetic acid or a salt thereof on $g(a)-,$g(b)-, or $g(g)-unsaturated alcohols, carbonyl compounds or cyclic or acyclic alkenes or by nucleophilic sub...
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WO/2001/076390A2 |
The invention relates to a process for flavouring foodstuffs by incorporating therein an effective amount of at least one compound R1-S-R2 with a specific, well defined structure such as (E)-2-methyl-1-(methylthio)-2-butene; S-ethyl thio...
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WO/2001/077359A2 |
This invention relates to the generation of natural flavouring thiols and their disulfides derivates by bioconversion and their use as enhancers or intensifiers of flavour in food product. The invention also relates to new aroma compound...
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WO/2001/070675A2 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...
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WO/2001/070671A2 |
This invention provides compounds of Formula (1), their N-oxides and agriculturally suitable salts wherein A, B, J, R?1¿, R?2¿, R?3¿ and R?4¿ and n are as defined in the disclosure. Also disclosed are methods for controlling arthropo...
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WO/2001/064650A2 |
The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally p...
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WO/2001/062722A2 |
This invention discloses a method of conversion of carboxylic acids to carbothiotic acids by reacting a caarbpxylic acid with a first base, an iodide salt, and a compound of formula (4) wherein the variables are as defined in the claims,...
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