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JP4463209B2 |
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JP2010077150A |
To provide methods for prophylaxis, management and treatment of specific diseases modulated by inhibition of enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by administration of a composition containing as an act...
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JP4435876B2 |
A fungicidal mixture comprisesa.1)a phenyl benzyl ether derivative of the formula I.a, I.b or I.c,ora.2) a carbamate of the formula I.d,where X is CH and N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl and C1-C4-haloalkyl, it being possi...
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JP2010053042A |
To provide a new compound having a potassium channel-controlling activity, especially a BK channel opening activity, and useful as a medicine, to provide a method for synthesizing the compound, to provide an intermediate useful for synth...
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JP2010507636A |
Phenyl derivatives (I) in the form of racemic and/or enantiomeric form and their salts are new. Phenyl derivatives of formula (I) in the form of racemic and/or enantiomeric form and their salts are new. A : heterocyclic moiety of formula...
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JP4421293B2 |
The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological...
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JP4421680B2 |
The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also comprises pharmaceutical compositions compri...
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JP4410562B2 |
The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological...
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JP2010501007A |
This invention relates to thiourea compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
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JP4394583B2 |
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JP4391237B2 |
The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed "tethering" where potential ligands are covalently bonded or "tethered" to a target and subsequently identified.
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JP4383177B2 |
Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseas...
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JP4384635B2 |
The present invention relates to a production method of asymmetric compound (IV) which includes conjugately adding nucleophilic reagent (III) to compound (II) in the presence of asymmetric urea compound (I). The present invention provide...
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JP2009538270A |
The present invention provides novel compounds that inhibit cell proliferation, in particular through the disruption of chromosome segregation and uses of these compounds for treating, ameliorating or preventing diseases, conditions or d...
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JP4346440B2 |
A process for preparing an intermediate compound of formula (II) where n is an integer of from 3 to 14; R1 is haloC1-10alkyl, C1-10alkyl, C2-10alkenyl, C2-10cycloalkyl, carboxyC1-10alkyl, C1-10alkoxycarbonylC1-10alkyl, aryl (such as phen...
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JP2009536622A |
RNase L Activators and methods of using the same are disclosed herein.
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JP2009221129A |
To provide a method for producing an N, N-dialkylthiourea compound industrially inexpensively and simply.The acylthiourea compound of general formula (5) is produced by causing a thiocyanate compound of general formula (1) to react with ...
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JP2009533315A |
What is provided herein is an aromatic compound substitution agent that is a tRNA synthetase inhibitor and thus can be used as an antibacterial agent. The compounds described herein are Gram-positive, Gram-negative, anaerobic or fungal m...
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JP2009209090A |
To provide an insecticide which exhibits a high insecticidal effect even in a low dosage.There are provided a compound represented by general formula (1) and an insecticide containing the compound as an active ingredient. In the formula ...
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JP2009526806A |
The present invention relates to benzoyl-substituted alanines of the formula I in which the variables R1 to R12 are as defined in the description, and to their agriculturally useful salts, to processes and intermediates for their prepara...
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JP4295357B2 |
The invention provides a compound of the formula wherein X is S, O, NR' where R' is H or alkyl of 1 to 6 carbons, or X is ÄC(R1)2Ün where R1 is independently H or alkyl of 1 to 6 carbons, and n is an integer between 0 and 2; R2 is hydr...
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JP2009149602A |
To provide a compound raising cellular ABCA-1 production in a mammalian animal and useful for treating coronary arterial diseases.This compound is expressed by formula I [wherein, R1 is H, trichloromethyl or the like; A is a covalent bon...
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JP4283681B2 |
The present invention provides HIV aspartyl protease inhibitors of the formula I: and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, Y is O, S, NH or N-CN...
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JP4276439B2 |
The invention relates to novel compounds that are used for the transfer of nucleic acids into cells. More specifically, said novel compounds are polythiourea lipid derivatives and are used for the in vitro, ex vivo or in vivo transfectio...
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JP2009521430A |
The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agoni...
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JP4267920B2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
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JP2009109515A |
To discover a ligand using combined technique.The present invention discloses a new method for discovery of a ligand. The technique relies on a process called "tethering", where a potential ligand is bound covalently to a target or "teth...
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JP2009519268A |
The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects lik...
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JP2009519269A |
The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects lik...
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JP4264205B2 |
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JP4260888B2 |
PCT No. PCT/IL97/00314 Sec. 371 Date Jun. 9, 1999 Sec. 102(e) Date Jun. 9, 1999 PCT Filed Sep. 25, 1997 PCT Pub. No. WO98/13036 PCT Pub. Date Apr. 2, 1998S-Alkylisothiouronium salts with phosphorus-containing acids are described. The com...
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JP4244139B2 |
The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arterioscle...
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JP4238026B2 |
The invention concerns 2-aminithiazoline derivatives of formula (I) wherein: either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, -CH-R3, -CH2-S-R4 or phenyl radical substituted by a nitro or NH-C(=NH)CH3 radica...
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JP4227807B2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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JP4217924B2 |
Compounds of the formula I and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III In the compounds of the formul...
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JP2009007440A |
To provide an additive for oils imparting an antifrictional characteristic or an abrasion-resistant characteristic.This additive for oils contains a nitrogen-containing compound expressed by general formula (I) or a salt thereof, where R...
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JP4206382B2 |
The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antivira...
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JP2008290985A |
To provide a method for producing a 3-sulfanylphenol compound from general-purpose raw materials safely, efficiently and industrially advantageously.The method for producing, for example, 3-methylsulfanylphenol comprises reacting a cycli...
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JP2008542233A |
The present invention relates to a method of combating animal pests which comprises contacting the animal pest, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are gro...
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JP2008540586A |
The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non-peptidic compounds...
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JP2008275671A |
To provide a holographic recording medium excellent in characteristics such as high diffraction efficiency, good storage property, low shrinkage, dry processing property and multiple recording characteristics (high recording density).A h...
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JP4181408B2 |
A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin ...
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JP4159363B2 |
Compounds of formula (i) and of formula (ii)wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic recep...
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JP4130519B2 |
Compounds of peptide mimetic nature having the general formula I wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several ...
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JP2008528691A |
1-Acylamino-2-hydroxy-3-amino-omega-arylalkanes of formula I. and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive, medicinally active ingredients.
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JP2008523118A |
The invention relates to a method for producing onium salts with tetrafluoroborate anion by reacting an onium halide with an oxonium tetrafluoroborate, sulfonium tetrafluoroborate, or triphenylcarbonium tetrafluoroborate.
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JP4109271B2 |
The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antivira...
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JP4105451B2 |
To provide a novel benzamide derivative and a novel anilide derivative having proliferation induction action. The novel benzamide derivative is represented by the following formula (1) and the novel anilide derivative is represented by t...
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JP4104984B2 |
Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, R1 is selected from an alkyl group ha...
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JP2008516976A |
The invention relates to novel compounds and processes for their preparation and their use for preparing medicaments for the treatment of disorders, especially hyper-proliferative disorders.
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