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JP3498372B2 |
PURPOSE: To obtain a new semicarbazone compound useful as a noxious organism-controlling agent, having excellent insecticidal or germicidal activity at low doses, land having little adverse effects on mammals, fish and beneficial insects...
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JP2004504270A |
This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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JP2004043480A |
To provide a medicine becoming a treating agent of diabetes mellitus and an intermediate for producing the same.This intermediate of a new 3-aryl-2-hydroxypropionic acid derivative is expressed by formula IV [wherein, Q is H; A is OH, a ...
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JP3491311B2 |
PURPOSE: To readily obtain an N-substituted-N-arylcyanamide derivative useful as intermediates for agricultural chemicals and medicines, especially herbicides, in high purity and high yield by reacting an N-arylcyanamide derivative with ...
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JP3487415B2 |
To obtain the subject new compound capable of binding to arachidonic acid cascade receptors, having a blood platelet coagulation-inhibiting action and useful for treating thrombosis, arteriosclerosis, or the like. A compound of formula I...
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JP2004501132A |
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor beta, to methods of preparing such compounds and to methods for using such compounds...
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JP2004500330A |
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligome...
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JP2003342253A |
To provide a method for producing a 2-alkyl-3-nitroisothiourea useful as a raw material for agrochemicals from an S-alkylisothiourea in a high yield. This method for producing the 2-alkyl-3-nitroisothiourea comprises reacting the S-alkyl...
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JP2003535915A |
3,4-Dihydroxybenzyl-substituted carbonic acid derivatives (I) are new. Carbonic acid derivatives of formula (I) (including their tautomers) are new. [Image] X1-X3O, S or NR3; R1H, R4, OH or OR4; R4alkyl, alkenyl, 1-oxoalkyl or 1-oxoalken...
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JP2003535868A |
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO2R', NO2, NH2, NHR', N(R')2, CN, halogen, C(-O)H, C(-O)CH3, CO2H, CO2CH3, ...
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JP2003532705A |
A method is provided for inhibiting free radical degradation in the skin of a human or nonhuman animal comprising contacting the skin with a skin treatment composition having a concentration of a 1-(3-methoxybenzyl)-3-substituted thioure...
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JP2003530429A |
Methods and compositions for the treatment of pain using thiourea derivatives. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.
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JP2003530430A |
Methods and compositions for the treatment of pain using this area derivatives. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.
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JP3457240B2 |
To provide a method for producing an episulfide compound by epithioation of the corresponding epoxy compound in high yield in such a way that the product episulfide compound does not run to tar. This method for producing an episulfide co...
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JP3446052B2 |
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JP3444306B2 |
PURPOSE: To economically and advantageously produce a solution of thiourea dioxide with small loss of chemicals and reduced energy consumption or to effectively bleach papermaking pulp with the produced solution of thiourea dioxide. CONS...
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JP2003525225A |
The present invention relates to novel substituted imide derivatives of the general formula (I)in whichR<1 >represents optionally substituted cycloalkyl,R<2 >represents optionally substituted alkyl or optionally substituted cycloalkyl,R<...
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JP2003524574A |
[Chemical 1]
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JP2003520843A |
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...
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JP2003146963A |
To provide an antioxidation agent for cosmetic and pharmaceutical preparation having strong specific free radical scavenging action and antioxidation action to protect the cells and tissues of mammals and provide a method for the product...
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JP2003103655A |
To provide an apparatus and a method for simply detecting and deciding a specific position of a cylindrical film close contact material in which cylindrical films are brought into close contact with each other without mistake.The apparat...
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JP2003513002A5 |
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JP2003509422A |
This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties.
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JP3383328B2 |
PURPOSE: To provide a compsn. useful to inhibit and/or treat infections by HIV and to treat or inhibit AIDS. CONSTITUTION: The compsn. contains as an effective component, a compd. expressed by formula I or its salt, or a compd. expressed...
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JP2003506355A5 |
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JP2003506355A |
Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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JP2003506348A |
Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thi...
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JP2003503350A |
Compounds that selectively inhibit the binding of ligands to alpha 4 beta 1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by formula (I). As selective inhi...
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JP3365633B2 |
The compounds of the formula (I) (I) in which R1-R4, W, X, Y and Z are as defined in claim 1 are suitable for controlling harmful plants in crops. Their preparation may employ the intermediates of the formulae II and III: (II) (III)
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JP2003500381A |
Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor,...
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JP3354090B2 |
To obtain a new benzamide derivative having differentiation inducing acton, useful as a medicine for treating and improving malignant tumor, autoimmune disease, dermatitis and parasitic infectious disease. This compound is shown by formu...
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JP2002540086A |
This invention provides combinatorial chemistry libraries containing thiourea and urea compounds. In addition, the invention relates to methods for constructing combinatorial chemistry libraries containing thiourea and urea compounds. Fu...
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JP3350035B2 |
A process for preparing a compound represented by formula (I), wherein R1 represents straight-chain or branched C1-5 alkyl, C1-5 haloalkyl, or C3-6 cycloalkyl, and R2 represents C1-3 alkyl or C1-3 haloalkyl.
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JP2002332266A |
To provide an excellent prophylactic and therapeutic agent for osteoporosis and the like.A compound represented by the following general formula (I) (A=phenyl or the like, B=aryl or the like, X=O or the like, n=0, 1) and a prophylactic a...
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JP2002533301A |
Compounds of formula (I) wherein R1-R5 are independently selected from hydrogen, or substituents R9-R12 are independently hydrogen, or substituents provided that at least one of R9-12 is not hydrogen; G is a monocyclic heteroaryl: X is a...
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JP2002532465A |
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the tre...
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JP3330374B2 |
The present invention relates to compounds exhibiting central nervous system (CNS) activity which are useful in the treatment of epilepsy and other CNS disorders. The compounds of this invention have the following general formula: and ph...
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JP2002531545A |
Compounds of formula (I), wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 ca...
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JP2002531544A |
Compounds of formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 car...
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JP2002531557A |
Compounds of formula (I) wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be...
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JP2002531555A |
Compounds having formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10...
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JP2002241355A |
To obtain a new compound capable of acting on a central nerve, especially having an antispasmodic action.The compounds are represented by formula (I) [R is an aryl, an aryl lower alkyl group or the like; R1 is hydrogen, a lower alkyl, a ...
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JP3309104B2 |
Sulfonic acid stilbenes are disclosed which block the infection of cells by HSV, HIV and CMV.
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JP2002193924A |
To provide a new agent for agricultural and horticultural use.The phenylacetic acid compound represented by formula (1) [A is hydrogen atom, a 1-6C alkyl or the like, B is -NU3U4, Y is hydrogen atom or the like, Z is -OR1 or the like, X ...
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JP2002520387A5 |
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JP2002517458A |
(57) [Summary] Methods for synthesizing large collections of diverse multimeric compounds and iterative processes for assessing key molecular constraints that confer multibinding properties on multimeric compounds are disclosed. A librar...
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JP2002517422A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002517423A |
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 l...
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JP2002517465A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002513385A |
Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
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