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WO/2001/055095A1 |
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...
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WO/2001/047888A1 |
Heterocyclic imino compounds of general formula (1) and agrochemically acceptable salts thereof; and agricultural chemicals, fungicides and insecticides, each containing as the active ingredient at least one member selected from the grou...
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WO/2001/046124A1 |
Aromatic diamide derivatives of general formula (I) or salts thereof; chemicals for agricultural or horticultural use; and usage thereof [wherein A?1¿ is optionally substituted C¿1-8? alkylene, C¿3-8? alkenylene, or the like; B is O- ...
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WO1999063937A9 |
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more prot...
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WO2001030749B1 |
The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially wel...
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WO/2001/036376A1 |
Phenylalanine derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof: wherein x represents an interatomic bond, -O-, etc.; Y and Z represent each -C(=O)-, etc.; A represents a specific substituted phe...
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WO/2001/036572A1 |
Compounds and lubricant compositions are disclosed that comprise a substituted linear thiourea of structure (I) wherein R¿1?, R¿2?, and R¿4? are independently selected from the group consisting of alkyl, alkenyl, aryl, alkaryl, aralky...
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WO/2001/032610A1 |
A urea derivative represented by the general formula (I) or a salt thereof: wherein R?1¿ is hydrogen, alkyl, etc.; X is hydrogen, halogeno, alkyl, aryl, arylamide, etc.; Y is oxygen or sulfur; and Z is a hydrocarbon or heterocyclic grou...
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WO/2001/032164A1 |
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney ...
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WO1999063939A9 |
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 l...
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WO/2001/025190A1 |
Diarylamide derivatives represented by general formula (1) or salts thereof, and pharmaceutical compositions containing the derivatives or the salts as the active ingredient, wherein A and B are each an aromatic ring such as benzene ring...
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WO/2001/025189A1 |
The invention relates to compounds of formula (I), wherein R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings cited in the Claims and are especially suitable as novel antiarrhythmic active agents, in partic...
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WO/2001/019822A1 |
This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties.
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WO/2001/009096A2 |
Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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WO/2001/009088A1 |
Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thi...
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WO1999064049A9 |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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WO/2001/004088A1 |
A process for preparing hydrochlorides of compounds of general formula (2): (wherein R¿1? is lower alkyl; R¿4? and R¿5? are each hydrogen or the like; Y¿1?, Y¿2?, Y¿3? and Y¿4? are each hydrogen or the like; and n is 0 or 1), char...
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WO/2001/002350A2 |
The invention relates to novel compounds of general formula (I) that are suitable as medicaments, to a method for the production thereof and to their utilization as medicaments, particularly as antiviral agents.
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WO/2001/000206A1 |
Compounds that selectively inhibit the binding of ligands to $g(a)4$g(b)1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by formula (I). As selective inhibi...
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WO/2000/071513A1 |
The present invention relates to cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives of formula (I) in which A(1), A(2), A(3), R(1), R(2), R(3), R(4), X, Y and Z have the meanings indicated in the claims. The compounds of form...
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WO/2000/063167A1 |
The present invention relates to crystalline forms of the sodium salt of 5- chloro -2- methoxy -N-(2- (4-methoxy -3- methyl aminothio carbonylamino sulfonyl phenyl) ethyl) -benzamide, processes for their preparation, their use and pharma...
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WO/2000/053663A1 |
The invention provides a polymeric or oligomeric compound of formula (I), wherein R¿1? is selected from linear and branched alkyl and alkenyl groups, C¿6? aromatic rings, substituted C¿6? aromatic rings, fused aromatic rings, substitu...
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WO/2000/050387A1 |
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The presen...
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WO/2000/047556A1 |
A substituted thiourea having general formula (1) characterised in that each of R?1¿ and R?2¿ independently comprises an alkyl, alkaryl or aryl group or a substituted derivative thereof, and contains at least one fluorine atom, and in ...
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WO1999064033A9 |
This invention relates to novel multibinding compounds that bind to the enzyme phosphodiesterase V (PDE V) and modulate its activity. The compounds of this invention comprise 2-10 PDE V modulator (particularly inhibitor) ligands covalent...
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WO1999063994A9 |
Disclosed are multibinding compounds which inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis. The multibinding compounds of this invention containing from 2 ...
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WO1999064048A9 |
Disclosed are multibinding compounds which inhibit the enzyme HIV reverse transcriptase, an enzyme which catalyzes the conversion of viral RNA to single stranded DNA. The multibinding compounds of this invention containing from 2 to 10 l...
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WO/2000/042004A1 |
The invention concerns benzenic sulphonamide derivatives corresponding to the general formula (I) wherein: the different symbols have different meanings, their optical isomers and the pharmaceutically acceptable salts of said derivatives...
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WO/2000/037434A1 |
Amide derivatives represented by general formula (I), which have an activity against $i(Helicobacter pylori) and are useful as the active ingredient of drugs, pharmaceutically acceptable salts thereof or solvates or hydrates of the same,...
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WO/2000/037430A2 |
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. T...
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WO/2000/035864A1 |
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the tre...
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WO/2000/034261A2 |
Compounds of formula (I) wherein R1-R5 are independently selected from hydrogen, or substituents R9-R12 are independently hydrogen, or substituents provided that at least one of R9-12 is not hydrogen; G is a monocyclic heteroaryl: X is a...
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WO/2000/034238A1 |
Compounds of formula (I), wherein R¿1?-R¿5? are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to...
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WO/2000/034237A2 |
Compounds of formula (I) wherein R¿1?-R¿5? are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to ...
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WO/2000/034268A1 |
Compounds of formula (I) wherein A is heteroaryl; R¿9?-R¿12? are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R¿9? and R¿10? or R¿11?...
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WO/2000/034260A2 |
Compounds having formula (I) wherein R¿1?-R¿5? are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3...
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WO1999063988A9 |
Disclosed are multibinding compounds which inhibit nitric oxide synthases (NOSs), enzymes which form nitric oxide and L-citrulline from L-arginine. The multibinding compounds of this invention contain from 2 to 10 ligands covalently atta...
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WO/2000/018766A1 |
A process for preparing a compound represented by formula (I), wherein R?1¿ represents straight-chain or branched C¿1-5? alkyl, C¿1-5? haloalkyl, or C¿3-6? cycloalkyl, and R?2¿ represents C¿1-3? alkyl or C¿1-3? haloalkyl.
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WO/2000/015204A2 |
Substituted benzenesulfonylureas and -thioureas of formula (I), in which R?1¿, R?2¿, E, X, Y and Z have the meanings given in the claims, show effects on the autonomous nervous system. The invention relates to the use of the compounds ...
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WO1999064047A9 |
Novel compounds are disclosed, useful as antiviral agents.
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WO1999063929A9 |
Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compound...
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WO1999064054A9 |
Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently at...
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WO/2000/009116A1 |
Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.
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WO/2000/003978A2 |
The compounds of formula (I) act as inhibitors on ATP-sensitive potassium canals and are suitable for the treatment of cardio-vascular disorders, especially the treatment of arrhythmias, prevention of sudden death from heart disease or a...
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WO/1999/064051A1 |
Novel multibinding compounds are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of inhibiting bacterial Type II DNA topoisomerase, thereby modulating the biol...
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WO/1999/063940A2 |
Disclosed are multibinding compounds which inhibit H?+¿/K?+¿-ATPase, an enzyme which is involved in the control of acid secretion in the stomach. The multibinding compounds of this invention containing from 2 to 10 ligands covalently a...
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WO/1999/064037A1 |
Novel multi-binding compounds are disclosed that modulate enzymatic processes. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an enzyme, enzyme substrate o...
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WO/1999/064032A1 |
Disclosed are methods for synthesizing large collections of diverse multimeric compounds as well as iterative processes for evaluating key molecular constraints imparting multibinding properties to multimeric compounds. Also disclosed ar...
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WO/1999/062870A1 |
A novel compound 3-{4-[2-(4-$i(tert)-Butoxycarbonylaminophenyl)ethoxy]phenyl}
-(S)-2-ethoxy propanoic acid having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediates for...
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WO/1999/062872A1 |
A novel 3-aryl-2-hydroxypropionic acid derivative, having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediate for its manufacture, pharmaceutical preparations containing ...
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