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Matches 351 - 400 out of 2,565

Document Document Title
WO/1992/001454A1
The present invention relates to the use of 20(R)-22-oxavitamin D analogues for treatment or prevention of skin ageing, and to the use of such compounds for preparation of pharmaceutical compositions for treatment and/or prevention of sk...  
WO/1991/017504A1
A fault tolerant computer system is disclosed which operates to automatically provide fault tolerant operation in a manner which reduces the frequency of checkpointing, while requiring neither simultaneity nor atomicity with respect to i...  
WO/1991/015475A1
The invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; Y is oxygen or sulphur or oxidized sulphur (S(O) or S(O2)); R1 and R2, which may be the same or different, stand for hydrogen or C1-C6 hydrocarb...  
WO/1991/015448A1
The description relates to novel 24-oxa derivatives in the vitamin D series of the general formula I in which : R?1�, R?2� and R?5� are mutually independently a hydrogen atom or an acyl group with 1 to 9 carbon atoms; R?3� is a h...  
WO/1991/012239A1
The invention provides new 24, 26, and/or 27 homologated vitamin D2 compounds, such as 26,27-dihomo-1alpha-hydroxyvitamin D2, 26,27-dihomo-1alpha-hydroxy-24-epi-vitamin D2 26,27-dihomo-1alpha,25-dihydroxy-24-epi-vitamin D2 and certain hy...  
WO/1991/012240A1
This invention relates to hydroxylated derivatives of vitamin D�2? and a process for preparing such compounds. In particular, a process for preparing the 24-epimer of 25-hydroxyvitamin D�2?, the 24-epimer of vitamin D�2? and the co...  
WO/1991/012238A1
The description relates to novel side-chain-homologous vitamin D derivatives of formula (I), in which R?1�, R?2�, R?3�, R?4�, R?5� and R?6� have the significance given in the description, B and D are either a hydrogen atom or...  
WO/1991/009841A1
The present invention relates to compounds of formula (I) in which R1 and R2 may be the same or different and stand for hydrogen, lower alkyl, lower cycloalkyl, or, taken together with the carbon atom (starred in formula I), bearing the ...  
WO/1991/000855A1
The present invention relates to compounds of formula (I), in which formula n is 2 or 3, m is 0 or an integer from 1-4; R1 and R2 (which may be the same or different) stand for hydrogen or C1-C8-hydrocarbyl, hydrocarbyl indicating the re...  
WO/1991/000271A1
The present invention relates to compounds of formula (I), in which formula, n is 0 or 1, m is 0 or an integer from 1-7, R1 and R2 (which may be the same or different) stand for hydrogen or C1-C8-hydrocarbyl, or, taken together with the ...  
WO/1990/010619A1
The invention provides a new vitamin D2 compound, 1alpha-hydroxy-24-epi-vitamin D2 and certain hydroxy-protected derivatives thereof. The new compound exhibits a distinctive activity pattern comprising high potency in stimulating intesti...  
WO/1990/010620A1
This invention provides a novel class of vitamin D-related compounds, namely the 1alpha-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting th...  
WO/1990/009992A1
The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in ...  
WO/1990/009991A1
The present invention relates to compounds of formula (I), in which formula R stands for an alkyl group containing from 7 to 12 carbon atoms optionally substituted with a hydroxy group; and derivatives of the compounds of formula (I) in ...  
WO/1990/000541A1
This invention provides novel 1alpha-hydroxyvitamin D compounds, methods for their preparation, and pharmaceutical compositions of these compounds. The new compounds, which are characterized structurally by having a cyclopentane ring as ...  
WO/1990/000560A1
Steroid compounds represented by general formulae (I), (II) or (III), wherein R1 and R2 each represents a hydrogen atom or a hydroxyprotecting group, R represents -CH2-X, a carboxyl group or a protected carboxyl group, X represents a sub...  
WO/1989/010353A1
This invention provides novel side chain homologs of 1alpha,25-dihydroxyvitamin D3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applic...  
WO/1989/010351A1
The present invention relates to compounds of formula (I), in which formula, n is an integer from 1-7; and R1 and R2, which may be the same or different, stand for hydrogen, or lower alkyl (but with the proviso that when n = 1, R1 and R2...  
WO/1989/010352A1
This invention provides novel vitamin D-related compounds characterized by extended unsaturated side chain structures. Such compounds exhibit increased activity in arresting the proliferation and promoting the differentiation of malignan...  
WO/1989/008640A1
Novel compounds represented by formula (II) are disclosed. They can be easily converted into a fragment corresponding to ring A to be used in a process for binding a fragment corresponding to ring A to fragments corresponding to rings C ...  
WO/1989/008641A1
Vitamin D2 and vitamin D3 or active vitamin D2 and active vitamin D3, or their derivatives represented by the foregoing formula (II) are prepared by subjecting 7,8-dihydroxyvitamin D2, 7,8-dihydroxyvitamin D3 or their derivatives, i.e., ...  
WO/1988/007527A1
The amino-9,10-secosteroids of formula (I) of the present invention contain an amino group attached to the terminal carbon atom of the C17-side chain and are useful as pharmaceutical agents for treating a number of conditions including s...  
WO/1988/007037A1
6-Oxoprostaglandin-E, derivatives having the formula (I), in which R1 signifies the residue COOR2 where R2 signifies a hydrogen atom, a C1-10 alkyl, a C5-6 cycloalkyl, a C6-C10 aryl group, a heterocyclic residue or the residue CONHSO2R5 ...  
WO/1988/005042A1
Therapeutical compositions containing products obtained from the addition of thiols to prostaglandines or analogues of prostaglandines. These compositions have an antitumoral activity.  
WO/1988/001615A1
Novel ester derivatives of carboxylic acid medicaments of formula (I), wherein R-COO - represents the acyloxy residue of a carboxylic acid drug or medicament, n is an integer from 1 to 3, and R1 and R2 are the same or different and are s...  
WO/1987/007604A1
New coenzyme A and N-hydroxysuccinimidyl esters of all-trans- and 13-cis-retinoic acid and to methods for preparing the same. A new method for preparing all-trans-retinoic acid anhydride is also disclosed.  
WO/1987/007599A2
Compounds having anti-inflammatory and other activities. The compounds are derived from diterpenes, indol alkaloids, polyacetates, diaminobenzyl alcohols, diacylglycerol and bryostatins.  
WO/1987/003282A1
24a, 24a-Difluoro-1alpha,25-dihydroxy-24-homovitamin D3 and process for its preparation. This compound has a strong vitamin D activity with low toxicity, thus being useful for prophylaxis and treatment of calcium metabolism abnormalism, ...  
WO/1987/001705A1
New derivative of vitamin D3, 26,26,26,27,27-pentafluoro-1alpha-hydroxy-27-methoxy-choleca lciferol and a process for preparing the same. The compound is characterized by some vitamin D-like activity except that it exhibits negligible ac...  
WO/1987/000834A1
Vitamin D analogues represented by general formula (I), in which formula X stands for hydrogen, lower alkyl, halogen or hydroxy; Y stands for hydrogen or hydroxy; R1 and R2, which may be the same or different, stand for lower alkyl, opti...  
WO/1986/007364A1
Ring A-diol units suitable for synthesizing 1alpha-hydroxyvitamin D compounds by subsequent condensation with appropriate C/D-ring fragments and to methods for preparing such ring A-diol units.  
WO/1986/006255A1
Seco-sterol compounds which are effective in inducing the differentiation of malignant cells and are therefore useful for the treatment of malignancies such as leukemia.  
WO/1986/005488A1
9-Halogen-15-cycloalkyl-prostaglandine derivates of formula (I), wherein R1 signifies hydrogen or methyl, R2 signifies fluorine or chlorine, n signifies 0 or 1, and, if R1 signifies hydrogen, their salts with physiologically tolerable ba...  
WO/1986/004333A1
Production of 26-homo Vitamin D-3 derivatives and intermediates in the production thereof. These compounds express excellent Vitamin-D like activity and could serve in the treatment of various disease states manifesting calcium and phosp...  
WO/1986/004059A1
The method for extracting carotene from carrots comprises a) crushing the carrots, b) pressing the crushing product obtained in order to extract a juice, c) subjecting said juice to an enzymatic process by means of a pectolitic enzyme, d...  
WO/1986/002923A1
A process for preparing bicyclo AD3.3.0 BDoctenes represented by general formula (II), wherein R11 represents H, a mono-equivalent cation or R1, Romega' represents Romega, and R21 represents H or R2, from a thiol compound represented by ...  
WO/1986/002648A1
Process for separating 1alpha-hydroxyvitamin D compounds from their corresponding 1alpha-hydroxy-5,6-trans isomers in a mixture thereof by treating the mixture with a dienophile and then separating the resulting dienophil-adduct of the 1...  
WO/1986/002649A1
Process for preparing 1-hydroxyvitamin D compounds by acid-catalyzed solvolysis of the corresponding 1-hydroxy-3,5-cyclovitamin D compound in an organic solvent medium whereby the free, non-acylated, 5,6-cis and 5,6-trans-1-hydroxylated ...  
WO/1986/002527A1
A method of treating psoriasis in a patient which comprises administering to said patient an effective amount of a vitamin D compound which is capable of stimulating the differentiation of cultured tumor cells or normal rodent or human f...  
WO/1986/002078A1
New 24-homo-vitamin D compounds, methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1alpha,25-dihydroxyvitamin D3, the recognized circulating hormon...  
WO/1985/005622A1
New derivatives of vitamin D3 and specifically (22E,24R)-1,24-dihydroxy-DELTA22-vitamin D3 and (22E,24S)-1,24-dihydroxy-DELTA22-vitamin D3. The compounds exhibit vitamin D-like activity in their ability to stimulate intestinal calcium tr...  
WO/1985/005110A1
A compound which is biologically active in maintaining calcium and phosphorous metabolism in animals, selected from the group consisting of formula (IA) and (IB): wherein the bond between carbons C-22 and C-23 is single or double; Y is h...  
WO/1985/004875A1
New derivatives 15(R+S)-fluorine-11,15-didesoxyprostaglandin E1 of general formula (I) where R' is ethyl, methyl, hydrogen, sodium; R2 or R3 is hydrogen or fluorine. The derivatives have a high antiaggregative activity of long duration.  
WO/1985/004656A1
9-halogen-prostane having the formula (I) wherein Hal represents a chlorine or fluorine atom in position alpha or beta; R1 represents the rest CH2OH or the formula (A) with R2 representing a hydrogen atom, an alkyl, cycloalkyl, aryl or h...  
WO/1985/004400A1
A novel perfume composition containing an effective amount of ( 9E)-cis-gamma-irone (formula (B)), which has not been heretofore applied in the field of perfumery, in perfumes or flavored articles, a method for imparting, changing or enh...  
WO/1985/003939A1
Novel vitamin D derivatives, analogs of vitamin D2 compounds which lack the 24-methyl substituent and are identified as 1alpha-hydroxy-28-norvitamin D2 and 1alpha,25-dihydroxy-28-norvitamin D2. The compounds of the invention are characte...  
WO/1985/003935A1
6-substituted prostaglandin E1's represented by formula (I), (wherein R1 represents H, C1 to C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted C3 to C10 cycloalkyl, substituted or unsubstituted phenyl(C1 to C2)...  
WO/1985/003706A1
Novel punaglandins AD5-(2,3-diacetoxy-6-methoxycarbonyl hexylidene)-2-chloro-4-)2,5-octadienyl)-4-hydroxy-2-cyclopen tenone, or 5-(2,3-diacetoxy-6-methoxycarbonylhexy-lidene)-2-chloro-4-(2 -octenyl)-4-hydroxy-2-cyclopentenone BD are isol...  
WO/1985/003299A1
Novel 1-hydroxylated vitamin D compounds containing a 22, 23-cis double bond in the side chain. The compounds are characterized by an unexpectedly high binding affinity for the protein receptor forecasting their ready applicability as su...  
WO/1985/003300A1
Novel vitamin D derivative, 1alpha,25-dihydroxy-22Z-dehydrovitamin D2. The compound is characterized by unexpectedly high ability to raise serum calcium levels. The compound could therefore, find ready application as a substitute for vit...  

Matches 351 - 400 out of 2,565