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WO/1998/023574A1 |
The present invention relates to asiatic acid derivatives represented by formula (1), and medicines for treating wounds, which contains the same as an active component.
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WO/1998/015178A1 |
Sordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.
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WO/1998/011045A1 |
A reaction between 6-bromo-2-naphthol and dimethyl sulfate is conducted in the presence of substantially stoichiometric amounts of sodium hydroxide and water and in an organic solvent to prevent the formation of sodium methyl sulfate whi...
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WO/1998/006692A1 |
Cyano and carboxy derivatives of substituted styrenes of formula (I), in which Y is -COZ, -C$m(Z)N, or lower alkyl of 1 to 5 carbon atoms; Z is -OH, -NR?6�R?6�, -R?7�, or -OR?7�; X, R?1�, R?2�, R?3�, R?4�, R?5�, R?6�,...
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WO/1998/004331A1 |
Process for the recovery of oleanolic and maslinic acids contained in the subproducts resulting from the milling and processing of olives or parts thereof, either proceding from three-phases or two-phases presses. This process enables to...
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WO/1997/047194A1 |
Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase inhibitors and can be used in treating pa...
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WO/1997/042154A1 |
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
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WO/1997/030017A1 |
A therapeutic agent for diabetes comprising a compound represented by general formula (I) [wherein X represents (a), (b) or (c)] [wherein R4 and R5, which may be the same or different, represent a hydrogen atom, or an optionally substitu...
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WO/1997/029070A1 |
This invention provides perfluoro(alkoxycycloalkane) carbonyl fluoride compounds wherein, pendant from the fluorinated ring, are from 2 to 5 perfluoroalkoxy groups having from 1 to 4, preferably 1 to 2, carbon atoms with the proviso that...
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WO/1997/028114A1 |
Compounds represented by general formula (I) and pharmacologically acceptable salts thereof {excluding (1R,2S)-2-[(2R)-(2-acetylamino-2-carboxyethyl)thiomethyl]-3-
oxo-1-cyclopentanecarboxylic acid (cystacycline)}, wherein X represents O...
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WO/1997/024115A1 |
Antitumor agents containing as the active ingredient 1,2,3,4,4a,7,8,8a-octahydro-1,4a,5-trimethyl-1-(3-methyl-5-o
xo-3-pentenyl)-2-naphthalenecarboxylic acids represented by chemical formula (I) or isomers or salts thereof.
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WO/1997/020805A1 |
Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in fo...
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WO/1997/020806A1 |
Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or anti-inflammatory activity as described, wherein in formul...
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WO/1997/020802A1 |
Indame dimer compounds and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or anti-inflammatory activity are described.
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WO/1997/014671A1 |
The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R3, R6, R7, R8, R11, R12, R13, A, Q, W, X, Y, Z and n are defined herein. The inven...
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WO/1997/014667A1 |
The invention concerns novel bicyclic cyclopentane-1,3-dione derivatives of formula (I), in which A, B, B', G, Q, X, Y and Z have the meanings indicated in the description, a method of producing said derivatives and their use as pest-con...
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WO/1997/003941A1 |
The compounds 3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dimethy
l-(1R,3R)-cyclopropane carboxylic acid, cis-3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dim
ethyl-cyclopropane carboxylic acid and (1R,5S)-4-(1,1-dichlor...
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WO/1997/001526A1 |
A process for the preparation of (+)-2-amino-bicyclo[3.1.0]-hexane-2-6-dicarboxylic acid, or a pharmaceutically acceptable salt thereof, which comprises hydrolysing (-)-2-spiro-5'-hydantoinbicyclo[3.1.0]hexane-6-carboxylic acid or a salt...
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WO/1996/032382A1 |
Substituted 1-phenylpyrazole-3-carboxamides of formula (I) are disclosed for use as compounds having high affinity for human neurotensin receptors.
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WO/1996/019990A1 |
The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and f...
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WO/1996/020156A1 |
The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-carboxylate dimers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for...
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WO/1996/020163A1 |
The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-carboxylate dimers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for...
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WO/1996/017819A1 |
The object of the present invention is to provide asiatic acid derivatives (I), its pharmaceutically acceptable salts or esters. Asiatic acid, its trisaccharide asiaticoside and madecassic acid, extracted from Centella asiatica have been...
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WO/1996/015096A1 |
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)xA-B-D-E-G, ...
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WO/1996/008473A1 |
An improved process for the preparation of R (+) 1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)m
ethyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operat...
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WO/1996/007405A1 |
The present invention provides compounds of formula (I) in which R is as defined in the specification, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are...
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WO/1996/005191A1 |
Compounds, methods and compositions are provided for inducing natriuresis in a mammal. Methods for isolating and synthesizing the natriuretic compounds are also provided. Therapeutic methods using the natriuretic compounds are also provi...
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WO/1996/005175A1 |
The present invention provides novel compounds that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders.
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WO/1996/004901A1 |
The present invention provides the use of an agonist which acts at negatively coupled cAMP-linked metabotropic glutamate receptors for the treatment of anxiety and related disorders.
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WO/1996/004900A1 |
The present invention provides the use of an agonist which acts at negatively coupled cAMP-linked metabotropic glutamate receptors for the manufacture of a medicament for the treatment of substance dependence disorders.
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WO/1996/003358A1 |
Halogenated compounds are prepared by ring opening reactions of highly fluorinated cyclopropanes with chlorine, bromine, iodine, or mixtures thereof at temperatures over 100 �C. A novel compound, which is one type of compound produced,...
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WO/1996/003366A1 |
The present invention relates to novel substituted bicyclic 2-mesityl cyclopentane-1,3-dione derivatives of the formula (I) in which A and Q together are alkane diyl or alkene diyl which may be substituted by alkyl, alkoxy, alkylthio, cy...
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WO/1996/001798A1 |
The present invention relates to novel 2-aryl-3-hydroxy-cyclopenet-2-en-1-one derivatives of formula (I) in which X is halogen, nitro, cyano, alkyl, alkoxy, alkenyloxy, alkylthio, alkyl sulphinyl, alkyl sulphonyl, halogen alkyl or haloge...
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WO/1995/021149A1 |
A cyclooctadiene derivative represented by general formula (I), and an agrohorticultural bactericide, antimold and antithrombocytic agent each containing the derivative (I) (i) or (ii), wherein A1 to A4 represent each COOR5 (R5 being H, ...
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WO/1995/015944A1 |
The invention describes compounds of formula (I), where A is an oxygen atom or a NH group; B is the radical -Zm-(CHQ)p-(CH=CH)q-(CH2)r-P, where Z is a -CO- group or -SO2-group, m is 0 or 1, p is 0, 1 or 2, q is 0, 1 or 2, r is 0, 1 or 2,...
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WO/1995/011242A1 |
Compounds of formula (I), wherein m is 1-4; R1-R4 independently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R6 is h...
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WO/1995/010266A1 |
A nitrogen monoxide synthesis inhibitor containing as the active ingredient at least one member selected from phenanthrene derivatives represented by the compounds of general formula (1) and salts thereof; it is useful for preventing and...
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WO/1995/008989A1 |
Novel compounds of general structural formula (I) have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cer...
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WO/1995/005354A1 |
Process for the hydroformylation of ethylenically unsaturated compounds, by reaction with carbon monoxide and hydrogen in the presence of a catalyst based on a metal of the platinum group, a source of anions other than halide anions and ...
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WO/1994/027947A1 |
This invention relates to substituted phenylcyclopropane derivatives, which carry various substituents on the cyclopropane ring, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for their...
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WO/1994/025013A1 |
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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WO/1994/024084A1 |
Novel cyclopentane derivatives are described which are endothelin receptor antagonists.
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WO/1994/018833A1 |
A plant growth promoter containing a jasmonic acid derivative represented by general formula (I) as the active ingredient (wherein R1 represents pentyl or pentenyl; and R2 represents hydrogen or alkyl). It has an excellent growth-promoti...
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WO/1994/009026A1 |
The new triterpenoids of general formulae (I), (II), (III) and (IV) where R1 represents a dialkyl, trialkyl, triphenyl, diphenylalkyl, alkyldiphenyl, dialkylphenyl, haloalkyl, halophenylalkyl, allylalkyl or alkylaminoalkyl group and R2 r...
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WO/1993/020035A1 |
A process for producing a compound represented by general formula[I] according to scheme (A), wherein R?1¿ represents alkyl; R?2¿ represents alkyl, optionally substituted phenyl, optionally substituted aralkyl or optionally substituted...
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WO/1993/018651A1 |
Novel cyclic anti-tumor promoter compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents.
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WO/1993/008799A1 |
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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WO/1993/007111A1 |
Compounds illustrated by general formula (I) useful as PDE IV inhibitors and for inhibiting the production of Tumor Necrosis Factor (TNF) are disclosed herein. In formula (I) R1 is C1-12 alkyl unsubstituted or substituted by 1 or more ha...
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WO/1992/019582A1 |
A novel (1R, 2S)-1-acyl-2-carboxycyclohex-4-ene derivative represented by general formula (I), and a process for producing the same. In the said formula, R?1� represents hydrogen, lower alkyl or (un)substituted aryl; and R?2� represe...
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WO/1992/019748A1 |
In addition to virions, herpesvirus-infected cells produce non-infectious particles, termed L-particles, which consist of tegument surrounded by envelope but lack the nucleocapsid. L-particles of a herpesvirus can be prepared substantial...
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