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JP4827189B2 |
Process of oxidizing an alcohol in an amide solvent with use of a mixed reagent containing hydrogen peroxide and a tungsten catalyst.
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JP2011528358A |
The present application describes modulators of MCP-1 or CCR-2 of formula (I), or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R1, R2, R4 and R6, are defined herein. In addition, methods ...
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JP4815883B2 |
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JP4796607B2 |
In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R<1> and R<2> independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or R<1> and R<...
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JP4741073B2 |
A process for the preparation of 1,6-hexanediol and 6-hydroxycaproic acid or esters thereof by catalytic hydrogenation of adipic acid, adipic acid monoesters or adipic acid diesters or streams of starting material which contain adipic ac...
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JP2011507909A |
Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.
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JP2011042791A |
To provide a photochromic material incorporatable in various polymer materials.The photochromic material includes a reaction product of (a) at least one ring-openable cyclic monomer and (b) a photochromic initiator. In other non-limiting...
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JP4626118B2 |
The process for producing a vic-dichloro acid fluoride compound in a short process and in good yield from the starting material which is inexpensive and readily available is provided. (R-EH1-)CRRCH2-OCOR(I) is fluorinated in a liquid pha...
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JP4615256B2 |
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JP4615710B2 |
The present invention relates to diterpene derivatives prepared from the components which are extracted from Acanthopanax Koreanum and represented by Chemical Formula (1).
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JP4615564B2 |
Various non-limiting embodiments disclosed herein related to photochromic materials comprising the reaction product of (a) at least one ring-opening cyclic monomer, and (b) a photochromic initiator. Other non-limiting embodiments related...
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JP2010540541A |
Compounds that reduce serum retinol levels are used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods, compounds, and compositio...
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JP4563997B2 |
A process for the production of 9-(Z)-retinoic acid is described which comprises reacting an alkali metal salt of 3-methyl-4-oxocrotonic acid with a C15-triphenyl-phosphonium salt. 9-(Z)-retinoic acid is used in the treatment of dermatol...
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JP4548863B2 |
Process for the recovery of oleanolic and maslinic acids contained in the subproducts resulting from the milling and processing of olives or parts thereof, either proceeding from three-phase or two-phase presses. This process enables to ...
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JP4550017B2 |
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JP4537576B2 |
The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogen...
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JP4527379B2 |
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JPWO2008111631A1 |
The present invention is to provide an important production intermediate of an optically active phthalazinone derivative [1] or a pharmaceutically acceptable salt thereof, which is useful as a drug. The present invention also provides a ...
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JP4472691B2 |
1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
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JP4463550B2 |
Are described compounds of Formula (I) in which R, R′, R″, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.
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JP4439265B2 |
This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-alpha or combinations thereof.
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JP2010508268A |
Diaryl ethers in which one of the aryl groups is a phenyl fused to a cycloalkyl or heterocyclic ring, to which is attached an acetic acid group, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compound...
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JP4435418B2 |
The present invention provides new retinoid compounds and uses of the compounds in humans and animals for chemoprevention of skin and/or breast cancer and for therapy of leukemia.
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JP2010053042A |
To provide a new compound having a potassium channel-controlling activity, especially a BK channel opening activity, and useful as a medicine, to provide a method for synthesizing the compound, to provide an intermediate useful for synth...
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JP2010505958A |
Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocat...
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JP4399932B2 |
The present inventions relate to a (1S,5R,6S)- or (1SR,5RS,6SR)-3-fluoro-2-oxobicycloÄ3.1.0Ühex-3-ene-6-carb
oxylic acid derivative represented by Formula (1): Äin the formula, R represents OR<1> or NR<1>R<2>, wherein R<1> and R<2> ar...
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JP2010006817A |
To provide a hydroxamic acid or carboxylic acid-functional compound (which can inhibit production of a tumor necrosis factor alpha (TNF-)), a pharmaceutical composition containing such a compound and a curing method using such a compound...
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JP4345413B2 |
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JP4345230B2 |
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. ...
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JP4344817B2 |
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JP2009530281A |
Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject where the variables are provided herein. Compositions and methods for using the compounds for pre...
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JP4313439B2 |
The present invention relates to novel 2-aryl-3-hydroxy-DELTA2-cyclopentene-1-one derivatives of the formula (I)in whichA, B, D1, D2, G, W, X, Y and Z are each as defined in the description,to processes for their preparation and to their...
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JP4231906B2 |
The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds eff...
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JP2009507846A |
Compounds are described that are active on at least one of PPARalpha, PPARdelta, and PPARgamma, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARalpha, PPARdelta, and PPARgamma.
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JP4222114B2 |
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JP4214537B2 |
Cyano and carboxy derivatives of substituted styrenes of formula I (a) X is -(CnH2n)- in which n has a value of 1, 2 or 3, and R<1> is alkyl of 1 to 10 carbon atoms, monocycloaIkyl of up to 10 carbon atoms, polycycloalkyl of up to 10 car...
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JP4212515B2 |
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JP4192331B2 |
Methods of resolving 2-oxobicyclo[3.1.0]hexane-6-carboxylates (I) into one enantiomer ester and the other enantiomer acid by contacting an enzyme with an ability to preferentially hydrolyze one enantiomer ester of 2-oxobicyclo[3.1.0]hexa...
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JP2008246401A |
To provide a solid catalyst for asymmetric Michael addition reaction easily separated from a product, enhanced in optical purity and prepared in an industrially inexpensive manner, and a manufacturing method of an optically active Michae...
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JP2008537957A |
Amooranin (AMR) has been found to cause tumor cell death through G2/m cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR ...
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JP4157770B2 |
The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury causedby radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound...
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JP4154707B2 |
To efficiently prepare a difluorodiene compound by an electrode reaction by electrolyzing a phenol compound using a mixed solution of hydrofuloric acid and a base (tetra- to hexahydrofluoride) as a solvent. A phenol compound of formula I...
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JP4129575B2 |
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JP4124656B2 |
A process for producing a 2-oxobicycloÄ3.1.0Ühex-3-ene-6-carboxylic acid derivative represented by a formula: (wherein R<1> represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkyl C1-6 alkyl group, a ...
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JP4120015B2 |
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JP4115523B2 |
The present invention relates to novel bicyclic cyclopentane-1,3-dione derivatives of the formula (I)to a process for their preparation and to their use as pesticides and herbicides.
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JP2008143912A |
To provide a novel immunotherapeutic agent and a method for reducing the level of cytokine and its derivatives with the use of this drug.The immunotherapeutic agent is a compound belonging to cyano and carboxy derivatives of substituted ...
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JP2008143850A |
To provide a dihydroxytetracyclododecanecarboxylic acid and its ester useful e.g. as a photosensitive resist raw material for semiconductor microfabrication, etc., and a resin raw material for optical materials having excellent optical p...
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JP2008133223A |
To provide an exo type hydroxytetracyclododecane carboxylic acids with a high exo/endo ratio.An exo type 9- or 8-hydroxy-3-carboxytetracyclo[4.4.0.12,5. 17,10]dodecanes having an exo/endo mol ratio of a carboxyl group of 80/20 to 100/0 a...
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JP4095153B2 |
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