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WO/2024/080872A1 |
Disclosed herein are dienophiles, in particular strained bicyclononenes, that can be used in fast bioorthogonal reactions, e.g. with dienes such as tetrazines. The strained bicyclononenes of the disclosure are stable under various condit...
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WO/2024/068511A1 |
A compound has the general Formula (I) (e.g., Floridiolic acid, 6-[(acetyloxy)methyl]-3,5- dihydroxy-4-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl (4aS,5R,6S,8aR)-5-[(3Z)-5-hydroxy-3- (hydroxymethyl)pent-3-en-l-yl]-5,6,8a-trimethyl-3,4,4a,...
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WO/2023/178061A1 |
Improved methods and intermediates thereof for preparing (1S,3S)-3-hydroxycyclohexane-1-carboxylic acid are described. These compounds are useful as intermediates for making carbamoyloxymethyl triazole cyclohexyl acid LPA antagonists.
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WO/2023/156429A1 |
The present invention relates to the field of organic synthesis and more specifically it concerns a process for preparing compound of formula (I). The compound of formula (V), the compound of formula (VI) and the compound of formula (VII...
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WO/2023/100574A1 |
Provided are: a radiation-sensitive resin composition that can be formed into a resist film having satisfactory levels of sensitivity and CDU performance even when a next-generation technology is applied; and a pattern formation method.ã...
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WO/2022/212833A9 |
The present invention relates to an improved method to produce isosteviol by acid hydrolysis using sulfuric acid. The use of isosteviol in the field of medicinal chemistry is also provided.
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WO/2023/055733A1 |
Disclosed herein are compounds, their pharmaceutical compositions, and their methods of use for treating a neurodegenerative disease, such as Alzheimer's disease, Lewy body dementia, or Parkinson' disease. In some embodiments, the compou...
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WO/2023/285883A1 |
Disclosed herein are embodiments of a bi-functionalized dicyclopentadiene monomer and polymer embodiments formed therefrom. The monomer embodiments exhibit tunability and can be used to form thermally stable homopolymers, copolymers, and...
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WO/2023/281040A1 |
The present invention relates to novel bi-functionalized trans-cyclooctenes of formula (I). It also relates to conjugates, compositions, medical uses of such compounds, and methods for producing such compounds as well as conjugates of su...
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WO/2023/282046A1 |
The present disclosure provides a compound represented by general formula (I). (In the formula, Ar represents an aromatic group. R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a nitro group, an alk...
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WO/2022/270230A1 |
Provided is an active-light-sensitive or radiation-sensitive resin composition that yields a pattern having exceptional cross-sectional rectangularity. This active-light-sensitive or radiation-sensitive resin composition contains: a resi...
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WO/2022/133544A1 |
Cannabidiol (CBD) cannabinoids and CBD cannabinoid analogues with, inter alia, antimicrobial activity, synthetic methods for the preparation thereof and medical uses and formulations containing same.
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WO/2022/103752A1 |
Disclosed herein is a process for achieving a palladium-catalyzed cyclative C(sp3)-H/C(sp2)-H coupling reaction using a native free carboxylic acid as a directing group, an amino acid ligand, and oxidant. The process is useful for synthe...
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WO/2022/097115A1 |
The present invention relates to an improved and efficient process for the preparation of Prohexadione and its calcium salt of formula (I). The present invention further relates to a one step process for preparation of ethyl 3,5-dioxo-4-...
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WO/2021/193565A1 |
In a preferred embodiment, this production method for a cyclic compound or a derivative thereof has: a drying step for subjecting a feedstock liquid containing the cyclic compound or the derivative thereof to a drying treatment to obtain...
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WO/2021/174475A1 |
Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.
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WO/2021/160192A2 |
Disclosed in the present invention is the use of kaurane compounds in a drug for preventing and treating sepsis, systemic inflammatory response syndrome (SIRS), and multiple organ failure caused by sepsis, said multiple organ failure inc...
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WO/2021/144812A1 |
The main object of present invention is to provide an industrially viable process for the preparation of cyclopropane acid of Formula I and intermediates thereof, that are useful in pharmaceutical and agrochemical industry, wherein R1 is...
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WO/2021/096849A1 |
This application relates to solid forms and salt forms of the PD-1/PD-L1 inhibitor 4,4'-(((((2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(azaned
iyl))bis(carbonyl))bis(1-methyl-1,4,6,7-tetrahydro-5H-imidaz
o[4,5-c]pyridine-2,5-diyl))bis(e...
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WO/2020/120837A1 |
A polymer composition and its use. The polymer composition contains antimicrobial material for inhibiting the growth of micro-organisms in close proximity to said polymer composition. The polymer composition comprises a polymeric substra...
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WO/2020/081837A1 |
This invention provides tablets comprising gemcabene calcium salt hydrate Crystal Forms 2 or C3, each having a PSD90 ranging from 35 urn to 90 urn as measured by laser light diffraction and wherein the tablet has a gemcabene dissolution ...
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WO/2019/175094A1 |
A cosmetic composition is provided, which comprises a carrier and a Vetiver root extract, in particular an extract from exhausted Vetiver root. This composition provides a stimulation of sebum production, stimulation of sebum antimicrobi...
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WO/2019/091194A1 |
Disclosed is a method for refining carnosic acid by means of molecular distillation, the method comprising the following steps: (1) the hydrotropy of carnosic acid: taking a product with a low content of carnosic acid and adding a hydrot...
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WO/2019/039553A1 |
Provided is a method for producing shikimic acid, by which shikimic acid is able to be obtained with high yield. A method for producing shikimic acid, which comprises a step for collecting shikimic acid from a solution that contains shik...
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WO/2019/040547A1 |
A versatile and effective manner to provide a single tablet or tablet arrangement or other medication delivery system for a combination of medications comprising of two or more active ingredients to be administered by, for example, sever...
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WO/2019/032879A1 |
The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs.
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WO/2018/227313A1 |
The invention relates to a selective dissolution method for obtaining at least one fraction of bark components, which comprises: (a) impregnating in vapour phase: a lignocellulosic material with a diameter less than 5 mm and a moisture c...
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WO/2018/159560A1 |
The purpose of the present invention is to provide: a radiation-sensitive resin composition which has excellent LWR performance, resolution, rectangularity of a cross-sectional shape, depth of focus and film shrinkage suppressing propert...
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WO/2018/096088A1 |
The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the prep...
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WO/2017/179727A1 |
The present invention is a radiation sensitive resin composition which contains a polymer having a first structural unit that contains an acid-cleavable group, a first radiation sensitive acid generator and a solvent, and wherein the fir...
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WO/2017/106279A1 |
Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater...
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WO/2017/095237A1 |
The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to prot...
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WO/2017/090656A1 |
Provided is a method for producing a trans-4-substituted-cyclohexanecarboxylic acid under mild conditions with high yield. A method for producing a trans-4-substituted-cyclohexanecarboxylic acid (1-A), involving a step of heating a mixtu...
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WO/2017/035271A1 |
The invention provides compounds having the general formula (I): (I) and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and c...
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WO/2016/192631A1 |
The present invention provides an abietane-type diterpene compound having lipid-lowering activity, a method for preparing same, and use of same. Specifically, the compound has the structure shown in formula I. The definitions of the grou...
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WO/2016/146588A1 |
The present invention relates to compounds of formula (I): in which R1 is a hydrogen atom, a phenyl radical, or a straight or branched, saturated or unsaturated hydrocarbon radical having 1 to 8 carbon atoms.
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WO/2016/109899A1 |
A method of restoring activity in phenylalanine hydroxylase is provided. The method comprises exposing the phenylalanine hydroxylase to shikimic acid, a functionally equivalent analogue thereof, a pharmaceutically acceptable salt of shik...
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WO/2016/081658A1 |
Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, br...
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WO/2016/040222A1 |
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein coupled receptor modulato...
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WO/2016/040223A1 |
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulato...
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WO/2016/040225A1 |
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulato...
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WO/2015/128200A1 |
The present invention relates to novel cannabigerol quinone derivatives of formula (I) wherein R is the carbon atom of a linear or branched group, represented by: aryl, alkenyl, alkynyl or alcoxycarbonil groups; or wherein R is the nitro...
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WO/2015/106050A1 |
The invention relates to (5)-3'-methyl-abscisic acid, and esters thereof, and methods of using and making these compounds.
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WO/2015/091328A1 |
The invention describes a method for separating a mandelic compound in salified form from an aqueous reaction medium resulting from the condensation reaction of a hydroxylated aromatic compound with glyoxylic acid in a basic medium, said...
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WO/2015/082034A1 |
The invention relates to a plasticizer containing at least a cyclohexanoic acid derivative of formula I, compositions containing said plasticizer and a polymer as well as the production thereof, and the use of cyclohexanoic acid derivati...
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WO/2015/078802A1 |
The present invention relates to compounds of general formula (I), wherein the groups R1, R2, R3, X, m and n are defined as in claim 1, wich have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate ...
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WO/2015/077611A1 |
Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ΕΚβ). The disclosed compounds may be formulated as pharmaceutical compositions and administe...
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WO/2015/056982A1 |
The present invention relates to a method for inducing customized pluripotent stem cells, pluripotent stem cells prepared by the method, and a composition comprising the pluripotent stem cells, wherein the customized pluripotent stem cel...
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WO/2014/193832A2 |
The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compos...
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WO/2014/190070A1 |
The present disclosure relates to novel fullerene derivatives, positive and negative photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for hig...
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