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Matches 751 - 800 out of 1,045

Document Document Title
JP3325370B2  
JP2002529533A
The invention relates to 1-aminoethylquinoline derivatives, to pharmaceutical compositions containing them, to therapeutic methods of using them and to processes for preparing them.  
JP2002528454A
The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.  
JP3315699B2
Compounds of Formula (I) wherein R<2>, R<3>, R<4>, R<10> and R<11> have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinary incontinence. Also disclosed are p...  
JP2002524102A
Xanthan esters and acridans are substrates for horseradish peroxidase. These stable, enzymatically cleavable chemiluminescent esters are substrates for horseradish peroxidase which, together with peroxide is among the extensively used en...  
JP2002521350A
A process for hydrogenating an unsaturated heterocyclic compound or a mixture of two or more thereof by contacting the unsaturated heterocyclic compounder the mixture of two or more thereof with a hydrogen-containing gas in the presence ...  
JP2002519412A
This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation...  
JP2002519404A
(57) [Summary] The present invention relates to a complex-forming agent of formula (I) containing a novel photosensitizer, which is used in bioaffinity assays, especially HTRF (homogeneous time-resolved fluorescence) assays. It can gener...  
JP2002518410A
Chemiluminescent labeling compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic double bond and further contain a labeling substituent which permits attachement to com...  
JP2002515913A
(57) [Summary] The present invention is based on the general formula (I) :.(In the formula, X, Y, Z, R1, R2And m are defined herein) in novel N-substituted azaheterocyclic compounds, or salts thereof, in methods for preparing them, in co...  
JP2002155080A
To provide a medicine that includes a novel hydrazide derivative having the APO B-relating lipoprotein excretion-inhibitory activity as an active ingredient.The objective compound is a hydrazide derivative represented by the following fo...  
JP3285963B2
PURPOSE: To prepare a new compd. useful as a cell potassium channel starting agent in mammals and to form treating agents for the incontinence of urine. CONSTITUTION: The compd. of the formula I [R1 is 1,2,3,4-tetrahydro-6-naphthyl, 1-na...  
JP3276960B2
Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cy...  
JP3271052B2
To obtain a new compound useful as a photo-polymerization initiator for ethylene unsaturated compound and a photo-reaction initiator for the photo- setting of a pigment system as a printing ink or a white lacquer. This compound is expres...  
JP2002506427A
Certain derivatives of acridones and benzothiadiazines have been found to have anti-cancer properties by virtue of their specific inhibition of the cyclin D dependant kinase CDK4. These molecules inhibit CDK4 activity more than they inhi...  
JP3248628B2
PURPOSE: To obtain a new chemiluminescent compound useful as a labeled compound in the chemiluminescence analysis and highly stable in neutral aqueous solution. CONSTITUTION: The compound is an acridinium compound expressed by formula I ...  
JP3231777B2
N-alkylacridan carboxylic acid derivative compounds (I) are used to generate chemiluminescence by the action of a peroxidase enzyme and an oxidant. The compounds I are useful in assays of all types.  
JP2001516760A5  
JP2001264828A
To easily manufacture an optical amplifying device, optical switching device or the like, to easily carry out hologram recording, and to provide an optical device which uses the nonlinear optical effect of a polymer composite material.Th...  
JP2001244076A
To provide a organic compound which is useful for manufacturing an organic EL element having a long life, high luminance and a high performance emission.A acridine derivative compound is useful as the materials for the organic compound l...  
JP2001513583A
The present invention relates to conjugates for differentiating between healthy and unhealthy tissue, methods of producing such conjugates as well as their use.  
JP2001512104A
The present invention relates to bis-acridinecarboxamides and the derivatives thereof substituted with aminoalkyl chains, have evidenced a remarkable antitumor activity, in particular in colon tumors.  
JP2001213865A
To provide a new charge controlling agent for toner of electrophotography.The objective charge controlling agent is composed of a compound selected from 1,4-dihydropyridine compounds expressed by general structural formula (the definitio...  
JP3190348B2
The invention relates to methods for simultaneously or sequentially detecting multiple nucleic acid analytes in a single medium utilizing oligonucleotide hybridization probes coupled to different chemiluminescent labeling reagents. The m...  
JP2001509142A
This invention provides methods for the treatment or inhibition of oral squamous cell carcinoma which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene B4 antagonist.  
JP2001509152A
This invention relates to substituted bis-acridines and related compounds which are ligands, in particular, antagonists of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated ...  
JP2001509143A
This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene B4 antagonist.  
JP3182720B2
To obtain a mew α-aminoacetophenone derivative bearing allyl or aralkyl group on the α-site, having especially high activity as a photoinitiator, and effectively usable in esp. printing inks. This new derivative is a compound (acid-add...  
JP2001172244A
To provide various kinds of polyamine analogs and derivatives useful as medicines, agrochemicals or environmentally useful agents.The polyamine analog or derivative is an N1-monosubstituted polyamine bonding to the polyamine bonding site...  
JP2001158794A
To provide a compound for the chemoluminescent detection of a phosphatase enzyme, stable to heat and hydrolysis at room temperature for a prolonged period and cuttable with the phosphatase enzyme cutting the phosphate site.The objective ...  
JP3176154B2
PURPOSE: To provide the light control element having high heat resistance and long life by specifying the constituting components of the complex crystal. CONSTITUTION: This complex crystal is constituted of the cation of a polycylic arom...  
JP3173731B2
PURPOSE: To obtain new π compounds having a molecular structure of an extended 5-conjugation and especially useful as an electronic organic material. CONSTITUTION: Compounds of formula I (Ar is heterocyclic aromatic; n is 1 or 2; Provid...  
JP3172522B2
In accordance with the present invention, specific binding assays are disclosed which utilize an chemiluminescent compound, i.e., moiety, which has increased stability in aqueous solution. The chemiluminescent moiety is an ester, thioest...  
JP2001506644A
The present invention relates to the preparation of novel catalysts made from transition metal compounds and "tridentate" 4,5-diphosphinoacridine ligands ("acriphos"). The novel ligands employed herein are diphosphine compounds of 4,5-di...  
JP3169383B2
Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or su...  
JP3157924B2
PURPOSE: To provide a new compd. which is useful as a potassium channel initiator in cells of mammals such as a human, and therefore, which is useful for the treatment for urinary incontinence. CONSTITUTION: This compound is a new compd....  
JP2001503977A
The present invention relates to genetic mutations in mitochondrial genes that segregate with diabetes mellitus. The invention provides methods for detecting such mutations, as a diagnostic for diabetes mellitus, either before or after t...  
JP2001504226A
Methods of detecting analytes or target species using two enzyme-labeled specific binding partners where the two enzymes function in concert to produce a detectable chemiluminescent signal are disclosed. The methods use a specific bindin...  
JP2001503399A
PCT No. PCT/GB97/02886 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17650 PCT Pub. Date Apr. 30, 1998A compound which is a bis(acridinecarboxamide) or bis(phenazinecarboxamide) deri...  
JP3145124B2
Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo u...  
JP2001502682A
PCT No. PCT/GB97/02884 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17649 PCT Pub. Date Apr. 30, 1998A process for producing an acridine carboxamide of formula (I): wherein each of ...  
JP2000344685A
To obtain a new compound having high binding specificity to β-amyloid protein, high blood-brain barrier permeability, usable as a graphic diagnosis probe for diseases accumulating amyloid, useful as a composition for graphic diagnosis.T...  
JP2000515520A
The invention concerns novel glyoxylic acid derivatives, a process for their preparation and their use as pesticides.  
JP2000508677A
Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...  
JP2000143634A
To stabilize the subject compound useful as a marker in chemiluminescence immunoassay by adding a luminescent acridinium compound to an aqueous medium containing a specific amount of specified dioxane so as not to reduce the luminescence...  
JP3038339B2
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeuticall...  
JP3033181B2
NEW MATERIAL:A compound of formula I [R<1> is alkyl; R<2> is alkyl, formula II ((l) is 1-3), etc., or R<1> and R<2> form formula III, etc., together with the adjacent N atom; the ring A is formula IV (R<5> is H, halogen), etc.; the ring ...  
JP2000502988A
A method of treating neoplastic disease which comprises the steps of: (a) administering to a patient in need of such treatment an effective amount of a radiation-activated cytotoxin prodrug (RACP) which has low toxicity, which can be red...  
JP3013989B2
To obtain a new amide derivative capable of providing a medicine having a analgesic effect through nociceptin competitive inhibiting activities, against acute pain or the like after operation. This new amide derivative is a compound of f...  
JP2000501092A
PCT No. PCT/GB96/02945 Sec. 371 Date Aug. 25, 1998 Sec. 102(e) Date Aug. 25, 1998 PCT Filed Nov. 28, 1996 PCT Pub. No. WO97/19929 PCT Pub. Date Jun. 5, 1997Compounds of Formula (I), methods for their preparation, pharmaceutical formulati...  

Matches 751 - 800 out of 1,045