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Patent Searching and Data


Matches 251 - 300 out of 1,045

Document Document Title
WO/2002/064545A1
The present invention relates to acylated indanyl amines according to the general formula (I) where R?1¿-R?4¿ have the meanings given in the description, A is CH¿2? CHOH or CH-(C¿1?-C¿3?-alkyl), B is CH¿2? or CH-(C¿1?-C¿3?-alkyl)...  
WO/2002/059096A1
Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-...  
WO/2002/055503A1
In accordance with the present invention, nanometer-scale reversable electronic switches are provided that can be assembled to make cross-bar circuits that provide memory, logic, and communications functions. The electronic switches, or ...  
WO/2002/051942A1
The present invention relates to a process for dyeing or printing manufactured natural polymer or synthetic hydrophobic fibre materials, characterized in that it comprises using dyes of the formula (I), where R¿1? is hydrogen, hydroxyl ...  
WO/2002/043449A1
A luminescent element which comprises an anode, a cathode, and a luminescent substance interposed therebetween and which luminesces upon reception of electric energy, characterized by having at least one of the following compounds (a) to...  
WO/2002/036568A1
Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ are any of a number of groups as defined in the specification, A and D are as defined in the specifi...  
WO/2002/032875A1
The invention relates to an agent which inactivates pathogens and to the use thereof. Said agent contains an element that bonds with the nucleic acids of the pathogens and a conjugate, which destroys nucleic acid. The conjugate is produc...  
WO/2002/028837A1
The present invention concerns compounds of formula. In a preferable embodiment, X represents O; R?1¿ represents C¿1-6?alkyl; cycloC¿3-12?alkyl or (cycloC¿3-12?alkyl)C¿1-6?alkyl, wherein one or more hydrogen atoms in a C¿1-6?alkyl-...  
WO/2002/008193A2
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is =O, L is -H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is...  
WO/2002/008192A1
The invention relates to novel heteroaryl derivatives of general formula (1), the production thereof and the use of the same as pharmaceuticals, especially for treating tumours.  
WO/2002/008194A1
The invention relates to novel acridine derivatives of general formula (1), the production thereof and the use of the same as pharmaceuticals, especially for treating tumours.  
WO/2002/008190A2
The invention relates to novel pyridine derivatives of general formula (1), the production and use thereof as medicaments, in particular for the treatment of tumours.  
WO/2002/000726A1
Methods are disclosed for producing electrochemiluminescence by electrochemically oxidizing an acridan compound at an electrode in the presence of a peroxide. Maintaining a sufficiently positive potential results in continuous oxidation ...  
WO2000064864A9
Compounds of formula (I) or (II), wherein X represents H, C1-6 alkyl or C1-6 alkoxy, said alkyl or alkoxy being optionally substituted with one or more groups; a is 0,1,2,3 or 4; Y represents H or C1-6 alkyl; 1, 2 or 3 of the members Z o...  
WO/2001/092218A2
Novel 'bispolyamine' inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...  
WO/2001/087830A2
The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredn...  
WO/2001/083484A1
The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.  
WO/2001/076567A1
The present invention provides an anti-tumor chemotherapeutic to a patient having a tumor, the composition comprising: microspheres incorporating the anti-tumor chemotherapeutic; and, a suspending solution which surrounds the microsphere...  
WO/2001/070699A1
Compounds of the general formula (II), particularly BF-009, useful as probes in the diagnostic imaging for diseases due to accumulation of amyloid; and compositions and kits for the diagnostic imaging for diseases due to accumulation of ...  
WO/2001/064645A2
The invention provides a compound of formula (I), wherein A, Ra, Rb, R¿1? to R¿5?, m and t are as defined as disclosed, or a pharmaceutically acceptable salt or ester thereof, useful as alpha-2 antagonist. The compounds I can be used f...  
WO/2001/060822A1
The invention concerns compounds of formula (I) wherein: 0$m(F)n$m(F)3; 0$m(F)m$m(F)6; R¿3? and R¿4? together form a phenyl ring; B represents a heteroaryl group; R¿1? and R¿2? represent a hydrogen atom or groups as defined in the de...  
WO/2001/060801A2
The invention is directed to novel 9-hydroxyalkylamino-, 9-alkoxyalkylamino-1-nitroacridine derivatives. Methods of preparation, pharmaceutical compositions comprising said derivatives and their medical use are also encompassed by this i...  
WO/2001/047899A1
The invention relates to substituted piperazine derivatives of general formula (I), wherein R¿a? to R¿c?, Y¿a?, Y¿b?, X and n have the meanings given in claim no.1, and isomers and salts thereof, especially physiologically suitable s...  
WO/2001/041773A1
Therapeutic compounds and compositions for the treatment of infectious diseases are disclosed. The compounds are xanthones and xanthone derivatives, such as 3,5-bis-$g(e)-(N,N-diethylamino)amyloxyxanthone. The described compositions incl...  
WO2001009372B1
Chemiluminescent substrates of hydrolytic enzymes are disclosed having general Formula Lumi-M-P, where Lumi is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached, wherein the ...  
WO/2001/037826A1
NPYY5 receptor antagonists which contain compounds represented bygeneral formula (I), prodrugs thereof, pharmaceutically acceptable salts thereof or solvates of the same wherein R?1¿ represents lower alkyl, cycloalkyl, etc.; R?2¿ repre...  
WO/2001/035103A1
The object of the present invention is to provide a new means of stabilizing a luminescent acridinium compound in an aqueous medium thereby preventing a decrease in the emission yield from the compound over time in storage in the aqueous...  
WO/2001/023497A1
An organic electroluminescent element which has a high color purity, high luminescent efficiency, and long life and emits a red color; and a novel compound. The organic electroluminescent element comprises at least one pair of electrodes...  
WO/2001/017529A1
A series of tacrine derivatives has been synthesized and disclosed. These tacrine derivatives were claimed to be new and be useful for the treatment of Alzheimer's disease alone or in combination with other drugs for Alzheimer's disease....  
WO/2001/012584A2
Compounds or their salts of general formula (I): A$m(Y)B$m(Y)N(O)¿s? wherein: s is an integer equal to 1 or 2; A = R$m(Y)T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1c?, R¿1c? is H or a...  
WO/2000/076982A1
The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and...  
WO/2000/066528A2
Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.  
WO/2000/066587A2
Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. A...  
WO/2000/066175A2
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are prov...  
WO/2000/066782A2
The present invention relates to genetic mutations in mitochondrial genes that segregate with diabetes mellitus. The invention provides methods for detecting such mutations, as a diagnostic for diabetes mellitus, either before or after t...  
WO/2000/061537A2
Compounds or their salts having general formulas (I) and (II): wherein s is and integer equal to 1 or 2, preferably s = 2; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C¿...  
WO/2000/061541A2
Compounds or their salts having general formulas (I) and (II) wherein: s = is an integer equal to 1 or 2, preferably s = 2; b0 = 0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the descript...  
WO/2000/046187A2
The present invention is directed to agmatine and polyamine analogs and their use as drugs, as well as agricultural or environmentally useful agents. As drugs, the analogs decrease cellular polyamine levels, possibly by inducing antizyme...  
WO/2000/040560A1
A compound of formula (I) wherein X¿1? is bond or -OCH¿2?-; X¿2? is -(CH¿2?)¿n?-, in which n is 1, 2 or 3; X¿3? is bond, -O-, -S-, -OCH¿2?-, or -NH-; R?1¿ is phenyl or pyridyl each of which may have one or two substituent(s) sele...  
WO/2000/037447A1
The present invention relates to new 9-aminoacridine derivatives of general formula (I), wherein A is hydrogen or (II) (wherein X is oxygen or sulfur, R¿1?, R¿2?, R¿3?, R¿4? and R¿5? are independently hydrogen, halogen, nitro, amino...  
WO/2000/035900A1
The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods....  
WO2000009487A9
Our results thus identify two sets of necessary and sufficient criteria for observing long-wavelength emission from acridinium compounds: Set A: (a) the creation of an extended conjugation system by the attachment of appropriate function...  
WO/2000/032175A2
The invention provides pharmaceutical non-peptidic organic compounds capable of interacting with a functionally defective form of a mutant or a wild-type tumor suppressor protein of the p53 family (such as p53, p63 or p73). The interacti...  
WO/2000/031543A1
The present invention discloses a method for the measurement of hydride using a chemiluminescent compound, such as an acridinium compound. The source of hydride for the reduction of acridinium compound may be of chemical or biochemical o...  
WO/2000/029379A1
The invention concerns compounds of general formula (I) wherein: A represents a hydrogen atom, an azido, a halogen, a hydroxy, a thiol, an amino, a phenyl, a C¿1?-C¿6? alkyl, C¿1?-C¿6? alkylamino, di(C¿1?-C¿6? alkyl)amino, hydroxyl...  
WO/2000/024743A1
The present invention provides novel compounds of formula (I) which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.  
WO/2000/021920A1
Compounds of the formula (1a), wherein R1 is a group of the formula (2) where R1, R2, A, B, U, V, W, X, Y, Z, k and n have the significance given in the specification, are useful to treat rheumatoid arthritis, psoriasis, multiple scleros...  
WO/2000/015617A1
The invention concerns a compound of formula (I) wherein: A represents a hydrogen atom or hydroxy; B represents a hydrogen atom, a C¿1?-C¿8? alkyl, a C¿2?-C¿8? alkenyl, a fluoro-C¿1?-C¿8? alkyl or a C¿1?-C¿2? perfluoroalkyl, a ph...  
WO/2000/015618A1
Xanthan-esters and acridans are substrates for horseradish peroxidase. These stable, enzymatically cleavable chemiluminescent esters are substrates for horseradish peroxidase which, together with peroxide is among the extensively used en...  
WO/2000/005184A1
The invention relates to a method for hydrogenating a heterocyclic compound or a mixture of two or more heterocyclic compounds by bringing said unsaturated heterocyclic compound or mixture of two or more heterocyclic compounds into conta...  

Matches 251 - 300 out of 1,045