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Matches 451 - 500 out of 5,290

Document Document Title
WO/2008/154347A1
The present invention is directed to a compound of Formula (I) or a form thereof: wherein U, V, W and Ring A are as defined herein, useful as vasopressin receptor antagonists.  
WO/2008/150842A1
The invention relates to an ionic liquid composition and a method for preparing the ionic liquid. The ionic liquid comprises a cation containing the Formula I, disclosed, and wherein: n is 1 or 2, R1 is selected from the group consisting...  
WO/2008/150954A1
Methods and compounds are disclosed for treating dry age-related macular degeneration, and preventing or delaying the onset of wet age-related macular degeneration.  
WO/2008/146308A2
The present invention encompasses a process for the preparation of highly pure ivabradine hydrochloride by treating ivabradine with alcoholic hydrogen chloride. The invention further encompasses amorphous ivabradine hydrochloride and pro...  
WO/2005/025498A3
Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic...  
WO/2008/141082A1
The aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepine derivative compounds of the present invention are represented by formulae (I) (A-E) having the following structure where the carbon atom designated * is in the R or S confi...  
WO/2008/141081A1
The aryl- and heteroaryl-substituted tetrahydrobenzo-l,4-diazepine derivative compounds of the present invention are represented by formulae 1(A-D) having the following structure: where the substituents X and R1 -R8 are as defined herein.  
WO/2008/066620A3
This invention relates to novel 11-[4-[2-(2-Hydroxyethoxy)ethyl]piperazin-1- y1]dibenzo[b,f][1,4]thiazepine derivatives, their acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides composi...  
WO/2008/135524A2
The present invention relates to substituted anthranilamides of general formula (I), wherein D, M, A4, A5, R2, R3, R4and R6 are defined as in the specification. The compounds have an antithrombotic and a factor Xa inhibiting activity.  
WO/2007/121432A3
The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, poly...  
WO/2008/125006A1
A novel preparation process for ivabradine which is the medicine for angina pectoris, wherein compound III is obtained from compound II by catalytic hydrogenation, and then compound III is alkylated with compound IV to obtain compound I....  
WO/2008/116308A1
The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS...  
WO2007104933A8
The invention provides a new method for treating disorders associated with activation of the Notch signal transduction pathway comprising administering an effective amount of a compound of Formula (I), in free form or in a pharmaceutical...  
WO/2008/108639A1
The present invention provides a novel crystalline form of a cocrystal of carbamazepine : glycolamide and of a co-crystal of carbamazepine : lactamide. The invention further provides methods for the preparation of a co-crystal of carbama...  
WO/2008/104589A1
The present invention relates to a novel dosage form, to a process for preparing the dosage form and to the use of the dosage form in the treatment of neurological and psychiatric disorders.  
WO/2008/105445A1
Disclosed is a transdermal pharmaceutical composition characterized by blending eptazocine hydrobromide with a fatty acid ester, a glycerin fatty acid ester and a glycol or a pyrrolidone. Also disclosed is a method for enhancing the tran...  
WO2008064887A8
The invention relates to a method for preparing an intermediate compound for a diisocyanate, comprising reacting a diamine represented by the formula H2N-(CH2)0-Y-(CH2)p-NH2 wherein Y is selected from CH(OX) or CH(COOX), o and p each are...  
WO/2008/059513A3
Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmac...  
WO2008053393A8
Electromechanical rotary actuator (52) for moving shutters (13) of gates or doors, comprising a motor enclosed in a casing (50), a rotating arm (56) connected to the motor for moving the shutter or swinging door, a movable catcher (72) f...  
WO/2007/145922A3
Benzazepinone compounds represented by Formula (I), or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other t...  
WO/2008/097546A2
Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a...  
WO/2008/092786A1
The invention relates to 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives of Formula (I) wherein R 1, R 2 and R 3 are as defined herein, as γ-secretase inhibitors useful in the treatment of Alzheimer's disease or common cancer i...  
WO/2008/070111A3
The present invention provides processes and intermediates for the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and salts thereof which are useful as serotonin-2C (5-HT2C) receptor agonists for the treatment o...  
WO/2008/093737A1
Disclosed is a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor. (I) wherein R1a represents a hydrogen atom, a C1-6 alkyl group which may be substituted, or the l...  
WO/2008/055068A8
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein (B), Q, J, L and Z are as defined in the specification.  
WO/2008/053393A3
Electromechanical rotary actuator (52) for moving shutters (13) of gates or doors, comprising a motor enclosed in a casing (50), a rotating arm (56) connected to the motor for moving the shutter or swinging door, a movable catcher (72) f...  
WO/2008/081726A1
Disclosed is a process for producing an amide or a lactam in a simple manner and in high yield by allowing the rearrangement reaction of an oxime compound to proceed while preventing the production of a by-product such as ammonium sulfat...  
WO/2007/149728A3
Aryl tetrahydrobenzazepine derivatives with minimal 5-HT2B activity relative to 5-HT2A and 5-HT2C activity that are useful for treating glaucoma are disclosed.  
WO/2008/075006A1
The invention provides compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, g, h and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharma...  
WO/2007/120517A3
The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor ago...  
WO/2008/070111A2
The present invention provides processes and intermediates for the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and salts thereof which are useful as serotonin-2C (5-HT2C) receptor agonists for the treatment o...  
WO/2008/064887A1
The invention relates to a method for preparing an intermediate compound for a diisocyanate, comprising reacting a diamine represented by the formula H2N-(CH2)0-Y-(CH2)p-NH2 wherein Y is selected from CH(OX) or CH(COOX), o and p each are...  
WO/2008/065681A2
The present invention provides a process for preparing Ivabradine of formula (I) or its pharmaceutically acceptable salts, solvates, hydrate thereof, by reacting 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trie n-7-yl]methyl}...  
WO/2008/059513A2
Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmac...  
WO/2008/055068A2
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein (B), Q, J, L and Z are as defined in the specification.  
WO2008012837A8
Disclosed herein is a process for producing 10-oxo-10,11-dihydro-5H-dibenz[bf] azepine-5-carboxamide of formula I via novel intermediates 11-alkoxy-10-halo-10,11-dihydro-5H-dibenzo [b,f ] azepine-5-carbonitrile [XIX] or 10-alkoxy-5H-dibe...  
WO/2008/054609A2
An approach to designing families of cocrystals with desired (tunable) pH dependent dissolution is developed. The solubility and dissolution rate of a family of cocrystals with the same API and a series of ligands that are weak acids or ...  
WO/2007/135293A3
The invention especially relates to 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation thereof, compositions containing the same, and the use thereof as medicaments, especially anticancer drugs. Formula (I).  
WO/2008/049808A1
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for prepar...  
WO/2008/011539A3
In one embodiment the invention provides novel compounds of Formula (I) as well as prodrugs, salts, hydrates, solvates and N-oxides thereof. The invention also provides pharmaceutical compositions that include such compounds as well as m...  
WO/2008/038053A1
Compounds of general formula (1) and pharmacologically acceptable salts and prodrugs thereof: Formula(1) wherein A and B are CH2 or CH2CH2, R1 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl or heteroaralkyl, R2, R3 and R4 are selected fro...  
WO/2008/038578A1
Disclosed are an optically active quaternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof by using the quaternary ammonium salt. The optically active quaternary ammonium salt h...  
WO/2007/115943A3
Process for the preparation of an N-alkyl lactam with improved colour quality, where 0.01 to 10% by weight of a C1-10-alcohol or a compound which releases 0.01 to 10% by weight of a C1-10-alcohol is added to the N-alkyl lactam. Mixture c...  
WO/2007/080131A3
Compounds of formula (I) wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredie...  
WO/2007/146838A3
Substituted phenyl acetic acid compounds of formula (I), pharmaceutical compositions, methods for their preparation and methods are provided that are useful in the treatment and prevention of disorders or conditions responsive to DP-2 re...  
WO/2008/022945A1
The invention relates to compounds of the general formula (I) in which A, B, D, Y, R1, R2, R3, R4 and R5 are defined as per claim 1, to their enantiomers, their diastereomers, their mixtures and their salts, especially their physiologica...  
WO/2008/019572A1
This invention belongs to pharmacy field. Meptazinol biligand derivatives,salts, preparation method and uses thereof in the treatment CNS degenerative diseases including Alzheimer's type and dementia. The method comprises crude materials...  
WO2006105304A8
Leukotrfene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and inflammatory conditions.  
WO/2008/012837A1
Disclosed herein is a process for producing 10-oxo-10,11-dihydro-5H-dibenz[bf] azepine-5-carboxamide of formula I via novel intermediates 11-alkoxy-10-halo-10,11-dihydro-5H-dibenzo [b,f ] azepine-5-carbonitrile [XIX] or 10-alkoxy-5H-dibe...  
WO/2008/012524A1
The present invention relates to novel analine derivatives and their use in therapy, in particular their use in the treatment of fungal infections.  

Matches 451 - 500 out of 5,290